Protein kinase domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

calcium/calmodulin-dependent protein kinase, putative

Species:

Leishmania major

UniProt:

E9AET0_LEIMA

TriTrypDb:

LmjF.35.1050 , LMJLV39_350016300 , LMJSD75_350015900

Length:

489

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:0005964	phosphorylase kinase complex	7	1
GO:0032991	protein-containing complex	1	1
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	1
GO:1902494	catalytic complex	2	1
GO:1902554	serine/threonine protein kinase complex	6	1
GO:1902911	protein kinase complex	5	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

E9AET0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AET0

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0007165	signal transduction	2	2
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	11
GO:0018105	peptidyl-serine phosphorylation	6	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018209	peptidyl-serine modification	6	2
GO:0019538	protein metabolic process	3	11
GO:0035556	intracellular signal transduction	3	2
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046777	protein autophosphorylation	6	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0065007	biological regulation	1	2
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:0000271	polysaccharide biosynthetic process	5	1
GO:0005975	carbohydrate metabolic process	3	1
GO:0005976	polysaccharide metabolic process	4	1
GO:0005977	glycogen metabolic process	6	1
GO:0005978	glycogen biosynthetic process	7	1
GO:0006073	obsolete cellular glucan metabolic process	5	1
GO:0006091	generation of precursor metabolites and energy	3	1
GO:0006112	energy reserve metabolic process	5	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009250	glucan biosynthetic process	6	1
GO:0015980	energy derivation by oxidation of organic compounds	4	1
GO:0016051	carbohydrate biosynthetic process	4	1
GO:0033692	obsolete cellular polysaccharide biosynthetic process	5	1
GO:0034637	obsolete cellular carbohydrate biosynthetic process	4	1
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	1
GO:0044042	glucan metabolic process	5	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044262	obsolete cellular carbohydrate metabolic process	3	1
GO:0044264	obsolete cellular polysaccharide metabolic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004672	protein kinase activity	3	11
GO:0004674	protein serine/threonine kinase activity	4	8
GO:0004683	calmodulin-dependent protein kinase activity	5	3
GO:0005488	binding	1	11
GO:0005515	protein binding	2	3
GO:0005516	calmodulin binding	3	3
GO:0005524	ATP binding	5	11
GO:0009931	calcium-dependent protein serine/threonine kinase activity	5	2
