OTU domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zn-finger in Ran binding protein and others/OTU-like cysteine protease, putative

Species:

Leishmania major

UniProt:

E9AEW2_LEIMA

TriTrypDb:

LmjF.35.1390 , LMJLV39_350020300 , LMJSD75_350019500

Length:

680

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0051286	cell tip	3	2
GO:0060187	cell pole	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AEW2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEW2

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0016579	protein deubiquitination	6	2
GO:0019538	protein metabolic process	3	3
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	3
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	3
GO:0070646	protein modification by small protein removal	5	2
GO:0070647	protein modification by small protein conjugation or removal	5	2
GO:0071704	organic substance metabolic process	2	3
GO:1901564	organonitrogen compound metabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0004843	cysteine-type deubiquitinase activity	5	2
GO:0005488	binding	1	11
GO:0008233	peptidase activity	3	3
GO:0008234	cysteine-type peptidase activity	4	2
GO:0016787	hydrolase activity	2	3
GO:0019783	ubiquitin-like protein peptidase activity	4	2
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0101005	deubiquitinase activity	5	2
GO:0140096	catalytic activity, acting on a protein	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.393
CLV_NRD_NRD_1	100	102	PF00675	0.342
CLV_NRD_NRD_1	155	157	PF00675	0.587
CLV_NRD_NRD_1	168	170	PF00675	0.561
CLV_NRD_NRD_1	333	335	PF00675	0.570
CLV_PCSK_FUR_1	153	157	PF00082	0.543
CLV_PCSK_FUR_1	566	570	PF00082	0.591
CLV_PCSK_KEX2_1	100	102	PF00082	0.342
CLV_PCSK_KEX2_1	155	157	PF00082	0.550
CLV_PCSK_KEX2_1	168	170	PF00082	0.534
CLV_PCSK_KEX2_1	333	335	PF00082	0.761
CLV_PCSK_KEX2_1	388	390	PF00082	0.473
CLV_PCSK_KEX2_1	565	567	PF00082	0.502
CLV_PCSK_KEX2_1	568	570	PF00082	0.517
CLV_PCSK_PC1ET2_1	388	390	PF00082	0.480
CLV_PCSK_PC1ET2_1	565	567	PF00082	0.564
CLV_PCSK_PC1ET2_1	568	570	PF00082	0.604
CLV_PCSK_SKI1_1	106	110	PF00082	0.438
CLV_PCSK_SKI1_1	180	184	PF00082	0.508
CLV_PCSK_SKI1_1	388	392	PF00082	0.455
CLV_PCSK_SKI1_1	456	460	PF00082	0.354
CLV_PCSK_SKI1_1	49	53	PF00082	0.548
CLV_PCSK_SKI1_1	565	569	PF00082	0.544
CLV_PCSK_SKI1_1	653	657	PF00082	0.639
DEG_APCC_DBOX_1	220	228	PF00400	0.460
DEG_Nend_UBRbox_2	1	3	PF02207	0.547
DEG_SCF_TRCP1_1	578	584	PF00400	0.586
DEG_SPOP_SBC_1	24	28	PF00917	0.607
DEG_SPOP_SBC_1	33	37	PF00917	0.775
DOC_CKS1_1	301	306	PF01111	0.435
