Putative reiske iron-sulfur protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

rieske iron-sulfur protein, mitochondrial precursor, putative

Species:

Leishmania major

UniProt:

E9AEX6_LEIMA

TriTrypDb:

LmjF.35.1540 , LMJLV39_350021800 , LMJSD75_350021000

Length:

297

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0005743	mitochondrial inner membrane	5	3
GO:0005750	mitochondrial respiratory chain complex III	4	2
GO:0016020	membrane	2	12
GO:0019866	organelle inner membrane	4	3
GO:0031090	organelle membrane	3	3
GO:0031966	mitochondrial membrane	4	3
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0045275	respiratory chain complex III	4	2
GO:0070069	cytochrome complex	3	2
GO:0098796	membrane protein complex	2	2
GO:0098798	mitochondrial protein-containing complex	2	2
GO:0098800	inner mitochondrial membrane protein complex	3	2
GO:0098803	respiratory chain complex	3	2
GO:0110165	cellular anatomical entity	1	12
GO:1902494	catalytic complex	2	2
GO:1902495	transmembrane transporter complex	3	2
GO:1990204	oxidoreductase complex	3	2
GO:1990351	transporter complex	2	2
GO:0070469	respirasome	2	1

Expansion

Sequence features

E9AEX6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEX6

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	2
GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c	7	2
GO:0008152	metabolic process	1	2
GO:0009060	aerobic respiration	6	2
GO:0009987	cellular process	1	2
GO:0015980	energy derivation by oxidation of organic compounds	4	2
GO:0019646	aerobic electron transport chain	6	2
GO:0022900	electron transport chain	4	2
GO:0022904	respiratory electron transport chain	5	2
GO:0044237	cellular metabolic process	2	2
GO:0045333	cellular respiration	5	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0005215	transporter activity	1	12
GO:0005488	binding	1	12
GO:0008121	ubiquinol-cytochrome-c reductase activity	4	12
GO:0008324	monoatomic cation transmembrane transporter activity	4	12
GO:0009055	electron transfer activity	3	12
GO:0015075	monoatomic ion transmembrane transporter activity	3	12
GO:0015078	proton transmembrane transporter activity	5	12
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	12
GO:0015399	primary active transmembrane transporter activity	4	12
GO:0015453	oxidoreduction-driven active transmembrane transporter activity	5	12
GO:0016491	oxidoreductase activity	2	12
GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	3	12
GO:0022804	active transmembrane transporter activity	3	12
GO:0022853	active monoatomic ion transmembrane transporter activity	4	12
GO:0022857	transmembrane transporter activity	2	12
GO:0022890	inorganic cation transmembrane transporter activity	4	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0051536	iron-sulfur cluster binding	3	12
GO:0051537	2 iron, 2 sulfur cluster binding	4	12
GO:0051540	metal cluster binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	113	115	PF00675	0.325
CLV_NRD_NRD_1	198	200	PF00675	0.424
CLV_NRD_NRD_1	3	5	PF00675	0.397
CLV_PCSK_KEX2_1	198	200	PF00082	0.399
CLV_PCSK_KEX2_1	3	5	PF00082	0.397
CLV_PCSK_SKI1_1	115	119	PF00082	0.327
CLV_PCSK_SKI1_1	192	196	PF00082	0.403
CLV_PCSK_SKI1_1	202	206	PF00082	0.393
CLV_PCSK_SKI1_1	60	64	PF00082	0.446
DEG_Nend_Nbox_1	1	3	PF02207	0.581
DOC_CKS1_1	208	213	PF01111	0.267
DOC_MAPK_DCC_7	269	279	PF00069	0.199
DOC_MAPK_gen_1	14	22	PF00069	0.625
DOC_MAPK_gen_1	229	237	PF00069	0.240