GO:0010857	calcium-dependent protein kinase activity	4	2
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0004689	phosphorylase kinase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	381	385	PF00656	0.744
CLV_NRD_NRD_1	281	283	PF00675	0.254
CLV_NRD_NRD_1	286	288	PF00675	0.254
CLV_NRD_NRD_1	350	352	PF00675	0.608
CLV_NRD_NRD_1	487	489	PF00675	0.658
CLV_NRD_NRD_1	79	81	PF00675	0.254
CLV_PCSK_KEX2_1	281	283	PF00082	0.254
CLV_PCSK_KEX2_1	286	288	PF00082	0.254
CLV_PCSK_KEX2_1	321	323	PF00082	0.298
CLV_PCSK_KEX2_1	349	351	PF00082	0.600
CLV_PCSK_KEX2_1	79	81	PF00082	0.258
CLV_PCSK_PC1ET2_1	321	323	PF00082	0.298
CLV_PCSK_PC7_1	282	288	PF00082	0.310
CLV_PCSK_SKI1_1	147	151	PF00082	0.269
CLV_PCSK_SKI1_1	247	251	PF00082	0.325
CLV_PCSK_SKI1_1	282	286	PF00082	0.254
CLV_PCSK_SKI1_1	321	325	PF00082	0.298
CLV_PCSK_SKI1_1	414	418	PF00082	0.607
CLV_PCSK_SKI1_1	466	470	PF00082	0.627
CLV_PCSK_SKI1_1	53	57	PF00082	0.255
CLV_PCSK_SKI1_1	60	64	PF00082	0.272
CLV_PCSK_SKI1_1	75	79	PF00082	0.332
CLV_Separin_Metazoa	283	287	PF03568	0.286
CLV_Separin_Metazoa	327	331	PF03568	0.386
CLV_Separin_Metazoa	76	80	PF03568	0.268
DEG_APCC_DBOX_1	281	289	PF00400	0.254
DEG_SCF_FBW7_1	215	222	PF00400	0.254
DEG_SPOP_SBC_1	390	394	PF00917	0.677
DOC_CKS1_1	11	16	PF01111	0.435
DOC_CKS1_1	93	98	PF01111	0.233
DOC_MAPK_gen_1	147	156	PF00069	0.254
DOC_MAPK_gen_1	286	294	PF00069	0.272
DOC_MAPK_gen_1	466	475	PF00069	0.621
DOC_MAPK_MEF2A_6	150	158	PF00069	0.272
DOC_PP1_RVXF_1	96	102	PF00149	0.333
DOC_USP7_MATH_1	366	370	PF00917	0.616
DOC_USP7_MATH_1	390	394	PF00917	0.604
DOC_USP7_UBL2_3	161	165	PF12436	0.185
DOC_USP7_UBL2_3	31	35	PF12436	0.367
DOC_WW_Pin1_4	10	15	PF00397	0.451
DOC_WW_Pin1_4	215	220	PF00397	0.254
DOC_WW_Pin1_4	375	380	PF00397	0.630
DOC_WW_Pin1_4	394	399	PF00397	0.460
DOC_WW_Pin1_4	92	97	PF00397	0.233
LIG_14-3-3_CanoR_1	116	121	PF00244	0.282
LIG_14-3-3_CanoR_1	247	253	PF00244	0.328
LIG_14-3-3_CanoR_1	322	329	PF00244	0.254
LIG_14-3-3_CanoR_1	79	87	PF00244	0.241
LIG_APCC_ABBAyCdc20_2	432	438	PF00400	0.631
LIG_deltaCOP1_diTrp_1	253	261	PF00928	0.254
LIG_eIF4E_1	100	106	PF01652	0.272
LIG_FHA_1	11	17	PF00498	0.435
LIG_FHA_1	422	428	PF00498	0.653
LIG_FHA_1	47	53	PF00498	0.378
LIG_FHA_2	117	123	PF00498	0.282
LIG_FHA_2	275	281	PF00498	0.256
LIG_FHA_2	322	328	PF00498	0.386
LIG_FHA_2	86	92	PF00498	0.298
LIG_LIR_Apic_2	222	228	PF02991	0.254
LIG_LIR_Gen_1	108	115	PF02991	0.277
LIG_LIR_Nem_3	108	114	PF02991	0.230
LIG_LIR_Nem_3	97	103	PF02991	0.291
LIG_PCNA_yPIPBox_3	107	118	PF02747	0.333
LIG_Rb_pABgroove_1	19	27	PF01858	0.383
LIG_REV1ctd_RIR_1	414	424	PF16727	0.682
LIG_SH2_CRK	339	343	PF00017	0.569
LIG_SH2_PTP2	225	228	PF00017	0.254
LIG_SH2_PTP2	262	265	PF00017	0.386
