NLI interacting factor-like phosphatase family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NLI interacting factor-like phosphatase/Zinc finger C-x8-C-x5-C-x3-H type (and similar), putative

Species:

Leishmania major

UniProt:

E9AEX3_LEIMA

TriTrypDb:

LmjF.35.1510 , LMJLV39_350021500 , LMJSD75_350020700

Length:

583

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AEX3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEX3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0003824	catalytic activity	1	2
GO:0004721	phosphoprotein phosphatase activity	3	2
GO:0005488	binding	1	7
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016791	phosphatase activity	5	2
GO:0042578	phosphoric ester hydrolase activity	4	2
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0097159	organic cyclic compound binding	2	2
GO:0140096	catalytic activity, acting on a protein	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	515	519	PF00656	0.718
CLV_C14_Caspase3-7	565	569	PF00656	0.689
CLV_NRD_NRD_1	2	4	PF00675	0.577
CLV_NRD_NRD_1	220	222	PF00675	0.636
CLV_NRD_NRD_1	320	322	PF00675	0.601
CLV_NRD_NRD_1	345	347	PF00675	0.581
CLV_NRD_NRD_1	384	386	PF00675	0.726
CLV_NRD_NRD_1	417	419	PF00675	0.731
CLV_NRD_NRD_1	527	529	PF00675	0.791
CLV_NRD_NRD_1	54	56	PF00675	0.453
CLV_NRD_NRD_1	549	551	PF00675	0.783
CLV_PCSK_KEX2_1	2	4	PF00082	0.577
CLV_PCSK_KEX2_1	220	222	PF00082	0.636
CLV_PCSK_KEX2_1	345	347	PF00082	0.597
CLV_PCSK_KEX2_1	383	385	PF00082	0.723
CLV_PCSK_KEX2_1	417	419	PF00082	0.725
CLV_PCSK_KEX2_1	527	529	PF00082	0.791
CLV_PCSK_KEX2_1	54	56	PF00082	0.453
CLV_PCSK_KEX2_1	549	551	PF00082	0.783
CLV_PCSK_PC7_1	379	385	PF00082	0.721
CLV_PCSK_SKI1_1	117	121	PF00082	0.412
CLV_PCSK_SKI1_1	203	207	PF00082	0.514
CLV_PCSK_SKI1_1	54	58	PF00082	0.441
CLV_PCSK_SKI1_1	86	90	PF00082	0.412
DEG_APCC_DBOX_1	116	124	PF00400	0.275
DEG_APCC_DBOX_1	54	62	PF00400	0.412
DEG_Nend_UBRbox_1	1	4	PF02207	0.531
DEG_SPOP_SBC_1	476	480	PF00917	0.682
DOC_CKS1_1	249	254	PF01111	0.731
DOC_MAPK_gen_1	331	341	PF00069	0.733
DOC_MAPK_gen_1	54	61	PF00069	0.432
DOC_MAPK_MEF2A_6	170	178	PF00069	0.412
DOC_MAPK_MEF2A_6	492	500	PF00069	0.709
DOC_MAPK_MEF2A_6	54	63	PF00069	0.478
DOC_PP4_FxxP_1	183	186	PF00568	0.412
DOC_SPAK_OSR1_1	5	9	PF12202	0.494
DOC_USP7_MATH_1	131	135	PF00917	0.503
DOC_USP7_MATH_1	254	258	PF00917	0.791
DOC_USP7_MATH_1	260	264	PF00917	0.717
DOC_USP7_MATH_1	374	378	PF00917	0.766
DOC_USP7_MATH_1	460	464	PF00917	0.741
DOC_USP7_MATH_1	465	469	PF00917	0.698
DOC_USP7_MATH_1	476	480	PF00917	0.789
DOC_USP7_MATH_1	496	500	PF00917	0.716
DOC_USP7_MATH_1	529	533	PF00917	0.660
