Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AEX7_LEIMA

TriTrypDb:

LmjF.35.1550 , LMJLV39_350021900 , LMJSD75_350021100

Length:

680

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AEX7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEX7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	131	135	PF00656	0.679
CLV_C14_Caspase3-7	381	385	PF00656	0.653
CLV_C14_Caspase3-7	554	558	PF00656	0.742
CLV_NRD_NRD_1	132	134	PF00675	0.745
CLV_NRD_NRD_1	230	232	PF00675	0.548
CLV_NRD_NRD_1	324	326	PF00675	0.539
CLV_NRD_NRD_1	345	347	PF00675	0.628
CLV_NRD_NRD_1	355	357	PF00675	0.584
CLV_NRD_NRD_1	412	414	PF00675	0.548
CLV_NRD_NRD_1	468	470	PF00675	0.469
CLV_NRD_NRD_1	505	507	PF00675	0.660
CLV_NRD_NRD_1	95	97	PF00675	0.506
CLV_PCSK_KEX2_1	132	134	PF00082	0.745
CLV_PCSK_KEX2_1	324	326	PF00082	0.539
CLV_PCSK_KEX2_1	345	347	PF00082	0.628
CLV_PCSK_KEX2_1	354	356	PF00082	0.579
CLV_PCSK_KEX2_1	411	413	PF00082	0.552
CLV_PCSK_KEX2_1	468	470	PF00082	0.469
CLV_PCSK_KEX2_1	504	506	PF00082	0.696
CLV_PCSK_KEX2_1	581	583	PF00082	0.456
CLV_PCSK_KEX2_1	95	97	PF00082	0.403
CLV_PCSK_PC1ET2_1	411	413	PF00082	0.612
CLV_PCSK_PC1ET2_1	581	583	PF00082	0.456
CLV_PCSK_PC7_1	464	470	PF00082	0.458
CLV_PCSK_SKI1_1	225	229	PF00082	0.621
CLV_PCSK_SKI1_1	231	235	PF00082	0.640
CLV_PCSK_SKI1_1	280	284	PF00082	0.448
CLV_PCSK_SKI1_1	360	364	PF00082	0.592
CLV_PCSK_SKI1_1	468	472	PF00082	0.458
CLV_PCSK_SKI1_1	578	582	PF00082	0.445
CLV_PCSK_SKI1_1	95	99	PF00082	0.515
DEG_APCC_DBOX_1	467	475	PF00400	0.448
DEG_APCC_DBOX_1	531	539	PF00400	0.476
DEG_APCC_DBOX_1	54	62	PF00400	0.424
DEG_APCC_DBOX_1	94	102	PF00400	0.446
DEG_Nend_Nbox_1	1	3	PF02207	0.514
DEG_SPOP_SBC_1	601	605	PF00917	0.552
DOC_CKS1_1	363	368	PF01111	0.646
DOC_CYCLIN_yCln2_LP_2	250	256	PF00134	0.510
DOC_CYCLIN_yCln2_LP_2	330	336	PF00134	0.594
DOC_MAPK_gen_1	104	113	PF00069	0.462
DOC_MAPK_gen_1	231	239	PF00069	0.609
DOC_MAPK_gen_1	324	332	PF00069	0.531
DOC_MAPK_gen_1	411	420	PF00069	0.493
DOC_MAPK_MEF2A_6	106	115	PF00069	0.451
DOC_MAPK_MEF2A_6	647	654	PF00069	0.655
DOC_MAPK_RevD_3	309	325	PF00069	0.683
DOC_PP2B_LxvP_1	119	122	PF13499	0.590
DOC_PP2B_LxvP_1	216	219	PF13499	0.574
DOC_PP2B_LxvP_1	330	333	PF13499	0.536
DOC_PP2B_LxvP_1	373	376	PF13499	0.614