LIG_SH2_STAT5	100	103	PF00017	0.254
LIG_SH2_STAT5	138	141	PF00017	0.272
LIG_SH2_STAT5	225	228	PF00017	0.254
LIG_SH2_STAT5	262	265	PF00017	0.386
LIG_SH3_2	461	466	PF14604	0.691
LIG_SH3_3	458	464	PF00018	0.603
LIG_SH3_3	5	11	PF00018	0.515
LIG_SH3_3	90	96	PF00018	0.282
LIG_SUMO_SIM_par_1	85	91	PF11976	0.333
LIG_TRAF2_1	324	327	PF00917	0.394
LIG_TRAF2_1	428	431	PF00917	0.552
LIG_TYR_ITIM	260	265	PF00017	0.386
LIG_UBA3_1	110	118	PF00899	0.298
LIG_WW_3	4	8	PF00397	0.443
MOD_CDC14_SPxK_1	397	400	PF00782	0.516
MOD_CDK_SPxK_1	394	400	PF00069	0.522
MOD_CDK_SPxK_1	92	98	PF00069	0.310
MOD_CK1_1	378	384	PF00069	0.573
MOD_CK1_1	391	397	PF00069	0.749
MOD_CK1_1	399	405	PF00069	0.738
MOD_CK1_1	408	414	PF00069	0.687
MOD_CK1_1	421	427	PF00069	0.732
MOD_CK2_1	116	122	PF00069	0.282
MOD_CK2_1	321	327	PF00069	0.386
MOD_CK2_1	425	431	PF00069	0.561
MOD_CK2_1	85	91	PF00069	0.333
MOD_Cter_Amidation	64	67	PF01082	0.333
MOD_GlcNHglycan	133	136	PF01048	0.333
MOD_GlcNHglycan	255	258	PF01048	0.272
MOD_GlcNHglycan	303	306	PF01048	0.316
MOD_GlcNHglycan	368	371	PF01048	0.555
MOD_GlcNHglycan	380	383	PF01048	0.649
MOD_GlcNHglycan	393	396	PF01048	0.655
MOD_GlcNHglycan	60	63	PF01048	0.391
MOD_GSK3_1	182	189	PF00069	0.352
MOD_GSK3_1	215	222	PF00069	0.258
MOD_GSK3_1	317	324	PF00069	0.272
MOD_GSK3_1	390	397	PF00069	0.651
MOD_GSK3_1	399	406	PF00069	0.658
MOD_GSK3_1	418	425	PF00069	0.721
MOD_GSK3_1	455	462	PF00069	0.598
MOD_N-GLC_1	116	121	PF02516	0.282
MOD_N-GLC_1	403	408	PF02516	0.696
MOD_NEK2_1	58	63	PF00069	0.381
MOD_NEK2_1	78	83	PF00069	0.225
MOD_NEK2_2	220	225	PF00069	0.254
MOD_NEK2_2	85	90	PF00069	0.377
MOD_PKA_1	321	327	PF00069	0.298
MOD_PKA_2	321	327	PF00069	0.249
MOD_PKA_2	78	84	PF00069	0.208
MOD_Plk_1	116	122	PF00069	0.282
MOD_Plk_1	140	146	PF00069	0.325
MOD_Plk_1	454	460	PF00069	0.590
MOD_Plk_2-3	20	26	PF00069	0.470
MOD_Plk_4	140	146	PF00069	0.298
MOD_Plk_4	20	26	PF00069	0.394
MOD_Plk_4	220	226	PF00069	0.254
MOD_Plk_4	405	411	PF00069	0.647
MOD_ProDKin_1	10	16	PF00069	0.444
MOD_ProDKin_1	215	221	PF00069	0.254
MOD_ProDKin_1	375	381	PF00069	0.628
MOD_ProDKin_1	394	400	PF00069	0.461
MOD_ProDKin_1	92	98	PF00069	0.233
MOD_SUMO_for_1	149	152	PF00179	0.254
MOD_SUMO_rev_2	143	151	PF00179	0.298
MOD_SUMO_rev_2	162	167	PF00179	0.125
MOD_SUMO_rev_2	193	202	PF00179	0.307
MOD_SUMO_rev_2	301	310	PF00179	0.274
MOD_SUMO_rev_2	462	471	PF00179	0.624
TRG_DiLeu_BaEn_1	306	311	PF01217	0.298
TRG_ENDOCYTIC_2	100	103	PF00928	0.262
TRG_ENDOCYTIC_2	262	265	PF00928	0.356
TRG_ER_diArg_1	285	287	PF00400	0.310
TRG_ER_diArg_1	348	351	PF00400	0.599
TRG_ER_diArg_1	432	435	PF00400	0.658
TRG_ER_diArg_1	78	80	PF00400	0.268
TRG_Pf-PMV_PEXEL_1	232	236	PF00026	0.386
TRG_Pf-PMV_PEXEL_1	350	354	PF00026	0.528

