Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AEU7_LEIMA

TriTrypDb:

LmjF.35.1240 , LMJLV39_350018800 , LMJSD75_350018000

Length:

847

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AEU7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEU7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	222	226	PF00656	0.481
CLV_NRD_NRD_1	177	179	PF00675	0.428
CLV_NRD_NRD_1	244	246	PF00675	0.484
CLV_NRD_NRD_1	302	304	PF00675	0.553
CLV_NRD_NRD_1	316	318	PF00675	0.441
CLV_NRD_NRD_1	339	341	PF00675	0.522
CLV_NRD_NRD_1	401	403	PF00675	0.524
CLV_NRD_NRD_1	438	440	PF00675	0.571
CLV_NRD_NRD_1	505	507	PF00675	0.559
CLV_NRD_NRD_1	621	623	PF00675	0.456
CLV_NRD_NRD_1	679	681	PF00675	0.531
CLV_NRD_NRD_1	719	721	PF00675	0.608
CLV_NRD_NRD_1	834	836	PF00675	0.527
CLV_NRD_NRD_1	89	91	PF00675	0.474
CLV_PCSK_FUR_1	818	822	PF00082	0.515
CLV_PCSK_KEX2_1	15	17	PF00082	0.503
CLV_PCSK_KEX2_1	177	179	PF00082	0.515
CLV_PCSK_KEX2_1	273	275	PF00082	0.522
CLV_PCSK_KEX2_1	302	304	PF00082	0.530
CLV_PCSK_KEX2_1	31	33	PF00082	0.373
CLV_PCSK_KEX2_1	316	318	PF00082	0.390
CLV_PCSK_KEX2_1	329	331	PF00082	0.312
CLV_PCSK_KEX2_1	339	341	PF00082	0.429
CLV_PCSK_KEX2_1	401	403	PF00082	0.443
CLV_PCSK_KEX2_1	679	681	PF00082	0.531
CLV_PCSK_KEX2_1	719	721	PF00082	0.521
CLV_PCSK_KEX2_1	737	739	PF00082	0.707
CLV_PCSK_KEX2_1	820	822	PF00082	0.561
CLV_PCSK_KEX2_1	89	91	PF00082	0.473
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.614
CLV_PCSK_PC1ET2_1	273	275	PF00082	0.504
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.368
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.619
CLV_PCSK_PC1ET2_1	737	739	PF00082	0.707
CLV_PCSK_PC1ET2_1	820	822	PF00082	0.569
CLV_PCSK_SKI1_1	15	19	PF00082	0.555
CLV_PCSK_SKI1_1	265	269	PF00082	0.641
CLV_PCSK_SKI1_1	330	334	PF00082	0.619
CLV_PCSK_SKI1_1	340	344	PF00082	0.554
CLV_PCSK_SKI1_1	448	452	PF00082	0.511
CLV_PCSK_SKI1_1	506	510	PF00082	0.488
CLV_PCSK_SKI1_1	709	713	PF00082	0.537
CLV_PCSK_SKI1_1	719	723	PF00082	0.514
CLV_PCSK_SKI1_1	765	769	PF00082	0.622
DEG_APCC_DBOX_1	315	323	PF00400	0.487
DEG_APCC_DBOX_1	477	485	PF00400	0.470
DEG_APCC_DBOX_1	621	629	PF00400	0.470
DEG_APCC_DBOX_1	708	716	PF00400	0.438
DEG_APCC_DBOX_1	799	807	PF00400	0.561
DOC_CYCLIN_RxL_1	75	85	PF00134	0.450
DOC_CYCLIN_RxL_1	762	770	PF00134	0.487
DOC_MAPK_gen_1	316	324	PF00069	0.485
DOC_MAPK_gen_1	413	420	PF00069	0.550