DOC_PP4_MxPP_1	672	675	PF00568	0.546
DOC_USP7_MATH_1	138	142	PF00917	0.652
DOC_USP7_MATH_1	335	339	PF00917	0.539
DOC_USP7_MATH_1	454	458	PF00917	0.506
DOC_USP7_MATH_1	86	90	PF00917	0.611
DOC_WW_Pin1_4	120	125	PF00397	0.630
DOC_WW_Pin1_4	134	139	PF00397	0.639
DOC_WW_Pin1_4	280	285	PF00397	0.672
DOC_WW_Pin1_4	295	300	PF00397	0.464
DOC_WW_Pin1_4	362	367	PF00397	0.705
DOC_WW_Pin1_4	398	403	PF00397	0.643
DOC_WW_Pin1_4	622	627	PF00397	0.671
DOC_WW_Pin1_4	633	638	PF00397	0.568
DOC_WW_Pin1_4	70	75	PF00397	0.712
LIG_14-3-3_CanoR_1	106	111	PF00244	0.486
LIG_14-3-3_CanoR_1	195	203	PF00244	0.483
LIG_14-3-3_CanoR_1	225	233	PF00244	0.632
LIG_14-3-3_CanoR_1	354	363	PF00244	0.593
LIG_14-3-3_CanoR_1	42	50	PF00244	0.485
LIG_14-3-3_CanoR_1	553	557	PF00244	0.547
LIG_14-3-3_CanoR_1	67	74	PF00244	0.731
LIG_14-3-3_CanoR_1	80	90	PF00244	0.499
LIG_AP2alpha_1	9	13	PF02296	0.496
LIG_APCC_ABBAyCdc20_2	411	417	PF00400	0.523
LIG_BRCT_BRCA1_1	223	227	PF00533	0.582
LIG_BRCT_BRCA1_1	306	310	PF00533	0.517
LIG_BRCT_BRCA1_1	635	639	PF00533	0.503
LIG_Clathr_ClatBox_1	403	407	PF01394	0.625
LIG_DLG_GKlike_1	106	113	PF00625	0.452
LIG_FHA_1	195	201	PF00498	0.537
LIG_FHA_1	232	238	PF00498	0.598
LIG_FHA_1	327	333	PF00498	0.533
LIG_FHA_1	385	391	PF00498	0.647
LIG_FHA_1	421	427	PF00498	0.394
LIG_FHA_1	443	449	PF00498	0.511
LIG_FHA_1	477	483	PF00498	0.580
LIG_FHA_1	633	639	PF00498	0.626
LIG_FHA_1	665	671	PF00498	0.711
LIG_FHA_1	73	79	PF00498	0.551
LIG_FHA_2	156	162	PF00498	0.628
LIG_FHA_2	281	287	PF00498	0.575
LIG_FHA_2	289	295	PF00498	0.548
LIG_FHA_2	552	558	PF00498	0.596
LIG_FHA_2	654	660	PF00498	0.539
LIG_LIR_Apic_2	631	637	PF02991	0.521
LIG_LIR_Gen_1	224	233	PF02991	0.705
LIG_LIR_Gen_1	267	277	PF02991	0.651
LIG_LIR_Gen_1	48	58	PF02991	0.488
LIG_LIR_Gen_1	512	519	PF02991	0.553
LIG_LIR_Nem_3	11	16	PF02991	0.485
LIG_LIR_Nem_3	224	230	PF02991	0.711
LIG_LIR_Nem_3	267	273	PF02991	0.621
LIG_LIR_Nem_3	298	303	PF02991	0.558
LIG_LIR_Nem_3	342	347	PF02991	0.642
LIG_LIR_Nem_3	512	517	PF02991	0.548
LIG_PCNA_yPIPBox_3	104	114	PF02747	0.588
LIG_Pex14_2	9	13	PF04695	0.496
LIG_RPA_C_Fungi	179	191	PF08784	0.565
LIG_RPA_C_Fungi	350	362	PF08784	0.571
LIG_SH2_CRK	344	348	PF00017	0.649
LIG_SH2_STAP1	10	14	PF00017	0.512
LIG_SH2_STAP1	152	156	PF00017	0.559
LIG_SH2_STAP1	357	361	PF00017	0.506
