Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

E9AEV9_LEIMA

TriTrypDb:

LmjF.35.1360 , LMJLV39_350020000 , LMJSD75_350019200

Length:

449

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AEV9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEV9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	135	139	PF00656	0.664
CLV_C14_Caspase3-7	184	188	PF00656	0.653
CLV_C14_Caspase3-7	381	385	PF00656	0.514
CLV_C14_Caspase3-7	416	420	PF00656	0.410
CLV_NRD_NRD_1	29	31	PF00675	0.470
CLV_NRD_NRD_1	298	300	PF00675	0.607
CLV_NRD_NRD_1	387	389	PF00675	0.491
CLV_NRD_NRD_1	394	396	PF00675	0.439
CLV_NRD_NRD_1	417	419	PF00675	0.617
CLV_PCSK_FUR_1	426	430	PF00082	0.500
CLV_PCSK_FUR_1	445	449	PF00082	0.433
CLV_PCSK_KEX2_1	29	31	PF00082	0.470
CLV_PCSK_KEX2_1	298	300	PF00082	0.635
CLV_PCSK_KEX2_1	389	391	PF00082	0.521
CLV_PCSK_KEX2_1	396	398	PF00082	0.493
CLV_PCSK_KEX2_1	417	419	PF00082	0.535
CLV_PCSK_KEX2_1	428	430	PF00082	0.645
CLV_PCSK_KEX2_1	444	446	PF00082	0.433
CLV_PCSK_KEX2_1	447	449	PF00082	0.445
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.630
CLV_PCSK_PC1ET2_1	389	391	PF00082	0.521
CLV_PCSK_PC1ET2_1	396	398	PF00082	0.493
CLV_PCSK_PC1ET2_1	428	430	PF00082	0.657
CLV_PCSK_PC1ET2_1	444	446	PF00082	0.431
CLV_PCSK_PC1ET2_1	447	449	PF00082	0.445
CLV_PCSK_PC7_1	392	398	PF00082	0.469
CLV_PCSK_SKI1_1	310	314	PF00082	0.642
CLV_PCSK_SKI1_1	397	401	PF00082	0.549
CLV_PCSK_SKI1_1	55	59	PF00082	0.646
DEG_APCC_DBOX_1	375	383	PF00400	0.446
DEG_Nend_UBRbox_3	1	3	PF02207	0.574
DEG_SCF_FBW7_1	361	367	PF00400	0.633
DEG_SPOP_SBC_1	201	205	PF00917	0.649
DOC_CKS1_1	245	250	PF01111	0.582
DOC_CKS1_1	361	366	PF01111	0.633
DOC_MAPK_gen_1	314	324	PF00069	0.524
DOC_USP7_MATH_1	113	117	PF00917	0.641
DOC_USP7_MATH_1	201	205	PF00917	0.743
DOC_USP7_MATH_1	226	230	PF00917	0.599
DOC_USP7_MATH_1	280	284	PF00917	0.690
DOC_USP7_MATH_1	294	298	PF00917	0.724
DOC_USP7_MATH_1	315	319	PF00917	0.689
DOC_USP7_MATH_1	336	340	PF00917	0.630
DOC_USP7_MATH_1	364	368	PF00917	0.673
DOC_USP7_UBL2_3	310	314	PF12436	0.702
DOC_USP7_UBL2_3	396	400	PF12436	0.500
DOC_USP7_UBL2_3	60	64	PF12436	0.584
DOC_WW_Pin1_4	244	249	PF00397	0.589
DOC_WW_Pin1_4	257	262	PF00397	0.691
DOC_WW_Pin1_4	298	303	PF00397	0.616
DOC_WW_Pin1_4	360	365	PF00397	0.672
LIG_14-3-3_CanoR_1	19	24	PF00244	0.485
LIG_14-3-3_CanoR_1	317	323	PF00244	0.527
LIG_14-3-3_CanoR_1	365	371	PF00244	0.625
LIG_14-3-3_CanoR_1	42	50	PF00244	0.640
LIG_BIR_III_2	335	339	PF00653	0.602
LIG_FHA_1	113	119	PF00498	0.661
LIG_FHA_1	273	279	PF00498	0.573
LIG_FHA_1	319	325	PF00498	0.787
LIG_FHA_1	32	38	PF00498	0.533
LIG_FHA_2	104	110	PF00498	0.668
LIG_FHA_2	341	347	PF00498	0.690
LIG_FHA_2	401	407	PF00498	0.380
LIG_FHA_2	9	15	PF00498	0.500
LIG_LIR_Nem_3	165	171	PF02991	0.537
LIG_LIR_Nem_3	177	182	PF02991	0.528
LIG_LIR_Nem_3	241	246	PF02991	0.613
LIG_Pex14_2	58	62	PF04695	0.607
LIG_PTB_Apo_2	334	341	PF02174	0.538
LIG_SH2_GRB2like	323	326	PF00017	0.635
LIG_SH2_STAP1	212	216	PF00017	0.565
LIG_SH2_STAT3	212	215	PF00017	0.738
LIG_SH2_STAT5	169	172	PF00017	0.518
