Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AES1_LEIMA

TriTrypDb:

LmjF.35.0960 , LMJLV39_350015400 , LMJSD75_350015000

Length:

794

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AES1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AES1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	319	325	PF00089	0.406
CLV_NRD_NRD_1	11	13	PF00675	0.451
CLV_NRD_NRD_1	131	133	PF00675	0.651
CLV_NRD_NRD_1	185	187	PF00675	0.429
CLV_NRD_NRD_1	200	202	PF00675	0.583
CLV_NRD_NRD_1	309	311	PF00675	0.438
CLV_NRD_NRD_1	579	581	PF00675	0.560
CLV_NRD_NRD_1	607	609	PF00675	0.570
CLV_NRD_NRD_1	688	690	PF00675	0.690
CLV_PCSK_FUR_1	577	581	PF00082	0.483
CLV_PCSK_KEX2_1	10	12	PF00082	0.456
CLV_PCSK_KEX2_1	131	133	PF00082	0.651
CLV_PCSK_KEX2_1	185	187	PF00082	0.449
CLV_PCSK_KEX2_1	200	202	PF00082	0.604
CLV_PCSK_KEX2_1	309	311	PF00082	0.438
CLV_PCSK_KEX2_1	579	581	PF00082	0.492
CLV_PCSK_KEX2_1	607	609	PF00082	0.570
CLV_PCSK_SKI1_1	104	108	PF00082	0.666
CLV_PCSK_SKI1_1	226	230	PF00082	0.483
CLV_PCSK_SKI1_1	267	271	PF00082	0.505
CLV_PCSK_SKI1_1	409	413	PF00082	0.434
CLV_PCSK_SKI1_1	554	558	PF00082	0.363
DEG_APCC_DBOX_1	553	561	PF00400	0.461
DEG_Nend_Nbox_1	1	3	PF02207	0.520
DEG_SCF_FBW7_1	410	416	PF00400	0.478
DEG_SCF_FBW7_1	718	724	PF00400	0.568
DEG_SIAH_1	121	129	PF03145	0.603
DEG_SPOP_SBC_1	148	152	PF00917	0.745
DOC_CDC14_PxL_1	754	762	PF14671	0.359
DOC_CKS1_1	24	29	PF01111	0.527
DOC_CKS1_1	410	415	PF01111	0.464
DOC_CKS1_1	491	496	PF01111	0.419
DOC_CKS1_1	718	723	PF01111	0.568
DOC_CYCLIN_RxL_1	264	272	PF00134	0.399
DOC_CYCLIN_RxL_1	551	559	PF00134	0.340
DOC_CYCLIN_yCln2_LP_2	491	497	PF00134	0.421
DOC_MAPK_gen_1	131	138	PF00069	0.651
DOC_MAPK_gen_1	577	584	PF00069	0.559
DOC_MAPK_gen_1	59	68	PF00069	0.386
DOC_MAPK_gen_1	689	700	PF00069	0.723
DOC_MAPK_MEF2A_6	483	491	PF00069	0.476
DOC_MAPK_MEF2A_6	554	562	PF00069	0.462
DOC_PP1_RVXF_1	63	69	PF00149	0.369
DOC_PP1_RVXF_1	695	701	PF00149	0.532
DOC_PP2B_LxvP_1	136	139	PF13499	0.708
DOC_PP2B_LxvP_1	278	281	PF13499	0.442
DOC_PP2B_LxvP_1	560	563	PF13499	0.467
DOC_USP7_MATH_1	137	141	PF00917	0.813
DOC_USP7_MATH_1	148	152	PF00917	0.708
DOC_USP7_MATH_1	159	163	PF00917	0.612
DOC_USP7_MATH_1	401	405	PF00917	0.469
DOC_USP7_MATH_1	455	459	PF00917	0.602
DOC_USP7_MATH_1	506	510	PF00917	0.626
DOC_USP7_MATH_1	590	594	PF00917	0.634
DOC_USP7_MATH_1	640	644	PF00917	0.689
DOC_USP7_MATH_1	721	725	PF00917	0.834
DOC_WW_Pin1_4	107	112	PF00397	0.678
DOC_WW_Pin1_4	131	136	PF00397	0.771
DOC_WW_Pin1_4	149	154	PF00397	0.578
DOC_WW_Pin1_4	190	195	PF00397	0.646
DOC_WW_Pin1_4	23	28	PF00397	0.476
DOC_WW_Pin1_4	269	274	PF00397	0.482
