Kri1_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleolar protein 111, putative

Species:

Leishmania major

UniProt:

E9AET3_LEIMA

TriTrypDb:

LmjF.35.1090 , LMJLV39_350016600 , LMJSD75_350016200

Length:

1049

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0030684	preribosome	3	2
GO:0030686	90S preribosome	4	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

E9AET3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AET3

Function

Biological processes
Term	Name	Level	Count
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	2
GO:0000469	cleavage involved in rRNA processing	7	2
GO:0000478	endonucleolytic cleavage involved in rRNA processing	8	2
GO:0000479	endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	2
GO:0090501	RNA phosphodiester bond hydrolysis	6	2
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	7	2
GO:1901360	organic cyclic compound metabolic process	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.701
CLV_C14_Caspase3-7	1007	1011	PF00656	0.749
CLV_C14_Caspase3-7	109	113	PF00656	0.709
CLV_C14_Caspase3-7	26	30	PF00656	0.675
CLV_C14_Caspase3-7	483	487	PF00656	0.572
CLV_C14_Caspase3-7	528	532	PF00656	0.787
CLV_C14_Caspase3-7	615	619	PF00656	0.594
CLV_C14_Caspase3-7	832	836	PF00656	0.665
CLV_C14_Caspase3-7	863	867	PF00656	0.416
CLV_C14_Caspase3-7	981	985	PF00656	0.627
CLV_MEL_PAP_1	275	281	PF00089	0.688
CLV_NRD_NRD_1	156	158	PF00675	0.715
CLV_NRD_NRD_1	204	206	PF00675	0.522
CLV_NRD_NRD_1	270	272	PF00675	0.515
CLV_NRD_NRD_1	342	344	PF00675	0.583
CLV_NRD_NRD_1	390	392	PF00675	0.593
CLV_NRD_NRD_1	510	512	PF00675	0.658
CLV_NRD_NRD_1	52	54	PF00675	0.613
CLV_NRD_NRD_1	609	611	PF00675	0.572
CLV_NRD_NRD_1	615	617	PF00675	0.543
CLV_NRD_NRD_1	623	625	PF00675	0.536
CLV_NRD_NRD_1	645	647	PF00675	0.366
CLV_NRD_NRD_1	702	704	PF00675	0.484
CLV_NRD_NRD_1	923	925	PF00675	0.334
CLV_NRD_NRD_1	929	931	PF00675	0.344
CLV_NRD_NRD_1	944	946	PF00675	0.542
CLV_PCSK_FUR_1	50	54	PF00082	0.621
CLV_PCSK_FUR_1	620	624	PF00082	0.563
CLV_PCSK_FUR_1	921	925	PF00082	0.416
CLV_PCSK_KEX2_1	156	158	PF00082	0.813
CLV_PCSK_KEX2_1	167	169	PF00082	0.710
CLV_PCSK_KEX2_1	204	206	PF00082	0.519
CLV_PCSK_KEX2_1	342	344	PF00082	0.518
CLV_PCSK_KEX2_1	347	349	PF00082	0.487
CLV_PCSK_KEX2_1	364	366	PF00082	0.507
CLV_PCSK_KEX2_1	456	458	PF00082	0.469
CLV_PCSK_KEX2_1	52	54	PF00082	0.599
CLV_PCSK_KEX2_1	622	624	PF00082	0.543
