Dolichyl-diphosphooligosaccharide--protein glycotransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

oligosaccharyl transferase-like protein

Species:

Leishmania major

UniProt:

E9AET7_LEIMA

TriTrypDb:

LmjF.35.1140 , LMJLV39_350017400 , LMJSD75_350016800

Length:

773

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 36

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 26
NetGPI	no	yes: 0, no: 26

Show entries

Cellular components
Term	Name	Level	Count
GO:0005635	nuclear envelope	4	5
GO:0005783	endoplasmic reticulum	5	5
GO:0016020	membrane	2	27
GO:0031967	organelle envelope	3	5
GO:0031975	envelope	2	5
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0043229	intracellular organelle	3	5
GO:0043231	intracellular membrane-bounded organelle	4	5
GO:0110165	cellular anatomical entity	1	27

Previous1Next

Expansion

Sequence features

E9AET7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AET7

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006486	protein glycosylation	4	27
GO:0006807	nitrogen compound metabolic process	2	27
GO:0008152	metabolic process	1	27
GO:0019538	protein metabolic process	3	27
GO:0036211	protein modification process	4	27
GO:0043170	macromolecule metabolic process	3	27
GO:0043412	macromolecule modification	4	27
GO:0043413	macromolecule glycosylation	3	27
GO:0044238	primary metabolic process	2	27
GO:0070085	glycosylation	2	27

Previous1 2Next

Show entries

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	27
GO:0004576	oligosaccharyl transferase activity	5	27
GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	6	27
GO:0005488	binding	1	27
GO:0016740	transferase activity	2	27
GO:0016757	glycosyltransferase activity	3	27
GO:0016758	hexosyltransferase activity	4	27
GO:0043167	ion binding	2	27
GO:0043169	cation binding	3	27
GO:0046872	metal ion binding	4	27

Previous1Next

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	582	586	PF00656	0.312
CLV_MEL_PAP_1	491	497	PF00089	0.250
CLV_NRD_NRD_1	380	382	PF00675	0.296
CLV_PCSK_KEX2_1	454	456	PF00082	0.511
CLV_PCSK_PC1ET2_1	454	456	PF00082	0.502
CLV_PCSK_SKI1_1	326	330	PF00082	0.447
CLV_PCSK_SKI1_1	480	484	PF00082	0.445
CLV_PCSK_SKI1_1	529	533	PF00082	0.565
CLV_PCSK_SKI1_1	599	603	PF00082	0.497
CLV_PCSK_SKI1_1	685	689	PF00082	0.623

Previous1 2 3 4 5…26Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IZ72	Bodo saltans	52%	94%
A0A1X0NFU7	Trypanosomatidae	59%	91%
A0A3Q8IHT0	Leishmania donovani	77%	90%
A0A3Q8II34	Leishmania donovani	58%	97%
A0A3Q8ILY7	Leishmania donovani	92%	99%
A0A3Q8IV37	Leishmania donovani	75%	92%
A0A422MX14	Trypanosoma rangeli	58%	93%
A4HFF9	Leishmania braziliensis	69%	90%
A4HMD5	Leishmania braziliensis	82%	100%
A4HMD6	Leishmania braziliensis	57%	94%

Previous1 2 3 4Next