PP28 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AER5_LEIMA

TriTrypDb:

LmjF.35.0900 , LMJLV39_350014700 , LMJSD75_350014200

Length:

235

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AER5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AER5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	122	124	PF00675	0.471
CLV_NRD_NRD_1	129	131	PF00675	0.484
CLV_NRD_NRD_1	13	15	PF00675	0.577
CLV_NRD_NRD_1	181	183	PF00675	0.599
CLV_NRD_NRD_1	185	187	PF00675	0.500
CLV_NRD_NRD_1	188	190	PF00675	0.493
CLV_NRD_NRD_1	33	35	PF00675	0.367
CLV_NRD_NRD_1	57	59	PF00675	0.489
CLV_PCSK_FUR_1	178	182	PF00082	0.486
CLV_PCSK_KEX2_1	122	124	PF00082	0.471
CLV_PCSK_KEX2_1	128	130	PF00082	0.487
CLV_PCSK_KEX2_1	13	15	PF00082	0.577
CLV_PCSK_KEX2_1	162	164	PF00082	0.467
CLV_PCSK_KEX2_1	174	176	PF00082	0.476
CLV_PCSK_KEX2_1	180	182	PF00082	0.490
CLV_PCSK_KEX2_1	185	187	PF00082	0.512
CLV_PCSK_KEX2_1	33	35	PF00082	0.367
CLV_PCSK_KEX2_1	57	59	PF00082	0.489
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.476
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.577
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.545
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.413
CLV_PCSK_PC7_1	181	187	PF00082	0.493
CLV_PCSK_SKI1_1	15	19	PF00082	0.575
CLV_PCSK_SKI1_1	150	154	PF00082	0.455
CLV_PCSK_SKI1_1	213	217	PF00082	0.630
CLV_PCSK_SKI1_1	33	37	PF00082	0.388
DOC_MAPK_gen_1	108	117	PF00069	0.551
DOC_PIKK_1	195	202	PF02985	0.563
DOC_USP7_UBL2_3	158	162	PF12436	0.535
DOC_USP7_UBL2_3	213	217	PF12436	0.605
DOC_USP7_UBL2_3	5	9	PF12436	0.644
DOC_WW_Pin1_4	25	30	PF00397	0.511
LIG_14-3-3_CanoR_1	141	146	PF00244	0.506
LIG_14-3-3_CanoR_1	85	89	PF00244	0.499
LIG_BIR_II_1	1	5	PF00653	0.619
LIG_FHA_2	16	22	PF00498	0.567
LIG_FHA_2	26	32	PF00498	0.443
LIG_FHA_2	6	12	PF00498	0.635
LIG_FHA_2	95	101	PF00498	0.576
LIG_LIR_Gen_1	93	104	PF02991	0.537
LIG_PCNA_yPIPBox_3	65	78	PF02747	0.483
LIG_TRAF2_1	170	173	PF00917	0.465
LIG_TRAF2_1	51	54	PF00917	0.499
MOD_CK2_1	202	208	PF00069	0.600
MOD_CK2_1	5	11	PF00069	0.637
MOD_CK2_1	94	100	PF00069	0.567
MOD_GlcNHglycan	220	223	PF01048	0.492
MOD_GSK3_1	5	12	PF00069	0.611
MOD_GSK3_1	80	87	PF00069	0.499
MOD_GSK3_1	94	101	PF00069	0.606
MOD_N-GLC_1	5	10	PF02516	0.636
MOD_PKA_1	9	15	PF00069	0.559
MOD_PKA_2	84	90	PF00069	0.450
MOD_Plk_1	94	100	PF00069	0.567
MOD_Plk_4	73	79	PF00069	0.506
MOD_ProDKin_1	25	31	PF00069	0.509
MOD_SUMO_rev_2	166	176	PF00179	0.470
MOD_SUMO_rev_2	38	48	PF00179	0.576
TRG_DiLeu_BaEn_1	100	105	PF01217	0.523
TRG_DiLeu_BaLyEn_6	189	194	PF01217	0.508
TRG_ER_diArg_1	180	182	PF00400	0.607
TRG_ER_diArg_1	32	34	PF00400	0.501
TRG_NLS_Bipartite_1	174	190	PF00514	0.514
TRG_NLS_MonoExtC_3	127	133	PF00514	0.448
TRG_NLS_MonoExtC_3	185	190	PF00514	0.572
TRG_NLS_MonoExtN_4	185	190	PF00514	0.572
TRG_Pf-PMV_PEXEL_1	15	19	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	192	197	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	33	37	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBR1	Leptomonas seymouri	71%	99%
A0A3S7X8W2	Leishmania donovani	98%	100%
A4HMC1	Leishmania braziliensis	84%	100%
A4IAY7	Leishmania infantum	98%	100%
E9B5X0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%