Putative peroxisome targeting signal 1 receptor

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peroxisome targeting signal 1 receptor, putative

Species:

Leishmania major

UniProt:

E9AEW5_LEIMA

TriTrypDb:

LmjF.35.1420 , LMJLV39_350020600 , LMJSD75_350019800

Length:

631

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005778	peroxisomal membrane	6	2
GO:0005829	cytosol	2	2
GO:0016020	membrane	2	12
GO:0031090	organelle membrane	3	2
GO:0031903	microbody membrane	5	2
GO:0042579	microbody	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0098588	bounding membrane of organelle	4	2
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	10

Expansion

Sequence features

E9AEW5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEW5

Function

Biological processes
Term	Name	Level	Count
GO:0008104	protein localization	4	3
GO:0009987	cellular process	1	3
GO:0016560	protein import into peroxisome matrix, docking	5	2
GO:0033036	macromolecule localization	2	3
GO:0051179	localization	1	3
GO:0051641	cellular localization	2	3
GO:0070727	cellular macromolecule localization	3	3
GO:0006810	transport	3	1
GO:0015031	protein transport	4	1
GO:0045184	establishment of protein localization	3	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0000268	peroxisome targeting sequence binding	5	2
GO:0005048	signal sequence binding	4	2
GO:0005052	peroxisome matrix targeting signal-1 binding	6	2
GO:0005488	binding	1	2
GO:0033218	amide binding	2	2
GO:0042277	peptide binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	31	35	PF00656	0.674
CLV_NRD_NRD_1	390	392	PF00675	0.471
CLV_NRD_NRD_1	500	502	PF00675	0.342
CLV_PCSK_SKI1_1	15	19	PF00082	0.522
CLV_PCSK_SKI1_1	221	225	PF00082	0.519
DEG_APCC_DBOX_1	597	605	PF00400	0.370
DEG_Nend_UBRbox_2	1	3	PF02207	0.588
DOC_CDC14_PxL_1	140	148	PF14671	0.635
DOC_CKS1_1	274	279	PF01111	0.523
DOC_PP2B_LxvP_1	258	261	PF13499	0.554
DOC_PP4_FxxP_1	192	195	PF00568	0.700
DOC_PP4_FxxP_1	265	268	PF00568	0.637
DOC_PP4_FxxP_1	453	456	PF00568	0.463
DOC_USP7_MATH_1	118	122	PF00917	0.720
DOC_USP7_MATH_1	417	421	PF00917	0.392
DOC_USP7_MATH_1	435	439	PF00917	0.605
DOC_USP7_MATH_1	454	458	PF00917	0.481
DOC_USP7_MATH_1	474	478	PF00917	0.215
DOC_USP7_MATH_1	571	575	PF00917	0.499
DOC_USP7_UBL2_3	512	516	PF12436	0.354
DOC_WW_Pin1_4	273	278	PF00397	0.700
DOC_WW_Pin1_4	43	48	PF00397	0.542
LIG_14-3-3_CanoR_1	598	602	PF00244	0.389
LIG_APCC_ABBA_1	504	509	PF00400	0.328
LIG_BRCT_BRCA1_1	476	480	PF00533	0.485
LIG_FHA_1	598	604	PF00498	0.403
LIG_FHA_2	199	205	PF00498	0.553
LIG_FHA_2	371	377	PF00498	0.367
LIG_FHA_2	462	468	PF00498	0.521
LIG_FHA_2	611	617	PF00498	0.559
LIG_FXI_DFP_1	329	333	PF00024	0.489
LIG_IBAR_NPY_1	325	327	PF08397	0.384
LIG_LIR_Apic_2	191	195	PF02991	0.701
LIG_LIR_Apic_2	262	268	PF02991	0.634
LIG_LIR_Apic_2	450	456	PF02991	0.538
LIG_LIR_Gen_1	183	194	PF02991	0.667
LIG_LIR_Gen_1	302	310	PF02991	0.529
LIG_LIR_Gen_1	364	375	PF02991	0.499
LIG_LIR_Gen_1	430	439	PF02991	0.546
LIG_LIR_Gen_1	477	486	PF02991	0.504
LIG_LIR_Nem_3	138	143	PF02991	0.745
LIG_LIR_Nem_3	183	189	PF02991	0.633
LIG_LIR_Nem_3	208	214	PF02991	0.503
LIG_LIR_Nem_3	364	370	PF02991	0.376
LIG_LIR_Nem_3	430	434	PF02991	0.481
LIG_LIR_Nem_3	477	483	PF02991	0.473
LIG_Pex14_1	182	186	PF04695	0.574
LIG_Pex14_1	299	303	PF04695	0.533
LIG_Pex14_1	53	57	PF04695	0.548
LIG_Pex14_2	621	625	PF04695	0.375
LIG_PTB_Apo_2	538	545	PF02174	0.297
LIG_PTB_Phospho_1	538	544	PF10480	0.297
LIG_SH2_CRK	140	144	PF00017	0.746
LIG_SH2_CRK	186	190	PF00017	0.697
LIG_SH2_GRB2like	555	558	PF00017	0.379
LIG_SH2_NCK_1	186	190	PF00017	0.612
