LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
E9AEX5_LEIMA
TriTrypDb:
LmjF.35.1530 * , LMJLV39_350021700 * , LMJSD75_350020900 *
Length:
354

Annotations

LeishMANIAdb annotations

No conserved TM segments are present in this protein.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AEX5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEX5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 14 18 PF00656 0.604
CLV_C14_Caspase3-7 149 153 PF00656 0.503
CLV_MEL_PAP_1 167 173 PF00089 0.497
CLV_NRD_NRD_1 146 148 PF00675 0.561
CLV_NRD_NRD_1 351 353 PF00675 0.416
CLV_PCSK_KEX2_1 146 148 PF00082 0.561
CLV_PCSK_SKI1_1 318 322 PF00082 0.476
DEG_Nend_UBRbox_3 1 3 PF02207 0.541
DEG_SCF_TRCP1_1 127 133 PF00400 0.455
DEG_SPOP_SBC_1 194 198 PF00917 0.631
DEG_SPOP_SBC_1 54 58 PF00917 0.599
DOC_MAPK_gen_1 253 261 PF00069 0.516
DOC_MAPK_gen_1 41 50 PF00069 0.625
DOC_USP7_MATH_1 230 234 PF00917 0.566
DOC_USP7_MATH_1 336 340 PF00917 0.557
DOC_USP7_MATH_1 54 58 PF00917 0.739
DOC_USP7_MATH_1 90 94 PF00917 0.640
DOC_WW_Pin1_4 213 218 PF00397 0.546
DOC_WW_Pin1_4 50 55 PF00397 0.627
DOC_WW_Pin1_4 94 99 PF00397 0.643
LIG_14-3-3_CanoR_1 12 21 PF00244 0.616
LIG_14-3-3_CanoR_1 120 124 PF00244 0.440
LIG_14-3-3_CanoR_1 130 135 PF00244 0.361
LIG_14-3-3_CanoR_1 146 154 PF00244 0.564
LIG_14-3-3_CanoR_1 168 176 PF00244 0.514
LIG_14-3-3_CanoR_1 318 326 PF00244 0.420
LIG_14-3-3_CanoR_1 41 50 PF00244 0.578
LIG_14-3-3_CanoR_1 84 91 PF00244 0.598
LIG_CtBP_PxDLS_1 343 347 PF00389 0.428
LIG_deltaCOP1_diTrp_1 17 21 PF00928 0.623
LIG_FHA_1 111 117 PF00498 0.515
LIG_FHA_1 207 213 PF00498 0.622
LIG_FHA_1 315 321 PF00498 0.390
LIG_FHA_1 345 351 PF00498 0.373
LIG_FHA_1 86 92 PF00498 0.572
LIG_FHA_2 147 153 PF00498 0.541
LIG_FHA_2 67 73 PF00498 0.642
LIG_Integrin_RGD_1 125 127 PF01839 0.426
LIG_LIR_Gen_1 44 54 PF02991 0.616
LIG_LIR_Gen_1 97 106 PF02991 0.475
LIG_LIR_Nem_3 44 50 PF02991 0.624
LIG_LIR_Nem_3 97 102 PF02991 0.461
LIG_Pex14_1 301 305 PF04695 0.379
LIG_Pex14_2 140 144 PF04695 0.399
LIG_RPA_C_Fungi 79 91 PF08784 0.576
LIG_SH2_PTP2 47 50 PF00017 0.626
LIG_SH2_STAP1 244 248 PF00017 0.411
LIG_SH2_STAP1 78 82 PF00017 0.649
LIG_SH2_STAT5 142 145 PF00017 0.500
LIG_SH2_STAT5 244 247 PF00017 0.439
LIG_SH2_STAT5 328 331 PF00017 0.506
LIG_SH2_STAT5 47 50 PF00017 0.774
LIG_SH3_3 48 54 PF00018 0.623
LIG_SUMO_SIM_par_1 112 118 PF11976 0.502
LIG_SUMO_SIM_par_1 208 214 PF11976 0.598
MOD_CDK_SPxxK_3 94 101 PF00069 0.548
MOD_CK1_1 110 116 PF00069 0.487
MOD_CK1_1 150 156 PF00069 0.577
MOD_CK1_1 174 180 PF00069 0.611
MOD_CK1_1 195 201 PF00069 0.628
MOD_CK1_1 233 239 PF00069 0.676
MOD_CK1_1 267 273 PF00069 0.570
MOD_CK1_1 52 58 PF00069 0.630
MOD_CK1_1 65 71 PF00069 0.515
