Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AEX4_LEIMA

TriTrypDb:

LmjF.35.1520 , LMJLV39_350021600 , LMJSD75_350020800

Length:

618

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 5
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AEX4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEX4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	138	140	PF00675	0.505
CLV_NRD_NRD_1	146	148	PF00675	0.543
CLV_NRD_NRD_1	44	46	PF00675	0.538
CLV_NRD_NRD_1	493	495	PF00675	0.477
CLV_PCSK_KEX2_1	138	140	PF00082	0.513
CLV_PCSK_KEX2_1	146	148	PF00082	0.494
CLV_PCSK_KEX2_1	44	46	PF00082	0.538
CLV_PCSK_KEX2_1	492	494	PF00082	0.483
CLV_PCSK_KEX2_1	70	72	PF00082	0.514
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.503
CLV_PCSK_SKI1_1	139	143	PF00082	0.544
CLV_PCSK_SKI1_1	254	258	PF00082	0.526
CLV_PCSK_SKI1_1	424	428	PF00082	0.575
CLV_PCSK_SKI1_1	477	481	PF00082	0.438
CLV_PCSK_SKI1_1	525	529	PF00082	0.461
DEG_SCF_FBW7_1	548	553	PF00400	0.637
DEG_SCF_FBW7_2	512	518	PF00400	0.620
DOC_CDC14_PxL_1	323	331	PF14671	0.615
DOC_CKS1_1	431	436	PF01111	0.696
DOC_CKS1_1	512	517	PF01111	0.622
DOC_CYCLIN_yClb5_NLxxxL_5	96	105	PF00134	0.630
DOC_CYCLIN_yCln2_LP_2	105	108	PF00134	0.760
DOC_CYCLIN_yCln2_LP_2	252	258	PF00134	0.705
DOC_CYCLIN_yCln2_LP_2	590	596	PF00134	0.342
DOC_MAPK_DCC_7	175	183	PF00069	0.550
DOC_MAPK_DCC_7	254	262	PF00069	0.670
DOC_MAPK_DCC_7	592	600	PF00069	0.342
DOC_MAPK_MEF2A_6	175	183	PF00069	0.550
DOC_MAPK_MEF2A_6	254	262	PF00069	0.670
DOC_MAPK_MEF2A_6	592	600	PF00069	0.348
DOC_PP1_RVXF_1	523	530	PF00149	0.652
DOC_PP2B_LxvP_1	105	108	PF13499	0.785
DOC_PP2B_PxIxI_1	178	184	PF00149	0.531
DOC_PP2B_PxIxI_1	257	263	PF00149	0.776
DOC_PP4_FxxP_1	265	268	PF00568	0.783
DOC_PP4_MxPP_1	81	84	PF00568	0.770
DOC_USP7_MATH_1	192	196	PF00917	0.664
DOC_USP7_MATH_1	248	252	PF00917	0.752
DOC_USP7_MATH_1	31	35	PF00917	0.686
DOC_USP7_MATH_1	337	341	PF00917	0.713
DOC_USP7_MATH_1	382	386	PF00917	0.711
DOC_USP7_MATH_1	558	562	PF00917	0.778
DOC_USP7_MATH_1	564	568	PF00917	0.700
DOC_WW_Pin1_4	153	158	PF00397	0.765
DOC_WW_Pin1_4	246	251	PF00397	0.745
DOC_WW_Pin1_4	307	312	PF00397	0.688
DOC_WW_Pin1_4	342	347	PF00397	0.566
DOC_WW_Pin1_4	430	435	PF00397	0.754
DOC_WW_Pin1_4	508	513	PF00397	0.762
DOC_WW_Pin1_4	546	551	PF00397	0.674
LIG_14-3-3_CanoR_1	273	278	PF00244	0.702
LIG_14-3-3_CanoR_1	336	342	PF00244	0.660
LIG_14-3-3_CanoR_1	352	359	PF00244	0.621
LIG_14-3-3_CanoR_1	407	412	PF00244	0.759
LIG_14-3-3_CanoR_1	440	448	PF00244	0.684
LIG_14-3-3_CanoR_1	74	80	PF00244	0.637
LIG_14-3-3_CanoR_1	9	14	PF00244	0.746
LIG_Actin_WH2_2	364	382	PF00022	0.664
LIG_APCC_ABBA_1	106	111	PF00400	0.653
LIG_BH_BH3_1	82	98	PF00452	0.756
LIG_BIR_III_4	383	387	PF00653	0.661
LIG_BRCT_BRCA1_1	14	18	PF00533	0.674
LIG_BRCT_BRCA1_1	192	196	PF00533	0.699
