C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

E9AES7_LEIMA

TriTrypDb:

LmjF.35.1020 , LMJLV39_350016000 , LMJSD75_350015600

Length:

432

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AES7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AES7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0003729	mRNA binding	5	6
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	24	28	PF00656	0.808
CLV_NRD_NRD_1	25	27	PF00675	0.736
CLV_PCSK_KEX2_1	138	140	PF00082	0.411
CLV_PCSK_KEX2_1	25	27	PF00082	0.736
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.411
CLV_PCSK_SKI1_1	154	158	PF00082	0.411
CLV_PCSK_SKI1_1	364	368	PF00082	0.688
CLV_PCSK_SKI1_1	97	101	PF00082	0.690
DEG_APCC_DBOX_1	363	371	PF00400	0.684
DEG_COP1_1	404	411	PF00400	0.548
DEG_Nend_UBRbox_3	1	3	PF02207	0.606
DEG_SCF_FBW7_1	1	7	PF00400	0.667
DEG_SPOP_SBC_1	17	21	PF00917	0.733
DEG_SPOP_SBC_1	341	345	PF00917	0.760
DOC_CKS1_1	1	6	PF01111	0.676
DOC_PP4_FxxP_1	368	371	PF00568	0.633
DOC_USP7_MATH_1	107	111	PF00917	0.808
DOC_USP7_MATH_1	17	21	PF00917	0.660
DOC_USP7_MATH_1	184	188	PF00917	0.717
DOC_USP7_MATH_1	210	214	PF00917	0.614
DOC_USP7_MATH_1	217	221	PF00917	0.600
DOC_USP7_MATH_1	291	295	PF00917	0.726
DOC_USP7_MATH_1	303	307	PF00917	0.474
DOC_USP7_MATH_1	333	337	PF00917	0.608
DOC_USP7_MATH_1	342	346	PF00917	0.528
DOC_USP7_MATH_1	356	360	PF00917	0.692
DOC_USP7_MATH_1	36	40	PF00917	0.478
DOC_USP7_MATH_1	401	405	PF00917	0.676
DOC_USP7_MATH_1	5	9	PF00917	0.591
DOC_USP7_MATH_1	88	92	PF00917	0.752
DOC_USP7_MATH_1	99	103	PF00917	0.688
DOC_USP7_UBL2_3	97	101	PF12436	0.690
DOC_WW_Pin1_4	111	116	PF00397	0.801
DOC_WW_Pin1_4	250	255	PF00397	0.843
DOC_WW_Pin1_4	258	263	PF00397	0.702
DOC_WW_Pin1_4	51	56	PF00397	0.694
DOC_WW_Pin1_4	68	73	PF00397	0.756
DOC_WW_Pin1_4	86	91	PF00397	0.563
LIG_14-3-3_CanoR_1	219	226	PF00244	0.653
LIG_BRCT_BRCA1_1	364	368	PF00533	0.688
LIG_DLG_GKlike_1	25	33	PF00625	0.721
LIG_FHA_1	1	7	PF00498	0.705
LIG_FHA_1	184	190	PF00498	0.704
LIG_FHA_1	243	249	PF00498	0.710
LIG_FHA_2	17	23	PF00498	0.736
LIG_LIR_Apic_2	365	371	PF02991	0.683
LIG_LIR_Gen_1	297	303	PF02991	0.569
LIG_LIR_Gen_1	31	40	PF02991	0.703
LIG_LIR_Gen_1	336	346	PF02991	0.665
LIG_LIR_Gen_1	395	401	PF02991	0.756
LIG_LIR_Gen_1	71	81	PF02991	0.725
LIG_LIR_Nem_3	146	151	PF02991	0.411
LIG_LIR_Nem_3	161	167	PF02991	0.554
LIG_LIR_Nem_3	297	301	PF02991	0.571
LIG_LIR_Nem_3	31	37	PF02991	0.703
LIG_LIR_Nem_3	336	341	PF02991	0.769
LIG_LIR_Nem_3	71	77	PF02991	0.753
LIG_LIR_Nem_3	81	86	PF02991	0.594
LIG_LYPXL_yS_3	65	68	PF13949	0.780
LIG_SH2_GRB2like	396	399	PF00017	0.602
LIG_SH2_STAP1	205	209	PF00017	0.549
LIG_SH2_STAP1	396	400	PF00017	0.528
LIG_SH2_STAT3	167	170	PF00017	0.687
LIG_SH2_STAT5	167	170	PF00017	0.585