MOD_CK2_1 208 214 PF00069 0.598
MOD_CK2_1 336 342 PF00069 0.590
MOD_GlcNHglycan 104 107 PF01048 0.497
MOD_GlcNHglycan 127 130 PF01048 0.588
MOD_GlcNHglycan 173 176 PF01048 0.538
MOD_GlcNHglycan 180 183 PF01048 0.641
MOD_GlcNHglycan 185 188 PF01048 0.606
MOD_GlcNHglycan 197 200 PF01048 0.501
MOD_GlcNHglycan 22 26 PF01048 0.608
MOD_GlcNHglycan 228 231 PF01048 0.690
MOD_GlcNHglycan 234 238 PF01048 0.646
MOD_GlcNHglycan 265 269 PF01048 0.550
MOD_GlcNHglycan 274 277 PF01048 0.368
MOD_GlcNHglycan 332 335 PF01048 0.613
MOD_GlcNHglycan 80 83 PF01048 0.614
MOD_GlcNHglycan 85 88 PF01048 0.642
MOD_GlcNHglycan 92 95 PF01048 0.515
MOD_GSK3_1 115 122 PF00069 0.393
MOD_GSK3_1 13 20 PF00069 0.571
MOD_GSK3_1 136 143 PF00069 0.375
MOD_GSK3_1 146 153 PF00069 0.551
MOD_GSK3_1 170 177 PF00069 0.615
MOD_GSK3_1 188 195 PF00069 0.602
MOD_GSK3_1 21 28 PF00069 0.541
MOD_GSK3_1 226 233 PF00069 0.665
MOD_GSK3_1 242 249 PF00069 0.439
MOD_GSK3_1 314 321 PF00069 0.468
MOD_GSK3_1 338 345 PF00069 0.515
MOD_GSK3_1 49 56 PF00069 0.654
MOD_GSK3_1 62 69 PF00069 0.667
MOD_GSK3_1 85 92 PF00069 0.731
MOD_LATS_1 145 151 PF00433 0.493
MOD_N-GLC_1 107 112 PF02516 0.516
MOD_N-GLC_1 147 152 PF02516 0.576
MOD_N-GLC_1 272 277 PF02516 0.350
MOD_NEK2_1 102 107 PF00069 0.561
MOD_NEK2_1 112 117 PF00069 0.509
MOD_NEK2_1 140 145 PF00069 0.440
MOD_NEK2_1 163 168 PF00069 0.385
MOD_NEK2_1 21 26 PF00069 0.652
MOD_NEK2_1 264 269 PF00069 0.551
MOD_NEK2_1 85 90 PF00069 0.613
MOD_PIKK_1 246 252 PF00454 0.399
MOD_PK_1 253 259 PF00069 0.556
MOD_PKA_1 146 152 PF00069 0.558
MOD_PKA_2 100 106 PF00069 0.546
MOD_PKA_2 11 17 PF00069 0.607
MOD_PKA_2 119 125 PF00069 0.449
MOD_PKA_2 146 152 PF00069 0.554
MOD_PKA_2 169 175 PF00069 0.531
MOD_PKA_2 83 89 PF00069 0.654
MOD_PKB_1 168 176 PF00069 0.537
MOD_PKB_1 316 324 PF00069 0.417
MOD_Plk_1 150 156 PF00069 0.574
MOD_Plk_1 246 252 PF00069 0.478
MOD_Plk_1 63 69 PF00069 0.602
MOD_Plk_2-3 17 23 PF00069 0.578
MOD_Plk_2-3 242 248 PF00069 0.505
MOD_Plk_4 119 125 PF00069 0.483
MOD_Plk_4 130 136 PF00069 0.367
MOD_Plk_4 208 214 PF00069 0.620
MOD_ProDKin_1 213 219 PF00069 0.547
MOD_ProDKin_1 50 56 PF00069 0.628
MOD_ProDKin_1 94 100 PF00069 0.636
MOD_SUMO_rev_2 103 113 PF00179 0.512
TRG_DiLeu_BaLyEn_6 315 320 PF01217 0.386
TRG_ENDOCYTIC_2 47 50 PF00928 0.638
TRG_ER_diArg_1 167 170 PF00400 0.486
TRG_ER_diArg_1 316 319 PF00400 0.355
TRG_Pf-PMV_PEXEL_1 318 322 PF00026 0.397
TRG_Pf-PMV_PEXEL_1 60 64 PF00026 0.600

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I4G5 Leptomonas seymouri 45% 94%
A0A3Q8II56 Leishmania donovani 89% 100%
A4HMH4 Leishmania braziliensis 65% 95%
A4IB54 Leishmania infantum 88% 71%
E9B631 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS