Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AES4_LEIMA

TriTrypDb:

LmjF.35.0990 , LMJLV39_350015700 , LMJSD75_350015300

Length:

857

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AES4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AES4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	328	332	PF00656	0.656
CLV_C14_Caspase3-7	613	617	PF00656	0.603
CLV_C14_Caspase3-7	81	85	PF00656	0.626
CLV_NRD_NRD_1	581	583	PF00675	0.459
CLV_NRD_NRD_1	620	622	PF00675	0.634
CLV_NRD_NRD_1	677	679	PF00675	0.676
CLV_NRD_NRD_1	787	789	PF00675	0.616
CLV_NRD_NRD_1	807	809	PF00675	0.763
CLV_NRD_NRD_1	820	822	PF00675	0.647
CLV_PCSK_FUR_1	785	789	PF00082	0.603
CLV_PCSK_KEX2_1	581	583	PF00082	0.488
CLV_PCSK_KEX2_1	620	622	PF00082	0.573
CLV_PCSK_KEX2_1	677	679	PF00082	0.668
CLV_PCSK_KEX2_1	759	761	PF00082	0.660
CLV_PCSK_KEX2_1	787	789	PF00082	0.616
CLV_PCSK_KEX2_1	807	809	PF00082	0.678
CLV_PCSK_KEX2_1	820	822	PF00082	0.609
CLV_PCSK_PC1ET2_1	759	761	PF00082	0.616
CLV_PCSK_SKI1_1	152	156	PF00082	0.375
CLV_PCSK_SKI1_1	359	363	PF00082	0.537
CLV_PCSK_SKI1_1	632	636	PF00082	0.679
DEG_COP1_1	130	140	PF00400	0.547
DEG_Nend_Nbox_1	1	3	PF02207	0.462
DEG_SCF_FBW7_1	191	197	PF00400	0.424
DEG_SPOP_SBC_1	467	471	PF00917	0.695
DOC_CDC14_PxL_1	284	292	PF14671	0.553
DOC_CKS1_1	191	196	PF01111	0.496
DOC_CKS1_1	220	225	PF01111	0.378
DOC_CYCLIN_yCln2_LP_2	107	113	PF00134	0.596
DOC_CYCLIN_yCln2_LP_2	18	24	PF00134	0.412
DOC_MAPK_HePTP_8	160	172	PF00069	0.374
DOC_MAPK_MEF2A_6	152	159	PF00069	0.400
DOC_MAPK_MEF2A_6	163	172	PF00069	0.402
DOC_MAPK_MEF2A_6	442	450	PF00069	0.465
DOC_PP1_RVXF_1	376	383	PF00149	0.516
DOC_PP1_RVXF_1	405	411	PF00149	0.393
DOC_PP1_RVXF_1	445	451	PF00149	0.342
DOC_PP2B_LxvP_1	455	458	PF13499	0.487
DOC_PP4_FxxP_1	204	207	PF00568	0.467
DOC_USP7_MATH_1	119	123	PF00917	0.400
DOC_USP7_MATH_1	14	18	PF00917	0.379
DOC_USP7_MATH_1	141	145	PF00917	0.449
DOC_USP7_MATH_1	244	248	PF00917	0.688
DOC_USP7_MATH_1	259	263	PF00917	0.504
DOC_USP7_MATH_1	335	339	PF00917	0.633
DOC_USP7_MATH_1	468	472	PF00917	0.654
DOC_USP7_MATH_1	527	531	PF00917	0.415
DOC_USP7_MATH_1	615	619	PF00917	0.704
DOC_USP7_MATH_1	638	642	PF00917	0.634
DOC_USP7_MATH_1	80	84	PF00917	0.723
DOC_USP7_MATH_1	844	848	PF00917	0.679
DOC_USP7_MATH_1	99	103	PF00917	0.569
DOC_USP7_UBL2_3	403	407	PF12436	0.615
DOC_WW_Pin1_4	174	179	PF00397	0.485
DOC_WW_Pin1_4	190	195	PF00397	0.584
DOC_WW_Pin1_4	209	214	PF00397	0.426
DOC_WW_Pin1_4	219	224	PF00397	0.380
DOC_WW_Pin1_4	239	244	PF00397	0.696
DOC_WW_Pin1_4	276	281	PF00397	0.570
DOC_WW_Pin1_4	397	402	PF00397	0.652
DOC_WW_Pin1_4	490	495	PF00397	0.665
DOC_WW_Pin1_4	611	616	PF00397	0.686
DOC_WW_Pin1_4	662	667	PF00397	0.769
DOC_WW_Pin1_4	764	769	PF00397	0.594
DOC_WW_Pin1_4	835	840	PF00397	0.740
LIG_14-3-3_CanoR_1	274	281	PF00244	0.565
LIG_14-3-3_CanoR_1	293	297	PF00244	0.518
LIG_14-3-3_CanoR_1	442	446	PF00244	0.477
LIG_14-3-3_CanoR_1	532	538	PF00244	0.433
LIG_14-3-3_CanoR_1	600	607	PF00244	0.491
LIG_14-3-3_CanoR_1	677	681	PF00244	0.608
LIG_14-3-3_CanoR_1	695	702	PF00244	0.465
LIG_Actin_WH2_2	589	607	PF00022	0.423
LIG_APCC_ABBA_1	446	451	PF00400	0.474
LIG_BIR_III_2	825	829	PF00653	0.624
LIG_BIR_III_4	565	569	PF00653	0.459
LIG_BRCT_BRCA1_1	739	743	PF00533	0.662
LIG_BRCT_BRCA1_1	74	78	PF00533	0.691
LIG_FHA_1	191	197	PF00498	0.424
LIG_FHA_1	210	216	PF00498	0.434
LIG_FHA_1	248	254	PF00498	0.607
LIG_FHA_1	311	317	PF00498	0.712
LIG_FHA_1	407	413	PF00498	0.459
LIG_FHA_1	468	474	PF00498	0.631
LIG_FHA_1	526	532	PF00498	0.526
LIG_FHA_1	540	546	PF00498	0.399
LIG_FHA_1	739	745	PF00498	0.692
LIG_FHA_2	156	162	PF00498	0.436
LIG_FHA_2	415	421	PF00498	0.643
LIG_FHA_2	425	431	PF00498	0.604
LIG_FHA_2	552	558	PF00498	0.522
LIG_FHA_2	611	617	PF00498	0.611
LIG_FHA_2	695	701	PF00498	0.586
LIG_FHA_2	89	95	PF00498	0.647
LIG_GBD_Chelix_1	156	164	PF00786	0.441
LIG_LIR_Gen_1	177	188	PF02991	0.516
LIG_LIR_Gen_1	225	235	PF02991	0.470
LIG_LIR_Gen_1	57	64	PF02991	0.601
LIG_LIR_Gen_1	570	580	PF02991	0.485
LIG_LIR_Gen_1	679	688	PF02991	0.665
LIG_LIR_Nem_3	17	23	PF02991	0.463
LIG_LIR_Nem_3	177	183	PF02991	0.502
LIG_LIR_Nem_3	225	230	PF02991	0.561
LIG_LIR_Nem_3	371	376	PF02991	0.436
LIG_LIR_Nem_3	57	63	PF02991	0.631
LIG_LIR_Nem_3	570	575	PF02991	0.449
LIG_LIR_Nem_3	810	815	PF02991	0.607
LIG_LYPXL_yS_3	20	23	PF13949	0.425
LIG_MLH1_MIPbox_1	75	79	PF16413	0.607
LIG_PTB_Apo_2	568	575	PF02174	0.406
LIG_RPA_C_Fungi	158	170	PF08784	0.467
LIG_SH2_CRK	227	231	PF00017	0.477
LIG_SH2_GRB2like	569	572	PF00017	0.469
LIG_SH2_NCK_1	227	231	PF00017	0.477
LIG_SH2_NCK_1	5	9	PF00017	0.518
LIG_SH2_STAP1	569	573	PF00017	0.462
LIG_SH2_STAT5	106	109	PF00017	0.562
LIG_SH2_STAT5	449	452	PF00017	0.537
LIG_SH2_STAT5	735	738	PF00017	0.618
LIG_SH3_3	135	141	PF00018	0.507
LIG_SH3_3	185	191	PF00018	0.562
LIG_SH3_3	314	320	PF00018	0.668
LIG_SH3_3	398	404	PF00018	0.562
LIG_SH3_3	450	456	PF00018	0.580
LIG_SH3_3	457	463	PF00018	0.584
LIG_SH3_3	609	615	PF00018	0.645
LIG_SH3_3	838	844	PF00018	0.669
LIG_SH3_4	403	410	PF00018	0.576
LIG_SUMO_SIM_anti_2	132	139	PF11976	0.577
LIG_SUMO_SIM_anti_2	166	171	PF11976	0.367
LIG_SUMO_SIM_par_1	212	217	PF11976	0.454
LIG_SUMO_SIM_par_1	22	28	PF11976	0.384
LIG_SUMO_SIM_par_1	605	610	PF11976	0.545
LIG_TRAF2_1	428	431	PF00917	0.472
LIG_TRAF2_1	689	692	PF00917	0.587
LIG_TYR_ITIM	18	23	PF00017	0.417
LIG_UBA3_1	22	29	PF00899	0.428
LIG_WRC_WIRS_1	156	161	PF05994	0.437
LIG_WRC_WIRS_1	253	258	PF05994	0.544
LIG_WRC_WIRS_1	30	35	PF05994	0.531
LIG_WW_3	578	582	PF00397	0.506
MOD_CDK_SPxK_1	397	403	PF00069	0.604
MOD_CDK_SPxxK_3	664	671	PF00069	0.614
MOD_CK1_1	242	248	PF00069	0.619
MOD_CK1_1	255	261	PF00069	0.538
MOD_CK1_1	347	353	PF00069	0.675
MOD_CK1_1	365	371	PF00069	0.601
MOD_CK1_1	415	421	PF00069	0.655
MOD_CK1_1	44	50	PF00069	0.712
MOD_CK1_1	523	529	PF00069	0.529
MOD_CK1_1	551	557	PF00069	0.591
MOD_CK1_1	584	590	PF00069	0.467
MOD_CK1_1	667	673	PF00069	0.641
MOD_CK1_1	713	719	PF00069	0.684
MOD_CK1_1	74	80	PF00069	0.731
MOD_CK1_1	830	836	PF00069	0.726
MOD_CK2_1	155	161	PF00069	0.434
MOD_CK2_1	414	420	PF00069	0.632
MOD_CK2_1	424	430	PF00069	0.466
MOD_CK2_1	51	57	PF00069	0.655
MOD_CK2_1	679	685	PF00069	0.589
MOD_CK2_1	694	700	PF00069	0.582
MOD_Cter_Amidation	728	731	PF01082	0.684
MOD_Cter_Amidation	757	760	PF01082	0.734
MOD_Cter_Amidation	818	821	PF01082	0.697
MOD_GlcNHglycan	207	210	PF01048	0.518
MOD_GlcNHglycan	216	219	PF01048	0.466
MOD_GlcNHglycan	246	249	PF01048	0.635
MOD_GlcNHglycan	257	260	PF01048	0.545
MOD_GlcNHglycan	261	264	PF01048	0.547
MOD_GlcNHglycan	276	279	PF01048	0.555
MOD_GlcNHglycan	283	287	PF01048	0.643
MOD_GlcNHglycan	350	353	PF01048	0.576
MOD_GlcNHglycan	413	417	PF01048	0.550
MOD_GlcNHglycan	43	46	PF01048	0.714
MOD_GlcNHglycan	470	473	PF01048	0.644
MOD_GlcNHglycan	522	525	PF01048	0.598
MOD_GlcNHglycan	53	56	PF01048	0.661
MOD_GlcNHglycan	601	604	PF01048	0.508
MOD_GlcNHglycan	647	650	PF01048	0.533
MOD_GlcNHglycan	775	778	PF01048	0.448
MOD_GlcNHglycan	789	792	PF01048	0.746
MOD_GlcNHglycan	829	832	PF01048	0.688
MOD_GlcNHglycan	846	849	PF01048	0.516
MOD_GSK3_1	155	162	PF00069	0.422
MOD_GSK3_1	190	197	PF00069	0.419
MOD_GSK3_1	205	212	PF00069	0.339
MOD_GSK3_1	238	245	PF00069	0.636
MOD_GSK3_1	255	262	PF00069	0.580
MOD_GSK3_1	344	351	PF00069	0.592
MOD_GSK3_1	357	364	PF00069	0.358
MOD_GSK3_1	392	399	PF00069	0.719
MOD_GSK3_1	408	415	PF00069	0.435
MOD_GSK3_1	515	522	PF00069	0.675
MOD_GSK3_1	523	530	PF00069	0.522
MOD_GSK3_1	58	65	PF00069	0.703
MOD_GSK3_1	611	618	PF00069	0.656
MOD_GSK3_1	658	665	PF00069	0.666
MOD_GSK3_1	710	717	PF00069	0.609
MOD_GSK3_1	82	89	PF00069	0.712
MOD_GSK3_1	827	834	PF00069	0.712
MOD_GSK3_1	840	847	PF00069	0.728
MOD_LATS_1	27	33	PF00433	0.492
MOD_N-GLC_1	100	105	PF02516	0.638
MOD_N-GLC_1	111	116	PF02516	0.548
MOD_N-GLC_1	119	124	PF02516	0.438
MOD_N-GLC_1	396	401	PF02516	0.472
MOD_NEK2_1	155	160	PF00069	0.380
MOD_NEK2_1	257	262	PF00069	0.524
MOD_NEK2_1	346	351	PF00069	0.582
MOD_NEK2_1	362	367	PF00069	0.453
MOD_NEK2_1	533	538	PF00069	0.479
MOD_NEK2_1	58	63	PF00069	0.704
MOD_NEK2_1	598	603	PF00069	0.434
MOD_NEK2_1	645	650	PF00069	0.561
MOD_NEK2_1	71	76	PF00069	0.554
MOD_NEK2_1	711	716	PF00069	0.568