CLV_PCSK_KEX2_1	639	641	PF00082	0.344
CLV_PCSK_KEX2_1	645	647	PF00082	0.344
CLV_PCSK_KEX2_1	923	925	PF00082	0.336
CLV_PCSK_KEX2_1	928	930	PF00082	0.340
CLV_PCSK_KEX2_1	944	946	PF00082	0.556
CLV_PCSK_KEX2_1	974	976	PF00082	0.549
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.721
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.519
CLV_PCSK_PC1ET2_1	347	349	PF00082	0.512
CLV_PCSK_PC1ET2_1	364	366	PF00082	0.507
CLV_PCSK_PC1ET2_1	456	458	PF00082	0.488
CLV_PCSK_PC1ET2_1	639	641	PF00082	0.366
CLV_PCSK_PC1ET2_1	645	647	PF00082	0.320
CLV_PCSK_PC1ET2_1	974	976	PF00082	0.638
CLV_PCSK_PC7_1	343	349	PF00082	0.643
CLV_PCSK_PC7_1	924	930	PF00082	0.403
CLV_PCSK_SKI1_1	167	171	PF00082	0.742
CLV_PCSK_SKI1_1	17	21	PF00082	0.667
CLV_PCSK_SKI1_1	265	269	PF00082	0.436
CLV_PCSK_SKI1_1	271	275	PF00082	0.463
CLV_PCSK_SKI1_1	364	368	PF00082	0.590
CLV_PCSK_SKI1_1	404	408	PF00082	0.568
CLV_PCSK_SKI1_1	42	46	PF00082	0.678
CLV_PCSK_SKI1_1	456	460	PF00082	0.485
CLV_PCSK_SKI1_1	497	501	PF00082	0.518
CLV_PCSK_SKI1_1	639	643	PF00082	0.341
CLV_PCSK_SKI1_1	663	667	PF00082	0.432
CLV_Separin_Metazoa	419	423	PF03568	0.760
DEG_APCC_DBOX_1	386	394	PF00400	0.671
DEG_APCC_DBOX_1	817	825	PF00400	0.622
DEG_Kelch_Keap1_1	520	525	PF01344	0.737
DEG_Kelch_Keap1_1	732	737	PF01344	0.408
DEG_SPOP_SBC_1	2	6	PF00917	0.793
DEG_SPOP_SBC_1	949	953	PF00917	0.549
DOC_ANK_TNKS_1	136	143	PF00023	0.718
DOC_CYCLIN_yCln2_LP_2	692	698	PF00134	0.444
DOC_CYCLIN_yCln2_LP_2	766	772	PF00134	0.517
DOC_MAPK_gen_1	219	228	PF00069	0.739
DOC_MAPK_gen_1	271	279	PF00069	0.621
DOC_MAPK_MEF2A_6	271	279	PF00069	0.663
DOC_PP1_RVXF_1	15	21	PF00149	0.748
DOC_PP2B_LxvP_1	692	695	PF13499	0.444
DOC_PP2B_LxvP_1	987	990	PF13499	0.707
DOC_PP4_FxxP_1	325	328	PF00568	0.484
DOC_PP4_FxxP_1	597	600	PF00568	0.631
DOC_USP7_MATH_1	1004	1008	PF00917	0.721
DOC_USP7_MATH_1	1011	1015	PF00917	0.702
DOC_USP7_MATH_1	290	294	PF00917	0.774
DOC_USP7_MATH_1	3	7	PF00917	0.802
DOC_USP7_MATH_1	304	308	PF00917	0.702
DOC_USP7_MATH_1	352	356	PF00917	0.616
DOC_USP7_MATH_1	427	431	PF00917	0.765
DOC_USP7_MATH_1	432	436	PF00917	0.760
DOC_USP7_MATH_1	472	476	PF00917	0.728
DOC_USP7_MATH_1	527	531	PF00917	0.765
DOC_USP7_MATH_1	756	760	PF00917	0.648
DOC_USP7_MATH_1	768	772	PF00917	0.544
DOC_USP7_MATH_1	862	866	PF00917	0.485
DOC_USP7_MATH_1	870	874	PF00917	0.353
DOC_USP7_UBL2_3	215	219	PF12436	0.650
DOC_USP7_UBL2_3	350	354	PF12436	0.683
DOC_USP7_UBL2_3	473	477	PF12436	0.735
DOC_USP7_UBL2_3	774	778	PF12436	0.740
DOC_WW_Pin1_4	112	117	PF00397	0.820
DOC_WW_Pin1_4	297	302	PF00397	0.810
LIG_14-3-3_CanoR_1	123	133	PF00244	0.761
LIG_14-3-3_CanoR_1	271	276	PF00244	0.504
LIG_14-3-3_CanoR_1	449	458	PF00244	0.650
LIG_14-3-3_CanoR_1	841	847	PF00244	0.568
LIG_Actin_WH2_2	263	280	PF00022	0.632
LIG_AP2alpha_1	786	790	PF02296	0.781
LIG_BIR_III_4	533	537	PF00653	0.688
LIG_BRCT_BRCA1_1	491	495	PF00533	0.680
LIG_BRCT_BRCA1_1	872	876	PF00533	0.408
LIG_FHA_1	145	151	PF00498	0.784
LIG_FHA_1	272	278	PF00498	0.618
LIG_FHA_1	415	421	PF00498	0.688
LIG_FHA_1	604	610	PF00498	0.664
LIG_FHA_1	740	746	PF00498	0.690
LIG_FHA_1	797	803	PF00498	0.608
LIG_FHA_1	885	891	PF00498	0.344
LIG_FHA_1	950	956	PF00498	0.549
LIG_FHA_2	104	110	PF00498	0.711
LIG_FHA_2	209	215	PF00498	0.665
LIG_FHA_2	356	362	PF00498	0.540
LIG_FHA_2	481	487	PF00498	0.691
LIG_FHA_2	488	494	PF00498	0.691
LIG_FHA_2	613	619	PF00498	0.598
LIG_FHA_2	832	838	PF00498	0.646
LIG_FHA_2	861	867	PF00498	0.330
LIG_GBD_Chelix_1	968	976	PF00786	0.634
LIG_LIR_Apic_2	596	600	PF02991	0.649
LIG_LIR_Gen_1	415	426	PF02991	0.743
LIG_LIR_Gen_1	542	551	PF02991	0.599
LIG_LIR_Nem_3	154	158	PF02991	0.742
LIG_LIR_Nem_3	415	421	PF02991	0.729
LIG_LIR_Nem_3	542	547	PF02991	0.602
LIG_LIR_Nem_3	800	806	PF02991	0.579
LIG_LIR_Nem_3	850	856	PF02991	0.344
LIG_LIR_Nem_3	943	949	PF02991	0.514
LIG_LYPXL_L_2	805	814	PF13949	0.629
LIG_Pex14_1	566	570	PF04695	0.504
LIG_Pex14_2	495	499	PF04695	0.515
LIG_Pex14_2	786	790	PF04695	0.781
LIG_Rb_pABgroove_1	703	711	PF01858	0.485
LIG_RPA_C_Fungi	397	409	PF08784	0.416
LIG_SH2_CRK	544	548	PF00017	0.544
LIG_SH2_CRK	946	950	PF00017	0.617
LIG_SH2_GRB2like	543	546	PF00017	0.633
LIG_SH2_NCK_1	428	432	PF00017	0.711
LIG_SH2_STAP1	196	200	PF00017	0.534
LIG_SH2_STAP1	910	914	PF00017	0.344
LIG_SH2_STAT3	200	203	PF00017	0.611
LIG_SH2_STAT3	575	578	PF00017	0.583
LIG_SH2_STAT5	726	729	PF00017	0.427
LIG_SH2_STAT5	803	806	PF00017	0.450
LIG_SH2_STAT5	913	916	PF00017	0.344
LIG_SH3_1	67	73	PF00018	0.768
LIG_SH3_3	298	304	PF00018	0.782
LIG_SH3_3	67	73	PF00018	0.768
LIG_SH3_3	692	698	PF00018	0.444
LIG_SH3_3	980	986	PF00018	0.686
LIG_SUMO_SIM_par_1	884	892	PF11976	0.347
LIG_TRAF2_1	106	109	PF00917	0.728
LIG_TRAF2_1	316	319	PF00917	0.591
LIG_TRAF2_1	328	331	PF00917	0.436
LIG_TRAF2_1	451	454	PF00917	0.612
LIG_TRAF2_1	523	526	PF00917	0.751
LIG_TRAF2_1	551	554	PF00917	0.604
LIG_TRAF2_1	759	762	PF00917	0.572
LIG_TRAF2_1	889	892	PF00917	0.344
LIG_TRAF2_2	957	962	PF00917	0.712
LIG_TRFH_1	803	807	PF08558	0.448
LIG_UBA3_1	838	847	PF00899	0.575
MOD_CK1_1	22	28	PF00069	0.612
MOD_CK1_1	300	306	PF00069	0.778
MOD_CK1_1	307	313	PF00069	0.745
MOD_CK1_1	355	361	PF00069	0.595
MOD_CK1_1	414	420	PF00069	0.623
MOD_CK1_1	520	526	PF00069	0.766
MOD_CK1_1	539	545	PF00069	0.691
MOD_CK1_1	6	12	PF00069	0.789
MOD_CK1_1	939	945	PF00069	0.608
MOD_CK1_1	98	104	PF00069	0.716
MOD_CK2_1	180	186	PF00069	0.796
MOD_CK2_1	208	214	PF00069	0.663
MOD_CK2_1	238	244	PF00069	0.721
MOD_CK2_1	25	31	PF00069	0.761
MOD_CK2_1	413	419	PF00069	0.693
MOD_CK2_1	449	455	PF00069	0.520
MOD_CK2_1	487	493	PF00069	0.652
MOD_CK2_1	520	526	PF00069	0.704
MOD_CK2_1	756	762	PF00069	0.567
MOD_CK2_1	831	837	PF00069	0.644
MOD_CK2_1	886	892	PF00069	0.344
MOD_CK2_1	99	105	PF00069	0.764
MOD_Cter_Amidation	164	167	PF01082	0.745
MOD_Cter_Amidation	475	478	PF01082	0.754
MOD_GlcNHglycan	1027	1030	PF01048	0.749
MOD_GlcNHglycan	1035	1038	PF01048	0.727
MOD_GlcNHglycan	281	284	PF01048	0.707
MOD_GlcNHglycan	292	295	PF01048	0.778
MOD_GlcNHglycan	429	432	PF01048	0.770
MOD_GlcNHglycan	467	470	PF01048	0.635
MOD_GlcNHglycan	474	477	PF01048	0.717
MOD_GlcNHglycan	519	522	PF01048	0.744
MOD_GlcNHglycan	537	541	PF01048	0.743
MOD_GlcNHglycan	589	592	PF01048	0.715
MOD_GlcNHglycan	59	62	PF01048	0.713
MOD_GlcNHglycan	73	76	PF01048	0.666
MOD_GlcNHglycan	734	737	PF01048	0.408
MOD_GlcNHglycan	747	750	PF01048	0.658
MOD_GlcNHglycan	770	773	PF01048	0.768
MOD_GlcNHglycan	8	11	PF01048	0.800
MOD_GlcNHglycan	872	875	PF01048	0.415
MOD_GSK3_1	1	8	PF00069	0.795
MOD_GSK3_1	1005	1012	PF00069	0.775
MOD_GSK3_1	115	122	PF00069	0.811
MOD_GSK3_1	123	130	PF00069	0.734
MOD_GSK3_1	19	26	PF00069	0.567
MOD_GSK3_1	300	307	PF00069	0.798
MOD_GSK3_1	507	514	PF00069	0.698
MOD_GSK3_1	71	78	PF00069	0.709
MOD_GSK3_1	825	832	PF00069	0.676
MOD_GSK3_1	936	943	PF00069	0.605
MOD_GSK3_1	95	102	PF00069	0.707
MOD_N-GLC_1	181	186	PF02516	0.637
MOD_N-GLC_1	259	264	PF02516	0.583
MOD_N-GLC_1	487	492	PF02516	0.660
MOD_N-GLC_1	739	744	PF02516	0.603
MOD_N-GLC_1	970	975	PF02516	0.607
MOD_NEK2_1	277	282	PF00069	0.698
MOD_NEK2_1	367	372	PF00069	0.616
MOD_NEK2_1	463	468	PF00069	0.604
MOD_NEK2_1	655	660	PF00069	0.333
