Rdx family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Rdx family protein

Gene product:

Rdx family, putative

Species:

Leishmania major

UniProt:

E9AET5_LEIMA

TriTrypDb:

LmjF.35.1110 , LMJLV39_350016800 , LMJSD75_350016400

Length:

329

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	2
GO:0016020	membrane	2	2
GO:0031090	organelle membrane	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AET5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AET5

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	2
GO:0019725	cellular homeostasis	2	2
GO:0042592	homeostatic process	3	2
GO:0045454	cell redox homeostasis	3	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0065007	biological regulation	1	2
GO:0065008	regulation of biological quality	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004791	thioredoxin-disulfide reductase activity	2	2
GO:0015035	protein-disulfide reductase activity	3	2
GO:0015036	disulfide oxidoreductase activity	4	2
GO:0016209	antioxidant activity	1	2
GO:0016491	oxidoreductase activity	2	2
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	2
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	4	2
GO:0047134	protein-disulfide reductase (NAD(P)) activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	59	63	PF00656	0.680
CLV_NRD_NRD_1	151	153	PF00675	0.593
CLV_NRD_NRD_1	189	191	PF00675	0.477
CLV_NRD_NRD_1	219	221	PF00675	0.552
CLV_NRD_NRD_1	258	260	PF00675	0.434
CLV_PCSK_FUR_1	149	153	PF00082	0.572
CLV_PCSK_FUR_1	256	260	PF00082	0.402
CLV_PCSK_KEX2_1	151	153	PF00082	0.593
CLV_PCSK_KEX2_1	219	221	PF00082	0.557
CLV_PCSK_KEX2_1	258	260	PF00082	0.434
CLV_PCSK_SKI1_1	100	104	PF00082	0.561
CLV_PCSK_SKI1_1	219	223	PF00082	0.501
CLV_PCSK_SKI1_1	274	278	PF00082	0.481
CLV_PCSK_SKI1_1	314	318	PF00082	0.356
CLV_PCSK_SKI1_1	81	85	PF00082	0.355
CLV_Separin_Metazoa	187	191	PF03568	0.453
DOC_CYCLIN_RxL_1	311	319	PF00134	0.413
DOC_MAPK_gen_1	87	94	PF00069	0.434
DOC_MAPK_RevD_3	75	89	PF00069	0.499
DOC_USP7_MATH_1	145	149	PF00917	0.586
DOC_USP7_MATH_1	160	164	PF00917	0.618
DOC_USP7_MATH_1	61	65	PF00917	0.738
DOC_USP7_MATH_2	6	12	PF00917	0.674
DOC_WW_Pin1_4	214	219	PF00397	0.497
DOC_WW_Pin1_4	64	69	PF00397	0.601
LIG_14-3-3_CanoR_1	259	269	PF00244	0.528
LIG_Actin_WH2_2	232	247	PF00022	0.469
LIG_APCC_ABBA_1	173	178	PF00400	0.357
LIG_APCC_ABBA_1	282	287	PF00400	0.344
LIG_BIR_II_1	1	5	PF00653	0.644
LIG_BIR_III_3	1	5	PF00653	0.644
LIG_BRCT_BRCA1_1	263	267	PF00533	0.374
LIG_FHA_1	232	238	PF00498	0.457
LIG_FHA_1	263	269	PF00498	0.324
LIG_FHA_1	301	307	PF00498	0.448
LIG_FHA_1	67	73	PF00498	0.545
LIG_FHA_2	57	63	PF00498	0.678
LIG_LIR_Gen_1	184	193	PF02991	0.574
LIG_LIR_Gen_1	289	297	PF02991	0.384
LIG_LIR_Nem_3	184	189	PF02991	0.573
LIG_LIR_Nem_3	289	295	PF02991	0.434
LIG_NRBOX	306	312	PF00104	0.436
LIG_NRBOX	79	85	PF00104	0.398
LIG_PTB_Apo_2	102	109	PF02174	0.343
LIG_PTB_Apo_2	276	283	PF02174	0.448
LIG_SH2_CRK	292	296	PF00017	0.452
LIG_SH2_NCK_1	176	180	PF00017	0.387
LIG_SH2_SRC	131	134	PF00017	0.512
LIG_SH3_2	215	220	PF14604	0.504
LIG_SH3_3	196	202	PF00018	0.429
LIG_SH3_3	212	218	PF00018	0.407
LIG_SUMO_SIM_anti_2	171	176	PF11976	0.459
LIG_SUMO_SIM_anti_2	249	256	PF11976	0.471
LIG_TYR_ITIM	290	295	PF00017	0.441
LIG_UBA3_1	107	113	PF00899	0.483
MOD_CDC14_SPxK_1	217	220	PF00782	0.511
MOD_CDK_SPK_2	214	219	PF00069	0.497
MOD_CDK_SPxK_1	214	220	PF00069	0.498
MOD_CK1_1	32	38	PF00069	0.559
MOD_CK1_1	64	70	PF00069	0.700
MOD_CK2_1	181	187	PF00069	0.468
MOD_GlcNHglycan	153	156	PF01048	0.692
MOD_GlcNHglycan	292	295	PF01048	0.450
MOD_GlcNHglycan	297	300	PF01048	0.423
MOD_GSK3_1	147	154	PF00069	0.686
MOD_GSK3_1	193	200	PF00069	0.558
MOD_GSK3_1	62	69	PF00069	0.520
MOD_N-GLC_1	295	300	PF02516	0.492
MOD_NEK2_1	231	236	PF00069	0.517
MOD_NEK2_1	261	266	PF00069	0.407
MOD_NEK2_1	290	295	PF00069	0.352
MOD_NEK2_1	312	317	PF00069	0.356
MOD_PIKK_1	133	139	PF00454	0.531
MOD_PKA_1	151	157	PF00069	0.548
MOD_PKA_2	151	157	PF00069	0.548
MOD_PKB_1	149	157	PF00069	0.644
MOD_Plk_1	312	318	PF00069	0.364
MOD_Plk_4	247	253	PF00069	0.470
MOD_ProDKin_1	214	220	PF00069	0.498
MOD_ProDKin_1	64	70	PF00069	0.593
MOD_SUMO_rev_2	73	83	PF00179	0.378
TRG_DiLeu_BaEn_1	79	84	PF01217	0.397
TRG_ENDOCYTIC_2	292	295	PF00928	0.354
TRG_ER_diArg_1	149	152	PF00400	0.584
TRG_ER_diArg_1	218	220	PF00400	0.573
TRG_ER_diArg_1	255	258	PF00400	0.423
TRG_Pf-PMV_PEXEL_1	191	195	PF00026	0.574
TRG_Pf-PMV_PEXEL_1	314	319	PF00026	0.417

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUE3	Leptomonas seymouri	51%	83%
A0A3Q8IP70	Leishmania donovani	90%	99%
A4IB07	Leishmania infantum	90%	99%
E9B5Z0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%