C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

E9AES7_LEIMA

TriTrypDb:

LmjF.35.1020 , LMJLV39_350016000 , LMJSD75_350015600

Length:

432

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AES7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AES7

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0003729	mRNA binding	5	6
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	24	28	PF00656	0.808
CLV_NRD_NRD_1	25	27	PF00675	0.736
CLV_PCSK_KEX2_1	138	140	PF00082	0.411
CLV_PCSK_KEX2_1	25	27	PF00082	0.736
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.411
CLV_PCSK_SKI1_1	154	158	PF00082	0.411
CLV_PCSK_SKI1_1	364	368	PF00082	0.688
CLV_PCSK_SKI1_1	97	101	PF00082	0.690
DEG_APCC_DBOX_1	363	371	PF00400	0.684
DEG_COP1_1	404	411	PF00400	0.548

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P318	Leptomonas seymouri	41%	74%
A0A3S7X8W6	Leishmania donovani	90%	100%
A4HMD2	Leishmania braziliensis	55%	99%
A4IAZ9	Leishmania infantum	89%	99%
E9B5Y2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%

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