Sideroflexin-4

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Sideroflexin-4

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AEW9_LEIMA

TriTrypDb:

LmjF.35.1460 , LMJLV39_350021000 , LMJSD75_350020200

Length:

329

Annotations

LeishMANIAdb annotations

A conserved mitochondrial transporter protein involed in organellar amino acid uptake. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	4
GO:0016020	membrane	2	2

Expansion

Sequence features

E9AEW9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEW9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	278	282	PF00656	0.377
CLV_NRD_NRD_1	21	23	PF00675	0.383
CLV_PCSK_KEX2_1	218	220	PF00082	0.627
CLV_PCSK_PC1ET2_1	218	220	PF00082	0.611
CLV_PCSK_SKI1_1	185	189	PF00082	0.283
CLV_PCSK_SKI1_1	22	26	PF00082	0.399
CLV_PCSK_SKI1_1	83	87	PF00082	0.499
CLV_PCSK_SKI1_1	94	98	PF00082	0.460
DEG_APCC_DBOX_1	190	198	PF00400	0.455
DOC_CKS1_1	247	252	PF01111	0.285
DOC_CYCLIN_RxL_1	182	192	PF00134	0.482
DOC_MAPK_FxFP_2	95	98	PF00069	0.376
DOC_PP4_FxxP_1	95	98	PF00568	0.300
DOC_USP7_MATH_1	221	225	PF00917	0.393
DOC_USP7_MATH_1	43	47	PF00917	0.556
DOC_WW_Pin1_4	246	251	PF00397	0.285
DOC_WW_Pin1_4	71	76	PF00397	0.335
DOC_WW_Pin1_4	8	13	PF00397	0.708
LIG_14-3-3_CanoR_1	109	119	PF00244	0.350
LIG_14-3-3_CanoR_1	284	288	PF00244	0.351
LIG_14-3-3_CanoR_1	313	317	PF00244	0.387
LIG_Actin_WH2_2	300	315	PF00022	0.380
LIG_BIR_II_1	1	5	PF00653	0.721
LIG_BIR_III_1	1	5	PF00653	0.632
LIG_BIR_III_3	1	5	PF00653	0.632
LIG_EH1_1	301	309	PF00400	0.355
LIG_eIF4E_1	287	293	PF01652	0.292
LIG_FHA_1	182	188	PF00498	0.498
LIG_FHA_1	247	253	PF00498	0.293
LIG_FHA_1	52	58	PF00498	0.331
LIG_FHA_1	76	82	PF00498	0.330
LIG_FHA_1	84	90	PF00498	0.287
LIG_FHA_2	15	21	PF00498	0.590
LIG_IRF3_LxIS_1	235	240	PF10401	0.407
LIG_LIR_Gen_1	114	125	PF02991	0.337
LIG_LIR_Gen_1	63	71	PF02991	0.252
LIG_LIR_Nem_3	201	205	PF02991	0.432
LIG_LIR_Nem_3	80	85	PF02991	0.330
LIG_LYPXL_L_2	270	279	PF13949	0.345
LIG_LYPXL_S_1	270	274	PF13949	0.548
LIG_PDZ_Class_1	324	329	PF00595	0.508
LIG_Pex14_1	209	213	PF04695	0.330
LIG_PTB_Apo_2	147	154	PF02174	0.408
LIG_SH2_SRC	213	216	PF00017	0.325
LIG_SH2_STAP1	64	68	PF00017	0.260
LIG_SH2_STAT5	128	131	PF00017	0.292
LIG_SH2_STAT5	287	290	PF00017	0.294
LIG_SH3_3	164	170	PF00018	0.609
LIG_SH3_3	232	238	PF00018	0.371
LIG_SUMO_SIM_par_1	57	63	PF11976	0.274
LIG_TRAF2_1	77	80	PF00917	0.412
MOD_CK1_1	208	214	PF00069	0.375
MOD_CK1_1	282	288	PF00069	0.370
MOD_CK1_1	37	43	PF00069	0.577
MOD_CK1_1	74	80	PF00069	0.395
MOD_CK2_1	124	130	PF00069	0.277
MOD_CK2_1	14	20	PF00069	0.584
MOD_CK2_1	74	80	PF00069	0.300
MOD_GlcNHglycan	145	148	PF01048	0.290
MOD_GlcNHglycan	174	177	PF01048	0.447
MOD_GlcNHglycan	210	213	PF01048	0.551
MOD_GlcNHglycan	36	39	PF01048	0.388
MOD_GSK3_1	111	118	PF00069	0.273
MOD_GSK3_1	124	131	PF00069	0.258
MOD_GSK3_1	237	244	PF00069	0.360
MOD_GSK3_1	279	286	PF00069	0.293
MOD_GSK3_1	71	78	PF00069	0.334
MOD_N-GLC_1	34	39	PF02516	0.362
MOD_N-GLC_2	102	104	PF02516	0.498
MOD_NEK2_1	124	129	PF00069	0.295
MOD_NEK2_1	255	260	PF00069	0.299
MOD_NEK2_1	279	284	PF00069	0.296
MOD_NEK2_1	312	317	PF00069	0.382
MOD_NEK2_2	272	277	PF00069	0.402
MOD_OFUCOSY	189	196	PF10250	0.255
MOD_PIKK_1	75	81	PF00454	0.334
MOD_PKA_2	190	196	PF00069	0.475
MOD_PKA_2	283	289	PF00069	0.291
MOD_PKA_2	312	318	PF00069	0.392
MOD_Plk_1	62	68	PF00069	0.253
MOD_Plk_4	102	108	PF00069	0.220
MOD_Plk_4	148	154	PF00069	0.290
MOD_Plk_4	156	162	PF00069	0.451
MOD_Plk_4	205	211	PF00069	0.369
MOD_Plk_4	255	261	PF00069	0.267
MOD_Plk_4	283	289	PF00069	0.291
MOD_Plk_4	312	318	PF00069	0.387
MOD_Plk_4	62	68	PF00069	0.251
MOD_Plk_4	84	90	PF00069	0.318
MOD_ProDKin_1	246	252	PF00069	0.288
MOD_ProDKin_1	71	77	PF00069	0.331
MOD_ProDKin_1	8	14	PF00069	0.706
MOD_SUMO_rev_2	230	235	PF00179	0.389
TRG_ENDOCYTIC_2	267	270	PF00928	0.295
TRG_ENDOCYTIC_2	271	274	PF00928	0.311
TRG_ENDOCYTIC_2	64	67	PF00928	0.248

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT03	Leptomonas seymouri	77%	100%
A0A0S4IXN4	Bodo saltans	39%	100%
A0A1X0NHY2	Trypanosomatidae	60%	100%
A0A3R7NG75	Trypanosoma rangeli	59%	100%
A0A3S5H7Y9	Leishmania donovani	99%	100%
A4HMG8	Leishmania braziliensis	89%	100%
A4IB40	Leishmania infantum	99%	100%
C9ZNP1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9B625	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q9Y7X4	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
V5B7S6	Trypanosoma cruzi	58%	100%