Arginase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Arginase

Gene product:

arginase

Species:

Leishmania major

UniProt:

E9AEX1_LEIMA

TriTrypDb:

LmjF.35.1480 , LMJLV39_350021200 , LMJSD75_350020400

Length:

329

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005777	peroxisome	6	2
GO:0005829	cytosol	2	2
GO:0020015	glycosome	7	2
GO:0042579	microbody	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AEX1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEX1

Function

Biological processes
Term	Name	Level	Count
GO:0000050	urea cycle	4	7
GO:0006082	organic acid metabolic process	3	7
GO:0006520	amino acid metabolic process	3	7
GO:0006525	arginine metabolic process	6	7
GO:0006527	arginine catabolic process	5	2
GO:0006576	biogenic amine metabolic process	5	2
GO:0006591	ornithine metabolic process	5	2
GO:0006595	polyamine metabolic process	6	2
GO:0006596	polyamine biosynthetic process	7	2
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009056	catabolic process	2	2
GO:0009058	biosynthetic process	2	7
GO:0009063	amino acid catabolic process	4	2
GO:0009064	glutamine family amino acid metabolic process	5	7
GO:0009065	glutamine family amino acid catabolic process	6	2
GO:0009308	amine metabolic process	4	2
GO:0009309	amine biosynthetic process	5	2
GO:0009987	cellular process	1	7
GO:0016054	organic acid catabolic process	4	2
GO:0019547	arginine catabolic process to ornithine	6	2
GO:0019627	urea metabolic process	3	7
GO:0019752	carboxylic acid metabolic process	5	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0042401	biogenic amine biosynthetic process	6	2
GO:0043436	oxoacid metabolic process	4	7
GO:0043603	amide metabolic process	3	7
GO:0043604	amide biosynthetic process	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044248	cellular catabolic process	3	2
GO:0044249	cellular biosynthetic process	3	7
GO:0044271	cellular nitrogen compound biosynthetic process	4	7
GO:0044281	small molecule metabolic process	2	7
GO:0044282	small molecule catabolic process	3	2
GO:0046395	carboxylic acid catabolic process	5	2
GO:0071704	organic substance metabolic process	2	7
GO:0071941	nitrogen cycle metabolic process	3	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:1901565	organonitrogen compound catabolic process	4	2
GO:1901566	organonitrogen compound biosynthetic process	4	7
GO:1901575	organic substance catabolic process	3	2
GO:1901576	organic substance biosynthetic process	3	7
GO:1901605	alpha-amino acid metabolic process	4	7
GO:1901606	alpha-amino acid catabolic process	5	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004053	arginase activity	5	7
GO:0005488	binding	1	7
GO:0016787	hydrolase activity	2	7
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	7
GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	4	7
GO:0030145	manganese ion binding	6	2
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0046914	transition metal ion binding	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	323	325	PF00675	0.520