DOC_WW_Pin1_4	337	342	PF00397	0.532
DOC_WW_Pin1_4	409	414	PF00397	0.481
DOC_WW_Pin1_4	419	424	PF00397	0.568
DOC_WW_Pin1_4	490	495	PF00397	0.645
DOC_WW_Pin1_4	633	638	PF00397	0.608
DOC_WW_Pin1_4	717	722	PF00397	0.685
LIG_14-3-3_CanoR_1	186	194	PF00244	0.608
LIG_14-3-3_CanoR_1	200	207	PF00244	0.609
LIG_14-3-3_CanoR_1	240	247	PF00244	0.595
LIG_14-3-3_CanoR_1	297	303	PF00244	0.551
LIG_14-3-3_CanoR_1	309	319	PF00244	0.368
LIG_14-3-3_CanoR_1	322	330	PF00244	0.567
LIG_14-3-3_CanoR_1	440	445	PF00244	0.440
LIG_14-3-3_CanoR_1	589	597	PF00244	0.549
LIG_14-3-3_CanoR_1	650	654	PF00244	0.552
LIG_14-3-3_CanoR_1	784	790	PF00244	0.379
LIG_14-3-3_CanoR_1	94	101	PF00244	0.514
LIG_Actin_WH2_2	222	239	PF00022	0.349
LIG_APCC_ABBA_1	381	386	PF00400	0.590
LIG_CSL_BTD_1	278	281	PF09270	0.442
LIG_EH1_1	670	678	PF00400	0.335
LIG_FHA_1	12	18	PF00498	0.527
LIG_FHA_1	121	127	PF00498	0.627
LIG_FHA_1	167	173	PF00498	0.734
LIG_FHA_1	242	248	PF00498	0.585
LIG_FHA_1	26	32	PF00498	0.541
LIG_FHA_1	325	331	PF00498	0.603
LIG_FHA_1	357	363	PF00498	0.459
LIG_FHA_1	459	465	PF00498	0.567
LIG_FHA_1	522	528	PF00498	0.687
LIG_FHA_1	546	552	PF00498	0.319
LIG_FHA_1	557	563	PF00498	0.348
LIG_FHA_1	633	639	PF00498	0.624
LIG_FHA_1	677	683	PF00498	0.498
LIG_FHA_1	735	741	PF00498	0.567
LIG_FHA_1	96	102	PF00498	0.559
LIG_FHA_2	375	381	PF00498	0.568
LIG_FHA_2	497	503	PF00498	0.437
LIG_FHA_2	542	548	PF00498	0.420
LIG_FHA_2	562	568	PF00498	0.259
LIG_FHA_2	741	747	PF00498	0.415
LIG_GBD_Chelix_1	391	399	PF00786	0.373
LIG_Integrin_isoDGR_2	513	515	PF01839	0.615
LIG_LIR_Apic_2	547	552	PF02991	0.326
LIG_LIR_Gen_1	177	184	PF02991	0.595
LIG_LIR_Gen_1	425	434	PF02991	0.484
LIG_LIR_Nem_3	107	112	PF02991	0.508
LIG_LIR_Nem_3	177	181	PF02991	0.563
LIG_LIR_Nem_3	230	236	PF02991	0.350
LIG_LIR_Nem_3	425	431	PF02991	0.473
LIG_LIR_Nem_3	788	793	PF02991	0.430
LIG_LYPXL_yS_3	757	760	PF13949	0.337
LIG_SH2_CRK	82	86	PF00017	0.330
LIG_SH2_GRB2like	613	616	PF00017	0.553
LIG_SH2_PTP2	54	57	PF00017	0.451
LIG_SH2_PTP2	549	552	PF00017	0.383
LIG_SH2_SRC	20	23	PF00017	0.549
LIG_SH2_SRC	539	542	PF00017	0.426
LIG_SH2_SRC	54	57	PF00017	0.472
LIG_SH2_SRC	613	616	PF00017	0.423
LIG_SH2_SRC	773	776	PF00017	0.423
LIG_SH2_STAP1	613	617	PF00017	0.632
LIG_SH2_STAP1	653	657	PF00017	0.354
LIG_SH2_STAP1	701	705	PF00017	0.448
LIG_SH2_STAT5	188	191	PF00017	0.612
LIG_SH2_STAT5	20	23	PF00017	0.468
LIG_SH2_STAT5	349	352	PF00017	0.391
LIG_SH2_STAT5	370	373	PF00017	0.531
LIG_SH2_STAT5	539	542	PF00017	0.386
LIG_SH2_STAT5	54	57	PF00017	0.355
LIG_SH2_STAT5	549	552	PF00017	0.295
LIG_SH2_STAT5	664	667	PF00017	0.461
