BRCT domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AET4_LEIMA

TriTrypDb:

LmjF.35.1100 , LMJLV39_350016700 , LMJSD75_350016300

Length:

681

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AET4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AET4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	430	434	PF00656	0.646
CLV_C14_Caspase3-7	57	61	PF00656	0.623
CLV_NRD_NRD_1	11	13	PF00675	0.692
CLV_NRD_NRD_1	130	132	PF00675	0.824
CLV_NRD_NRD_1	222	224	PF00675	0.694
CLV_NRD_NRD_1	382	384	PF00675	0.720
CLV_NRD_NRD_1	555	557	PF00675	0.554
CLV_NRD_NRD_1	596	598	PF00675	0.800
CLV_NRD_NRD_1	618	620	PF00675	0.764
CLV_NRD_NRD_1	632	634	PF00675	0.610
CLV_NRD_NRD_1	651	653	PF00675	0.757
CLV_NRD_NRD_1	89	91	PF00675	0.736
CLV_PCSK_FUR_1	128	132	PF00082	0.831
CLV_PCSK_KEX2_1	10	12	PF00082	0.745
CLV_PCSK_KEX2_1	130	132	PF00082	0.814
CLV_PCSK_KEX2_1	222	224	PF00082	0.665
CLV_PCSK_KEX2_1	382	384	PF00082	0.720
CLV_PCSK_KEX2_1	554	556	PF00082	0.562
CLV_PCSK_KEX2_1	596	598	PF00082	0.800
CLV_PCSK_KEX2_1	632	634	PF00082	0.687
CLV_PCSK_KEX2_1	651	653	PF00082	0.757
CLV_PCSK_KEX2_1	91	93	PF00082	0.740
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.745
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.740
CLV_PCSK_SKI1_1	567	571	PF00082	0.609
DEG_SCF_FBW7_1	486	492	PF00400	0.624
DEG_SIAH_1	537	545	PF03145	0.786
DEG_SPOP_SBC_1	343	347	PF00917	0.762
DEG_SPOP_SBC_1	374	378	PF00917	0.794
DEG_SPOP_SBC_1	588	592	PF00917	0.772
DOC_CKS1_1	178	183	PF01111	0.729
DOC_CKS1_1	214	219	PF01111	0.726
DOC_CKS1_1	291	296	PF01111	0.796
DOC_CKS1_1	486	491	PF01111	0.725
DOC_CYCLIN_RxL_1	398	409	PF00134	0.800
DOC_CYCLIN_yCln2_LP_2	214	220	PF00134	0.724
DOC_MAPK_MEF2A_6	416	423	PF00069	0.807
DOC_PP2B_LxvP_1	396	399	PF13499	0.703
DOC_PP2B_LxvP_1	585	588	PF13499	0.817
DOC_PP4_MxPP_1	1	4	PF00568	0.821
DOC_PP4_MxPP_1	63	66	PF00568	0.614
DOC_USP7_MATH_1	129	133	PF00917	0.831
DOC_USP7_MATH_1	233	237	PF00917	0.743
DOC_USP7_MATH_1	243	247	PF00917	0.693
DOC_USP7_MATH_1	250	254	PF00917	0.618
DOC_USP7_MATH_1	338	342	PF00917	0.805
DOC_USP7_MATH_1	35	39	PF00917	0.737
DOC_USP7_MATH_1	365	369	PF00917	0.820
DOC_USP7_MATH_1	390	394	PF00917	0.750
DOC_USP7_MATH_1	399	403	PF00917	0.651
DOC_USP7_MATH_1	484	488	PF00917	0.684
DOC_USP7_MATH_1	497	501	PF00917	0.669
DOC_USP7_MATH_1	589	593	PF00917	0.738
DOC_USP7_MATH_1	618	622	PF00917	0.810
DOC_USP7_MATH_1	624	628	PF00917	0.761
DOC_USP7_MATH_1	650	654	PF00917	0.700
DOC_USP7_MATH_1	82	86	PF00917	0.756
DOC_USP7_MATH_1	93	97	PF00917	0.822
DOC_USP7_MATH_2	28	34	PF00917	0.811
DOC_WW_Pin1_4	108	113	PF00397	0.728
DOC_WW_Pin1_4	142	147	PF00397	0.735
DOC_WW_Pin1_4	170	175	PF00397	0.747
DOC_WW_Pin1_4	177	182	PF00397	0.816
DOC_WW_Pin1_4	201	206	PF00397	0.766
DOC_WW_Pin1_4	213	218	PF00397	0.706
DOC_WW_Pin1_4	234	239	PF00397	0.800
DOC_WW_Pin1_4	24	29	PF00397	0.816
DOC_WW_Pin1_4	246	251	PF00397	0.621
DOC_WW_Pin1_4	287	292	PF00397	0.688
DOC_WW_Pin1_4	485	490	PF00397	0.726
DOC_WW_Pin1_4	506	511	PF00397	0.655
DOC_WW_Pin1_4	534	539	PF00397	0.629
DOC_WW_Pin1_4	580	585	PF00397	0.672
DOC_WW_Pin1_4	64	69	PF00397	0.763
DOC_WW_Pin1_4	642	647	PF00397	0.731
DOC_WW_Pin1_4	73	78	PF00397	0.834
LIG_14-3-3_CanoR_1	104	112	PF00244	0.826
LIG_14-3-3_CanoR_1	11	15	PF00244	0.658
LIG_14-3-3_CanoR_1	257	265	PF00244	0.714
LIG_14-3-3_CanoR_1	355	364	PF00244	0.829
LIG_14-3-3_CanoR_1	435	440	PF00244	0.590
LIG_14-3-3_CanoR_1	469	476	PF00244	0.686
LIG_14-3-3_CanoR_1	498	502	PF00244	0.749
LIG_14-3-3_CanoR_1	632	640	PF00244	0.661
LIG_14-3-3_CanoR_1	651	661	PF00244	0.655
LIG_BIR_III_2	574	578	PF00653	0.741
LIG_BRCT_BRCA1_1	131	135	PF00533	0.839
LIG_BRCT_BRCA1_1	653	657	PF00533	0.630
LIG_FHA_1	116	122	PF00498	0.733
LIG_FHA_1	143	149	PF00498	0.751
LIG_FHA_1	180	186	PF00498	0.729
LIG_FHA_1	275	281	PF00498	0.707
LIG_FHA_1	344	350	PF00498	0.771
LIG_FHA_1	359	365	PF00498	0.590
LIG_FHA_1	367	373	PF00498	0.618
LIG_FHA_1	471	477	PF00498	0.793
LIG_FHA_1	54	60	PF00498	0.645
LIG_FHA_2	375	381	PF00498	0.763
LIG_LIR_Gen_1	293	301	PF02991	0.680
LIG_LIR_Gen_1	509	518	PF02991	0.600
LIG_LIR_Gen_1	654	664	PF02991	0.544
LIG_LIR_Nem_3	293	299	PF02991	0.680
LIG_LIR_Nem_3	509	514	PF02991	0.611
LIG_LIR_Nem_3	566	572	PF02991	0.602
LIG_LIR_Nem_3	654	660	PF02991	0.557
LIG_RPA_C_Fungi	630	642	PF08784	0.588
LIG_SH2_CRK	194	198	PF00017	0.783
LIG_SH2_CRK	286	290	PF00017	0.702
LIG_SH2_CRK	511	515	PF00017	0.696
LIG_SH2_NCK_1	286	290	PF00017	0.799
LIG_SH2_STAT5	286	289	PF00017	0.750
LIG_SH3_3	109	115	PF00018	0.820
LIG_SH3_3	202	208	PF00018	0.822
LIG_SH3_3	285	291	PF00018	0.711
LIG_SH3_3	369	375	PF00018	0.808
LIG_SH3_3	581	587	PF00018	0.710
LIG_SH3_3	62	68	PF00018	0.814
LIG_SH3_3	640	646	PF00018	0.787
LIG_SUMO_SIM_par_1	21	27	PF11976	0.776
LIG_TRAF2_1	204	207	PF00917	0.824
LIG_WW_3	2	6	PF00397	0.672
MOD_CDC14_SPxK_1	490	493	PF00782	0.730
MOD_CDC14_SPxK_1	583	586	PF00782	0.720
MOD_CDK_SPxK_1	487	493	PF00069	0.728
