LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
E9AEV0_LEIMA
TriTrypDb:
LmjF.35.1270 , LMJLV39_350019100 * , LMJSD75_350018300
Length:
358

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AEV0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEV0

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 267 269 PF00675 0.761
CLV_NRD_NRD_1 332 334 PF00675 0.562
CLV_NRD_NRD_1 336 338 PF00675 0.539
CLV_PCSK_FUR_1 330 334 PF00082 0.697
CLV_PCSK_KEX2_1 267 269 PF00082 0.816
CLV_PCSK_KEX2_1 332 334 PF00082 0.559
CLV_PCSK_KEX2_1 335 337 PF00082 0.542
CLV_PCSK_PC7_1 332 338 PF00082 0.710
CLV_PCSK_SKI1_1 136 140 PF00082 0.467
CLV_PCSK_SKI1_1 198 202 PF00082 0.655
CLV_PCSK_SKI1_1 315 319 PF00082 0.585
CLV_PCSK_SKI1_1 344 348 PF00082 0.629
DEG_Nend_UBRbox_3 1 3 PF02207 0.714
DEG_SCF_FBW7_1 75 81 PF00400 0.722
DEG_SCF_TRCP1_1 70 76 PF00400 0.604
DOC_ANK_TNKS_1 147 154 PF00023 0.541
DOC_CKS1_1 75 80 PF01111 0.755
DOC_CYCLIN_yCln2_LP_2 201 204 PF00134 0.770
DOC_MAPK_DCC_7 198 207 PF00069 0.768
DOC_MAPK_MEF2A_6 198 207 PF00069 0.768
DOC_PP2B_LxvP_1 188 191 PF13499 0.591
DOC_PP2B_LxvP_1 201 204 PF13499 0.668
DOC_PP4_FxxP_1 38 41 PF00568 0.581
DOC_USP7_MATH_1 273 277 PF00917 0.818
DOC_USP7_MATH_1 282 286 PF00917 0.693
DOC_USP7_MATH_1 289 293 PF00917 0.549
DOC_USP7_MATH_1 89 93 PF00917 0.727
DOC_WW_Pin1_4 226 231 PF00397 0.827
DOC_WW_Pin1_4 71 76 PF00397 0.831
DOC_WW_Pin1_4 85 90 PF00397 0.572
LIG_14-3-3_CanoR_1 136 146 PF00244 0.514
LIG_14-3-3_CanoR_1 14 20 PF00244 0.661
LIG_14-3-3_CanoR_1 22 28 PF00244 0.495
LIG_14-3-3_CanoR_1 226 230 PF00244 0.791
LIG_14-3-3_CanoR_1 288 297 PF00244 0.796
LIG_14-3-3_CanoR_1 303 310 PF00244 0.482
LIG_BRCT_BRCA1_1 146 150 PF00533 0.612
LIG_Clathr_ClatBox_1 166 170 PF01394 0.619
LIG_CtBP_PxDLS_1 204 208 PF00389 0.668
LIG_eIF4E_1 183 189 PF01652 0.517
LIG_FHA_1 343 349 PF00498 0.540
LIG_FHA_1 56 62 PF00498 0.745
LIG_FHA_2 182 188 PF00498 0.608
LIG_FHA_2 28 34 PF00498 0.534
LIG_FHA_2 314 320 PF00498 0.528
LIG_FHA_2 58 64 PF00498 0.791
LIG_LIR_Gen_1 299 309 PF02991 0.768
LIG_LIR_Nem_3 299 304 PF02991 0.773
LIG_SH2_CRK 135 139 PF00017 0.508
LIG_SH2_NCK_1 183 187 PF00017 0.493
LIG_SH2_STAP1 116 120 PF00017 0.619
LIG_SH2_STAT5 114 117 PF00017 0.610
LIG_SH2_STAT5 183 186 PF00017 0.582
LIG_SH2_STAT5 297 300 PF00017 0.741
LIG_SH3_3 197 203 PF00018 0.656
LIG_SH3_3 227 233 PF00018 0.717
LIG_SH3_3 72 78 PF00018 0.756
LIG_SUMO_SIM_anti_2 184 190 PF11976 0.639
LIG_TRAF2_1 210 213 PF00917 0.743
LIG_WW_2 230 233 PF00397 0.688
MOD_CK1_1 192 198 PF00069 0.582
MOD_CK1_1 258 264 PF00069 0.705
MOD_CK1_1 26 32 PF00069 0.484
MOD_CK1_1 313 319 PF00069 0.641
MOD_CK1_1 71 77 PF00069 0.820
MOD_CK1_1 92 98 PF00069 0.482
MOD_CK2_1 181 187 PF00069 0.597
MOD_CK2_1 27 33 PF00069 0.424
MOD_CK2_1 313 319 PF00069 0.587
MOD_CK2_1 40 46 PF00069 0.739
MOD_CK2_1 57 63 PF00069 0.655
MOD_DYRK1A_RPxSP_1 226 230 PF00069 0.830
MOD_GlcNHglycan 15 18 PF01048 0.668
MOD_GlcNHglycan 161 164 PF01048 0.660
MOD_GlcNHglycan 191 194 PF01048 0.578
MOD_GlcNHglycan 207 210 PF01048 0.643
MOD_GlcNHglycan 221 224 PF01048 0.664
MOD_GlcNHglycan 260 263 PF01048 0.695
MOD_GlcNHglycan 284 287 PF01048 0.822
MOD_GlcNHglycan 70 73 PF01048 0.777
MOD_GSK3_1 211 218 PF00069 0.703
MOD_GSK3_1 23 30 PF00069 0.497
MOD_GSK3_1 66 73 PF00069 0.832
MOD_GSK3_1 74 81 PF00069 0.710
MOD_GSK3_1 83 90 PF00069 0.528
MOD_GSK3_1 92 99 PF00069 0.376
MOD_N-GLC_1 263 268 PF02516 0.791
MOD_N-GLC_1 321 326 PF02516 0.566
MOD_N-GLC_1 342 347 PF02516 0.611
MOD_NEK2_1 137 142 PF00069 0.600
MOD_NEK2_1 156 161 PF00069 0.275
MOD_NEK2_1 23 28 PF00069 0.465
MOD_NEK2_1 263 268 PF00069 0.733
MOD_NEK2_1 310 315 PF00069 0.542
MOD_NEK2_1 318 323 PF00069 0.452
MOD_PIKK_1 211 217 PF00454 0.703
MOD_PIKK_1 303 309 PF00454 0.766
MOD_PKA_1 268 274 PF00069 0.823
MOD_PKA_2 13 19 PF00069 0.652
MOD_PKA_2 215 221 PF00069 0.753
MOD_PKA_2 225 231 PF00069 0.683
MOD_PKA_2 287 293 PF00069 0.730
MOD_PKA_2 83 89 PF00069 0.803
MOD_Plk_1 157 163 PF00069 0.534
MOD_Plk_1 321 327 PF00069 0.567
MOD_Plk_1 342 348 PF00069 0.609
MOD_Plk_2-3 40 46 PF00069 0.597
MOD_Plk_2-3 57 63 PF00069 0.631
MOD_Plk_4 289 295 PF00069 0.758
MOD_Plk_4 313 319 PF00069 0.566
MOD_Plk_4 321 327 PF00069 0.338
MOD_Plk_4 342 348 PF00069 0.607
MOD_ProDKin_1 226 232 PF00069 0.825
MOD_ProDKin_1 71 77 PF00069 0.832
MOD_ProDKin_1 85 91 PF00069 0.564
MOD_SUMO_for_1 51 54 PF00179 0.827
TRG_AP2beta_CARGO_1 299 308 PF09066 0.769
TRG_DiLeu_BaLyEn_6 151 156 PF01217 0.537
TRG_ENDOCYTIC_2 135 138 PF00928 0.519
TRG_ENDOCYTIC_2 183 186 PF00928 0.582
TRG_ER_diArg_1 330 333 PF00400 0.565
TRG_ER_diArg_1 335 337 PF00400 0.531
TRG_Pf-PMV_PEXEL_1 154 158 PF00026 0.500
TRG_Pf-PMV_PEXEL_1 243 247 PF00026 0.713

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P694 Leptomonas seymouri 52% 100%
A0A3Q8IM05 Leishmania donovani 93% 100%
A4HME9 Leishmania braziliensis 81% 100%
A4IB21 Leishmania infantum 93% 100%
E9B606 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS