Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AET1_LEIMA

TriTrypDb:

LmjF.35.1060 , LMJLV39_350016400 , LMJSD75_350016000

Length:

590

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AET1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AET1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	244	248	PF00656	0.642
CLV_C14_Caspase3-7	289	293	PF00656	0.726
CLV_C14_Caspase3-7	96	100	PF00656	0.722
CLV_NRD_NRD_1	114	116	PF00675	0.658
CLV_NRD_NRD_1	136	138	PF00675	0.589
CLV_NRD_NRD_1	139	141	PF00675	0.591
CLV_NRD_NRD_1	16	18	PF00675	0.719
CLV_NRD_NRD_1	162	164	PF00675	0.723
CLV_NRD_NRD_1	166	168	PF00675	0.688
CLV_NRD_NRD_1	191	193	PF00675	0.617
CLV_NRD_NRD_1	220	222	PF00675	0.706
CLV_NRD_NRD_1	245	247	PF00675	0.660
CLV_NRD_NRD_1	25	27	PF00675	0.634
CLV_NRD_NRD_1	278	280	PF00675	0.734
CLV_NRD_NRD_1	310	312	PF00675	0.731
CLV_NRD_NRD_1	395	397	PF00675	0.552
CLV_NRD_NRD_1	43	45	PF00675	0.551
CLV_NRD_NRD_1	584	586	PF00675	0.521
CLV_NRD_NRD_1	73	75	PF00675	0.683
CLV_PCSK_FUR_1	137	141	PF00082	0.683
CLV_PCSK_FUR_1	308	312	PF00082	0.711
CLV_PCSK_FUR_1	38	42	PF00082	0.595
CLV_PCSK_FUR_1	393	397	PF00082	0.544
CLV_PCSK_KEX2_1	114	116	PF00082	0.678
CLV_PCSK_KEX2_1	136	138	PF00082	0.630
CLV_PCSK_KEX2_1	139	141	PF00082	0.591
CLV_PCSK_KEX2_1	144	146	PF00082	0.645
CLV_PCSK_KEX2_1	16	18	PF00082	0.615
CLV_PCSK_KEX2_1	166	168	PF00082	0.691
CLV_PCSK_KEX2_1	191	193	PF00082	0.617
CLV_PCSK_KEX2_1	220	222	PF00082	0.706
CLV_PCSK_KEX2_1	237	239	PF00082	0.508
CLV_PCSK_KEX2_1	245	247	PF00082	0.628
CLV_PCSK_KEX2_1	25	27	PF00082	0.632
CLV_PCSK_KEX2_1	278	280	PF00082	0.744
CLV_PCSK_KEX2_1	3	5	PF00082	0.686
CLV_PCSK_KEX2_1	308	310	PF00082	0.739
CLV_PCSK_KEX2_1	395	397	PF00082	0.552
CLV_PCSK_KEX2_1	40	42	PF00082	0.529
CLV_PCSK_KEX2_1	43	45	PF00082	0.550
CLV_PCSK_KEX2_1	584	586	PF00082	0.521
CLV_PCSK_KEX2_1	73	75	PF00082	0.683
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.720
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.674
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.675
CLV_PCSK_PC7_1	140	146	PF00082	0.716
CLV_PCSK_PC7_1	21	27	PF00082	0.654
CLV_PCSK_PC7_1	38	44	PF00082	0.592
CLV_PCSK_SKI1_1	237	241	PF00082	0.680
CLV_PCSK_SKI1_1	362	366	PF00082	0.628
CLV_PCSK_SKI1_1	399	403	PF00082	0.648
CLV_PCSK_SKI1_1	479	483	PF00082	0.673
CLV_PCSK_SKI1_1	517	521	PF00082	0.657
DEG_APCC_DBOX_1	361	369	PF00400	0.504
DEG_APCC_KENBOX_2	519	523	PF00400	0.655
DOC_ANK_TNKS_1	260	267	PF00023	0.518
DOC_CKS1_1	539	544	PF01111	0.698
DOC_CYCLIN_RxL_1	235	244	PF00134	0.680
DOC_PP1_RVXF_1	236	243	PF00149	0.681
DOC_PP2B_LxvP_1	422	425	PF13499	0.634
