C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc finger CCCH domain containing protein 11

Species:

Leishmania major

UniProt:

E9AES9_LEIMA

TriTrypDb:

LmjF.35.1040 , LMJLV39_350016200 , LMJSD75_350015800

Length:

317

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AES9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AES9

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	2
GO:0009266	response to temperature stimulus	3	2
GO:0009408	response to heat	3	2
GO:0009628	response to abiotic stimulus	2	2
GO:0009892	negative regulation of metabolic process	4	2
GO:0009893	positive regulation of metabolic process	4	2
GO:0009894	regulation of catabolic process	4	2
GO:0009895	negative regulation of catabolic process	5	2
GO:0010468	regulation of gene expression	5	2
GO:0010604	positive regulation of macromolecule metabolic process	5	2
GO:0010605	negative regulation of macromolecule metabolic process	5	2
GO:0010608	post-transcriptional regulation of gene expression	6	2
GO:0010628	positive regulation of gene expression	6	2
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	2
GO:0019222	regulation of metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031324	negative regulation of cellular metabolic process	5	2
GO:0031329	regulation of cellular catabolic process	5	2
GO:0031330	negative regulation of cellular catabolic process	6	2
GO:0043487	regulation of RNA stability	3	2
GO:0043488	regulation of mRNA stability	4	2
GO:0043489	RNA stabilization	4	2
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	2
GO:0048255	mRNA stabilization	5	2
GO:0048518	positive regulation of biological process	3	2
GO:0048519	negative regulation of biological process	3	2
GO:0048523	negative regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0050896	response to stimulus	1	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051172	negative regulation of nitrogen compound metabolic process	5	2
GO:0051252	regulation of RNA metabolic process	5	2
GO:0051253	negative regulation of RNA metabolic process	6	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0061013	regulation of mRNA catabolic process	6	2
GO:0065007	biological regulation	1	2
GO:0065008	regulation of biological quality	2	2
GO:0080090	regulation of primary metabolic process	4	2
GO:1902369	negative regulation of RNA catabolic process	7	2
GO:1902373	negative regulation of mRNA catabolic process	7	2
GO:1903311	regulation of mRNA metabolic process	6	2
GO:1903312	negative regulation of mRNA metabolic process	7	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0003729	mRNA binding	5	7
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	26	30	PF00656	0.667
CLV_NRD_NRD_1	100	102	PF00675	0.595
CLV_PCSK_KEX2_1	21	23	PF00082	0.695
CLV_PCSK_KEX2_1	99	101	PF00082	0.591
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.695
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.591
CLV_PCSK_SKI1_1	101	105	PF00082	0.597
CLV_PCSK_SKI1_1	35	39	PF00082	0.633
CLV_PCSK_SKI1_1	61	65	PF00082	0.387
DOC_CDC14_PxL_1	243	251	PF14671	0.754
DOC_MAPK_gen_1	153	161	PF00069	0.729
DOC_PP2B_LxvP_1	161	164	PF13499	0.587
DOC_USP7_MATH_1	270	274	PF00917	0.675
DOC_USP7_MATH_1	292	296	PF00917	0.596
DOC_USP7_MATH_1	305	309	PF00917	0.635
LIG_14-3-3_CanoR_1	298	305	PF00244	0.668
LIG_14-3-3_CanoR_1	72	78	PF00244	0.547
LIG_Actin_WH2_2	56	74	PF00022	0.411
LIG_APCC_ABBA_1	210	215	PF00400	0.733
LIG_FHA_1	11	17	PF00498	0.808
LIG_FHA_2	24	30	PF00498	0.713
LIG_FHA_2	298	304	PF00498	0.670
LIG_FHA_2	71	77	PF00498	0.545
LIG_IBAR_NPY_1	196	198	PF08397	0.621
LIG_LIR_Apic_2	232	237	PF02991	0.667
LIG_LIR_Nem_3	251	257	PF02991	0.770
LIG_LIR_Nem_3	290	296	PF02991	0.693
LIG_PCNA_PIPBox_1	186	195	PF02747	0.647
LIG_SH2_CRK	293	297	PF00017	0.698
LIG_SH2_SRC	213	216	PF00017	0.620
LIG_SH2_STAT3	257	260	PF00017	0.663
LIG_SH2_STAT5	193	196	PF00017	0.621
LIG_SH2_STAT5	198	201	PF00017	0.623
LIG_SH2_STAT5	235	238	PF00017	0.659
LIG_SH2_STAT5	254	257	PF00017	0.525
LIG_SH2_STAT5	50	53	PF00017	0.513
LIG_SH3_3	161	167	PF00018	0.833
LIG_SH3_3	241	247	PF00018	0.626
LIG_SH3_3	311	317	PF00018	0.670
LIG_TRAF2_1	163	166	PF00917	0.746
LIG_TRAF2_1	229	232	PF00917	0.629
LIG_TRAF2_1	276	279	PF00917	0.779
LIG_TRFH_1	200	204	PF08558	0.718
MOD_CK1_1	10	16	PF00069	0.770
MOD_CK1_1	24	30	PF00069	0.794
MOD_CK1_1	248	254	PF00069	0.770
MOD_CK1_1	271	277	PF00069	0.743
MOD_CK1_1	285	291	PF00069	0.542
MOD_CK2_1	12	18	PF00069	0.729
MOD_CK2_1	273	279	PF00069	0.775
MOD_CK2_1	297	303	PF00069	0.672
MOD_GlcNHglycan	270	273	PF01048	0.772
MOD_GlcNHglycan	286	290	PF01048	0.545
MOD_GSK3_1	10	17	PF00069	0.712
MOD_GSK3_1	115	122	PF00069	0.797
MOD_GSK3_1	284	291	PF00069	0.693
MOD_N-GLC_1	119	124	PF02516	0.733
MOD_N-GLC_1	125	130	PF02516	0.582
MOD_NEK2_1	23	28	PF00069	0.560
MOD_PIKK_1	248	254	PF00454	0.672
MOD_PKA_1	21	27	PF00069	0.674
MOD_PKA_2	21	27	PF00069	0.674
MOD_PKA_2	297	303	PF00069	0.672
MOD_PKA_2	71	77	PF00069	0.545
MOD_Plk_1	125	131	PF00069	0.653
MOD_Plk_4	184	190	PF00069	0.573
MOD_Plk_4	245	251	PF00069	0.663
MOD_SUMO_rev_2	29	37	PF00179	0.639
TRG_DiLeu_BaEn_3	32	38	PF01217	0.713
TRG_DiLeu_BaEn_4	33	39	PF01217	0.694
TRG_ENDOCYTIC_2	213	216	PF00928	0.736
TRG_ENDOCYTIC_2	293	296	PF00928	0.776
TRG_ER_diArg_1	150	153	PF00400	0.673

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2D6	Leptomonas seymouri	44%	100%
A0A3Q8IG28	Leishmania donovani	94%	100%
A4HMD4	Leishmania braziliensis	74%	100%
A4IB01	Leishmania infantum	94%	100%
E9B5Y4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%