LIG_SH2_STAT5	389	392	PF00017	0.609
LIG_SH2_STAT5	415	418	PF00017	0.659
LIG_SH3_1	84	90	PF00018	0.601
LIG_SH3_3	115	121	PF00018	0.789
LIG_SH3_3	241	247	PF00018	0.772
LIG_SH3_3	251	257	PF00018	0.731
LIG_SH3_3	406	412	PF00018	0.682
LIG_SH3_3	84	90	PF00018	0.697
LIG_SUMO_SIM_par_1	322	328	PF11976	0.775
LIG_TRAF2_1	78	81	PF00917	0.732
LIG_WRC_WIRS_1	295	300	PF05994	0.566
MOD_CK1_1	103	109	PF00069	0.702
MOD_CK1_1	111	117	PF00069	0.779
MOD_CK1_1	125	131	PF00069	0.517
MOD_CK1_1	21	27	PF00069	0.723
MOD_CK1_1	258	264	PF00069	0.756
MOD_CK1_1	294	300	PF00069	0.709
MOD_CK1_1	413	419	PF00069	0.679
MOD_CK1_1	7	13	PF00069	0.707
MOD_CK1_1	70	76	PF00069	0.724
MOD_CK2_1	16	22	PF00069	0.683
MOD_CK2_1	25	31	PF00069	0.587
MOD_CK2_1	7	13	PF00069	0.787
MOD_CK2_1	75	81	PF00069	0.734
MOD_GlcNHglycan	104	108	PF01048	0.627
MOD_GlcNHglycan	144	148	PF01048	0.315
MOD_GlcNHglycan	211	215	PF01048	0.621
MOD_GlcNHglycan	221	224	PF01048	0.653
MOD_GlcNHglycan	238	241	PF01048	0.719
MOD_GlcNHglycan	404	407	PF01048	0.590
MOD_GlcNHglycan	412	415	PF01048	0.764
MOD_GlcNHglycan	7	10	PF01048	0.607
MOD_GlcNHglycan	90	93	PF01048	0.713
MOD_GlcNHglycan	97	100	PF01048	0.709
MOD_GSK3_1	103	110	PF00069	0.739
MOD_GSK3_1	122	129	PF00069	0.678
MOD_GSK3_1	130	137	PF00069	0.555
MOD_GSK3_1	17	24	PF00069	0.768
MOD_GSK3_1	238	245	PF00069	0.775
MOD_GSK3_1	258	265	PF00069	0.508
MOD_GSK3_1	410	417	PF00069	0.657
MOD_GSK3_1	75	82	PF00069	0.709
MOD_GSK3_1	95	102	PF00069	0.723
MOD_N-GLC_1	107	112	PF02516	0.685
MOD_N-GLC_1	250	255	PF02516	0.669
MOD_N-GLC_1	401	406	PF02516	0.578
MOD_N-GLC_1	95	100	PF02516	0.695
MOD_NEK2_1	143	148	PF00069	0.411
MOD_NEK2_1	275	280	PF00069	0.643
MOD_NEK2_1	324	329	PF00069	0.641
MOD_NEK2_1	95	100	PF00069	0.690
MOD_PIKK_1	252	258	PF00454	0.729
MOD_PIKK_1	262	268	PF00454	0.665
MOD_PIKK_1	303	309	PF00454	0.752
MOD_PIKK_1	43	49	PF00454	0.702
MOD_PKA_1	25	31	PF00069	0.724
MOD_PKA_2	25	31	PF00069	0.724
MOD_Plk_1	30	36	PF00069	0.786
MOD_Plk_1	95	101	PF00069	0.737
MOD_Plk_2-3	392	398	PF00069	0.527
MOD_Plk_4	30	36	PF00069	0.760
MOD_Plk_4	342	348	PF00069	0.534
MOD_Plk_4	56	62	PF00069	0.560
MOD_Plk_4	7	13	PF00069	0.690
MOD_ProDKin_1	111	117	PF00069	0.802
MOD_ProDKin_1	250	256	PF00069	0.844
MOD_ProDKin_1	258	264	PF00069	0.702
MOD_ProDKin_1	51	57	PF00069	0.694
MOD_ProDKin_1	68	74	PF00069	0.760
MOD_ProDKin_1	86	92	PF00069	0.564
TRG_DiLeu_BaLyEn_6	320	325	PF01217	0.783
TRG_ENDOCYTIC_2	396	399	PF00928	0.761
TRG_ENDOCYTIC_2	65	68	PF00928	0.780
TRG_NLS_MonoExtN_4	136	142	PF00514	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P318	Leptomonas seymouri	41%	74%
A0A3S7X8W6	Leishmania donovani	90%	100%
A4HMD2	Leishmania braziliensis	55%	99%
A4IAZ9	Leishmania infantum	89%	99%
E9B5Y2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%