DOC_PP4_FxxP_1	544	547	PF00568	0.632
DOC_PP4_MxPP_1	270	273	PF00568	0.677
DOC_USP7_MATH_1	184	188	PF00917	0.673
DOC_USP7_MATH_1	200	204	PF00917	0.619
DOC_USP7_MATH_1	248	252	PF00917	0.528
DOC_USP7_MATH_1	404	408	PF00917	0.636
DOC_USP7_MATH_1	425	429	PF00917	0.684
DOC_USP7_MATH_1	437	441	PF00917	0.709
DOC_USP7_MATH_1	448	452	PF00917	0.588
DOC_USP7_MATH_1	485	489	PF00917	0.652
DOC_USP7_MATH_1	569	573	PF00917	0.504
DOC_USP7_MATH_1	80	84	PF00917	0.616
DOC_USP7_MATH_1	95	99	PF00917	0.547
DOC_WW_Pin1_4	203	208	PF00397	0.603
DOC_WW_Pin1_4	528	533	PF00397	0.694
DOC_WW_Pin1_4	538	543	PF00397	0.614
LIG_14-3-3_CanoR_1	125	133	PF00244	0.713
LIG_14-3-3_CanoR_1	170	174	PF00244	0.659
LIG_14-3-3_CanoR_1	311	317	PF00244	0.853
LIG_14-3-3_CanoR_1	85	95	PF00244	0.723
LIG_14-3-3_CterR_2	585	590	PF00244	0.523
LIG_BIR_III_4	247	251	PF00653	0.677
LIG_BIR_III_4	484	488	PF00653	0.630
LIG_EVH1_1	533	537	PF00568	0.658
LIG_FHA_1	457	463	PF00498	0.649
LIG_FHA_2	206	212	PF00498	0.629
LIG_FHA_2	320	326	PF00498	0.625
LIG_Integrin_isoDGR_2	582	584	PF01839	0.559
LIG_LIR_Apic_2	337	343	PF02991	0.670
LIG_LIR_Apic_2	541	547	PF02991	0.633
LIG_LIR_Nem_3	101	107	PF02991	0.712
LIG_MAD2	85	93	PF02301	0.687
LIG_PTB_Apo_2	574	581	PF02174	0.530
LIG_PTB_Phospho_1	574	580	PF10480	0.533
LIG_SH2_GRB2like	580	583	PF00017	0.555
LIG_SH2_NCK_1	340	344	PF00017	0.661
LIG_SH2_SRC	545	548	PF00017	0.649
LIG_SH2_SRC	580	583	PF00017	0.555
LIG_SH2_STAT5	545	548	PF00017	0.673
LIG_SH2_STAT5	580	583	PF00017	0.555
LIG_SH3_3	265	271	PF00018	0.763
LIG_SH3_3	391	397	PF00018	0.542
LIG_SH3_3	531	537	PF00018	0.694
LIG_SH3_3	549	555	PF00018	0.436
LIG_SUMO_SIM_par_1	557	562	PF11976	0.511
LIG_WRC_WIRS_1	104	109	PF05994	0.592
MOD_CK1_1	20	26	PF00069	0.712
MOD_CK1_1	203	209	PF00069	0.679
MOD_CK1_1	210	216	PF00069	0.621
MOD_CK1_1	283	289	PF00069	0.585
MOD_CK1_1	332	338	PF00069	0.693
MOD_CK1_1	375	381	PF00069	0.520
MOD_CK1_1	428	434	PF00069	0.638
MOD_CK1_1	435	441	PF00069	0.670
MOD_CK1_1	456	462	PF00069	0.645
MOD_CK1_1	489	495	PF00069	0.651
MOD_CK2_1	123	129	PF00069	0.711
MOD_CK2_1	169	175	PF00069	0.657
MOD_CK2_1	205	211	PF00069	0.630
MOD_CK2_1	319	325	PF00069	0.637
MOD_CK2_1	97	103	PF00069	0.609
MOD_Cter_Amidation	1	4	PF01082	0.669
MOD_Cter_Amidation	137	140	PF01082	0.724
MOD_Cter_Amidation	142	145	PF01082	0.665
MOD_Cter_Amidation	161	164	PF01082	0.533
MOD_Cter_Amidation	582	585	PF01082	0.559
MOD_GlcNHglycan	180	183	PF01048	0.610
MOD_GlcNHglycan	202	205	PF01048	0.643
MOD_GlcNHglycan	247	251	PF01048	0.677
MOD_GlcNHglycan	285	288	PF01048	0.765
MOD_GlcNHglycan	295	298	PF01048	0.747
MOD_GlcNHglycan	435	438	PF01048	0.611