DOC_CKS1_1	95	100	PF01111	0.366
DOC_MAPK_gen_1	219	226	PF00069	0.547
DOC_MAPK_gen_1	478	486	PF00069	0.531
DOC_MAPK_gen_1	49	58	PF00069	0.485
DOC_MAPK_gen_1	69	78	PF00069	0.377
DOC_MAPK_HePTP_8	68	80	PF00069	0.485
DOC_MAPK_MEF2A_6	478	486	PF00069	0.436
DOC_MAPK_MEF2A_6	71	80	PF00069	0.459
DOC_MAPK_MEF2A_6	84	92	PF00069	0.328
DOC_MIT_MIM_1	387	397	PF04212	0.499
DOC_PIKK_1	369	377	PF02985	0.475
DOC_PP1_RVXF_1	55	61	PF00149	0.512
DOC_PP2B_LxvP_1	90	93	PF13499	0.440
DOC_PP4_FxxP_1	207	210	PF00568	0.531
DOC_PP4_FxxP_1	420	423	PF00568	0.467
DOC_USP7_MATH_1	22	26	PF00917	0.665
DOC_USP7_MATH_1	220	224	PF00917	0.462
DOC_USP7_MATH_1	326	330	PF00917	0.735
DOC_USP7_MATH_1	33	37	PF00917	0.647
DOC_USP7_MATH_1	435	439	PF00917	0.482
DOC_USP7_MATH_1	576	580	PF00917	0.666
DOC_USP7_MATH_1	585	589	PF00917	0.623
DOC_USP7_MATH_1	598	602	PF00917	0.774
DOC_USP7_MATH_1	615	619	PF00917	0.707
DOC_USP7_MATH_1	634	638	PF00917	0.681
DOC_USP7_UBL2_3	335	339	PF12436	0.571
DOC_WW_Pin1_4	121	126	PF00397	0.557
DOC_WW_Pin1_4	300	305	PF00397	0.454
DOC_WW_Pin1_4	535	540	PF00397	0.467
DOC_WW_Pin1_4	543	548	PF00397	0.369
DOC_WW_Pin1_4	572	577	PF00397	0.691
DOC_WW_Pin1_4	63	68	PF00397	0.449
DOC_WW_Pin1_4	630	635	PF00397	0.645
DOC_WW_Pin1_4	667	672	PF00397	0.684
DOC_WW_Pin1_4	94	99	PF00397	0.354
LIG_14-3-3_CanoR_1	100	108	PF00244	0.294
LIG_14-3-3_CanoR_1	221	225	PF00244	0.431
LIG_14-3-3_CanoR_1	264	273	PF00244	0.543
LIG_14-3-3_CanoR_1	49	58	PF00244	0.596
LIG_14-3-3_CanoR_1	569	576	PF00244	0.658
LIG_14-3-3_CanoR_1	621	627	PF00244	0.788
LIG_14-3-3_CanoR_1	648	657	PF00244	0.663
LIG_14-3-3_CanoR_1	84	88	PF00244	0.487
LIG_deltaCOP1_diTrp_1	492	498	PF00928	0.479
LIG_eIF4E_1	527	533	PF01652	0.357
LIG_FHA_1	124	130	PF00498	0.600
LIG_FHA_1	177	183	PF00498	0.447
LIG_FHA_1	212	218	PF00498	0.582
LIG_FHA_1	515	521	PF00498	0.481
LIG_FHA_1	581	587	PF00498	0.670
LIG_FHA_2	301	307	PF00498	0.395
LIG_FHA_2	371	377	PF00498	0.497
LIG_FHA_2	43	49	PF00498	0.531
LIG_FHA_2	464	470	PF00498	0.529
LIG_FHA_2	523	529	PF00498	0.452
LIG_GSK3_LRP6_1	667	673	PF00069	0.619
LIG_IRF3_LxIS_1	394	400	PF10401	0.485
LIG_LIR_Apic_2	184	189	PF02991	0.426
LIG_LIR_Gen_1	104	114	PF02991	0.494
LIG_LIR_Gen_1	441	452	PF02991	0.452
LIG_LIR_Gen_1	492	498	PF02991	0.434
LIG_LIR_Gen_1	601	611	PF02991	0.598
LIG_LIR_Gen_1	86	95	PF02991	0.456
LIG_LIR_Nem_3	104	110	PF02991	0.470
LIG_LIR_Nem_3	131	137	PF02991	0.599
LIG_LIR_Nem_3	441	447	PF02991	0.449
LIG_LIR_Nem_3	451	457	PF02991	0.477
LIG_LIR_Nem_3	492	497	PF02991	0.434
LIG_LIR_Nem_3	525	530	PF02991	0.556
LIG_LIR_Nem_3	531	536	PF02991	0.408
LIG_LIR_Nem_3	601	606	PF02991	0.594