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4E3	Leptomonas seymouri	24%	73%
A0A0N0P6T0	Leptomonas seymouri	25%	89%
A0A0N0P787	Leptomonas seymouri	24%	100%
A0A0N0P8H5	Leptomonas seymouri	26%	100%
A0A0N1HZY0	Leptomonas seymouri	26%	82%
A0A0N1I0C1	Leptomonas seymouri	24%	100%
A0A0N1I6Q7	Leptomonas seymouri	25%	100%
A0A0N1I9B7	Leptomonas seymouri	25%	100%
A0A0N1IHY4	Leptomonas seymouri	24%	100%
A0A0N1IM47	Leptomonas seymouri	26%	100%
A0A0N1IM89	Leptomonas seymouri	25%	97%
A0A0N1PBE9	Leptomonas seymouri	74%	97%
A0A0N1PC32	Leptomonas seymouri	29%	100%
A0A0N1PE80	Leptomonas seymouri	30%	87%
A0A0S4IV16	Bodo saltans	24%	100%
A0A0S4IVQ6	Bodo saltans	27%	100%
A0A0S4IZ14	Bodo saltans	30%	82%
A0A0S4IZY3	Bodo saltans	26%	100%
A0A0S4J1U0	Bodo saltans	26%	67%
A0A0S4J575	Bodo saltans	23%	79%
A0A0S4J9Q7	Bodo saltans	25%	100%
A0A0S4JA09	Bodo saltans	25%	100%
A0A0S4JC94	Bodo saltans	22%	69%
A0A0S4JCK1	Bodo saltans	27%	100%
A0A0S4JER5	Bodo saltans	28%	100%
A0A0S4JPZ7	Bodo saltans	26%	100%
A0A0S4JVD7	Bodo saltans	23%	100%
A0A0S4JWD5	Bodo saltans	54%	100%
A0A0S4JXW9	Bodo saltans	23%	100%
A0A0S4KFT7	Bodo saltans	26%	100%
A0A0S4KKJ1	Bodo saltans	29%	77%
A0A1X0NF53	Trypanosomatidae	58%	100%
A0A1X0NJV4	Trypanosomatidae	29%	95%
A0A1X0NLN7	Trypanosomatidae	27%	100%
A0A1X0NUQ4	Trypanosomatidae	25%	100%
A0A1X0P150	Trypanosomatidae	27%	79%
A0A1X0P1A2	Trypanosomatidae	28%	100%
A0A1X0P2H8	Trypanosomatidae	28%	100%
A0A1X0P5B1	Trypanosomatidae	27%	100%
A0A1X0P5F2	Trypanosomatidae	28%	100%
A0A1X0P5U3	Trypanosomatidae	24%	95%
A0A1X0P692	Trypanosomatidae	27%	100%
A0A1X0P6E7	Trypanosomatidae	26%	100%
A0A1X0P6U6	Trypanosomatidae	24%	100%
A0A1X0P795	Trypanosomatidae	27%	72%
A0A1X0P859	Trypanosomatidae	25%	100%
A0A1X0P8F7	Trypanosomatidae	26%	100%
A0A1X0P919	Trypanosomatidae	24%	100%
A0A2I0BVG8	Plasmodium falciparum (isolate NF54)	29%	93%
A0A3Q8IAQ1	Leishmania donovani	25%	100%
A0A3Q8IB30	Leishmania donovani	26%	100%
A0A3Q8IB74	Leishmania donovani	25%	100%
A0A3Q8IC87	Leishmania donovani	28%	100%
A0A3Q8IE25	Leishmania donovani	24%	74%
A0A3Q8INQ4	Leishmania donovani	29%	100%
A0A3Q8IVR8	Leishmania donovani	25%	100%
A0A3R7K5U6	Trypanosoma rangeli	24%	83%
A0A3R7K681	Trypanosoma rangeli	48%	96%
A0A3R7L9Q6	Trypanosoma rangeli	27%	100%
A0A3R7LU08	Trypanosoma rangeli	26%	78%
A0A3R7MHW5	Trypanosoma rangeli	26%	100%
A0A3R7MPF2	Trypanosoma rangeli	31%	76%
A0A3R7MWP2	Trypanosoma rangeli	25%	100%
A0A3R7N5S4	Trypanosoma rangeli	27%	100%
A0A3S5H5G0	Leishmania donovani	25%	100%
A0A3S5H5U5	Leishmania donovani	24%	100%
A0A3S5H789	Leishmania donovani	27%	100%
A0A3S7WTN9	Leishmania donovani	22%	100%
A0A3S7WV74	Leishmania donovani	25%	77%
A0A3S7WVR6	Leishmania donovani	26%	79%
A0A3S7WY10	Leishmania donovani	28%	90%
A0A3S7X8Z8	Leishmania donovani	94%	100%
A0A3S7X9R4	Leishmania donovani	28%	100%
A0A3S7X9S2	Leishmania donovani	28%	100%
A0A3S7XA45	Leishmania donovani	29%	100%
A0A422N3U8	Trypanosoma rangeli	29%	68%
A0A422NCX4	Trypanosoma rangeli	25%	100%
A0A422P2B2	Trypanosoma rangeli	23%	100%
A0A422P3N8	Trypanosoma rangeli	27%	83%
A0A509AHB6	Plasmodium berghei (strain Anka)	29%	93%
A0A509AQE6	Plasmodium berghei (strain Anka)	30%	87%