LIG_SH2_STAT5	67	70	PF00017	0.329
LIG_SH2_STAT5	768	771	PF00017	0.370
LIG_SH2_STAT5	773	776	PF00017	0.384
LIG_SH3_2	718	723	PF14604	0.634
LIG_SH3_3	122	128	PF00018	0.699
LIG_SH3_3	169	175	PF00018	0.504
LIG_SH3_3	21	27	PF00018	0.538
LIG_SH3_3	335	341	PF00018	0.706
LIG_SH3_3	357	363	PF00018	0.473
LIG_SH3_3	404	410	PF00018	0.373
LIG_SH3_3	639	645	PF00018	0.701
LIG_SH3_3	660	666	PF00018	0.315
LIG_SH3_3	68	74	PF00018	0.411
LIG_SH3_3	715	721	PF00018	0.629
LIG_SUMO_SIM_par_1	134	141	PF11976	0.653
LIG_SUMO_SIM_par_1	643	649	PF11976	0.464
LIG_TYR_ITIM	80	85	PF00017	0.395
LIG_WRC_WIRS_1	402	407	PF05994	0.362
MOD_CDK_SPK_2	190	195	PF00069	0.536
MOD_CDK_SPxK_1	23	29	PF00069	0.529
MOD_CDK_SPxK_1	717	723	PF00069	0.569
MOD_CDK_SPxxK_3	419	426	PF00069	0.459
MOD_CK1_1	162	168	PF00069	0.534
MOD_CK1_1	190	196	PF00069	0.591
MOD_CK1_1	296	302	PF00069	0.611
MOD_CK1_1	304	310	PF00069	0.466
MOD_CK1_1	324	330	PF00069	0.665
MOD_CK1_1	458	464	PF00069	0.624
MOD_CK1_1	509	515	PF00069	0.641
MOD_CK1_1	649	655	PF00069	0.418
MOD_CK1_1	722	728	PF00069	0.677
MOD_CK1_1	736	742	PF00069	0.572
MOD_CK2_1	496	502	PF00069	0.423
MOD_CK2_1	541	547	PF00069	0.475
MOD_CK2_1	561	567	PF00069	0.249
MOD_CK2_1	615	621	PF00069	0.466
MOD_CK2_1	740	746	PF00069	0.412
MOD_Cter_Amidation	687	690	PF01082	0.546
MOD_DYRK1A_RPxSP_1	409	413	PF00069	0.434
MOD_DYRK1A_RPxSP_1	717	721	PF00069	0.567
MOD_GlcNHglycan	145	148	PF01048	0.596
MOD_GlcNHglycan	189	192	PF01048	0.663
MOD_GlcNHglycan	211	215	PF01048	0.540
MOD_GlcNHglycan	252	255	PF01048	0.667
MOD_GlcNHglycan	282	285	PF01048	0.507
MOD_GlcNHglycan	300	303	PF01048	0.678
MOD_GlcNHglycan	323	326	PF01048	0.520
MOD_GlcNHglycan	356	359	PF01048	0.443
MOD_GlcNHglycan	41	44	PF01048	0.522
MOD_GlcNHglycan	442	445	PF01048	0.585
MOD_GlcNHglycan	458	461	PF01048	0.586
MOD_GlcNHglycan	477	480	PF01048	0.509
MOD_GlcNHglycan	508	511	PF01048	0.618
MOD_GlcNHglycan	532	535	PF01048	0.744
MOD_GlcNHglycan	592	595	PF01048	0.550
MOD_GlcNHglycan	604	607	PF01048	0.577
MOD_GlcNHglycan	617	620	PF01048	0.539
MOD_GlcNHglycan	775	778	PF01048	0.475
MOD_GSK3_1	138	145	PF00069	0.706
MOD_GSK3_1	159	166	PF00069	0.736
MOD_GSK3_1	235	242	PF00069	0.657
MOD_GSK3_1	280	287	PF00069	0.503
MOD_GSK3_1	293	300	PF00069	0.648
MOD_GSK3_1	354	361	PF00069	0.499
MOD_GSK3_1	409	416	PF00069	0.540
MOD_GSK3_1	471	478	PF00069	0.632
MOD_GSK3_1	502	509	PF00069	0.591
MOD_GSK3_1	517	524	PF00069	0.572
MOD_GSK3_1	541	548	PF00069	0.424
MOD_GSK3_1	615	622	PF00069	0.561
MOD_GSK3_1	717	724	PF00069	0.623
MOD_GSK3_1	729	736	PF00069	0.786
MOD_GSK3_1	785	792	PF00069	0.415
MOD_LATS_1	470	476	PF00433	0.547
MOD_N-GLC_1	240	245	PF02516	0.601
