Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AER8_LEIMA

TriTrypDb:

LmjF.35.0930 , LMJLV39_350015100 , LMJSD75_350014700

Length:

169

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9AER8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AER8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	133	135	PF00675	0.404
CLV_NRD_NRD_1	136	138	PF00675	0.409
CLV_NRD_NRD_1	46	48	PF00675	0.469
CLV_NRD_NRD_1	91	93	PF00675	0.348
CLV_PCSK_FUR_1	134	138	PF00082	0.307
CLV_PCSK_KEX2_1	135	137	PF00082	0.365
CLV_PCSK_KEX2_1	46	48	PF00082	0.469
CLV_PCSK_KEX2_1	91	93	PF00082	0.354
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.381
CLV_PCSK_PC7_1	132	138	PF00082	0.384
CLV_PCSK_PC7_1	42	48	PF00082	0.321
CLV_PCSK_SKI1_1	146	150	PF00082	0.290
CLV_Separin_Metazoa	88	92	PF03568	0.572
DOC_MAPK_MEF2A_6	146	154	PF00069	0.465
DOC_USP7_MATH_1	14	18	PF00917	0.607
DOC_USP7_MATH_1	21	25	PF00917	0.739
DOC_USP7_UBL2_3	115	119	PF12436	0.633
DOC_WW_Pin1_4	121	126	PF00397	0.569
DOC_WW_Pin1_4	22	27	PF00397	0.733
DOC_WW_Pin1_4	92	97	PF00397	0.638
LIG_14-3-3_CanoR_1	66	74	PF00244	0.469
LIG_14-3-3_CanoR_1	91	95	PF00244	0.622
LIG_BIR_II_1	1	5	PF00653	0.650
LIG_BRCT_BRCA1_1	156	160	PF00533	0.352
LIG_deltaCOP1_diTrp_1	143	148	PF00928	0.582
LIG_FHA_1	145	151	PF00498	0.504
LIG_FHA_2	54	60	PF00498	0.669
LIG_FHA_2	7	13	PF00498	0.665
LIG_LIR_Gen_1	147	155	PF02991	0.354
LIG_LIR_Nem_3	143	148	PF02991	0.550
LIG_LIR_Nem_3	163	168	PF02991	0.267
LIG_LIR_Nem_3	97	102	PF02991	0.522
LIG_Pex14_1	144	148	PF04695	0.545
LIG_REV1ctd_RIR_1	165	169	PF16727	0.487
LIG_SH2_STAT3	67	70	PF00017	0.579
LIG_SUMO_SIM_anti_2	147	153	PF11976	0.289
LIG_SUMO_SIM_anti_2	86	91	PF11976	0.612
LIG_TRAF2_1	56	59	PF00917	0.571
LIG_UBA3_1	161	169	PF00899	0.343
LIG_WRC_WIRS_1	145	150	PF05994	0.517
MOD_CK1_1	17	23	PF00069	0.730
MOD_CK1_1	24	30	PF00069	0.708
MOD_CK1_1	69	75	PF00069	0.576
MOD_CK1_1	95	101	PF00069	0.590
MOD_CK2_1	121	127	PF00069	0.587
MOD_CK2_1	53	59	PF00069	0.570
MOD_CK2_1	95	101	PF00069	0.571
MOD_DYRK1A_RPxSP_1	92	96	PF00069	0.612
MOD_GlcNHglycan	19	22	PF01048	0.486
MOD_GlcNHglycan	31	34	PF01048	0.456
MOD_GSK3_1	15	22	PF00069	0.751
MOD_GSK3_1	24	31	PF00069	0.763
MOD_GSK3_1	90	97	PF00069	0.623
MOD_NEK2_1	160	165	PF00069	0.348
MOD_NEK2_1	90	95	PF00069	0.609
MOD_PIKK_1	53	59	PF00454	0.617
MOD_PIKK_1	66	72	PF00454	0.627
MOD_PKA_2	90	96	PF00069	0.621
MOD_Plk_4	144	150	PF00069	0.466
MOD_ProDKin_1	121	127	PF00069	0.569
MOD_ProDKin_1	22	28	PF00069	0.733
MOD_ProDKin_1	92	98	PF00069	0.635
MOD_SUMO_for_1	114	117	PF00179	0.596
MOD_SUMO_rev_2	116	121	PF00179	0.595
TRG_ENDOCYTIC_2	145	148	PF00928	0.548
TRG_ER_diArg_1	131	134	PF00400	0.563
TRG_ER_diArg_1	45	47	PF00400	0.568
TRG_ER_diArg_1	90	92	PF00400	0.531
TRG_NLS_MonoCore_2	133	138	PF00514	0.619
TRG_NLS_MonoExtN_4	132	139	PF00514	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCT3	Leptomonas seymouri	56%	79%
A0A0S4IZW1	Bodo saltans	26%	100%
A0A3Q8IV31	Leishmania donovani	90%	100%
A0A3R7JZ23	Trypanosoma rangeli	37%	91%
A4HMC4	Leishmania braziliensis	78%	70%
A4IAZ0	Leishmania infantum	91%	100%
C9ZNI8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	81%
E9B5X3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%