Methyltransf_11 domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methyltransferase domain containing protein, putative

Species:

Leishmania major

UniProt:

E9AEX9_LEIMA

TriTrypDb:

LmjF.35.1570 , LMJLV39_350022100 , LMJSD75_350021300

Length:

346

Annotations

LeishMANIAdb annotations

Homologous to yeast mitochondrial OMS1 methyltransferase, but many Kinetoplastid homologs lack the transit signal.. One sub-group of these proteins have an N-terminal membrane anchor, while others might possess an internal Tm segment potentially targeted to mitochondria.. Localization: Mitochondrial (by homology) / Others (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E9AEX9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEX9

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	2
GO:0032259	methylation	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0008168	methyltransferase activity	4	4
GO:0016740	transferase activity	2	4
GO:0016741	transferase activity, transferring one-carbon groups	3	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	220	224	PF00656	0.333
CLV_C14_Caspase3-7	54	58	PF00656	0.572
CLV_NRD_NRD_1	47	49	PF00675	0.449
CLV_PCSK_FUR_1	112	116	PF00082	0.400
CLV_PCSK_KEX2_1	114	116	PF00082	0.388
CLV_PCSK_KEX2_1	215	217	PF00082	0.443
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.388
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.545
CLV_PCSK_SKI1_1	115	119	PF00082	0.387
CLV_PCSK_SKI1_1	254	258	PF00082	0.443
CLV_PCSK_SKI1_1	48	52	PF00082	0.360
CLV_PCSK_SKI1_1	91	95	PF00082	0.449
DOC_CYCLIN_yCln2_LP_2	242	248	PF00134	0.229
DOC_MAPK_gen_1	114	123	PF00069	0.561
DOC_MAPK_gen_1	254	264	PF00069	0.243
DOC_MAPK_MEF2A_6	257	265	PF00069	0.243
DOC_PP4_FxxP_1	35	38	PF00568	0.578
DOC_USP7_MATH_1	9	13	PF00917	0.682
DOC_USP7_UBL2_3	114	118	PF12436	0.581
DOC_USP7_UBL2_3	211	215	PF12436	0.345
DOC_WW_Pin1_4	267	272	PF00397	0.243
DOC_WW_Pin1_4	294	299	PF00397	0.295
LIG_14-3-3_CanoR_1	203	212	PF00244	0.243
LIG_14-3-3_CanoR_1	216	225	PF00244	0.243
LIG_14-3-3_CanoR_1	287	295	PF00244	0.295
LIG_AP2alpha_1	278	282	PF02296	0.268
LIG_BIR_III_2	57	61	PF00653	0.575
LIG_FHA_1	23	29	PF00498	0.706
LIG_FHA_1	319	325	PF00498	0.260
LIG_FHA_1	84	90	PF00498	0.596
LIG_FHA_2	337	343	PF00498	0.385
LIG_LIR_Gen_1	227	237	PF02991	0.243
LIG_LIR_Nem_3	106	110	PF02991	0.594
LIG_LIR_Nem_3	139	143	PF02991	0.424
LIG_LIR_Nem_3	162	166	PF02991	0.254
LIG_LIR_Nem_3	207	212	PF02991	0.243
LIG_LIR_Nem_3	227	233	PF02991	0.150
LIG_LIR_Nem_3	270	275	PF02991	0.257
LIG_LIR_Nem_3	320	325	PF02991	0.258
LIG_LYPXL_SIV_4	271	279	PF13949	0.254
