Rhodanese domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

rhodanese-like domain containing protein, putative

Species:

Leishmania major

UniProt:

E9AEU0_LEIMA

TriTrypDb:

LmjF.35.1170 , LMJLV39_350018000 , LMJSD75_350017200

Length:

607

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AEU0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEU0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004792	thiosulfate sulfurtransferase activity	5	2
GO:0016740	transferase activity	2	2
GO:0016782	transferase activity, transferring sulphur-containing groups	3	2
GO:0016783	sulfurtransferase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	126	130	PF00656	0.569
CLV_C14_Caspase3-7	139	143	PF00656	0.634
CLV_C14_Caspase3-7	192	196	PF00656	0.709
CLV_C14_Caspase3-7	201	205	PF00656	0.644
CLV_C14_Caspase3-7	578	582	PF00656	0.562
CLV_MEL_PAP_1	31	37	PF00089	0.534
CLV_NRD_NRD_1	135	137	PF00675	0.559
CLV_NRD_NRD_1	239	241	PF00675	0.421
CLV_NRD_NRD_1	434	436	PF00675	0.523
CLV_NRD_NRD_1	448	450	PF00675	0.512
CLV_NRD_NRD_1	540	542	PF00675	0.674
CLV_NRD_NRD_1	564	566	PF00675	0.498
CLV_NRD_NRD_1	605	607	PF00675	0.753
CLV_NRD_NRD_1	76	78	PF00675	0.718
CLV_PCSK_FUR_1	538	542	PF00082	0.590
CLV_PCSK_KEX2_1	135	137	PF00082	0.621
CLV_PCSK_KEX2_1	239	241	PF00082	0.438
CLV_PCSK_KEX2_1	434	436	PF00082	0.523
CLV_PCSK_KEX2_1	448	450	PF00082	0.488
CLV_PCSK_KEX2_1	540	542	PF00082	0.674
CLV_PCSK_KEX2_1	564	566	PF00082	0.498
CLV_PCSK_KEX2_1	605	607	PF00082	0.753
CLV_PCSK_KEX2_1	76	78	PF00082	0.718
CLV_PCSK_SKI1_1	259	263	PF00082	0.541
CLV_PCSK_SKI1_1	322	326	PF00082	0.412
CLV_PCSK_SKI1_1	449	453	PF00082	0.617
CLV_PCSK_SKI1_1	565	569	PF00082	0.774
DEG_Nend_Nbox_1	1	3	PF02207	0.654
DEG_SPOP_SBC_1	145	149	PF00917	0.633
DEG_SPOP_SBC_1	167	171	PF00917	0.623
DEG_SPOP_SBC_1	179	183	PF00917	0.535
DEG_SPOP_SBC_1	299	303	PF00917	0.600
DOC_MAPK_gen_1	383	391	PF00069	0.490
DOC_MAPK_MEF2A_6	561	570	PF00069	0.584
DOC_PP1_RVXF_1	276	282	PF00149	0.405
DOC_PP4_FxxP_1	381	384	PF00568	0.450
DOC_USP7_MATH_1	12	16	PF00917	0.633
DOC_USP7_MATH_1	145	149	PF00917	0.721
DOC_USP7_MATH_1	167	171	PF00917	0.770
DOC_USP7_MATH_1	178	182	PF00917	0.564
DOC_USP7_MATH_1	291	295	PF00917	0.723
DOC_USP7_MATH_1	525	529	PF00917	0.731
DOC_USP7_MATH_1	531	535	PF00917	0.776
DOC_USP7_MATH_1	80	84	PF00917	0.592
DOC_USP7_UBL2_3	247	251	PF12436	0.415
DOC_USP7_UBL2_3	37	41	PF12436	0.627
DOC_USP7_UBL2_3	501	505	PF12436	0.524
DOC_WW_Pin1_4	169	174	PF00397	0.744
DOC_WW_Pin1_4	24	29	PF00397	0.632
DOC_WW_Pin1_4	259	264	PF00397	0.460
DOC_WW_Pin1_4	368	373	PF00397	0.446
DOC_WW_Pin1_4	482	487	PF00397	0.600
DOC_WW_Pin1_4	589	594	PF00397	0.706
DOC_WW_Pin1_4	595	600	PF00397	0.734
LIG_14-3-3_CanoR_1	111	116	PF00244	0.645
LIG_14-3-3_CanoR_1	20	28	PF00244	0.610
LIG_14-3-3_CanoR_1	34	43	PF00244	0.744
LIG_14-3-3_CanoR_1	448	454	PF00244	0.609
LIG_14-3-3_CanoR_1	565	571	PF00244	0.675
LIG_14-3-3_CanoR_1	70	78	PF00244	0.809