LIG_SH2_STAT3	425	428	PF00017	0.449
LIG_SH2_STAT5	16	19	PF00017	0.476
LIG_SH2_STAT5	425	428	PF00017	0.387
LIG_SH2_STAT5	534	537	PF00017	0.707
LIG_SH3_2	459	464	PF14604	0.460
LIG_SH3_3	256	262	PF00018	0.602
LIG_SH3_3	296	302	PF00018	0.436
LIG_SH3_3	415	421	PF00018	0.510
LIG_SH3_3	456	462	PF00018	0.622
LIG_SH3_3	623	629	PF00018	0.678
LIG_SUMO_SIM_anti_2	109	115	PF11976	0.579
LIG_SUMO_SIM_anti_2	167	172	PF11976	0.534
LIG_SUMO_SIM_anti_2	521	527	PF11976	0.553
LIG_SUMO_SIM_anti_2	572	577	PF11976	0.588
LIG_SUMO_SIM_par_1	650	657	PF11976	0.537
LIG_TRAF2_1	264	267	PF00917	0.490
LIG_WRPW_2	300	303	PF00400	0.429
MOD_CDC14_SPxK_1	298	301	PF00782	0.563
MOD_CDK_SPK_2	622	627	PF00069	0.618
MOD_CDK_SPxK_1	295	301	PF00069	0.570
MOD_CDK_SPxxK_3	398	405	PF00069	0.623
MOD_CDK_SPxxK_3	633	640	PF00069	0.537
MOD_CK1_1	123	129	PF00069	0.748
MOD_CK1_1	155	161	PF00069	0.660
MOD_CK1_1	457	463	PF00069	0.569
MOD_CK1_1	512	518	PF00069	0.586
MOD_CK1_1	536	542	PF00069	0.644
MOD_CK1_1	555	561	PF00069	0.702
MOD_CK1_1	69	75	PF00069	0.642
MOD_CK1_1	84	90	PF00069	0.471
MOD_CK2_1	155	161	PF00069	0.655
MOD_CK2_1	175	181	PF00069	0.454
MOD_CK2_1	288	294	PF00069	0.595
MOD_CK2_1	653	659	PF00069	0.507
MOD_Cter_Amidation	502	505	PF01082	0.518
MOD_DYRK1A_RPxSP_1	280	284	PF00069	0.448
MOD_GlcNHglycan	164	167	PF01048	0.684
MOD_GlcNHglycan	177	180	PF01048	0.560
MOD_GlcNHglycan	357	360	PF01048	0.642
MOD_GlcNHglycan	384	387	PF01048	0.649
MOD_GlcNHglycan	486	489	PF01048	0.656
MOD_GlcNHglycan	511	514	PF01048	0.596
MOD_GlcNHglycan	539	542	PF01048	0.648
MOD_GlcNHglycan	557	560	PF01048	0.440
MOD_GSK3_1	122	129	PF00069	0.706
MOD_GSK3_1	134	141	PF00069	0.612
MOD_GSK3_1	14	21	PF00069	0.519
MOD_GSK3_1	151	158	PF00069	0.565
MOD_GSK3_1	162	169	PF00069	0.616
MOD_GSK3_1	217	224	PF00069	0.594
MOD_GSK3_1	378	385	PF00069	0.697
MOD_GSK3_1	476	483	PF00069	0.537
MOD_GSK3_1	533	540	PF00069	0.692
MOD_GSK3_1	551	558	PF00069	0.550
MOD_GSK3_1	597	604	PF00069	0.606
MOD_GSK3_1	61	68	PF00069	0.619
MOD_GSK3_1	618	625	PF00069	0.614
MOD_GSK3_1	628	635	PF00069	0.598
MOD_GSK3_1	653	660	PF00069	0.531
MOD_GSK3_1	69	76	PF00069	0.610
MOD_GSK3_1	80	87	PF00069	0.501
MOD_N-GLC_1	144	149	PF02516	0.641
MOD_N-GLC_1	640	645	PF02516	0.597
MOD_NEK2_1	1	6	PF00069	0.534
