NLI interacting factor-like phosphatase family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NLI interacting factor-like phosphatase/Zinc finger C-x8-C-x5-C-x3-H type (and similar), putative

Species:

Leishmania major

UniProt:

E9AEX3_LEIMA

TriTrypDb:

LmjF.35.1510 , LMJLV39_350021500 , LMJSD75_350020700

Length:

583

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

E9AEX3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEX3

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0003824	catalytic activity	1	2
GO:0004721	phosphoprotein phosphatase activity	3	2
GO:0005488	binding	1	7
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016791	phosphatase activity	5	2
GO:0042578	phosphoric ester hydrolase activity	4	2
GO:0043167	ion binding	2	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	515	519	PF00656	0.718
CLV_C14_Caspase3-7	565	569	PF00656	0.689
CLV_NRD_NRD_1	2	4	PF00675	0.577
CLV_NRD_NRD_1	220	222	PF00675	0.636
CLV_NRD_NRD_1	320	322	PF00675	0.601
CLV_NRD_NRD_1	345	347	PF00675	0.581
CLV_NRD_NRD_1	384	386	PF00675	0.726
CLV_NRD_NRD_1	417	419	PF00675	0.731
CLV_NRD_NRD_1	527	529	PF00675	0.791
CLV_NRD_NRD_1	54	56	PF00675	0.453

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P590	Leptomonas seymouri	50%	87%
A0A3Q8IM24	Leishmania donovani	94%	100%
A4HMH2	Leishmania braziliensis	78%	91%
A4IB52	Leishmania infantum	94%	100%
E9B629	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	97%

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