LIG_14-3-3_CanoR_1	91	99	PF00244	0.679
LIG_Actin_WH2_2	262	280	PF00022	0.438
LIG_BIR_III_2	204	208	PF00653	0.525
LIG_BRCT_BRCA1_1	146	150	PF00533	0.640
LIG_eIF4E_1	396	402	PF01652	0.447
LIG_FHA_1	182	188	PF00498	0.599
LIG_FHA_1	260	266	PF00498	0.538
LIG_FHA_1	38	44	PF00498	0.733
LIG_FHA_1	537	543	PF00498	0.671
LIG_FHA_1	546	552	PF00498	0.630
LIG_FHA_1	595	601	PF00498	0.645
LIG_FHA_1	80	86	PF00498	0.741
LIG_FHA_2	181	187	PF00498	0.687
LIG_FHA_2	190	196	PF00498	0.667
LIG_FHA_2	211	217	PF00498	0.650
LIG_FHA_2	243	249	PF00498	0.482
LIG_FHA_2	262	268	PF00498	0.342
LIG_FHA_2	299	305	PF00498	0.585
LIG_FHA_2	326	332	PF00498	0.483
LIG_FHA_2	341	347	PF00498	0.393
LIG_FHA_2	369	375	PF00498	0.440
LIG_FHA_2	553	559	PF00498	0.576
LIG_FHA_2	576	582	PF00498	0.592
LIG_LIR_Apic_2	208	212	PF02991	0.600
LIG_LIR_Apic_2	378	384	PF02991	0.450
LIG_LIR_Gen_1	333	344	PF02991	0.324
LIG_LIR_Gen_1	363	372	PF02991	0.465
LIG_LIR_Gen_1	426	437	PF02991	0.595
LIG_LIR_Gen_1	466	475	PF02991	0.518
LIG_LIR_Nem_3	333	339	PF02991	0.324
LIG_LIR_Nem_3	348	353	PF02991	0.465
LIG_LIR_Nem_3	363	368	PF02991	0.447
LIG_LIR_Nem_3	408	412	PF02991	0.447
LIG_LIR_Nem_3	426	432	PF02991	0.592
LIG_LIR_Nem_3	466	470	PF02991	0.517
LIG_LIR_Nem_3	498	503	PF02991	0.472
LIG_PCNA_yPIPBox_3	427	437	PF02747	0.476
LIG_Pex14_1	425	429	PF04695	0.447
LIG_Rb_LxCxE_1	87	108	PF01857	0.569
LIG_SH2_CRK	429	433	PF00017	0.525
LIG_SH2_CRK	500	504	PF00017	0.476
LIG_SH2_SRC	332	335	PF00017	0.414
LIG_SH2_STAT5	393	396	PF00017	0.447
LIG_SH2_STAT5	412	415	PF00017	0.447
LIG_SH2_STAT5	478	481	PF00017	0.669
LIG_SH3_1	596	602	PF00018	0.669
LIG_SH3_3	204	210	PF00018	0.617
LIG_SH3_3	266	272	PF00018	0.507
LIG_SH3_3	510	516	PF00018	0.562
LIG_SH3_3	53	59	PF00018	0.581
LIG_SH3_3	596	602	PF00018	0.736
LIG_TRAF2_1	130	133	PF00917	0.557
LIG_TRAF2_1	318	321	PF00917	0.519
LIG_TRAF2_1	371	374	PF00917	0.530
LIG_TRAF2_1	471	474	PF00917	0.541
LIG_UBA3_1	406	414	PF00899	0.530
LIG_WRC_WIRS_1	450	455	PF05994	0.611
LIG_WW_3	602	606	PF00397	0.691
MOD_CDC14_SPxK_1	485	488	PF00782	0.580
MOD_CDK_SPK_2	24	29	PF00069	0.632
MOD_CDK_SPxK_1	482	488	PF00069	0.570
MOD_CDK_SPxxK_3	169	176	PF00069	0.622
MOD_CDK_SPxxK_3	589	596	PF00069	0.737
MOD_CDK_SPxxK_3	598	605	PF00069	0.698
MOD_CK1_1	107	113	PF00069	0.671
MOD_CK1_1	114	120	PF00069	0.622
MOD_CK1_1	181	187	PF00069	0.685
MOD_CK1_1	534	540	PF00069	0.665
MOD_CK1_1	598	604	PF00069	0.809
MOD_CK1_1	98	104	PF00069	0.670
MOD_CK2_1	242	248	PF00069	0.613
MOD_CK2_1	261	267	PF00069	0.353
MOD_CK2_1	298	304	PF00069	0.621
MOD_CK2_1	315	321	PF00069	0.338
MOD_CK2_1	325	331	PF00069	0.456
MOD_CK2_1	340	346	PF00069	0.464
MOD_CK2_1	368	374	PF00069	0.457
MOD_CK2_1	440	446	PF00069	0.525
MOD_CK2_1	98	104	PF00069	0.601
MOD_GlcNHglycan	10	13	PF01048	0.676
MOD_GlcNHglycan	157	160	PF01048	0.655
MOD_GlcNHglycan	163	166	PF01048	0.624
MOD_GlcNHglycan	198	203	PF01048	0.732
MOD_GlcNHglycan	295	298	PF01048	0.754
MOD_GlcNHglycan	309	312	PF01048	0.478