MOD_NEK2_1	14	19	PF00069	0.642
MOD_NEK2_1	144	149	PF00069	0.674
MOD_NEK2_1	194	199	PF00069	0.532
MOD_NEK2_1	303	308	PF00069	0.494
MOD_NEK2_1	347	352	PF00069	0.639
MOD_NEK2_1	475	480	PF00069	0.467
MOD_NEK2_1	499	504	PF00069	0.676
MOD_NEK2_1	61	66	PF00069	0.668
MOD_NEK2_2	335	340	PF00069	0.544
MOD_NEK2_2	66	71	PF00069	0.612
MOD_PIKK_1	14	20	PF00454	0.649
MOD_PIKK_1	169	175	PF00454	0.654
MOD_PIKK_1	194	200	PF00454	0.585
MOD_PIKK_1	81	87	PF00454	0.600
MOD_PKA_1	231	237	PF00069	0.612
MOD_PKA_1	355	361	PF00069	0.660
MOD_PKA_2	194	200	PF00069	0.483
MOD_PKA_2	288	294	PF00069	0.701
MOD_PKA_2	347	353	PF00069	0.637
MOD_PKA_2	355	361	PF00069	0.650
MOD_PKA_2	41	47	PF00069	0.477
MOD_PKA_2	552	558	PF00069	0.611
MOD_PKA_2	66	72	PF00069	0.728
MOD_PKB_1	104	112	PF00069	0.464
MOD_Plk_1	166	172	PF00069	0.681
MOD_Plk_4	1	7	PF00069	0.534
MOD_Plk_4	106	112	PF00069	0.526
MOD_Plk_4	166	172	PF00069	0.652
MOD_Plk_4	304	310	PF00069	0.582
MOD_Plk_4	326	332	PF00069	0.576
MOD_Plk_4	335	341	PF00069	0.542
MOD_Plk_4	569	575	PF00069	0.558
MOD_Plk_4	608	614	PF00069	0.496
MOD_ProDKin_1	120	126	PF00069	0.634
MOD_ProDKin_1	134	140	PF00069	0.636
MOD_ProDKin_1	280	286	PF00069	0.670
MOD_ProDKin_1	295	301	PF00069	0.458
MOD_ProDKin_1	362	368	PF00069	0.706
MOD_ProDKin_1	398	404	PF00069	0.642
MOD_ProDKin_1	622	628	PF00069	0.673
MOD_ProDKin_1	633	639	PF00069	0.562
MOD_ProDKin_1	70	76	PF00069	0.711
TRG_DiLeu_BaLyEn_6	399	404	PF01217	0.621
TRG_ENDOCYTIC_2	10	13	PF00928	0.477
TRG_ENDOCYTIC_2	300	303	PF00928	0.560
TRG_ENDOCYTIC_2	344	347	PF00928	0.647
TRG_ENDOCYTIC_2	50	53	PF00928	0.463
TRG_ER_diArg_1	184	187	PF00400	0.556
TRG_ER_diArg_1	323	325	PF00400	0.529
TRG_ER_diArg_1	344	346	PF00400	0.658
TRG_ER_diArg_1	354	356	PF00400	0.654
TRG_ER_diArg_1	412	414	PF00400	0.553
TRG_ER_diArg_1	468	470	PF00400	0.469
TRG_ER_diArg_1	504	506	PF00400	0.696
TRG_Pf-PMV_PEXEL_1	36	40	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	469	473	PF00026	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXS6	Leptomonas seymouri	47%	91%
A0A3Q8IF12	Leishmania donovani	91%	100%
A4HMH6	Leishmania braziliensis	78%	100%
A4IB56	Leishmania infantum	91%	100%
C9ZZG3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B633	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%