A0AUV4	Mus musculus	27%	96%
A3B529	Oryza sativa subsp. japonica	28%	100%
A4H459	Leishmania braziliensis	27%	100%
A4H4S9	Leishmania braziliensis	25%	100%
A4H8C4	Leishmania braziliensis	25%	100%
A4H9L8	Leishmania braziliensis	26%	100%
A4H9X5	Leishmania braziliensis	24%	100%
A4HA94	Leishmania braziliensis	25%	100%
A4HA97	Leishmania braziliensis	25%	86%
A4HCE6	Leishmania braziliensis	25%	100%
A4HD79	Leishmania braziliensis	29%	90%
A4HED7	Leishmania braziliensis	28%	100%
A4HFC9	Leishmania braziliensis	24%	74%
A4HFF3	Leishmania braziliensis	79%	98%
A4HHE4	Leishmania braziliensis	27%	83%
A4HHN1	Leishmania braziliensis	27%	100%
A4HJT5	Leishmania braziliensis	25%	100%
A4HLN2	Leishmania braziliensis	25%	76%
A4HN71	Leishmania braziliensis	28%	100%
A4HNG3	Leishmania braziliensis	29%	100%
A4HNT2	Leishmania braziliensis	26%	100%
A4HSE2	Leishmania infantum	25%	100%
A4HWP5	Leishmania infantum	22%	100%
A4HXY2	Leishmania infantum	26%	100%
A4HYH4	Leishmania infantum	25%	100%
A4HYH7	Leishmania infantum	26%	79%
A4HYX6	Leishmania infantum	27%	100%
A4HZV1	Leishmania infantum	28%	100%
A4HZW8	Leishmania infantum	25%	100%
A4I1T4	Leishmania infantum	29%	100%
A4I2K6	Leishmania infantum	24%	74%
A4IB02	Leishmania infantum	94%	100%
A4IBT4	Leishmania infantum	28%	100%
A4IBT9	Leishmania infantum	28%	100%
A4IC54	Leishmania infantum	29%	100%
A4ICR2	Leishmania infantum	25%	100%
A8WXF6	Caenorhabditis briggsae	31%	92%
A8X6H4	Caenorhabditis briggsae	30%	100%
B3WFY8	Caenorhabditis elegans	26%	100%
B6DTE5	Bodo saltans	27%	100%
B9FKW9	Oryza sativa subsp. japonica	27%	94%
C6K3W8	Leptomonas seymouri	27%	93%
C9ZKU8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	84%
C9ZMG9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	76%
C9ZQL9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	77%
C9ZUD1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZW68	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
C9ZWL6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	76%
C9ZX15	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	98%
C9ZXP1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
C9ZYF0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
C9ZYS7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
C9ZYT4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0A0D6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
D0A0U8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
D0A2M0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
D0A2P2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
D0A509	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
D0A5C6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
D0A8X3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
D3ZML2	Rattus norvegicus	28%	67%
E8NHS0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9ACY7	Leishmania major	24%	74%
E9ADZ1	Leishmania major	27%	83%
E9AEB9	Leishmania major	23%	98%
E9AFM1	Leishmania major	29%	100%
E9AFX4	Leishmania major	29%	100%
E9AG71	Leishmania infantum	24%	100%
E9AGR6	Leishmania infantum	25%	77%
E9AGS0	Leishmania infantum	25%	100%
E9AH34	Leishmania infantum	28%	90%