LIG_BRCT_BRCA1_1	252	256	PF00533	0.791
LIG_BRCT_BRCA1_1	384	388	PF00533	0.727
LIG_eIF4E_1	172	178	PF01652	0.746
LIG_FHA_1	100	106	PF00498	0.702
LIG_FHA_1	213	219	PF00498	0.700
LIG_FHA_1	229	235	PF00498	0.779
LIG_FHA_1	346	352	PF00498	0.590
LIG_FHA_1	551	557	PF00498	0.697
LIG_FHA_1	602	608	PF00498	0.409
LIG_FHA_2	18	24	PF00498	0.688
LIG_FHA_2	444	450	PF00498	0.653
LIG_FHA_2	526	532	PF00498	0.619
LIG_GBD_Chelix_1	93	101	PF00786	0.470
LIG_LIR_Apic_2	263	268	PF02991	0.744
LIG_LIR_Gen_1	15	25	PF02991	0.687
LIG_LIR_Gen_1	320	330	PF02991	0.625
LIG_LIR_Gen_1	357	367	PF02991	0.657
LIG_LIR_Gen_1	433	442	PF02991	0.701
LIG_LIR_Gen_1	453	464	PF02991	0.630
LIG_LIR_Gen_1	520	529	PF02991	0.675
LIG_LIR_Gen_1	61	69	PF02991	0.641
LIG_LIR_Nem_3	15	21	PF02991	0.689
LIG_LIR_Nem_3	253	259	PF02991	0.784
LIG_LIR_Nem_3	320	326	PF02991	0.635
LIG_LIR_Nem_3	328	333	PF02991	0.558
LIG_LIR_Nem_3	357	362	PF02991	0.687
LIG_LIR_Nem_3	366	371	PF02991	0.587
LIG_LIR_Nem_3	405	411	PF02991	0.727
LIG_LIR_Nem_3	433	439	PF02991	0.639
LIG_LIR_Nem_3	453	459	PF02991	0.626
LIG_LIR_Nem_3	520	526	PF02991	0.672
LIG_LIR_Nem_3	528	532	PF02991	0.565
LIG_LIR_Nem_3	543	548	PF02991	0.595
LIG_LIR_Nem_3	567	572	PF02991	0.395
LIG_LIR_Nem_3	584	590	PF02991	0.608
LIG_LIR_Nem_3	61	65	PF02991	0.638
LIG_MLH1_MIPbox_1	384	388	PF16413	0.727
LIG_PCNA_yPIPBox_3	287	301	PF02747	0.797
LIG_Pex14_2	599	603	PF04695	0.415
LIG_SH2_CRK	368	372	PF00017	0.621
LIG_SH2_CRK	523	527	PF00017	0.678
LIG_SH2_GRB2like	56	59	PF00017	0.641
LIG_SH2_NCK_1	319	323	PF00017	0.671
LIG_SH2_NCK_1	56	60	PF00017	0.641
LIG_SH2_PTP2	436	439	PF00017	0.678
LIG_SH2_SRC	56	59	PF00017	0.637
LIG_SH2_STAP1	319	323	PF00017	0.671
LIG_SH2_STAP1	368	372	PF00017	0.655
LIG_SH2_STAP1	373	377	PF00017	0.672
LIG_SH2_STAP1	56	60	PF00017	0.640
LIG_SH2_STAT5	436	439	PF00017	0.678
LIG_SH2_STAT5	540	543	PF00017	0.655
LIG_SH3_2	282	287	PF14604	0.824
LIG_SH3_3	252	258	PF00018	0.764
LIG_SH3_3	279	285	PF00018	0.823
LIG_SH3_3	509	515	PF00018	0.788
LIG_SH3_3	590	596	PF00018	0.371
LIG_TRAF2_1	447	450	PF00917	0.622
LIG_TRFH_1	323	327	PF08558	0.618
LIG_TRFH_1	359	363	PF08558	0.693
LIG_UBA3_1	325	331	PF00899	0.649
LIG_WRC_WIRS_1	526	531	PF05994	0.668
LIG_WW_1	83	86	PF00397	0.768
MOD_CK1_1	12	18	PF00069	0.721
MOD_CK1_1	162	168	PF00069	0.681
MOD_CK1_1	190	196	PF00069	0.689
MOD_CK1_1	289	295	PF00069	0.769
MOD_CK1_1	312	318	PF00069	0.710
MOD_CK1_1	340	346	PF00069	0.587
MOD_CK1_1	390	396	PF00069	0.779
MOD_CK1_1	410	416	PF00069	0.747
MOD_CK1_1	443	449	PF00069	0.717
MOD_CK1_1	511	517	PF00069	0.695
MOD_CK2_1	443	449	PF00069	0.642
MOD_DYRK1A_RPxSP_1	246	250	PF00069	0.666
MOD_GlcNHglycan	189	192	PF01048	0.484
MOD_GlcNHglycan	246	249	PF01048	0.616
MOD_GlcNHglycan	288	291	PF01048	0.577
MOD_GlcNHglycan	33	36	PF01048	0.552
MOD_GlcNHglycan	356	359	PF01048	0.479