DOC_USP7_MATH_1	553	557	PF00917	0.785
DOC_USP7_MATH_1	79	83	PF00917	0.514
DOC_WW_Pin1_4	164	169	PF00397	0.353
DOC_WW_Pin1_4	248	253	PF00397	0.746
LIG_14-3-3_CanoR_1	13	23	PF00244	0.485
LIG_14-3-3_CanoR_1	151	157	PF00244	0.412
LIG_14-3-3_CanoR_1	269	273	PF00244	0.577
LIG_14-3-3_CanoR_1	35	39	PF00244	0.518
LIG_14-3-3_CanoR_1	417	422	PF00244	0.775
LIG_14-3-3_CanoR_1	78	88	PF00244	0.412
LIG_APCC_ABBA_1	122	127	PF00400	0.412
LIG_Clathr_ClatBox_1	58	62	PF01394	0.412
LIG_EH1_1	156	164	PF00400	0.412
LIG_eIF4E_1	116	122	PF01652	0.412
LIG_FHA_1	159	165	PF00498	0.412
LIG_FHA_1	196	202	PF00498	0.440
LIG_FHA_1	394	400	PF00498	0.585
LIG_FHA_1	48	54	PF00498	0.484
LIG_FHA_1	489	495	PF00498	0.723
LIG_FHA_1	568	574	PF00498	0.719
LIG_FHA_1	96	102	PF00498	0.499
LIG_FHA_2	25	31	PF00498	0.490
LIG_FHA_2	333	339	PF00498	0.611
LIG_FHA_2	513	519	PF00498	0.627
LIG_GBD_Chelix_1	572	580	PF00786	0.659
LIG_GBD_Chelix_1	59	67	PF00786	0.412
LIG_IBAR_NPY_1	137	139	PF08397	0.412
LIG_Integrin_RGD_1	303	305	PF01839	0.404
LIG_LIR_Gen_1	155	164	PF02991	0.412
LIG_LIR_Gen_1	406	413	PF02991	0.665
LIG_LIR_Gen_1	82	92	PF02991	0.412
LIG_LIR_Gen_1	9	16	PF02991	0.565
LIG_LIR_Nem_3	110	116	PF02991	0.412
LIG_LIR_Nem_3	155	159	PF02991	0.448
LIG_LIR_Nem_3	82	87	PF02991	0.412
LIG_LIR_Nem_3	9	14	PF02991	0.556
LIG_MYND_1	484	488	PF01753	0.815
LIG_PCNA_yPIPBox_3	103	113	PF02747	0.385
LIG_SH2_GRB2like	409	412	PF00017	0.704
LIG_SH2_PTP2	11	14	PF00017	0.442
LIG_SH2_STAP1	409	413	PF00017	0.702
LIG_SH2_STAP1	44	48	PF00017	0.502
LIG_SH2_STAT5	11	14	PF00017	0.432
LIG_SH3_2	370	375	PF14604	0.702
LIG_SH3_3	127	133	PF00018	0.348
LIG_SH3_3	246	252	PF00018	0.721
LIG_SH3_3	367	373	PF00018	0.680
LIG_SH3_3	43	49	PF00018	0.510
LIG_SH3_3	482	488	PF00018	0.722
LIG_SH3_3	490	496	PF00018	0.681
LIG_SH3_4	372	379	PF00018	0.722
LIG_SUMO_SIM_anti_2	204	210	PF11976	0.591
LIG_SUMO_SIM_par_1	160	167	PF11976	0.412
LIG_SUMO_SIM_par_1	204	210	PF11976	0.488
LIG_SUMO_SIM_par_1	496	502	PF11976	0.741
LIG_SUMO_SIM_par_1	57	62	PF11976	0.412
LIG_SUMO_SIM_par_1	92	99	PF11976	0.412
LIG_TRAF2_1	236	239	PF00917	0.604
LIG_TRAF2_1	335	338	PF00917	0.607
LIG_TRFH_1	75	79	PF08558	0.412
LIG_UBA3_1	195	203	PF00899	0.514
LIG_WW_3	372	376	PF00397	0.711
MOD_CDC14_SPxK_1	167	170	PF00782	0.412
MOD_CDK_SPxK_1	164	170	PF00069	0.412
MOD_CK1_1	155	161	PF00069	0.514
MOD_CK1_1	247	253	PF00069	0.730
MOD_CK1_1	320	326	PF00069	0.562
MOD_CK1_1	447	453	PF00069	0.697
MOD_CK1_1	463	469	PF00069	0.833
MOD_CK1_1	516	522	PF00069	0.631
MOD_CK2_1	233	239	PF00069	0.583
MOD_CK2_1	277	283	PF00069	0.664
MOD_CK2_1	332	338	PF00069	0.610
MOD_GlcNHglycan	133	136	PF01048	0.440