DOC_MAPK_gen_1	620	630	PF00069	0.561
DOC_MAPK_gen_1	833	843	PF00069	0.488
DOC_MAPK_MEF2A_6	690	698	PF00069	0.520
DOC_USP7_MATH_1	107	111	PF00917	0.381
DOC_USP7_MATH_1	528	532	PF00917	0.463
DOC_USP7_MATH_1	739	743	PF00917	0.731
DOC_USP7_MATH_1	771	775	PF00917	0.657
DOC_USP7_MATH_1	790	794	PF00917	0.320
DOC_USP7_MATH_1	831	835	PF00917	0.397
DOC_USP7_MATH_1	91	95	PF00917	0.551
DOC_USP7_UBL2_3	413	417	PF12436	0.466
DOC_WW_Pin1_4	357	362	PF00397	0.623
DOC_WW_Pin1_4	665	670	PF00397	0.574
DOC_WW_Pin1_4	756	761	PF00397	0.651
LIG_14-3-3_CanoR_1	16	24	PF00244	0.552
LIG_14-3-3_CanoR_1	32	36	PF00244	0.457
LIG_14-3-3_CanoR_1	4	10	PF00244	0.623
LIG_14-3-3_CanoR_1	466	471	PF00244	0.570
LIG_14-3-3_CanoR_1	499	503	PF00244	0.550
LIG_14-3-3_CanoR_1	679	683	PF00244	0.524
LIG_14-3-3_CanoR_1	719	729	PF00244	0.625
LIG_14-3-3_CanoR_1	807	811	PF00244	0.434
LIG_BIR_II_1	1	5	PF00653	0.603
LIG_CaM_IQ_9	810	825	PF13499	0.564
LIG_Clathr_ClatBox_1	698	702	PF01394	0.459
LIG_eIF4E_1	682	688	PF01652	0.581
LIG_eIF4E_1	693	699	PF01652	0.455
LIG_FHA_1	16	22	PF00498	0.523
LIG_FHA_1	174	180	PF00498	0.574
LIG_FHA_1	219	225	PF00498	0.446
LIG_FHA_1	23	29	PF00498	0.531
LIG_FHA_1	388	394	PF00498	0.549
LIG_FHA_1	493	499	PF00498	0.523
LIG_FHA_1	703	709	PF00498	0.429
LIG_FHA_1	777	783	PF00498	0.441
LIG_FHA_2	393	399	PF00498	0.505
LIG_FHA_2	807	813	PF00498	0.539
LIG_Integrin_RGD_1	260	262	PF01839	0.429
LIG_LIR_Gen_1	159	168	PF02991	0.555
LIG_LIR_Nem_3	159	165	PF02991	0.562
LIG_NRP_CendR_1	844	847	PF00754	0.560
LIG_PCNA_yPIPBox_3	31	45	PF02747	0.517
LIG_PTAP_UEV_1	752	757	PF05743	0.537
LIG_Rb_LxCxE_1	320	341	PF01857	0.431
LIG_SH2_SRC	632	635	PF00017	0.444
LIG_SH2_STAP1	277	281	PF00017	0.550
LIG_SH2_STAP1	632	636	PF00017	0.592
LIG_SH2_STAT3	277	280	PF00017	0.552
LIG_SH2_STAT5	218	221	PF00017	0.581
LIG_SH2_STAT5	581	584	PF00017	0.484
LIG_SH2_STAT5	693	696	PF00017	0.527
LIG_SH2_STAT5	777	780	PF00017	0.361
LIG_SH3_3	650	656	PF00018	0.552
LIG_SH3_3	750	756	PF00018	0.565
LIG_SUMO_SIM_anti_2	320	328	PF11976	0.563
LIG_SUMO_SIM_anti_2	40	46	PF11976	0.440
LIG_SUMO_SIM_par_1	320	328	PF11976	0.537
LIG_SUMO_SIM_par_1	366	372	PF11976	0.477
LIG_SUMO_SIM_par_1	697	702	PF11976	0.459
LIG_TRAF2_1	422	425	PF00917	0.619
LIG_TRAF2_1	508	511	PF00917	0.667
LIG_TRAF2_1	540	543	PF00917	0.520
LIG_TYR_ITIM	630	635	PF00017	0.422
LIG_WRC_WIRS_1	393	398	PF05994	0.503
MOD_CK1_1	419	425	PF00069	0.466