DOC_MAPK_MEF2A_6	14	22	PF00069	0.618
DOC_MAPK_MEF2A_6	229	237	PF00069	0.208
DOC_PP2B_LxvP_1	279	282	PF13499	0.199
DOC_PP4_FxxP_1	255	258	PF00568	0.199
DOC_PP4_FxxP_1	45	48	PF00568	0.582
DOC_PP4_MxPP_1	46	49	PF00568	0.649
DOC_USP7_MATH_1	136	140	PF00917	0.235
DOC_USP7_MATH_1	16	20	PF00917	0.687
DOC_USP7_MATH_1	162	166	PF00917	0.318
DOC_USP7_MATH_1	37	41	PF00917	0.582
DOC_USP7_UBL2_3	115	119	PF12436	0.527
DOC_WW_Pin1_4	207	212	PF00397	0.225
LIG_14-3-3_CanoR_1	129	137	PF00244	0.506
LIG_14-3-3_CanoR_1	17	21	PF00244	0.698
LIG_14-3-3_CanoR_1	182	188	PF00244	0.311
LIG_14-3-3_CanoR_1	198	204	PF00244	0.145
LIG_14-3-3_CanoR_1	3	7	PF00244	0.567
LIG_BRCT_BRCA1_1	18	22	PF00533	0.621
LIG_BRCT_BRCA1_1	41	45	PF00533	0.586
LIG_BRCT_BRCA1_2	41	47	PF00533	0.589
LIG_deltaCOP1_diTrp_1	39	45	PF00928	0.574
LIG_FHA_1	183	189	PF00498	0.250
LIG_FHA_1	93	99	PF00498	0.585
LIG_FHA_2	30	36	PF00498	0.587
LIG_FHA_2	72	78	PF00498	0.588
LIG_FHA_2	80	86	PF00498	0.586
LIG_GBD_Chelix_1	233	241	PF00786	0.410
LIG_LIR_Apic_2	42	48	PF02991	0.576
LIG_LIR_Nem_3	19	25	PF02991	0.635
LIG_LIR_Nem_3	249	255	PF02991	0.199
LIG_LIR_Nem_3	55	61	PF02991	0.632
LIG_PCNA_yPIPBox_3	131	145	PF02747	0.410
LIG_Pex14_1	108	112	PF04695	0.532
LIG_Pex14_1	41	45	PF04695	0.586
LIG_Pex14_2	2	6	PF04695	0.681
LIG_Pex14_2	252	256	PF04695	0.224
LIG_PTB_Apo_2	250	257	PF02174	0.242
LIG_REV1ctd_RIR_1	110	119	PF16727	0.526
LIG_SH2_CRK	151	155	PF00017	0.235
LIG_SH2_NCK_1	64	68	PF00017	0.570
LIG_SH2_SRC	264	267	PF00017	0.302
LIG_SH2_STAP1	103	107	PF00017	0.587
LIG_SH2_STAT3	158	161	PF00017	0.278
LIG_SH2_STAT5	158	161	PF00017	0.289
LIG_SH3_3	156	162	PF00018	0.289
LIG_SH3_3	241	247	PF00018	0.266
LIG_SUMO_SIM_par_1	233	239	PF11976	0.210
MOD_CK1_1	5	11	PF00069	0.608
MOD_CK2_1	71	77	PF00069	0.577
MOD_CK2_1	79	85	PF00069	0.593
MOD_GlcNHglycan	138	141	PF01048	0.268
MOD_GlcNHglycan	199	202	PF01048	0.433
MOD_GlcNHglycan	212	215	PF01048	0.416
MOD_GlcNHglycan	265	269	PF01048	0.417
MOD_GlcNHglycan	50	53	PF01048	0.472
MOD_GlcNHglycan	7	10	PF01048	0.427
MOD_GSK3_1	48	55	PF00069	0.664
MOD_NEK2_1	10	15	PF00069	0.577
MOD_NEK2_1	2	7	PF00069	0.580
MOD_PKA_2	130	136	PF00069	0.504
MOD_PKA_2	16	22	PF00069	0.661
MOD_PKA_2	197	203	PF00069	0.237
MOD_PKA_2	2	8	PF00069	0.570
MOD_Plk_1	103	109	PF00069	0.555
MOD_Plk_1	288	294	PF00069	0.257
MOD_Plk_2-3	217	223	PF00069	0.311
MOD_Plk_2-3	39	45	PF00069	0.574
MOD_Plk_4	103	109	PF00069	0.555
MOD_Plk_4	16	22	PF00069	0.616
MOD_Plk_4	162	168	PF00069	0.298
MOD_Plk_4	183	189	PF00069	0.210
MOD_Plk_4	288	294	PF00069	0.257
MOD_ProDKin_1	207	213	PF00069	0.225
TRG_ENDOCYTIC_2	151	154	PF00928	0.235
TRG_ENDOCYTIC_2	284	287	PF00928	0.265
TRG_ER_diArg_1	129	132	PF00400	0.509
TRG_ER_diArg_1	197	199	PF00400	0.221
TRG_ER_diArg_1	2	4	PF00400	0.602
TRG_Pf-PMV_PEXEL_1	285	289	PF00026	0.532
TRG_PTS2	1	25	PF00400	0.639

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P592	Leptomonas seymouri	90%	100%
A0A0S4J243	Bodo saltans	71%	100%
A0A1X0P5Z9	Trypanosomatidae	84%	100%
A0A3Q8IV54	Leishmania donovani	99%	100%
A0A422NQ65	Trypanosoma rangeli	84%	100%
A4HMH5	Leishmania braziliensis	96%	100%
A4IB55	Leishmania infantum	99%	100%
C9ZZG2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	85%	100%
E9B632	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q69BJ6	Symphalangus syndactylus	36%	100%
Q69BK5	Pan troglodytes	36%	100%
Q69BK6	Pan paniscus	36%	100%
V5DKE1	Trypanosoma cruzi	85%	100%