E9AKB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AKE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	67%
E9AQF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9ARP5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9ARW5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	78%
E9ARW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AS98	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9ASA1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	79%
E9ASJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AVR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AVS7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AWL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	90%
E9AXW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AYR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	74%
E9B0K7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	96%
E9B296	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B5Y5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	99%
E9B6S4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B6S9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B727	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
O08605	Mus musculus	28%	100%
O08679	Rattus norvegicus	29%	68%
O08875	Rattus norvegicus	33%	100%
O15075	Homo sapiens	33%	66%
O22932	Arabidopsis thaliana	27%	100%
O22971	Arabidopsis thaliana	31%	97%
O43293	Homo sapiens	28%	100%
O55099	Rattus norvegicus	29%	100%
O61267	Drosophila melanogaster	28%	100%
O62305	Caenorhabditis elegans	31%	68%
O65554	Arabidopsis thaliana	30%	100%
O94547	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	84%
P06782	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	77%
P08414	Mus musculus	29%	100%
P10665	Xenopus laevis	28%	67%
P12688	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	72%
P15735	Homo sapiens	29%	100%
P23298	Mus musculus	27%	72%
P23443	Homo sapiens	26%	93%
P27466	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
P28582	Daucus carota	28%	92%
P31325	Rattus norvegicus	30%	100%
P34100	Dictyostelium discoideum	28%	68%
P34331	Caenorhabditis elegans	31%	75%
P34947	Homo sapiens	29%	83%
P38623	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	80%
P43249	Bos taurus	29%	83%
P45894	Caenorhabditis elegans	29%	83%
P49101	Zea mays	27%	95%
P49673	Ascaris suum	26%	100%
P52304	Drosophila melanogaster	26%	85%
P52497	Candida albicans	32%	79%
P62205	Xenopus tropicalis	30%	82%
P62343	Plasmodium falciparum (isolate K1 / Thailand)	29%	93%
P62344	Plasmodium falciparum (isolate 3D7)	29%	93%
P67998	Oryctolagus cuniculus	26%	93%
P67999	Rattus norvegicus	26%	93%
P70032	Xenopus laevis	29%	82%
Q00372	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	30%	80%
Q00771	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	28%	100%
Q07832	Mus musculus	31%	81%
Q09170	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
Q0VD22	Bos taurus	29%	100%
Q15349	Homo sapiens	28%	67%
Q1PFH8	Arabidopsis thaliana	27%	89%
Q27687	Leishmania major	26%	100%
Q2HJF7	Bos taurus	31%	100%
Q2QVG8	Oryza sativa subsp. japonica	28%	87%
Q2QX45	Oryza sativa subsp. japonica	29%	93%
Q38868	Arabidopsis thaliana	25%	90%