MOD_CK1_1	754	760	PF00069	0.622
MOD_CK1_1	770	776	PF00069	0.475
MOD_CK2_1	103	109	PF00069	0.592
MOD_CK2_1	31	37	PF00069	0.530
MOD_CK2_1	419	425	PF00069	0.604
MOD_CK2_1	806	812	PF00069	0.539
MOD_Cter_Amidation	399	402	PF01082	0.563
MOD_Cter_Amidation	437	440	PF01082	0.371
MOD_GlcNHglycan	105	108	PF01048	0.649
MOD_GlcNHglycan	119	122	PF01048	0.465
MOD_GlcNHglycan	137	140	PF01048	0.487
MOD_GlcNHglycan	536	540	PF01048	0.534
MOD_GlcNHglycan	661	664	PF01048	0.439
MOD_GlcNHglycan	753	756	PF01048	0.656
MOD_GlcNHglycan	769	772	PF01048	0.399
MOD_GlcNHglycan	829	832	PF01048	0.365
MOD_GSK3_1	135	142	PF00069	0.673
MOD_GSK3_1	156	163	PF00069	0.657
MOD_GSK3_1	27	34	PF00069	0.514
MOD_GSK3_1	353	360	PF00069	0.641
MOD_GSK3_1	493	500	PF00069	0.656
MOD_GSK3_1	659	666	PF00069	0.562
MOD_GSK3_1	715	722	PF00069	0.538
MOD_GSK3_1	766	773	PF00069	0.582
MOD_GSK3_1	827	834	PF00069	0.534
MOD_GSK3_1	839	846	PF00069	0.583
MOD_GSK3_1	99	106	PF00069	0.526
MOD_N-GLC_1	10	15	PF02516	0.527
MOD_N-GLC_1	745	750	PF02516	0.653
MOD_NEK2_1	10	15	PF00069	0.582
MOD_NEK2_1	157	162	PF00069	0.537
MOD_NEK2_1	451	456	PF00069	0.440
MOD_NEK2_1	477	482	PF00069	0.480
MOD_NEK2_1	492	497	PF00069	0.453
MOD_NEK2_1	498	503	PF00069	0.496
MOD_NEK2_1	659	664	PF00069	0.517
MOD_NEK2_1	715	720	PF00069	0.557
MOD_NEK2_1	767	772	PF00069	0.494
MOD_NEK2_1	785	790	PF00069	0.397
MOD_NEK2_1	806	811	PF00069	0.538
MOD_NEK2_1	827	832	PF00069	0.463
MOD_NEK2_2	494	499	PF00069	0.500
MOD_NEK2_2	740	745	PF00069	0.568
MOD_PIKK_1	219	225	PF00454	0.381
MOD_PIKK_1	260	266	PF00454	0.631
MOD_PIKK_1	331	337	PF00454	0.568
MOD_PIKK_1	512	518	PF00454	0.608
MOD_PIKK_1	746	752	PF00454	0.736
MOD_PIKK_1	790	796	PF00454	0.510
MOD_PIKK_1	96	102	PF00454	0.652
MOD_PK_1	31	37	PF00069	0.477
MOD_PKA_1	15	21	PF00069	0.556
MOD_PKA_1	31	37	PF00069	0.530
MOD_PKA_1	719	725	PF00069	0.527
MOD_PKA_2	15	21	PF00069	0.515
MOD_PKA_2	31	37	PF00069	0.418
MOD_PKA_2	477	483	PF00069	0.445
MOD_PKA_2	498	504	PF00069	0.561
MOD_PKA_2	678	684	PF00069	0.532
MOD_PKA_2	715	721	PF00069	0.558
MOD_PKA_2	806	812	PF00069	0.451
MOD_PKA_2	827	833	PF00069	0.483
MOD_PKA_2	91	97	PF00069	0.470
MOD_PKB_1	115	123	PF00069	0.467
MOD_PKB_1	258	266	PF00069	0.520
MOD_Plk_1	108	114	PF00069	0.490
MOD_Plk_1	295	301	PF00069	0.458
MOD_Plk_1	528	534	PF00069	0.560
MOD_Plk_1	703	709	PF00069	0.525
MOD_Plk_1	785	791	PF00069	0.585
MOD_Plk_1	796	802	PF00069	0.513
