PSP1 C-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cell cycle sequence binding phosphoprotein (RBP33), putative

Species:

Leishmania major

UniProt:

E9AES0_LEIMA

TriTrypDb:

LmjF.35.0950 , LMJLV39_350015300 , LMJSD75_350014900

Length:

412

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AES0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AES0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.669
CLV_C14_Caspase3-7	180	184	PF00656	0.714
CLV_C14_Caspase3-7	378	382	PF00656	0.628
CLV_NRD_NRD_1	225	227	PF00675	0.480
CLV_NRD_NRD_1	258	260	PF00675	0.469
CLV_PCSK_KEX2_1	221	223	PF00082	0.473
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.473
CLV_PCSK_SKI1_1	42	46	PF00082	0.563
DEG_COP1_1	119	129	PF00400	0.652
DOC_CYCLIN_RxL_1	312	324	PF00134	0.371
DOC_MAPK_gen_1	312	321	PF00069	0.379
DOC_MAPK_MEF2A_6	315	323	PF00069	0.375
DOC_PP1_RVXF_1	335	342	PF00149	0.365
DOC_USP7_MATH_1	146	150	PF00917	0.774
DOC_USP7_MATH_1	164	168	PF00917	0.575
DOC_USP7_MATH_1	209	213	PF00917	0.569
DOC_USP7_MATH_1	25	29	PF00917	0.696
DOC_USP7_MATH_1	266	270	PF00917	0.496
DOC_USP7_MATH_1	31	35	PF00917	0.640
DOC_USP7_MATH_1	380	384	PF00917	0.634
DOC_USP7_MATH_1	74	78	PF00917	0.668
DOC_USP7_MATH_1	99	103	PF00917	0.642
DOC_WW_Pin1_4	103	108	PF00397	0.666
DOC_WW_Pin1_4	111	116	PF00397	0.681
DOC_WW_Pin1_4	125	130	PF00397	0.680
DOC_WW_Pin1_4	19	24	PF00397	0.626
LIG_14-3-3_CanoR_1	289	296	PF00244	0.376
LIG_14-3-3_CanoR_1	42	47	PF00244	0.564
LIG_14-3-3_CanoR_1	94	98	PF00244	0.589
LIG_APCC_ABBA_1	12	17	PF00400	0.614
LIG_BIR_II_1	1	5	PF00653	0.616
LIG_BIR_III_4	381	385	PF00653	0.652
LIG_BRCT_BRCA1_1	339	343	PF00533	0.389
LIG_BRCT_BRCA1_1	347	351	PF00533	0.462
LIG_FHA_1	103	109	PF00498	0.542
LIG_FHA_1	263	269	PF00498	0.509
LIG_Integrin_isoDGR_2	284	286	PF01839	0.505
LIG_LIR_Nem_3	348	354	PF02991	0.360
LIG_LIR_Nem_3	357	362	PF02991	0.326
LIG_MLH1_MIPbox_1	339	343	PF16413	0.365
LIG_SH2_NCK_1	193	197	PF00017	0.662
LIG_SH2_PTP2	239	242	PF00017	0.427
LIG_SH2_STAP1	193	197	PF00017	0.706
LIG_SH2_STAT5	228	231	PF00017	0.430
LIG_SH2_STAT5	239	242	PF00017	0.322
LIG_SH2_STAT5	3	6	PF00017	0.604
LIG_SH3_3	101	107	PF00018	0.591
LIG_SH3_3	123	129	PF00018	0.704
LIG_SUMO_SIM_par_1	22	28	PF11976	0.519
LIG_TRAF2_1	173	176	PF00917	0.567
LIG_TRAF2_1	291	294	PF00917	0.322
LIG_WRC_WIRS_1	359	364	PF05994	0.365
MOD_CK1_1	100	106	PF00069	0.674
MOD_CK1_1	128	134	PF00069	0.779
MOD_CK1_1	167	173	PF00069	0.667
MOD_CK1_1	34	40	PF00069	0.603
MOD_CK2_1	156	162	PF00069	0.585
