Aldose 1-epimerase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

aldose 1-epimerase-like protein

Species:

Leishmania major

UniProt:

E9AES3_LEIMA

TriTrypDb:

LmjF.35.0980 , LMJLV39_350015600 , LMJSD75_350015200

Length:

377

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 28

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AES3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AES3

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	21
GO:0005996	monosaccharide metabolic process	3	7
GO:0006006	glucose metabolic process	5	4
GO:0006012	galactose metabolic process	5	4
GO:0008152	metabolic process	1	21
GO:0009056	catabolic process	2	4
GO:0016052	carbohydrate catabolic process	4	4
GO:0019318	hexose metabolic process	4	7
GO:0019320	hexose catabolic process	5	4
GO:0019388	galactose catabolic process	6	4
GO:0033499	galactose catabolic process via UDP-galactose	7	4
GO:0044238	primary metabolic process	2	21
GO:0044281	small molecule metabolic process	2	7
GO:0044282	small molecule catabolic process	3	4
GO:0046365	monosaccharide catabolic process	4	4
GO:0071704	organic substance metabolic process	2	21
GO:1901575	organic substance catabolic process	3	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	21
GO:0004034	aldose 1-epimerase activity	5	16
GO:0005488	binding	1	21
GO:0016853	isomerase activity	2	21
GO:0016854	racemase and epimerase activity	3	16
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	4	16
GO:0030246	carbohydrate binding	2	21

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	355	357	PF00675	0.258
CLV_PCSK_KEX2_1	355	357	PF00082	0.311
CLV_PCSK_SKI1_1	281	285	PF00082	0.311
DOC_MAPK_gen_1	19	27	PF00069	0.389
DOC_MAPK_gen_1	196	205	PF00069	0.372
DOC_MAPK_gen_1	325	334	PF00069	0.456
DOC_MAPK_MEF2A_6	19	27	PF00069	0.471
DOC_PP2B_LxvP_1	215	218	PF13499	0.496
DOC_USP7_MATH_2	142	148	PF00917	0.509
DOC_WW_Pin1_4	131	136	PF00397	0.453
DOC_WW_Pin1_4	170	175	PF00397	0.460
DOC_WW_Pin1_4	287	292	PF00397	0.459
LIG_14-3-3_CanoR_1	360	366	PF00244	0.474
LIG_Actin_WH2_2	11	26	PF00022	0.352
LIG_APCC_ABBA_1	282	287	PF00400	0.477
LIG_APCC_ABBAyCdc20_2	281	287	PF00400	0.477
LIG_BIR_III_2	176	180	PF00653	0.499
LIG_FHA_1	148	154	PF00498	0.488
LIG_FHA_1	18	24	PF00498	0.495
LIG_FHA_1	360	366	PF00498	0.372
LIG_FHA_1	81	87	PF00498	0.531
LIG_FHA_2	120	126	PF00498	0.405
LIG_FHA_2	161	167	PF00498	0.538
LIG_FHA_2	239	245	PF00498	0.475
LIG_FHA_2	59	65	PF00498	0.501
LIG_LIR_Apic_2	129	135	PF02991	0.492
LIG_LIR_Gen_1	232	243	PF02991	0.572
LIG_LIR_Nem_3	163	168	PF02991	0.519
LIG_LIR_Nem_3	232	238	PF02991	0.527
LIG_LIR_Nem_3	64	70	PF02991	0.562
LIG_Pex14_2	303	307	PF04695	0.470
LIG_PTB_Apo_2	181	188	PF02174	0.445
LIG_PTB_Phospho_1	181	187	PF10480	0.445
LIG_SH2_CRK	132	136	PF00017	0.498
LIG_SH2_CRK	67	71	PF00017	0.509
LIG_SH2_GRB2like	187	190	PF00017	0.445
LIG_SH2_SRC	268	271	PF00017	0.450
LIG_SH2_STAP1	165	169	PF00017	0.511
LIG_SH2_STAT5	132	135	PF00017	0.495
LIG_SH2_STAT5	168	171	PF00017	0.546
LIG_SH2_STAT5	309	312	PF00017	0.477
LIG_SH2_STAT5	338	341	PF00017	0.465
LIG_SH3_3	344	350	PF00018	0.478
LIG_SH3_3	36	42	PF00018	0.520
LIG_SUMO_SIM_anti_2	256	262	PF11976	0.541
LIG_SUMO_SIM_par_1	269	275	PF11976	0.488
LIG_TYR_ITSM	63	70	PF00017	0.405
LIG_UBA3_1	15	19	PF00899	0.263
MOD_CK1_1	147	153	PF00069	0.517
MOD_CK1_1	290	296	PF00069	0.460
MOD_CK1_1	359	365	PF00069	0.487
MOD_CK2_1	119	125	PF00069	0.472
MOD_CK2_1	54	60	PF00069	0.497
MOD_GlcNHglycan	318	321	PF01048	0.282
MOD_GlcNHglycan	56	59	PF01048	0.384
MOD_GSK3_1	117	124	PF00069	0.499
MOD_GSK3_1	126	133	PF00069	0.447
MOD_GSK3_1	149	156	PF00069	0.517
MOD_GSK3_1	160	167	PF00069	0.489
MOD_GSK3_1	234	241	PF00069	0.523
MOD_GSK3_1	54	61	PF00069	0.492
MOD_N-GLC_1	130	135	PF02516	0.309
MOD_N-GLC_2	294	296	PF02516	0.277
MOD_NEK2_1	130	135	PF00069	0.494
MOD_NEK2_1	30	35	PF00069	0.437
MOD_NEK2_1	361	366	PF00069	0.544
MOD_NEK2_1	68	73	PF00069	0.478
MOD_NEK2_2	80	85	PF00069	0.563
MOD_NEK2_2	99	104	PF00069	0.420
MOD_PKA_2	327	333	PF00069	0.479
MOD_PKA_2	359	365	PF00069	0.514
MOD_PKA_2	99	105	PF00069	0.504
MOD_Plk_2-3	234	240	PF00069	0.477
MOD_Plk_4	164	170	PF00069	0.492
MOD_Plk_4	361	367	PF00069	0.476
MOD_ProDKin_1	131	137	PF00069	0.453
MOD_ProDKin_1	170	176	PF00069	0.460
MOD_ProDKin_1	287	293	PF00069	0.459
TRG_DiLeu_BaEn_1	278	283	PF01217	0.515
TRG_ENDOCYTIC_2	187	190	PF00928	0.445
TRG_ENDOCYTIC_2	300	303	PF00928	0.465
TRG_ENDOCYTIC_2	67	70	PF00928	0.405
TRG_ER_diArg_1	22	25	PF00400	0.389
TRG_ER_diArg_1	354	356	PF00400	0.511
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.279
TRG_PTS1	374	377	PF00515	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0E0RXA9	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	26%	87%
A0A0N0P441	Leptomonas seymouri	64%	100%
A0A0N0P558	Leptomonas seymouri	36%	93%
A0A0N1PBB3	Leptomonas seymouri	53%	100%
A0A1X0NJ33	Trypanosomatidae	55%	100%
A0A1X0NX70	Trypanosomatidae	39%	99%
A0A3R7MXQ5	Trypanosoma rangeli	39%	100%
A0A3S7WXI1	Leishmania donovani	36%	92%
A0A3S7X8W5	Leishmania donovani	70%	100%
A0A3S7X8Z3	Leishmania donovani	97%	100%
A0A422N115	Trypanosoma rangeli	51%	100%
A4HCQ7	Leishmania braziliensis	37%	92%
A4I082	Leishmania infantum	35%	92%
A4IAZ4	Leishmania infantum	70%	100%
D4AMB9	Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371)	28%	86%
E9AES2	Leishmania major	71%	99%
E9AW46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	92%
E9B5X7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
E9B5X8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
P05149	Acinetobacter calcoaceticus	31%	99%
P0A9C3	Escherichia coli (strain K12)	29%	100%
P0A9C4	Shigella flexneri	29%	100%
P21955	Streptococcus thermophilus	21%	100%
P31765	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	28%	100%
P53757	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
Q03PA4	Levilactobacillus brevis (strain ATCC 367 / BCRC 12310 / CIP 105137 / JCM 1170 / LMG 11437 / NCIMB 947 / NCTC 947)	25%	100%
Q4QBD1	Leishmania major	36%	92%
Q5EA79	Bos taurus	29%	100%
Q5R8U1	Pongo abelii	29%	100%
Q66HG4	Rattus norvegicus	28%	100%
Q8K157	Mus musculus	28%	100%
Q96C23	Homo sapiens	29%	100%
Q9GKX6	Sus scrofa	28%	100%
V5B7Z0	Trypanosoma cruzi	37%	98%