LIG_LIR_Nem_3	86	90	PF02991	0.394
LIG_NRBOX	554	560	PF00104	0.524
LIG_PCNA_yPIPBox_3	180	194	PF02747	0.461
LIG_PDZ_Class_2	675	680	PF00595	0.589
LIG_Pex14_1	494	498	PF04695	0.436
LIG_PTB_Apo_2	414	421	PF02174	0.467
LIG_SH2_CRK	301	305	PF00017	0.351
LIG_SH2_CRK	444	448	PF00017	0.441
LIG_SH2_NCK_1	301	305	PF00017	0.512
LIG_SH2_NCK_1	542	546	PF00017	0.358
LIG_SH2_SRC	542	545	PF00017	0.324
LIG_SH2_STAP1	444	448	PF00017	0.449
LIG_SH2_STAT5	294	297	PF00017	0.543
LIG_SH2_STAT5	3	6	PF00017	0.426
LIG_SH2_STAT5	427	430	PF00017	0.482
LIG_SH2_STAT5	457	460	PF00017	0.479
LIG_SH2_STAT5	536	539	PF00017	0.404
LIG_SH2_STAT5	87	90	PF00017	0.391
LIG_SH3_1	609	615	PF00018	0.521
LIG_SH3_1	665	671	PF00018	0.728
LIG_SH3_2	612	617	PF14604	0.552
LIG_SH3_3	119	125	PF00018	0.526
LIG_SH3_3	134	140	PF00018	0.421
LIG_SH3_3	210	216	PF00018	0.460
LIG_SH3_3	604	610	PF00018	0.631
LIG_SH3_3	639	645	PF00018	0.680
LIG_SH3_3	660	666	PF00018	0.672
LIG_SH3_4	359	366	PF00018	0.467
LIG_SUMO_SIM_anti_2	86	92	PF11976	0.438
LIG_TRAF2_1	231	234	PF00917	0.488
LIG_TRAF2_1	373	376	PF00917	0.532
LIG_TRAF2_1	489	492	PF00917	0.520
LIG_TYR_ITIM	540	545	PF00017	0.339
LIG_TYR_ITSM	523	530	PF00017	0.436
LIG_WRC_WIRS_1	182	187	PF05994	0.479
LIG_WRC_WIRS_1	190	195	PF05994	0.428
MOD_CDC14_SPxK_1	66	69	PF00782	0.454
MOD_CDK_SPxK_1	63	69	PF00069	0.447
MOD_CDK_SPxK_1	94	100	PF00069	0.347
MOD_CDK_SPxxK_3	94	101	PF00069	0.347
MOD_CK1_1	121	127	PF00069	0.579
MOD_CK1_1	181	187	PF00069	0.526
MOD_CK1_1	25	31	PF00069	0.580
MOD_CK1_1	277	283	PF00069	0.379
MOD_CK1_1	431	437	PF00069	0.481
MOD_CK1_1	438	444	PF00069	0.270
MOD_CK1_1	579	585	PF00069	0.717
MOD_CK1_1	601	607	PF00069	0.637
MOD_CK1_1	651	657	PF00069	0.784
MOD_CK1_1	670	676	PF00069	0.731
MOD_CK1_1	86	92	PF00069	0.438
MOD_CK2_1	228	234	PF00069	0.656
MOD_CK2_1	370	376	PF00069	0.438
MOD_CK2_1	486	492	PF00069	0.388
MOD_CK2_1	522	528	PF00069	0.477
MOD_CK2_1	626	632	PF00069	0.686
MOD_GlcNHglycan	148	151	PF01048	0.487
MOD_GlcNHglycan	164	167	PF01048	0.609
MOD_GlcNHglycan	171	174	PF01048	0.628
MOD_GlcNHglycan	230	233	PF01048	0.559
MOD_GlcNHglycan	27	30	PF01048	0.673
MOD_GlcNHglycan	328	331	PF01048	0.563
MOD_GlcNHglycan	52	55	PF01048	0.629
MOD_GlcNHglycan	559	562	PF01048	0.475
MOD_GlcNHglycan	578	581	PF01048	0.495
MOD_GlcNHglycan	583	586	PF01048	0.644
MOD_GlcNHglycan	587	590	PF01048	0.614
MOD_GSK3_1	141	148	PF00069	0.562
MOD_GSK3_1	174	181	PF00069	0.560
MOD_GSK3_1	235	242	PF00069	0.631
MOD_GSK3_1	24	31	PF00069	0.642
MOD_GSK3_1	322	329	PF00069	0.513
MOD_GSK3_1	431	438	PF00069	0.481
MOD_GSK3_1	570	577	PF00069	0.676