CLV_NRD_NRD_1	67	69	PF00675	0.252
CLV_NRD_NRD_1	98	100	PF00675	0.252
CLV_PCSK_FUR_1	79	83	PF00082	0.280
CLV_PCSK_KEX2_1	81	83	PF00082	0.307
CLV_PCSK_KEX2_1	98	100	PF00082	0.241
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.307
CLV_PCSK_SKI1_1	198	202	PF00082	0.252
CLV_PCSK_SKI1_1	266	270	PF00082	0.241
CLV_PCSK_SKI1_1	325	329	PF00082	0.615
DEG_Nend_UBRbox_2	1	3	PF02207	0.587
DOC_CKS1_1	320	325	PF01111	0.504
DOC_MAPK_gen_1	181	190	PF00069	0.452
DOC_MAPK_gen_1	198	206	PF00069	0.452
DOC_MAPK_gen_1	8	17	PF00069	0.365
DOC_MAPK_MEF2A_6	11	19	PF00069	0.290
DOC_PP1_RVXF_1	47	53	PF00149	0.452
DOC_PP2B_LxvP_1	250	253	PF13499	0.452
DOC_USP7_MATH_1	295	299	PF00917	0.480
DOC_WW_Pin1_4	228	233	PF00397	0.452
DOC_WW_Pin1_4	254	259	PF00397	0.478
DOC_WW_Pin1_4	319	324	PF00397	0.529
LIG_14-3-3_CanoR_1	260	266	PF00244	0.452
LIG_APCC_ABBA_1	125	130	PF00400	0.507
LIG_Clathr_ClatBox_1	161	165	PF01394	0.452
LIG_Clathr_ClatBox_1	281	285	PF01394	0.452
LIG_FHA_1	233	239	PF00498	0.452
LIG_FHA_1	301	307	PF00498	0.441
LIG_FHA_1	88	94	PF00498	0.459
LIG_FHA_2	52	58	PF00498	0.489
LIG_LIR_Gen_1	171	180	PF02991	0.452
LIG_LIR_Nem_3	171	176	PF02991	0.452
LIG_LIR_Nem_3	91	97	PF02991	0.482
LIG_PCNA_yPIPBox_3	49	60	PF02747	0.489
LIG_SH2_CRK	94	98	PF00017	0.507
LIG_SH2_PTP2	187	190	PF00017	0.452
LIG_SH2_SRC	251	254	PF00017	0.452
LIG_SH2_STAT5	187	190	PF00017	0.452
LIG_SH2_STAT5	251	254	PF00017	0.465
LIG_SH2_STAT5	321	324	PF00017	0.492
LIG_SH2_STAT5	37	40	PF00017	0.452
LIG_SH3_3	15	21	PF00018	0.507
LIG_SH3_3	176	182	PF00018	0.441
LIG_SH3_3	77	83	PF00018	0.480
LIG_SUMO_SIM_par_1	235	241	PF11976	0.452
LIG_SUMO_SIM_par_1	280	285	PF11976	0.452
LIG_TYR_ITIM	185	190	PF00017	0.452
MOD_CDK_SPK_2	228	233	PF00069	0.507
MOD_CDK_SPK_2	319	324	PF00069	0.465
MOD_CDK_SPxK_1	254	260	PF00069	0.478
MOD_CDK_SPxK_1	319	325	PF00069	0.476
MOD_CK2_1	261	267	PF00069	0.452
MOD_CK2_1	51	57	PF00069	0.489
MOD_GlcNHglycan	145	148	PF01048	0.252
MOD_GlcNHglycan	149	152	PF01048	0.252
MOD_GlcNHglycan	22	25	PF01048	0.252
MOD_GSK3_1	141	148	PF00069	0.452
MOD_GSK3_1	228	235	PF00069	0.455
MOD_GSK3_1	315	322	PF00069	0.450
MOD_GSK3_1	83	90	PF00069	0.452
MOD_NEK2_1	145	150	PF00069	0.452
MOD_NEK2_1	315	320	PF00069	0.508
MOD_NEK2_2	123	128	PF00069	0.507
MOD_NEK2_2	207	212	PF00069	0.452
MOD_NEK2_2	261	266	PF00069	0.452
MOD_PK_1	13	19	PF00069	0.408
MOD_PKA_1	13	19	PF00069	0.328
MOD_PKA_2	83	89	PF00069	0.441
MOD_Plk_1	112	118	PF00069	0.452
MOD_Plk_2-3	243	249	PF00069	0.507
MOD_Plk_4	123	129	PF00069	0.489
MOD_Plk_4	13	19	PF00069	0.367
MOD_Plk_4	156	162	PF00069	0.464
MOD_Plk_4	315	321	PF00069	0.409
MOD_ProDKin_1	228	234	PF00069	0.452
MOD_ProDKin_1	254	260	PF00069	0.478
MOD_ProDKin_1	319	325	PF00069	0.541
MOD_SUMO_rev_2	194	201	PF00179	0.457
MOD_SUMO_rev_2	57	65	PF00179	0.452
TRG_DiLeu_BaEn_1	277	282	PF01217	0.466
TRG_DiLeu_BaEn_3	195	201	PF01217	0.461
TRG_DiLeu_BaEn_4	196	202	PF01217	0.480
TRG_DiLeu_LyEn_5	288	293	PF01217	0.452
TRG_ENDOCYTIC_2	187	190	PF00928	0.452
TRG_ENDOCYTIC_2	94	97	PF00928	0.479
TRG_ER_diArg_1	82	85	PF00400	0.441
TRG_ER_diArg_1	97	99	PF00400	0.465
TRG_NLS_Bipartite_1	68	85	PF00514	0.507
TRG_NLS_MonoCore_2	80	85	PF00514	0.507
TRG_NLS_MonoExtN_4	79	85	PF00514	0.480
TRG_PTS1	326	329	PF00515	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDY5	Leptomonas seymouri	80%	100%
A0A0S4J155	Bodo saltans	37%	90%
A0A3S7X949	Leishmania donovani	97%	100%
A1AFC5	Escherichia coli O1:K1 / APEC	24%	100%
A1KVF9	Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18)	26%	100%
A4HMH0	Leishmania braziliensis	89%	100%
A4IB49	Leishmania infantum	97%	100%
A4WE75	Enterobacter sp. (strain 638)	25%	100%
A6TDU9	Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)	25%	100%
A7ZR59	Escherichia coli O139:H28 (strain E24377A / ETEC)	25%	100%
A8A477	Escherichia coli O9:H4 (strain HS)	24%	100%
A8APF8	Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)	25%	100%
A9M254	Neisseria meningitidis serogroup C (strain 053442)	26%	100%
A9N3R6	Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)	24%	100%
B1IT67	Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks)	25%	100%
B1LDE6	Escherichia coli (strain SMS-3-5 / SECEC)	25%	100%
B1XF99	Escherichia coli (strain K12 / DH10B)	25%	100%
B2U0V8	Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)	25%	100%
B4F1A3	Proteus mirabilis (strain HI4320)	25%	100%
B4RP98	Neisseria gonorrhoeae (strain NCCP11945)	26%	100%
B4T5I5	Salmonella newport (strain SL254)	24%	100%
B4THG3	Salmonella heidelberg (strain SL476)	24%	100%
B4TV53	Salmonella schwarzengrund (strain CVM19633)	24%	100%
B5BFP3	Salmonella paratyphi A (strain AKU_12601)	24%	100%
B5F5K3	Salmonella agona (strain SL483)	24%	100%
B5FUJ0	Salmonella dublin (strain CT_02021853)	24%	100%
B5QXK5	Salmonella enteritidis PT4 (strain P125109)	24%	100%
B5RE39	Salmonella gallinarum (strain 287/91 / NCTC 13346)	24%	100%
B5XUB2	Klebsiella pneumoniae (strain 342)	25%	100%
B5YQD4	Escherichia coli O157:H7 (strain EC4115 / EHEC)	25%	100%
B6I775	Escherichia coli (strain SE11)	25%	100%
B7LFJ6	Escherichia coli (strain 55989 / EAEC)	25%	100%
B7LPE7	Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73)	25%	100%
B7LYW6	Escherichia coli O8 (strain IAI1)	25%	100%
B7MMC5	Escherichia coli O45:K1 (strain S88 / ExPEC)	24%	100%
B7MZN5	Escherichia coli O81 (strain ED1a)	24%	100%
B7N7I9	Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)	25%	100%
B7NI01	Escherichia coli O7:K1 (strain IAI39 / ExPEC)	25%	100%
B7UHY3	Escherichia coli O127:H6 (strain E2348/69 / EPEC)	24%	100%
C0PY54	Salmonella paratyphi C (strain RKS4594)	24%	100%
C5A0K6	Escherichia coli (strain K12 / MC4100 / BW2952)	25%	100%
C9ZUY0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	99%
E9B627	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O08691	Mus musculus	40%	93%
O08701	Rattus norvegicus	40%	93%
P00812	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	58%	99%
P05089	Homo sapiens	43%	100%
P07824	Rattus norvegicus	41%	100%
P0A2X9	Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)	30%	100%
P0A2Y0	Brucella suis biovar 1 (strain 1330)	30%	100%
P0A2Y1	Brucella abortus biovar 1 (strain 9-941)	30%	100%
P14012	Agrobacterium fabrum (strain C58 / ATCC 33970)	32%	100%
P30759	Xenopus laevis	40%	100%
P33280	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	42%	92%
P37818	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	44%	100%
P39138	Bacillus subtilis (strain 168)	33%	100%
P40906	Coccidioides posadasii (strain C735)	40%	100%
P49900	Lithobates catesbeianus	41%	100%
P53608	Bacillus caldovelox	37%	100%
P60086	Staphylococcus aureus (strain COL)	36%	100%
P60087	Staphylococcus aureus (strain Mu50 / ATCC 700699)	36%	100%
P60088	Staphylococcus aureus (strain N315)	36%	100%
P60651	Escherichia coli (strain K12)	25%	100%
P60652	Escherichia coli O157:H7	25%	100%
P60653	Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491)	26%	100%
P60654	Neisseria meningitidis serogroup B (strain MC58)	26%	100%
P60655	Salmonella typhi	24%	100%
P60656	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	24%	100%
P60657	Shigella flexneri	25%	100%
P70999	Bacillus subtilis (strain 168)	25%	100%
P78540	Homo sapiens	38%	93%
Q0T0V7	Shigella flexneri serotype 5b (strain 8401)	25%	100%
Q0TDR4	Escherichia coli O6:K15:H31 (strain 536 / UPEC)	24%	100%
Q10066	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	47%	100%
Q12611	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	40%	100%
Q1E180	Coccidioides immitis (strain RS)	41%	100%
Q1R791	Escherichia coli (strain UTI89 / UPEC)	24%	100%
Q2KJ64	Bos taurus	42%	100%
Q31WK0	Shigella boydii serotype 4 (strain Sb227)	25%	100%
Q32C02	Shigella dysenteriae serotype 1 (strain Sd197)	25%	100%
Q3YXT4	Shigella sonnei (strain Ss046)	25%	100%
Q4VK78	Oryctolagus cuniculus	38%	93%
Q57K36	Salmonella choleraesuis (strain SC-B67)	24%	100%
Q58DL1	Bos taurus	39%	93%
Q5F6R3	Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090)	26%	100%
Q5JI38	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	26%	100%
Q5PJH7	Salmonella paratyphi A (strain ATCC 9150 / SARB42)	24%	100%
Q61176	Mus musculus	42%	100%
Q6CLS8	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	63%	100%
Q6G7E9	Staphylococcus aureus (strain MSSA476)	36%	100%
Q6GER3	Staphylococcus aureus (strain MRSA252)	36%	100%
Q74ZW4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	64%	82%
Q7M0Z3	Brevibacillus brevis	35%	100%
Q7P0S6	Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)	25%	100%
Q7VRG4	Blochmannia floridanus	23%	100%
Q7X3P1	Proteus mirabilis	25%	100%
Q814Q2	Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711)	24%	100%
Q81JT1	Bacillus anthracis	24%	100%
Q8FE36	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	24%	100%
Q8NVE3	Staphylococcus aureus (strain MW2)	36%	100%
Q91553	Xenopus laevis	39%	91%
Q91554	Xenopus laevis	39%	91%
Q91555	Xenopus laevis	40%	91%
Q95JC8	Sus scrofa	42%	100%
Q95KM0	Oryctolagus cuniculus	44%	100%
Q9I6K2	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	27%	100%
Q9K6B9	Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)	24%	100%