LIG_SH2_STAT5	181	184	PF00017	0.552
LIG_SH2_STAT5	230	233	PF00017	0.531
LIG_SH2_STAT5	234	237	PF00017	0.515
LIG_SH2_STAT5	244	247	PF00017	0.555
LIG_SH2_STAT5	323	326	PF00017	0.654
LIG_SH2_STAT5	6	9	PF00017	0.515
LIG_SH3_3	20	26	PF00018	0.566
LIG_SH3_3	309	315	PF00018	0.632
LIG_SH3_3	346	352	PF00018	0.708
LIG_SH3_3	90	96	PF00018	0.630
LIG_SUMO_SIM_anti_2	378	384	PF11976	0.524
LIG_SUMO_SIM_par_1	378	384	PF11976	0.440
LIG_TRAF2_1	286	289	PF00917	0.552
LIG_TRAF2_2	261	266	PF00917	0.637
MOD_CDK_SPK_2	360	365	PF00069	0.633
MOD_CK1_1	205	211	PF00069	0.628
MOD_CK1_1	269	275	PF00069	0.699
MOD_CK1_1	318	324	PF00069	0.690
MOD_CK1_1	367	373	PF00069	0.569
MOD_CK1_1	440	446	PF00069	0.552
MOD_CK1_1	48	54	PF00069	0.723
MOD_CK2_1	221	227	PF00069	0.566
MOD_CK2_1	342	348	PF00069	0.658
MOD_CK2_1	367	373	PF00069	0.643
MOD_CK2_1	400	406	PF00069	0.643
MOD_GlcNHglycan	138	141	PF01048	0.697
MOD_GlcNHglycan	150	154	PF01048	0.571
MOD_GlcNHglycan	268	271	PF01048	0.707
MOD_GlcNHglycan	275	278	PF01048	0.590
MOD_GlcNHglycan	39	42	PF01048	0.728
MOD_GlcNHglycan	51	54	PF01048	0.545
MOD_GSK3_1	15	22	PF00069	0.500
MOD_GSK3_1	197	204	PF00069	0.717
MOD_GSK3_1	257	264	PF00069	0.731
MOD_GSK3_1	266	273	PF00069	0.634
MOD_GSK3_1	280	287	PF00069	0.663
MOD_GSK3_1	294	301	PF00069	0.578
MOD_GSK3_1	336	343	PF00069	0.649
MOD_GSK3_1	360	367	PF00069	0.634
MOD_GSK3_1	45	52	PF00069	0.612
MOD_GSK3_1	99	106	PF00069	0.772
MOD_LATS_1	47	53	PF00433	0.584
MOD_NEK2_1	1	6	PF00069	0.594
MOD_NEK2_1	185	190	PF00069	0.623
MOD_NEK2_1	340	345	PF00069	0.616
MOD_NEK2_1	37	42	PF00069	0.669
MOD_PIKK_1	202	208	PF00454	0.697
MOD_PIKK_1	211	217	PF00454	0.542
MOD_PIKK_1	261	267	PF00454	0.689
MOD_PK_1	19	25	PF00069	0.475
MOD_PKA_2	18	24	PF00069	0.483
MOD_PKA_2	318	324	PF00069	0.609
MOD_PKA_2	364	370	PF00069	0.629
MOD_PKA_2	43	49	PF00069	0.731
MOD_Plk_1	113	119	PF00069	0.589
MOD_Plk_1	367	373	PF00069	0.585
MOD_Plk_4	1	7	PF00069	0.551
MOD_Plk_4	206	212	PF00069	0.607
MOD_Plk_4	226	232	PF00069	0.447
MOD_Plk_4	238	244	PF00069	0.511
MOD_Plk_4	318	324	PF00069	0.670
MOD_Plk_4	336	342	PF00069	0.584
MOD_Plk_4	352	358	PF00069	0.528
MOD_Plk_4	437	443	PF00069	0.500
MOD_ProDKin_1	244	250	PF00069	0.594
MOD_ProDKin_1	257	263	PF00069	0.692
MOD_ProDKin_1	298	304	PF00069	0.611
MOD_ProDKin_1	360	366	PF00069	0.671
MOD_SUMO_rev_2	381	391	PF00179	0.480
TRG_DiLeu_BaEn_2	393	399	PF01217	0.446
TRG_ENDOCYTIC_2	179	182	PF00928	0.565
TRG_ER_diArg_1	388	391	PF00400	0.517
TRG_ER_diArg_1	395	398	PF00400	0.495
TRG_NLS_Bipartite_1	428	448	PF00514	0.502
TRG_NLS_MonoCore_2	443	448	PF00514	0.538
TRG_NLS_MonoExtC_3	297	302	PF00514	0.622
TRG_NLS_MonoExtC_3	388	394	PF00514	0.460
TRG_NLS_MonoExtC_3	443	448	PF00514	0.538
TRG_NLS_MonoExtN_4	296	302	PF00514	0.625
TRG_NLS_MonoExtN_4	388	393	PF00514	0.463
TRG_Pf-PMV_PEXEL_1	397	401	PF00026	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5V5	Leptomonas seymouri	35%	88%
A0A3Q8IV47	Leishmania donovani	89%	100%
A4HMF8	Leishmania braziliensis	54%	100%
A4IB29	Leishmania infantum	89%	100%
E9B615	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%