MOD_GlcNHglycan	209	212	PF01048	0.472
MOD_GlcNHglycan	235	238	PF01048	0.595
MOD_GlcNHglycan	256	259	PF01048	0.705
MOD_GlcNHglycan	262	265	PF01048	0.610
MOD_GlcNHglycan	322	325	PF01048	0.663
MOD_GlcNHglycan	419	422	PF01048	0.725
MOD_GlcNHglycan	435	438	PF01048	0.653
MOD_GlcNHglycan	447	450	PF01048	0.772
MOD_GlcNHglycan	479	482	PF01048	0.728
MOD_GlcNHglycan	50	53	PF01048	0.466
MOD_GlcNHglycan	518	521	PF01048	0.780
MOD_GlcNHglycan	98	101	PF01048	0.412
MOD_GSK3_1	244	251	PF00069	0.778
MOD_GSK3_1	254	261	PF00069	0.746
MOD_GSK3_1	268	275	PF00069	0.571
MOD_GSK3_1	395	402	PF00069	0.700
MOD_GSK3_1	44	51	PF00069	0.497
MOD_GSK3_1	459	466	PF00069	0.842
MOD_GSK3_1	472	479	PF00069	0.517
MOD_GSK3_1	498	505	PF00069	0.712
MOD_GSK3_1	512	519	PF00069	0.594
MOD_N-GLC_1	522	527	PF02516	0.739
MOD_N-GLC_1	529	534	PF02516	0.637
MOD_N-GLC_1	79	84	PF02516	0.514
MOD_NEK2_1	101	106	PF00069	0.412
MOD_NEK2_1	207	212	PF00069	0.478
MOD_NEK2_1	287	292	PF00069	0.391
MOD_NEK2_1	433	438	PF00069	0.798
MOD_NEK2_1	472	477	PF00069	0.689
MOD_NEK2_1	87	92	PF00069	0.412
MOD_PIKK_1	238	244	PF00454	0.580
MOD_PIKK_1	356	362	PF00454	0.614
MOD_PIKK_1	460	466	PF00454	0.827
MOD_PIKK_1	553	559	PF00454	0.780
MOD_PKA_1	417	423	PF00069	0.712
MOD_PKA_2	102	108	PF00069	0.412
MOD_PKA_2	14	20	PF00069	0.534
MOD_PKA_2	268	274	PF00069	0.572
MOD_PKA_2	320	326	PF00069	0.621
MOD_PKA_2	34	40	PF00069	0.261
MOD_PKA_2	374	380	PF00069	0.803
MOD_PKA_2	417	423	PF00069	0.712
MOD_PKA_2	553	559	PF00069	0.654
MOD_PKA_2	71	77	PF00069	0.391
MOD_Plk_1	44	50	PF00069	0.495
MOD_Plk_1	567	573	PF00069	0.708
MOD_Plk_2-3	277	283	PF00069	0.664
MOD_Plk_2-3	34	40	PF00069	0.489
MOD_Plk_4	158	164	PF00069	0.485
MOD_Plk_4	268	274	PF00069	0.666
MOD_Plk_4	465	471	PF00069	0.806
MOD_Plk_4	71	77	PF00069	0.391
MOD_ProDKin_1	164	170	PF00069	0.353
MOD_ProDKin_1	248	254	PF00069	0.746
MOD_SUMO_rev_2	233	241	PF00179	0.631
TRG_DiLeu_BaLyEn_6	210	215	PF01217	0.485
TRG_ENDOCYTIC_2	11	14	PF00928	0.442
TRG_ENDOCYTIC_2	116	119	PF00928	0.412
TRG_ENDOCYTIC_2	409	412	PF00928	0.673
TRG_ER_diArg_1	1	3	PF00400	0.615
TRG_ER_diArg_1	12	15	PF00400	0.450
TRG_ER_diArg_1	220	222	PF00400	0.636
TRG_ER_diArg_1	352	355	PF00400	0.671
TRG_ER_diArg_1	383	385	PF00400	0.708
TRG_ER_diArg_1	53	55	PF00400	0.455
TRG_NES_CRM1_1	197	209	PF08389	0.412
TRG_Pf-PMV_PEXEL_1	220	224	PF00026	0.646

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P590	Leptomonas seymouri	50%	87%
A0A3Q8IM24	Leishmania donovani	94%	100%
A4HMH2	Leishmania braziliensis	78%	91%
A4IB52	Leishmania infantum	94%	100%
E9B629	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	97%