MOD_CDK_SPxK_1	580	586	PF00069	0.707
MOD_CK1_1	134	140	PF00069	0.748
MOD_CK1_1	195	201	PF00069	0.835
MOD_CK1_1	236	242	PF00069	0.700
MOD_CK1_1	246	252	PF00069	0.662
MOD_CK1_1	253	259	PF00069	0.599
MOD_CK1_1	290	296	PF00069	0.696
MOD_CK1_1	310	316	PF00069	0.729
MOD_CK1_1	356	362	PF00069	0.802
MOD_CK1_1	38	44	PF00069	0.764
MOD_CK1_1	487	493	PF00069	0.665
MOD_CK1_1	500	506	PF00069	0.674
MOD_CK1_1	509	515	PF00069	0.556
MOD_CK1_1	54	60	PF00069	0.765
MOD_CK1_1	590	596	PF00069	0.712
MOD_CK1_1	6	12	PF00069	0.784
MOD_CK1_1	612	618	PF00069	0.729
MOD_CK1_1	67	73	PF00069	0.567
MOD_CK1_1	78	84	PF00069	0.829
MOD_CK2_1	201	207	PF00069	0.631
MOD_CK2_1	24	30	PF00069	0.751
MOD_CK2_1	257	263	PF00069	0.753
MOD_CK2_1	374	380	PF00069	0.797
MOD_CK2_1	546	552	PF00069	0.592
MOD_CK2_1	652	658	PF00069	0.731
MOD_GlcNHglycan	131	134	PF01048	0.639
MOD_GlcNHglycan	194	197	PF01048	0.833
MOD_GlcNHglycan	245	248	PF01048	0.756
MOD_GlcNHglycan	253	256	PF01048	0.582
MOD_GlcNHglycan	312	315	PF01048	0.788
MOD_GlcNHglycan	340	343	PF01048	0.776
MOD_GlcNHglycan	355	358	PF01048	0.666
MOD_GlcNHglycan	369	372	PF01048	0.662
MOD_GlcNHglycan	37	40	PF01048	0.823
MOD_GlcNHglycan	42	45	PF01048	0.670
MOD_GlcNHglycan	470	473	PF01048	0.746
MOD_GlcNHglycan	48	51	PF01048	0.723
MOD_GlcNHglycan	482	485	PF01048	0.550
MOD_GlcNHglycan	635	638	PF01048	0.691
MOD_GlcNHglycan	654	657	PF01048	0.630
MOD_GlcNHglycan	676	679	PF01048	0.691
MOD_GlcNHglycan	80	83	PF01048	0.741
MOD_GlcNHglycan	84	87	PF01048	0.756
MOD_GlcNHglycan	95	98	PF01048	0.799
MOD_GSK3_1	180	187	PF00069	0.801
MOD_GSK3_1	233	240	PF00069	0.693
MOD_GSK3_1	24	31	PF00069	0.744
MOD_GSK3_1	246	253	PF00069	0.636
MOD_GSK3_1	306	313	PF00069	0.773
MOD_GSK3_1	338	345	PF00069	0.665
MOD_GSK3_1	34	41	PF00069	0.692
MOD_GSK3_1	353	360	PF00069	0.790
MOD_GSK3_1	363	370	PF00069	0.828
MOD_GSK3_1	480	487	PF00069	0.796
MOD_GSK3_1	496	503	PF00069	0.663
MOD_GSK3_1	51	58	PF00069	0.759
MOD_GSK3_1	528	535	PF00069	0.681
MOD_GSK3_1	6	13	PF00069	0.674
MOD_GSK3_1	631	638	PF00069	0.649
MOD_GSK3_1	66	73	PF00069	0.803
MOD_GSK3_1	672	679	PF00069	0.677
MOD_GSK3_1	78	85	PF00069	0.657
MOD_GSK3_1	99	106	PF00069	0.783
MOD_N-GLC_1	338	343	PF02516	0.658
MOD_N-GLC_1	390	395	PF02516	0.804
MOD_NEK2_1	164	169	PF00069	0.813
MOD_NEK2_1	322	327	PF00069	0.811
MOD_NEK2_1	34	39	PF00069	0.730
MOD_NEK2_1	53	58	PF00069	0.683
MOD_NEK2_1	578	583	PF00069	0.644
MOD_NEK2_1	72	77	PF00069	0.773
MOD_PIKK_1	103	109	PF00454	0.833
MOD_PIKK_1	180	186	PF00454	0.729