MOD_GSK3_1	581	588	PF00069	0.655
MOD_GSK3_1	601	608	PF00069	0.777
MOD_GSK3_1	615	622	PF00069	0.525
MOD_GSK3_1	626	633	PF00069	0.591
MOD_GSK3_1	644	651	PF00069	0.704
MOD_GSK3_1	653	660	PF00069	0.699
MOD_GSK3_1	666	673	PF00069	0.613
MOD_N-GLC_1	569	574	PF02516	0.635
MOD_N-GLC_1	601	606	PF02516	0.594
MOD_NEK2_1	129	134	PF00069	0.685
MOD_NEK2_1	145	150	PF00069	0.559
MOD_NEK2_1	164	169	PF00069	0.738
MOD_NEK2_1	178	183	PF00069	0.586
MOD_NEK2_1	397	402	PF00069	0.520
MOD_NEK2_1	428	433	PF00069	0.397
MOD_NEK2_1	503	508	PF00069	0.583
MOD_NEK2_1	626	631	PF00069	0.582
MOD_NEK2_1	78	83	PF00069	0.354
MOD_PIKK_1	274	280	PF00454	0.466
MOD_PK_1	118	124	PF00069	0.500
MOD_PKA_1	100	106	PF00069	0.392
MOD_PKA_2	100	106	PF00069	0.267
MOD_PKA_2	167	173	PF00069	0.597
MOD_PKA_2	220	226	PF00069	0.465
MOD_PKA_2	263	269	PF00069	0.516
MOD_PKA_2	620	626	PF00069	0.791
MOD_PKA_2	83	89	PF00069	0.407
MOD_PKB_1	646	654	PF00069	0.705
MOD_Plk_1	601	607	PF00069	0.631
MOD_Plk_2-3	370	376	PF00069	0.468
MOD_Plk_2-3	463	469	PF00069	0.404
MOD_Plk_4	129	135	PF00069	0.567
MOD_Plk_4	141	147	PF00069	0.534
MOD_Plk_4	181	187	PF00069	0.501
MOD_Plk_4	189	195	PF00069	0.444
MOD_Plk_4	528	534	PF00069	0.455
MOD_Plk_4	83	89	PF00069	0.481
MOD_ProDKin_1	121	127	PF00069	0.556
MOD_ProDKin_1	300	306	PF00069	0.455
MOD_ProDKin_1	535	541	PF00069	0.465
MOD_ProDKin_1	543	549	PF00069	0.383
MOD_ProDKin_1	572	578	PF00069	0.697
MOD_ProDKin_1	63	69	PF00069	0.447
MOD_ProDKin_1	630	636	PF00069	0.646
MOD_ProDKin_1	667	673	PF00069	0.684
MOD_ProDKin_1	94	100	PF00069	0.347
TRG_DiLeu_BaEn_1	159	164	PF01217	0.529
TRG_DiLeu_BaEn_2	202	208	PF01217	0.560
TRG_DiLeu_BaEn_4	159	165	PF01217	0.627
TRG_DiLeu_BaLyEn_6	386	391	PF01217	0.504
TRG_DiLeu_LyEn_5	159	164	PF01217	0.529
TRG_ENDOCYTIC_2	134	137	PF00928	0.570
TRG_ENDOCYTIC_2	444	447	PF00928	0.292
TRG_ENDOCYTIC_2	527	530	PF00928	0.429
TRG_ENDOCYTIC_2	542	545	PF00928	0.258
TRG_ENDOCYTIC_2	87	90	PF00928	0.439
TRG_ER_diArg_1	152	155	PF00400	0.502
TRG_ER_diArg_1	645	648	PF00400	0.664
TRG_NLS_MonoExtC_3	564	569	PF00514	0.496
TRG_Pf-PMV_PEXEL_1	413	418	PF00026	0.303
TRG_Pf-PMV_PEXEL_1	609	614	PF00026	0.766

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5V7	Leptomonas seymouri	56%	100%
A0A1X0NIV4	Trypanosomatidae	32%	87%
A0A3Q8IJ90	Leishmania donovani	94%	100%
A0A3R7MGK1	Trypanosoma rangeli	39%	98%
A4HMG1	Leishmania braziliensis	68%	96%
A4IB32	Leishmania infantum	94%	100%
C9ZNN0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	74%
E9B618	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BC93	Trypanosoma cruzi	35%	100%