MOD_GlcNHglycan	439	442	PF01048	0.601
MOD_GlcNHglycan	488	491	PF01048	0.660
MOD_GlcNHglycan	502	505	PF01048	0.579
MOD_GlcNHglycan	6	9	PF01048	0.713
MOD_GlcNHglycan	69	72	PF01048	0.733
MOD_GSK3_1	174	181	PF00069	0.581
MOD_GSK3_1	203	210	PF00069	0.698
MOD_GSK3_1	211	218	PF00069	0.631
MOD_GSK3_1	246	253	PF00069	0.544
MOD_GSK3_1	312	319	PF00069	0.603
MOD_GSK3_1	328	335	PF00069	0.704
MOD_GSK3_1	368	375	PF00069	0.531
MOD_GSK3_1	425	432	PF00069	0.696
MOD_GSK3_1	433	440	PF00069	0.640
MOD_GSK3_1	449	456	PF00069	0.675
MOD_GSK3_1	463	470	PF00069	0.517
MOD_GSK3_1	485	492	PF00069	0.729
MOD_LATS_1	57	63	PF00433	0.708
MOD_N-GLC_1	280	285	PF02516	0.684
MOD_N-GLC_1	293	298	PF02516	0.598
MOD_N-GLC_1	329	334	PF02516	0.712
MOD_N-GLC_1	428	433	PF02516	0.577
MOD_N-GLC_1	448	453	PF02516	0.656
MOD_NEK2_1	370	375	PF00069	0.631
MOD_NEK2_1	450	455	PF00069	0.641
MOD_PKA_1	43	49	PF00069	0.661
MOD_PKA_2	110	116	PF00069	0.712
MOD_PKA_2	146	152	PF00069	0.675
MOD_PKA_2	169	175	PF00069	0.676
MOD_PKA_2	20	26	PF00069	0.706
MOD_PKA_2	283	289	PF00069	0.585
MOD_PKA_2	43	49	PF00069	0.723
MOD_PKA_2	60	66	PF00069	0.574
MOD_PKA_2	67	73	PF00069	0.667
MOD_PKB_1	223	231	PF00069	0.578
MOD_PKB_1	309	317	PF00069	0.632
MOD_PKB_1	41	49	PF00069	0.657
MOD_Plk_1	10	16	PF00069	0.658
MOD_Plk_1	210	216	PF00069	0.641
MOD_Plk_1	280	286	PF00069	0.683
MOD_Plk_1	328	334	PF00069	0.713
MOD_Plk_1	368	374	PF00069	0.527
MOD_Plk_1	428	434	PF00069	0.576
MOD_Plk_1	457	463	PF00069	0.664
MOD_Plk_2-3	103	109	PF00069	0.632
MOD_Plk_2-3	211	217	PF00069	0.631
MOD_Plk_2-3	45	51	PF00069	0.725
MOD_Plk_4	335	341	PF00069	0.682
MOD_Plk_4	376	382	PF00069	0.494
MOD_Plk_4	457	463	PF00069	0.635
MOD_Plk_4	467	473	PF00069	0.553
MOD_ProDKin_1	203	209	PF00069	0.604
MOD_ProDKin_1	528	534	PF00069	0.692
MOD_ProDKin_1	538	544	PF00069	0.616
TRG_ENDOCYTIC_2	104	107	PF00928	0.712
TRG_ER_diArg_1	114	117	PF00400	0.715
TRG_ER_diArg_1	136	139	PF00400	0.690
TRG_ER_diArg_1	15	17	PF00400	0.699
TRG_ER_diArg_1	165	167	PF00400	0.621
TRG_ER_diArg_1	220	223	PF00400	0.710
TRG_ER_diArg_1	277	279	PF00400	0.711
TRG_ER_diArg_1	282	285	PF00400	0.682
TRG_ER_diArg_1	308	311	PF00400	0.722
TRG_ER_diArg_1	38	41	PF00400	0.594
TRG_ER_diArg_1	392	395	PF00400	0.542
TRG_ER_diArg_1	42	44	PF00400	0.644
TRG_ER_diArg_1	584	586	PF00400	0.521
TRG_ER_diArg_1	92	95	PF00400	0.714
TRG_NLS_MonoExtC_3	162	167	PF00514	0.691

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X8W4	Leishmania donovani	86%	100%
A4HFF4	Leishmania braziliensis	67%	100%
A4IB03	Leishmania infantum	87%	100%
E9B5Y6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%