MOD_N-GLC_1	455	460	PF02516	0.510
MOD_N-GLC_1	521	526	PF02516	0.744
MOD_N-GLC_1	619	624	PF02516	0.585
MOD_N-GLC_1	683	688	PF02516	0.662
MOD_N-GLC_1	727	732	PF02516	0.529
MOD_NEK2_1	1	6	PF00069	0.529
MOD_NEK2_1	143	148	PF00069	0.664
MOD_NEK2_1	161	166	PF00069	0.660
MOD_NEK2_1	236	241	PF00069	0.471
MOD_NEK2_1	439	444	PF00069	0.467
MOD_NEK2_1	47	52	PF00069	0.366
MOD_NEK2_1	471	476	PF00069	0.476
MOD_NEK2_1	556	561	PF00069	0.378
MOD_NEK2_1	646	651	PF00069	0.477
MOD_NEK2_2	379	384	PF00069	0.599
MOD_NEK2_2	785	790	PF00069	0.404
MOD_PIKK_1	138	144	PF00454	0.715
MOD_PIKK_1	241	247	PF00454	0.712
MOD_PKA_1	104	110	PF00069	0.620
MOD_PKA_1	11	17	PF00069	0.548
MOD_PKA_1	200	206	PF00069	0.597
MOD_PKA_2	11	17	PF00069	0.523
MOD_PKA_2	199	205	PF00069	0.582
MOD_PKA_2	236	242	PF00069	0.635
MOD_PKA_2	296	302	PF00069	0.731
MOD_PKA_2	321	327	PF00069	0.570
MOD_PKA_2	374	380	PF00069	0.743
MOD_PKA_2	439	445	PF00069	0.459
MOD_PKA_2	471	477	PF00069	0.691
MOD_PKA_2	502	508	PF00069	0.440
MOD_PKA_2	514	520	PF00069	0.525
MOD_PKA_2	585	591	PF00069	0.609
MOD_PKA_2	601	607	PF00069	0.624
MOD_PKA_2	61	67	PF00069	0.376
MOD_PKA_2	649	655	PF00069	0.359
MOD_PKA_2	93	99	PF00069	0.543
MOD_Plk_1	217	223	PF00069	0.405
MOD_Plk_1	379	385	PF00069	0.599
MOD_Plk_1	472	478	PF00069	0.453
MOD_Plk_4	545	551	PF00069	0.345
MOD_Plk_4	785	791	PF00069	0.406
MOD_ProDKin_1	107	113	PF00069	0.681
MOD_ProDKin_1	131	137	PF00069	0.773
MOD_ProDKin_1	149	155	PF00069	0.578
MOD_ProDKin_1	190	196	PF00069	0.651
MOD_ProDKin_1	23	29	PF00069	0.473
MOD_ProDKin_1	269	275	PF00069	0.478
MOD_ProDKin_1	337	343	PF00069	0.518
MOD_ProDKin_1	409	415	PF00069	0.490
MOD_ProDKin_1	419	425	PF00069	0.562
MOD_ProDKin_1	490	496	PF00069	0.642
MOD_ProDKin_1	633	639	PF00069	0.606
MOD_ProDKin_1	717	723	PF00069	0.687
MOD_SUMO_rev_2	335	341	PF00179	0.545
TRG_DiLeu_BaLyEn_6	4	9	PF01217	0.550
TRG_DiLeu_BaLyEn_6	642	647	PF01217	0.492
TRG_ENDOCYTIC_2	54	57	PF00928	0.376
TRG_ENDOCYTIC_2	757	760	PF00928	0.337
TRG_ENDOCYTIC_2	82	85	PF00928	0.331
TRG_ER_diArg_1	131	133	PF00400	0.586
TRG_ER_diArg_1	185	187	PF00400	0.429
TRG_ER_diArg_1	309	311	PF00400	0.437
TRG_ER_diArg_1	577	580	PF00400	0.538
TRG_ER_diArg_1	9	12	PF00400	0.482
TRG_Pf-PMV_PEXEL_1	656	661	PF00026	0.331

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Q0	Leptomonas seymouri	47%	95%
A0A1X0NJG4	Trypanosomatidae	28%	97%
A0A3S7X8V4	Leishmania donovani	89%	100%
A0A422N118	Trypanosoma rangeli	30%	100%
A4HMC7	Leishmania braziliensis	72%	99%
A4IAZ3	Leishmania infantum	89%	100%
E9B5X6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5B090	Trypanosoma cruzi	30%	100%