LIG_LYPXL_yS_3	272	275	PF13949	0.293
LIG_LYPXL_yS_3	327	330	PF13949	0.303
LIG_PCNA_yPIPBox_3	294	303	PF02747	0.243
LIG_Pex14_1	277	281	PF04695	0.245
LIG_Pex14_1	97	101	PF04695	0.590
LIG_Pex14_2	140	144	PF04695	0.429
LIG_Pex14_2	278	282	PF04695	0.243
LIG_PTB_Apo_2	312	319	PF02174	0.292
LIG_PTB_Phospho_1	312	318	PF10480	0.296
LIG_REV1ctd_RIR_1	138	146	PF16727	0.447
LIG_RPA_C_Fungi	302	314	PF08784	0.333
LIG_SH2_CRK	163	167	PF00017	0.283
LIG_SH2_CRK	202	206	PF00017	0.280
LIG_SH2_STAT3	101	104	PF00017	0.472
LIG_SH2_STAT3	281	284	PF00017	0.340
LIG_SH2_STAT5	107	110	PF00017	0.469
LIG_SH2_STAT5	281	284	PF00017	0.304
LIG_SH2_STAT5	302	305	PF00017	0.296
LIG_SH2_STAT5	323	326	PF00017	0.295
LIG_SH3_3	142	148	PF00018	0.394
LIG_SH3_3	252	258	PF00018	0.293
LIG_SH3_3	268	274	PF00018	0.242
LIG_SH3_3	322	328	PF00018	0.338
LIG_SUMO_SIM_par_1	259	266	PF11976	0.281
LIG_TYR_ITIM	325	330	PF00017	0.343
LIG_TYR_ITSM	318	325	PF00017	0.313
LIG_WRC_WIRS_1	137	142	PF05994	0.321
MOD_CDC14_SPxK_1	297	300	PF00782	0.315
MOD_CDK_SPxK_1	294	300	PF00069	0.315
MOD_CK1_1	20	26	PF00069	0.736
MOD_CK1_1	66	72	PF00069	0.512
MOD_CK2_1	303	309	PF00069	0.329
MOD_CK2_1	336	342	PF00069	0.476
MOD_GlcNHglycan	19	22	PF01048	0.663
MOD_GlcNHglycan	258	261	PF01048	0.296
MOD_GlcNHglycan	9	12	PF01048	0.707
MOD_GSK3_1	63	70	PF00069	0.575
MOD_NEK2_1	159	164	PF00069	0.296
MOD_NEK2_1	189	194	PF00069	0.322
MOD_NEK2_1	303	308	PF00069	0.296
MOD_NEK2_2	136	141	PF00069	0.379
MOD_PKA_2	7	13	PF00069	0.615
MOD_PKB_1	216	224	PF00069	0.423
MOD_Plk_4	136	142	PF00069	0.300
MOD_Plk_4	318	324	PF00069	0.316
MOD_ProDKin_1	267	273	PF00069	0.280
MOD_ProDKin_1	294	300	PF00069	0.353
MOD_SUMO_rev_2	305	313	PF00179	0.296
MOD_SUMO_rev_2	332	341	PF00179	0.419
TRG_ENDOCYTIC_2	107	110	PF00928	0.497
TRG_ENDOCYTIC_2	163	166	PF00928	0.283
TRG_ENDOCYTIC_2	272	275	PF00928	0.315
TRG_ENDOCYTIC_2	322	325	PF00928	0.296
TRG_ENDOCYTIC_2	327	330	PF00928	0.359
TRG_NLS_MonoExtC_3	214	220	PF00514	0.423
TRG_Pf-PMV_PEXEL_1	115	119	PF00026	0.482
TRG_Pf-PMV_PEXEL_1	149	153	PF00026	0.317

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I341	Leptomonas seymouri	86%	86%
A0A0S4J626	Bodo saltans	70%	88%
A0A1X0P6L5	Trypanosomatidae	74%	88%
A0A3Q8IIX0	Leishmania donovani	98%	99%
A0A422NQ76	Trypanosoma rangeli	75%	91%
A4HMH8	Leishmania braziliensis	90%	84%
A4IB48	Leishmania infantum	97%	100%
A4IB58	Leishmania infantum	98%	99%
C9ZZG6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	78%	90%
E9B635	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	99%
V5DKE6	Trypanosoma cruzi	73%	91%