MOD_NEK2_1	824	829	PF00069	0.672
MOD_NEK2_1	842	847	PF00069	0.519
MOD_PKA_1	271	277	PF00069	0.526
MOD_PKA_1	511	517	PF00069	0.677
MOD_PKA_2	1025	1031	PF00069	0.755
MOD_PKA_2	277	283	PF00069	0.701
MOD_PKA_2	940	946	PF00069	0.546
MOD_Plk_1	259	265	PF00069	0.587
MOD_Plk_1	884	890	PF00069	0.344
MOD_Plk_2-3	181	187	PF00069	0.587
MOD_Plk_2-3	208	214	PF00069	0.627
MOD_Plk_2-3	238	244	PF00069	0.689
MOD_Plk_2-3	99	105	PF00069	0.726
MOD_Plk_4	539	545	PF00069	0.686
MOD_Plk_4	762	768	PF00069	0.642
MOD_Plk_4	950	956	PF00069	0.623
MOD_ProDKin_1	112	118	PF00069	0.823
MOD_ProDKin_1	297	303	PF00069	0.811
MOD_SUMO_for_1	316	319	PF00179	0.641
MOD_SUMO_rev_2	103	113	PF00179	0.799
MOD_SUMO_rev_2	361	366	PF00179	0.644
MOD_SUMO_rev_2	452	458	PF00179	0.529
MOD_SUMO_rev_2	636	641	PF00179	0.444
MOD_SUMO_rev_2	697	706	PF00179	0.344
MOD_SUMO_rev_2	958	968	PF00179	0.574
TRG_DiLeu_BaEn_1	454	459	PF01217	0.497
TRG_DiLeu_BaEn_1	762	767	PF01217	0.434
TRG_DiLeu_BaEn_4	636	642	PF01217	0.444
TRG_DiLeu_BaEn_4	851	857	PF01217	0.444
TRG_DiLeu_BaEn_4	891	897	PF01217	0.444
TRG_DiLeu_BaLyEn_6	165	170	PF01217	0.553
TRG_DiLeu_LyEn_5	454	459	PF01217	0.470
TRG_ENDOCYTIC_2	544	547	PF00928	0.554
TRG_ENDOCYTIC_2	853	856	PF00928	0.344
TRG_ENDOCYTIC_2	878	881	PF00928	0.344
TRG_ENDOCYTIC_2	946	949	PF00928	0.515
TRG_ER_diArg_1	155	157	PF00400	0.727
TRG_ER_diArg_1	342	344	PF00400	0.635
TRG_ER_diArg_1	620	623	PF00400	0.546
TRG_ER_diArg_1	928	930	PF00400	0.334
TRG_ER_diArg_1	944	946	PF00400	0.546
TRG_NLS_Bipartite_1	156	170	PF00514	0.596
TRG_NLS_Bipartite_1	271	288	PF00514	0.642
TRG_NLS_Bipartite_1	622	643	PF00514	0.444
TRG_NLS_MonoExtC_3	390	395	PF00514	0.663
TRG_NLS_MonoExtC_3	510	515	PF00514	0.743
TRG_NLS_MonoExtC_3	775	780	PF00514	0.771
TRG_NLS_MonoExtN_4	511	516	PF00514	0.679
TRG_NLS_MonoExtN_4	774	781	PF00514	0.772
TRG_Pf-PMV_PEXEL_1	391	396	PF00026	0.614
TRG_Pf-PMV_PEXEL_1	457	461	PF00026	0.504
TRG_Pf-PMV_PEXEL_1	599	603	PF00026	0.578
TRG_Pf-PMV_PEXEL_1	974	978	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZY8	Leptomonas seymouri	61%	100%
A0A3R7NCJ6	Trypanosoma rangeli	40%	100%
A0A3S7X904	Leishmania donovani	92%	100%
A4HFF6	Leishmania braziliensis	80%	99%
A4IB05	Leishmania infantum	93%	100%
C9ZNK6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B5Y8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5ATL2	Trypanosoma cruzi	37%	100%