LIG_SH2_NCK_1	561	565	PF00017	0.416
LIG_SH2_STAP1	431	435	PF00017	0.523
LIG_SH2_STAP1	466	470	PF00017	0.529
LIG_SH2_STAT3	614	617	PF00017	0.493
LIG_SH2_STAT5	248	251	PF00017	0.538
LIG_SH2_STAT5	285	288	PF00017	0.735
LIG_SH2_STAT5	544	547	PF00017	0.317
LIG_SH3_3	145	151	PF00018	0.648
LIG_SH3_3	230	236	PF00018	0.524
LIG_SH3_3	237	243	PF00018	0.552
LIG_SH3_3	261	267	PF00018	0.612
LIG_SH3_3	317	323	PF00018	0.439
LIG_SH3_3	423	429	PF00018	0.481
LIG_SH3_3	434	440	PF00018	0.525
LIG_SH3_3	505	511	PF00018	0.418
LIG_SUMO_SIM_anti_2	380	386	PF11976	0.389
LIG_TRAF2_1	201	204	PF00917	0.541
LIG_TYR_ITSM	182	189	PF00017	0.686
LIG_UBA3_1	384	392	PF00899	0.426
LIG_WRC_WIRS_1	189	194	PF05994	0.691
MOD_CK1_1	556	562	PF00069	0.464
MOD_CK2_1	198	204	PF00069	0.558
MOD_CK2_1	358	364	PF00069	0.461
MOD_CK2_1	370	376	PF00069	0.302
MOD_CK2_1	461	467	PF00069	0.490
MOD_CK2_1	610	616	PF00069	0.522
MOD_GlcNHglycan	170	173	PF01048	0.607
MOD_GlcNHglycan	192	195	PF01048	0.661
MOD_GlcNHglycan	26	29	PF01048	0.672
MOD_GlcNHglycan	271	274	PF01048	0.753
MOD_GlcNHglycan	38	41	PF01048	0.646
MOD_GlcNHglycan	581	584	PF01048	0.542
MOD_GlcNHglycan	89	92	PF01048	0.609
MOD_GSK3_1	11	18	PF00069	0.644
MOD_GSK3_1	180	187	PF00069	0.681
MOD_GSK3_1	24	31	PF00069	0.738
MOD_GSK3_1	269	276	PF00069	0.697
MOD_GSK3_1	402	409	PF00069	0.465
MOD_GSK3_1	474	481	PF00069	0.527
MOD_GSK3_1	579	586	PF00069	0.506
MOD_N-GLC_1	144	149	PF02516	0.708
MOD_N-GLC_1	314	319	PF02516	0.452
MOD_N-GLC_1	556	561	PF02516	0.462
MOD_NEK2_1	36	41	PF00069	0.646
MOD_NEK2_1	370	375	PF00069	0.367
MOD_NEK2_1	404	409	PF00069	0.371
MOD_NEK2_1	517	522	PF00069	0.297
MOD_NEK2_1	597	602	PF00069	0.393
MOD_NEK2_1	76	81	PF00069	0.567
MOD_NEK2_2	417	422	PF00069	0.415
MOD_PIKK_1	118	124	PF00454	0.686
MOD_PIKK_1	135	141	PF00454	0.717
MOD_PIKK_1	175	181	PF00454	0.664
MOD_PIKK_1	184	190	PF00454	0.694
MOD_PIKK_1	370	376	PF00454	0.371
MOD_PIKK_1	474	480	PF00454	0.532
MOD_PIKK_1	556	562	PF00454	0.464
MOD_PIKK_1	571	577	PF00454	0.404
MOD_PIKK_1	76	82	PF00454	0.710
MOD_PKA_2	597	603	PF00069	0.385
MOD_Plk_1	144	150	PF00069	0.734
MOD_Plk_1	15	21	PF00069	0.564
MOD_Plk_1	184	190	PF00069	0.694
MOD_Plk_1	198	204	PF00069	0.579
MOD_Plk_1	556	562	PF00069	0.464
MOD_Plk_2-3	198	204	PF00069	0.618
MOD_Plk_2-3	461	467	PF00069	0.542
MOD_Plk_4	110	116	PF00069	0.690
MOD_Plk_4	144	150	PF00069	0.528
MOD_Plk_4	15	21	PF00069	0.662
MOD_Plk_4	281	287	PF00069	0.579
MOD_Plk_4	447	453	PF00069	0.613
MOD_Plk_4	583	589	PF00069	0.589
MOD_ProDKin_1	273	279	PF00069	0.698
MOD_ProDKin_1	43	49	PF00069	0.543
MOD_SUMO_rev_2	193	202	PF00179	0.692
MOD_SUMO_rev_2	509	513	PF00179	0.384
TRG_DiLeu_BaEn_1	228	233	PF01217	0.603
TRG_DiLeu_BaEn_1	32	37	PF01217	0.581
TRG_DiLeu_BaEn_2	209	215	PF01217	0.557
TRG_ENDOCYTIC_2	140	143	PF00928	0.739
TRG_ENDOCYTIC_2	186	189	PF00928	0.633
TRG_ENDOCYTIC_2	212	215	PF00928	0.504
TRG_ENDOCYTIC_2	303	306	PF00928	0.515
TRG_ENDOCYTIC_2	431	434	PF00928	0.377
TRG_ENDOCYTIC_2	555	558	PF00928	0.379
TRG_NES_CRM1_1	616	628	PF08389	0.448
TRG_Pf-PMV_PEXEL_1	463	467	PF00026	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBT5	Leptomonas seymouri	81%	100%
A0A0S4KFV0	Bodo saltans	47%	100%
A0A1X0NH73	Trypanosomatidae	50%	97%
A0A3S7X906	Leishmania donovani	94%	100%
A0A422N9P3	Trypanosoma rangeli	48%	96%
A4HMG4	Leishmania braziliensis	85%	100%
A4IB35	Leishmania infantum	95%	100%
C9ZNN6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	96%
E9B621	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O70525	Cavia porcellus	31%	99%
Q9FMA3	Arabidopsis thaliana	32%	87%
V5B7T1	Trypanosoma cruzi	49%	95%