MOD_GlcNHglycan	317	320	PF01048	0.574
MOD_GlcNHglycan	442	445	PF01048	0.519
MOD_GlcNHglycan	47	50	PF01048	0.761
MOD_GlcNHglycan	525	528	PF01048	0.547
MOD_GlcNHglycan	82	85	PF01048	0.766
MOD_GlcNHglycan	86	89	PF01048	0.594
MOD_GSK3_1	1	8	PF00069	0.692
MOD_GSK3_1	107	114	PF00069	0.713
MOD_GSK3_1	20	27	PF00069	0.483
MOD_GSK3_1	228	235	PF00069	0.499
MOD_GSK3_1	255	262	PF00069	0.577
MOD_GSK3_1	566	573	PF00069	0.587
MOD_GSK3_1	575	582	PF00069	0.541
MOD_GSK3_1	594	601	PF00069	0.682
MOD_GSK3_1	80	87	PF00069	0.692
MOD_N-GLC_1	111	116	PF02516	0.597
MOD_N-GLC_1	189	194	PF02516	0.783
MOD_N-GLC_1	570	575	PF02516	0.452
MOD_NEK2_1	1	6	PF00069	0.691
MOD_NEK2_1	144	149	PF00069	0.677
MOD_NEK2_1	168	173	PF00069	0.650
MOD_NEK2_1	228	233	PF00069	0.431
MOD_NEK2_1	298	303	PF00069	0.607
MOD_NEK2_1	324	329	PF00069	0.424
MOD_NEK2_1	479	484	PF00069	0.596
MOD_NEK2_2	146	151	PF00069	0.505
MOD_PIKK_1	531	537	PF00454	0.713
MOD_PK_1	111	117	PF00069	0.520
MOD_PK_1	95	101	PF00069	0.513
MOD_PKA_2	479	485	PF00069	0.609
MOD_PKA_2	69	75	PF00069	0.634
MOD_PKA_2	78	84	PF00069	0.752
MOD_PKA_2	90	96	PF00069	0.649
MOD_PKB_1	77	85	PF00069	0.596
MOD_Plk_1	111	117	PF00069	0.571
MOD_Plk_1	189	195	PF00069	0.744
MOD_Plk_1	217	223	PF00069	0.485
MOD_Plk_1	345	351	PF00069	0.447
MOD_Plk_2-3	340	346	PF00069	0.447
MOD_Plk_4	228	234	PF00069	0.453
MOD_Plk_4	405	411	PF00069	0.482
MOD_Plk_4	575	581	PF00069	0.611
MOD_ProDKin_1	169	175	PF00069	0.743
MOD_ProDKin_1	24	30	PF00069	0.633
MOD_ProDKin_1	259	265	PF00069	0.463
MOD_ProDKin_1	368	374	PF00069	0.446
MOD_ProDKin_1	482	488	PF00069	0.602
MOD_ProDKin_1	589	595	PF00069	0.709
MOD_ProDKin_1	598	604	PF00069	0.732
MOD_SUMO_rev_2	315	324	PF00179	0.520
MOD_SUMO_rev_2	588	598	PF00179	0.674
TRG_DiLeu_BaEn_1	320	325	PF01217	0.464
TRG_DiLeu_BaEn_4	132	138	PF01217	0.537
TRG_DiLeu_BaEn_4	320	326	PF01217	0.485
TRG_ENDOCYTIC_2	412	415	PF00928	0.447
TRG_ENDOCYTIC_2	429	432	PF00928	0.469
TRG_ENDOCYTIC_2	500	503	PF00928	0.474
TRG_ER_diArg_1	134	136	PF00400	0.466
TRG_ER_diArg_1	19	22	PF00400	0.616
TRG_ER_diArg_1	233	236	PF00400	0.387
TRG_ER_diArg_1	238	240	PF00400	0.407
TRG_ER_diArg_1	433	435	PF00400	0.511
TRG_ER_diArg_1	447	449	PF00400	0.522
TRG_ER_diArg_1	538	541	PF00400	0.639
TRG_ER_diArg_1	563	565	PF00400	0.490
TRG_ER_diArg_1	604	606	PF00400	0.742
TRG_ER_diArg_1	75	77	PF00400	0.733
TRG_NES_CRM1_1	462	474	PF08389	0.517
TRG_Pf-PMV_PEXEL_1	135	139	PF00026	0.652
TRG_Pf-PMV_PEXEL_1	219	223	PF00026	0.448
TRG_Pf-PMV_PEXEL_1	236	241	PF00026	0.408
TRG_Pf-PMV_PEXEL_1	540	544	PF00026	0.616
TRG_Pf-PMV_PEXEL_1	549	553	PF00026	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5U9	Leptomonas seymouri	63%	100%
A0A0S4IZW5	Bodo saltans	46%	100%
A0A1X0NF45	Trypanosomatidae	56%	100%
A0A3Q8IEZ4	Leishmania donovani	91%	100%
A4HMD8	Leishmania braziliensis	77%	100%
A4IB11	Leishmania infantum	92%	100%
C9ZNL2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9B5Z6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%