MOD_NEK2_2	335	340	PF00069	0.373
MOD_NEK2_2	527	532	PF00069	0.433
MOD_PIKK_1	473	479	PF00454	0.580
MOD_PIKK_1	670	676	PF00454	0.641
MOD_PIKK_1	802	808	PF00454	0.545
MOD_PK_1	163	169	PF00069	0.412
MOD_PK_1	581	587	PF00069	0.442
MOD_PKA_1	581	587	PF00069	0.514
MOD_PKA_1	787	793	PF00069	0.751
MOD_PKA_2	292	298	PF00069	0.678
MOD_PKA_2	441	447	PF00069	0.507
MOD_PKA_2	473	479	PF00069	0.594
MOD_PKA_2	533	539	PF00069	0.426
MOD_PKA_2	581	587	PF00069	0.421
MOD_PKA_2	599	605	PF00069	0.436
MOD_PKA_2	670	676	PF00069	0.687
MOD_PKA_2	694	700	PF00069	0.706
MOD_PKA_2	787	793	PF00069	0.634
MOD_PKB_1	272	280	PF00069	0.533
MOD_PKB_1	785	793	PF00069	0.623
MOD_Plk_1	100	106	PF00069	0.660
MOD_Plk_1	119	125	PF00069	0.415
MOD_Plk_1	510	516	PF00069	0.508
MOD_Plk_1	56	62	PF00069	0.541
MOD_Plk_4	119	125	PF00069	0.680
MOD_Plk_4	155	161	PF00069	0.463
MOD_Plk_4	163	169	PF00069	0.378
MOD_Plk_4	222	228	PF00069	0.416
MOD_Plk_4	230	236	PF00069	0.309
MOD_Plk_4	252	258	PF00069	0.607
MOD_Plk_4	29	35	PF00069	0.520
MOD_Plk_4	357	363	PF00069	0.545
MOD_Plk_4	368	374	PF00069	0.484
MOD_Plk_4	441	447	PF00069	0.417
MOD_Plk_4	515	521	PF00069	0.505
MOD_Plk_4	638	644	PF00069	0.540
MOD_Plk_4	74	80	PF00069	0.617
MOD_ProDKin_1	174	180	PF00069	0.483
MOD_ProDKin_1	190	196	PF00069	0.585
MOD_ProDKin_1	209	215	PF00069	0.421
MOD_ProDKin_1	219	225	PF00069	0.376
MOD_ProDKin_1	239	245	PF00069	0.697
MOD_ProDKin_1	276	282	PF00069	0.573
MOD_ProDKin_1	397	403	PF00069	0.653
MOD_ProDKin_1	490	496	PF00069	0.665
MOD_ProDKin_1	611	617	PF00069	0.690
MOD_ProDKin_1	662	668	PF00069	0.765
MOD_ProDKin_1	764	770	PF00069	0.588
MOD_ProDKin_1	835	841	PF00069	0.733
MOD_SUMO_for_1	508	511	PF00179	0.582
MOD_SUMO_rev_2	751	761	PF00179	0.671
TRG_DiLeu_BaEn_1	132	137	PF01217	0.582
TRG_DiLeu_BaLyEn_6	18	23	PF01217	0.352
TRG_DiLeu_BaLyEn_6	285	290	PF01217	0.618
TRG_ENDOCYTIC_2	180	183	PF00928	0.502
TRG_ENDOCYTIC_2	20	23	PF00928	0.425
TRG_ENDOCYTIC_2	227	230	PF00928	0.471
TRG_ENDOCYTIC_2	5	8	PF00928	0.516
TRG_ENDOCYTIC_2	569	572	PF00928	0.469
TRG_ENDOCYTIC_2	812	815	PF00928	0.607
TRG_ER_diArg_1	531	534	PF00400	0.415
TRG_ER_diArg_1	580	582	PF00400	0.492
TRG_ER_diArg_1	785	788	PF00400	0.598
TRG_ER_diArg_1	807	809	PF00400	0.763
TRG_ER_diArg_1	820	822	PF00400	0.647
TRG_ER_FFAT_2	251	262	PF00635	0.427
TRG_NES_CRM1_1	6	19	PF08389	0.458
TRG_Pf-PMV_PEXEL_1	820	825	PF00026	0.709

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P319	Leptomonas seymouri	49%	95%
A0A1X0NIZ7	Trypanosomatidae	28%	100%
A0A3R7KEZ9	Trypanosoma rangeli	29%	100%
A0A3S7X8X6	Leishmania donovani	90%	100%
A4HMC9	Leishmania braziliensis	77%	100%
A4IAZ6	Leishmania infantum	90%	100%
E9B5X9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%