Q3E9C0	Arabidopsis thaliana	29%	93%
Q3UHL1	Mus musculus	27%	96%
Q4G050	Rattus norvegicus	28%	100%
Q4KTY1	Pinctada fucata	28%	100%
Q4Q204	Leishmania major	25%	100%
Q4Q7M5	Leishmania major	24%	96%
Q4Q9K2	Leishmania major	29%	100%
Q4QAV8	Leishmania major	28%	91%
Q4QBQ2	Leishmania major	25%	100%
Q4QBR6	Leishmania major	27%	100%
Q4QCR3	Leishmania major	26%	100%
Q4QD63	Leishmania major	26%	79%
Q4QD66	Leishmania major	25%	100%
Q4QDK3	Leishmania major	25%	100%
Q4QDK7	Leishmania major	25%	77%
Q4QF23	Leishmania major	23%	100%
Q4QIV8	Leishmania major	25%	100%
Q4QJJ0	Leishmania major	28%	100%
Q54BF0	Dictyostelium discoideum	29%	82%
Q54VI1	Dictyostelium discoideum	29%	69%
Q58D94	Bos taurus	27%	100%
Q5RCC4	Pongo abelii	29%	100%
Q5VQQ5	Oryza sativa subsp. japonica	28%	95%
Q60EY8	Oryza sativa subsp. japonica	28%	100%
Q62833	Rattus norvegicus	29%	83%
Q63092	Rattus norvegicus	27%	97%
Q64617	Rattus norvegicus	27%	72%
Q66I46	Xenopus tropicalis	28%	100%
Q66JF3	Xenopus tropicalis	28%	100%
Q69Z98	Mus musculus	28%	67%
Q6AVM3	Oryza sativa subsp. japonica	29%	95%
Q6C3J2	Yarrowia lipolytica (strain CLIB 122 / E 150)	30%	100%
Q6C7U0	Yarrowia lipolytica (strain CLIB 122 / E 150)	26%	69%
Q6DEH3	Danio rerio	28%	100%
Q6GLS4	Xenopus laevis	25%	100%
Q6NLQ6	Arabidopsis thaliana	26%	91%
Q6P431	Xenopus laevis	28%	100%
Q6SA08	Homo sapiens	28%	100%
Q6TJY3	Bos taurus	26%	93%
Q75GE8	Oryza sativa subsp. japonica	29%	91%
Q7RAH3	Plasmodium yoelii yoelii	29%	91%
Q7SY49	Danio rerio	25%	100%
Q7XIM0	Oryza sativa subsp. japonica	27%	86%
Q7XSQ5	Oryza sativa subsp. japonica	28%	92%
Q7YRC6	Bos taurus	28%	100%
Q86YV6	Homo sapiens	28%	100%
Q8BSK8	Mus musculus	26%	93%
Q8INB9	Drosophila melanogaster	27%	80%
Q8IWQ3	Homo sapiens	28%	66%
Q8NCB2	Homo sapiens	27%	98%
Q8RWL2	Arabidopsis thaliana	29%	92%
Q8VDF3	Mus musculus	29%	100%
Q8VEB1	Mus musculus	29%	83%
Q924X7	Mus musculus	28%	100%
Q94C40	Arabidopsis thaliana	28%	100%
Q965G5	Caenorhabditis elegans	28%	100%
Q9BYT3	Homo sapiens	30%	95%
Q9C6P3	Arabidopsis thaliana	25%	94%
Q9D411	Mus musculus	30%	100%
Q9DB30	Mus musculus	30%	100%
Q9FMP5	Arabidopsis thaliana	28%	93%
Q9GNR4	Leishmania major	29%	100%
Q9LWM4	Oryza sativa subsp. japonica	28%	100%
Q9M101	Arabidopsis thaliana	27%	94%
Q9N0X0	Sus scrofa	30%	100%
Q9NAH6	Caenorhabditis elegans	29%	89%
Q9SEZ7	Arabidopsis thaliana	30%	100%
Q9SIQ7	Arabidopsis thaliana	29%	84%
Q9U6V4	Leishmania donovani	25%	100%
Q9UBS0	Homo sapiens	27%	100%
Q9UQM7	Homo sapiens	29%	100%
Q9WUT3	Mus musculus	29%	67%
Q9XUJ7	Caenorhabditis elegans	28%	68%
Q9YGW0	Xenopus laevis	28%	100%
Q9Z1M4	Mus musculus	27%	100%
V5B6E9	Trypanosoma cruzi	26%	100%
V5B871	Trypanosoma cruzi	30%	100%
V5B8U8	Trypanosoma cruzi	25%	100%
V5B9Y9	Trypanosoma cruzi	25%	100%
V5BAZ8	Trypanosoma cruzi	26%	100%
V5BI43	Trypanosoma cruzi	48%	97%
V5BL06	Trypanosoma cruzi	30%	76%
V5BPE2	Trypanosoma cruzi	27%	100%
V5BPK4	Trypanosoma cruzi	29%	81%
V5BSA6	Trypanosoma cruzi	27%	75%
V5BVV5	Trypanosoma cruzi	25%	80%
V5DAY8	Trypanosoma cruzi	29%	100%
V5DCD4	Trypanosoma cruzi	27%	83%
V5DI55	Trypanosoma cruzi	28%	100%
V5DTI3	Trypanosoma cruzi	26%	78%
V5DTI8	Trypanosoma cruzi	26%	100%