MOD_GlcNHglycan	383	387	PF01048	0.536
MOD_GlcNHglycan	389	392	PF01048	0.521
MOD_GlcNHglycan	560	563	PF01048	0.589
MOD_GSK3_1	149	156	PF00069	0.759
MOD_GSK3_1	240	247	PF00069	0.790
MOD_GSK3_1	269	276	PF00069	0.749
MOD_GSK3_1	350	357	PF00069	0.671
MOD_GSK3_1	378	385	PF00069	0.702
MOD_GSK3_1	410	417	PF00069	0.711
MOD_GSK3_1	440	447	PF00069	0.678
MOD_GSK3_1	507	514	PF00069	0.773
MOD_GSK3_1	536	543	PF00069	0.644
MOD_GSK3_1	546	553	PF00069	0.751
MOD_GSK3_1	558	565	PF00069	0.765
MOD_GSK3_1	9	16	PF00069	0.693
MOD_N-GLC_1	149	154	PF02516	0.517
MOD_N-GLC_1	237	242	PF02516	0.598
MOD_N-GLC_1	501	506	PF02516	0.553
MOD_N-GLC_1	75	80	PF02516	0.457
MOD_N-GLC_1	99	104	PF02516	0.521
MOD_NEK2_1	203	208	PF00069	0.637
MOD_NEK2_1	286	291	PF00069	0.772
MOD_NEK2_1	350	355	PF00069	0.645
MOD_NEK2_1	387	392	PF00069	0.778
MOD_NEK2_1	536	541	PF00069	0.621
MOD_NEK2_1	601	606	PF00069	0.403
MOD_PIKK_1	351	357	PF00454	0.666
MOD_PIKK_1	470	476	PF00454	0.683
MOD_PKA_2	25	31	PF00069	0.708
MOD_PKA_2	286	292	PF00069	0.736
MOD_PKA_2	351	357	PF00069	0.633
MOD_PKA_2	558	564	PF00069	0.705
MOD_Plk_1	149	155	PF00069	0.688
MOD_Plk_1	162	168	PF00069	0.681
MOD_Plk_1	228	234	PF00069	0.761
MOD_Plk_1	50	56	PF00069	0.660
MOD_Plk_1	75	81	PF00069	0.711
MOD_Plk_2-3	444	450	PF00069	0.711
MOD_Plk_4	17	23	PF00069	0.666
MOD_Plk_4	177	183	PF00069	0.647
MOD_Plk_4	273	279	PF00069	0.688
MOD_Plk_4	325	331	PF00069	0.620
MOD_Plk_4	337	343	PF00069	0.564
MOD_Plk_4	345	351	PF00069	0.426
MOD_Plk_4	451	457	PF00069	0.612
MOD_Plk_4	50	56	PF00069	0.661
MOD_Plk_4	536	542	PF00069	0.676
MOD_Plk_4	565	571	PF00069	0.546
MOD_ProDKin_1	153	159	PF00069	0.767
MOD_ProDKin_1	246	252	PF00069	0.745
MOD_ProDKin_1	307	313	PF00069	0.685
MOD_ProDKin_1	342	348	PF00069	0.563
MOD_ProDKin_1	430	436	PF00069	0.755
MOD_ProDKin_1	508	514	PF00069	0.759
MOD_ProDKin_1	546	552	PF00069	0.679
MOD_SUMO_for_1	227	230	PF00179	0.692
MOD_SUMO_rev_2	66	72	PF00179	0.692
TRG_DiLeu_BaEn_2	67	73	PF01217	0.694
TRG_ENDOCYTIC_2	186	189	PF00928	0.702
TRG_ENDOCYTIC_2	368	371	PF00928	0.649
TRG_ENDOCYTIC_2	436	439	PF00928	0.678
TRG_ENDOCYTIC_2	523	526	PF00928	0.672
TRG_ENDOCYTIC_2	86	89	PF00928	0.661
TRG_ER_diArg_1	137	139	PF00400	0.706
TRG_ER_diArg_1	145	147	PF00400	0.747
TRG_ER_diArg_1	293	296	PF00400	0.735
TRG_ER_diArg_1	43	45	PF00400	0.723
TRG_ER_diArg_1	492	494	PF00400	0.676
TRG_Pf-PMV_PEXEL_1	440	444	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	47	51	PF00026	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5N3	Leptomonas seymouri	37%	84%
A0A3S7X910	Leishmania donovani	94%	100%
A4HMH3	Leishmania braziliensis	80%	100%
A4IB53	Leishmania infantum	94%	100%
C9ZZG0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E9B630	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	85%
V5B3W1	Trypanosoma cruzi	23%	100%