MOD_CK2_1	380	386	PF00069	0.700
MOD_DYRK1A_RPxSP_1	125	129	PF00069	0.662
MOD_DYRK1A_RPxSP_1	19	23	PF00069	0.625
MOD_GlcNHglycan	111	114	PF01048	0.629
MOD_GlcNHglycan	115	118	PF01048	0.605
MOD_GlcNHglycan	121	124	PF01048	0.691
MOD_GlcNHglycan	166	169	PF01048	0.705
MOD_GlcNHglycan	179	182	PF01048	0.651
MOD_GlcNHglycan	19	22	PF01048	0.631
MOD_GlcNHglycan	194	197	PF01048	0.758
MOD_GlcNHglycan	27	30	PF01048	0.674
MOD_GlcNHglycan	381	385	PF01048	0.647
MOD_GlcNHglycan	76	79	PF01048	0.680
MOD_GSK3_1	109	116	PF00069	0.747
MOD_GSK3_1	125	132	PF00069	0.637
MOD_GSK3_1	140	147	PF00069	0.606
MOD_GSK3_1	15	22	PF00069	0.621
MOD_GSK3_1	152	159	PF00069	0.706
MOD_GSK3_1	262	269	PF00069	0.519
MOD_GSK3_1	93	100	PF00069	0.631
MOD_LATS_1	156	162	PF00433	0.653
MOD_LATS_1	40	46	PF00433	0.567
MOD_N-GLC_1	100	105	PF02516	0.734
MOD_N-GLC_1	129	134	PF02516	0.644
MOD_N-GLC_1	152	157	PF02516	0.695
MOD_N-GLC_1	191	196	PF02516	0.661
MOD_N-GLC_1	262	267	PF02516	0.514
MOD_N-GLC_1	34	39	PF02516	0.550
MOD_NEK2_1	15	20	PF00069	0.617
MOD_NEK2_1	177	182	PF00069	0.621
MOD_NEK2_1	24	29	PF00069	0.655
MOD_NEK2_1	358	363	PF00069	0.393
MOD_NEK2_1	97	102	PF00069	0.652
MOD_NEK2_2	310	315	PF00069	0.413
MOD_PK_1	52	58	PF00069	0.524
MOD_PKA_1	337	343	PF00069	0.413
MOD_PKA_2	245	251	PF00069	0.444
MOD_PKA_2	74	80	PF00069	0.637
MOD_PKA_2	93	99	PF00069	0.411
MOD_Plk_1	100	106	PF00069	0.602
MOD_Plk_1	139	145	PF00069	0.627
MOD_Plk_1	262	268	PF00069	0.469
MOD_Plk_1	34	40	PF00069	0.546
MOD_Plk_1	345	351	PF00069	0.342
MOD_Plk_4	42	48	PF00069	0.676
MOD_Plk_4	52	58	PF00069	0.495
MOD_Plk_4	59	65	PF00069	0.400
MOD_ProDKin_1	103	109	PF00069	0.668
MOD_ProDKin_1	111	117	PF00069	0.680
MOD_ProDKin_1	125	131	PF00069	0.679
MOD_ProDKin_1	19	25	PF00069	0.630
MOD_SUMO_for_1	280	283	PF00179	0.489
MOD_SUMO_rev_2	271	280	PF00179	0.474
MOD_SUMO_rev_2	329	339	PF00179	0.413
TRG_DiLeu_BaEn_2	212	218	PF01217	0.456
TRG_DiLeu_BaEn_4	203	209	PF01217	0.627
TRG_DiLeu_BaLyEn_6	49	54	PF01217	0.526
TRG_ENDOCYTIC_2	239	242	PF00928	0.419
TRG_ENDOCYTIC_2	359	362	PF00928	0.313
TRG_ER_diArg_1	222	225	PF00400	0.460
TRG_Pf-PMV_PEXEL_1	286	290	PF00026	0.371
TRG_Pf-PMV_PEXEL_1	352	357	PF00026	0.406

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I362	Leptomonas seymouri	69%	100%
A0A3Q8IEY4	Leishmania donovani	98%	100%
A4HMC6	Leishmania braziliensis	86%	100%
A4IAZ2	Leishmania infantum	98%	100%
E9B5X5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9B726	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%