MOD_PIKK_1	322	328	PF00454	0.701
MOD_PIKK_1	424	430	PF00454	0.794
MOD_PIKK_1	437	443	PF00454	0.632
MOD_PIKK_1	509	515	PF00454	0.640
MOD_PIKK_1	546	552	PF00454	0.606
MOD_PIKK_1	590	596	PF00454	0.842
MOD_PIKK_1	598	604	PF00454	0.743
MOD_PK_1	110	116	PF00069	0.619
MOD_PKA_1	10	16	PF00069	0.657
MOD_PKA_1	651	657	PF00069	0.738
MOD_PKA_2	10	16	PF00069	0.688
MOD_PKA_2	103	109	PF00069	0.745
MOD_PKA_2	129	135	PF00069	0.734
MOD_PKA_2	256	262	PF00069	0.733
MOD_PKA_2	310	316	PF00069	0.763
MOD_PKA_2	46	52	PF00069	0.717
MOD_PKA_2	468	474	PF00069	0.606
MOD_PKA_2	497	503	PF00069	0.750
MOD_PKA_2	532	538	PF00069	0.739
MOD_PKA_2	609	615	PF00069	0.812
MOD_PKA_2	618	624	PF00069	0.702
MOD_PKA_2	631	637	PF00069	0.621
MOD_PKA_2	650	656	PF00069	0.677
MOD_PKA_2	93	99	PF00069	0.735
MOD_PKB_1	633	641	PF00069	0.589
MOD_Plk_1	165	171	PF00069	0.620
MOD_Plk_1	518	524	PF00069	0.540
MOD_Plk_1	54	60	PF00069	0.825
MOD_Plk_2-3	55	61	PF00069	0.624
MOD_Plk_4	225	231	PF00069	0.773
MOD_Plk_4	325	331	PF00069	0.807
MOD_Plk_4	626	632	PF00069	0.777
MOD_Plk_4	67	73	PF00069	0.678
MOD_ProDKin_1	108	114	PF00069	0.726
MOD_ProDKin_1	142	148	PF00069	0.738
MOD_ProDKin_1	170	176	PF00069	0.748
MOD_ProDKin_1	177	183	PF00069	0.816
MOD_ProDKin_1	201	207	PF00069	0.767
MOD_ProDKin_1	213	219	PF00069	0.705
MOD_ProDKin_1	234	240	PF00069	0.800
MOD_ProDKin_1	24	30	PF00069	0.817
MOD_ProDKin_1	246	252	PF00069	0.620
MOD_ProDKin_1	287	293	PF00069	0.688
MOD_ProDKin_1	485	491	PF00069	0.725
MOD_ProDKin_1	506	512	PF00069	0.649
MOD_ProDKin_1	534	540	PF00069	0.627
MOD_ProDKin_1	580	586	PF00069	0.676
MOD_ProDKin_1	64	70	PF00069	0.766
MOD_ProDKin_1	642	648	PF00069	0.727
MOD_ProDKin_1	73	79	PF00069	0.836
MOD_SUMO_for_1	664	667	PF00179	0.542
TRG_DiLeu_BaLyEn_6	317	322	PF01217	0.821
TRG_ENDOCYTIC_2	194	197	PF00928	0.783
TRG_ENDOCYTIC_2	511	514	PF00928	0.605
TRG_ER_diArg_1	128	131	PF00400	0.763
TRG_ER_diArg_1	222	224	PF00400	0.691
TRG_ER_diArg_1	382	384	PF00400	0.720
TRG_ER_diArg_1	457	460	PF00400	0.699
TRG_ER_diArg_1	553	556	PF00400	0.557
TRG_ER_diArg_1	595	597	PF00400	0.808
TRG_ER_diArg_1	631	633	PF00400	0.694
TRG_NLS_MonoExtC_3	89	94	PF00514	0.738
TRG_NLS_MonoExtN_4	618	623	PF00514	0.746
TRG_Pf-PMV_PEXEL_1	51	55	PF00026	0.624

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCI7	Leptomonas seymouri	48%	99%
A0A3S7X8Y6	Leishmania donovani	88%	98%
A4IB06	Leishmania infantum	87%	98%
E9B5Y9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%