MOD_Plk_2-3	22	28	PF00069	0.541
MOD_Plk_4	157	163	PF00069	0.510
MOD_Plk_4	295	301	PF00069	0.458
MOD_Plk_4	392	398	PF00069	0.604
MOD_Plk_4	416	422	PF00069	0.463
MOD_Plk_4	466	472	PF00069	0.475
MOD_Plk_4	477	483	PF00069	0.470
MOD_Plk_4	5	11	PF00069	0.526
MOD_Plk_4	557	563	PF00069	0.548
MOD_ProDKin_1	357	363	PF00069	0.617
MOD_ProDKin_1	665	671	PF00069	0.568
MOD_ProDKin_1	756	762	PF00069	0.647
MOD_SUMO_for_1	272	275	PF00179	0.636
MOD_SUMO_for_1	763	766	PF00179	0.428
MOD_SUMO_rev_2	71	77	PF00179	0.494
TRG_DiLeu_BaEn_1	132	137	PF01217	0.599
TRG_DiLeu_BaEn_1	320	325	PF01217	0.566
TRG_DiLeu_BaEn_1	328	333	PF01217	0.484
TRG_DiLeu_BaEn_1	40	45	PF01217	0.449
TRG_DiLeu_BaEn_1	447	452	PF01217	0.550
TRG_DiLeu_BaEn_1	683	688	PF01217	0.490
TRG_DiLeu_BaEn_3	295	301	PF01217	0.370
TRG_DiLeu_BaLyEn_6	521	526	PF01217	0.498
TRG_DiLeu_BaLyEn_6	544	549	PF01217	0.502
TRG_DiLeu_BaLyEn_6	655	660	PF01217	0.550
TRG_ENDOCYTIC_2	632	635	PF00928	0.335
TRG_ENDOCYTIC_2	693	696	PF00928	0.527
TRG_ER_diArg_1	143	146	PF00400	0.646
TRG_ER_diArg_1	177	179	PF00400	0.428
TRG_ER_diArg_1	301	303	PF00400	0.464
TRG_ER_diArg_1	628	631	PF00400	0.432
TRG_ER_diArg_1	678	680	PF00400	0.534
TRG_ER_diArg_1	719	721	PF00400	0.521
TRG_ER_diArg_1	800	803	PF00400	0.469
TRG_ER_diArg_1	89	92	PF00400	0.498
TRG_NES_CRM1_1	209	223	PF08389	0.450
TRG_NES_CRM1_1	449	461	PF08389	0.498
TRG_NES_CRM1_1	596	610	PF08389	0.473
TRG_NLS_MonoExtC_3	245	251	PF00514	0.408
TRG_NLS_MonoExtN_4	243	250	PF00514	0.406
TRG_NLS_MonoExtN_4	620	626	PF00514	0.518
TRG_Pf-PMV_PEXEL_1	117	122	PF00026	0.537
TRG_Pf-PMV_PEXEL_1	15	19	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.567
TRG_Pf-PMV_PEXEL_1	330	335	PF00026	0.641
TRG_Pf-PMV_PEXEL_1	347	351	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	472	476	PF00026	0.469
TRG_Pf-PMV_PEXEL_1	507	511	PF00026	0.586
TRG_Pf-PMV_PEXEL_1	524	529	PF00026	0.384
TRG_Pf-PMV_PEXEL_1	547	552	PF00026	0.539
TRG_Pf-PMV_PEXEL_1	645	649	PF00026	0.612

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX59	Leptomonas seymouri	53%	99%
A0A1X0NHD9	Trypanosomatidae	25%	100%
A0A3R7K5V9	Trypanosoma rangeli	27%	100%
A0A3S5H7Y8	Leishmania donovani	92%	100%
A4HME6	Leishmania braziliensis	78%	100%
A4IB18	Leishmania infantum	93%	100%
C9ZNP9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	98%
E9B603	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%