Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AER3_LEIMA

TriTrypDb:

LmjF.35.0880 , LMJLV39_350014500 , LMJSD75_350014000

Length:

519

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AER3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AER3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	211	215	PF00656	0.479
CLV_C14_Caspase3-7	242	246	PF00656	0.751
CLV_C14_Caspase3-7	64	68	PF00656	0.624
CLV_C14_Caspase3-7	92	96	PF00656	0.550
CLV_NRD_NRD_1	116	118	PF00675	0.585
CLV_NRD_NRD_1	126	128	PF00675	0.494
CLV_NRD_NRD_1	25	27	PF00675	0.508
CLV_NRD_NRD_1	302	304	PF00675	0.601
CLV_NRD_NRD_1	378	380	PF00675	0.604
CLV_NRD_NRD_1	442	444	PF00675	0.659
CLV_NRD_NRD_1	509	511	PF00675	0.560
CLV_PCSK_FUR_1	386	390	PF00082	0.517
CLV_PCSK_FUR_1	448	452	PF00082	0.694
CLV_PCSK_FUR_1	505	509	PF00082	0.609
CLV_PCSK_KEX2_1	107	109	PF00082	0.518
CLV_PCSK_KEX2_1	126	128	PF00082	0.616
CLV_PCSK_KEX2_1	148	150	PF00082	0.551
CLV_PCSK_KEX2_1	25	27	PF00082	0.566
CLV_PCSK_KEX2_1	301	303	PF00082	0.570
CLV_PCSK_KEX2_1	378	380	PF00082	0.574
CLV_PCSK_KEX2_1	388	390	PF00082	0.465
CLV_PCSK_KEX2_1	442	444	PF00082	0.653
CLV_PCSK_KEX2_1	447	449	PF00082	0.627
CLV_PCSK_KEX2_1	450	452	PF00082	0.625
CLV_PCSK_KEX2_1	507	509	PF00082	0.563
CLV_PCSK_PC1ET2_1	107	109	PF00082	0.567
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.551
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.604
CLV_PCSK_PC1ET2_1	388	390	PF00082	0.521
CLV_PCSK_PC1ET2_1	447	449	PF00082	0.709
CLV_PCSK_PC1ET2_1	450	452	PF00082	0.715
CLV_PCSK_PC7_1	21	27	PF00082	0.486
CLV_PCSK_PC7_1	443	449	PF00082	0.710
CLV_PCSK_PC7_1	505	511	PF00082	0.657
CLV_PCSK_SKI1_1	100	104	PF00082	0.505
CLV_PCSK_SKI1_1	107	111	PF00082	0.485
CLV_PCSK_SKI1_1	235	239	PF00082	0.569
CLV_PCSK_SKI1_1	262	266	PF00082	0.548
CLV_PCSK_SKI1_1	340	344	PF00082	0.625
CLV_PCSK_SKI1_1	358	362	PF00082	0.464
CLV_PCSK_SKI1_1	42	46	PF00082	0.652
CLV_PCSK_SKI1_1	486	490	PF00082	0.685
CLV_PCSK_SKI1_1	50	54	PF00082	0.530
CLV_PCSK_SKI1_1	501	505	PF00082	0.562
DEG_APCC_DBOX_1	13	21	PF00400	0.572
DEG_APCC_DBOX_1	139	147	PF00400	0.569
DEG_APCC_DBOX_1	377	385	PF00400	0.606
DEG_SPOP_SBC_1	5	9	PF00917	0.592
DOC_CYCLIN_RxL_1	355	363	PF00134	0.568
DOC_MAPK_gen_1	12	20	PF00069	0.523
DOC_MAPK_gen_1	126	133	PF00069	0.604
DOC_MAPK_gen_1	45	55	PF00069	0.561
DOC_MAPK_MEF2A_6	126	133	PF00069	0.604
DOC_MAPK_MEF2A_6	48	57	PF00069	0.583
DOC_MAPK_NFAT4_5	126	134	PF00069	0.571
DOC_MAPK_RevD_3	289	302	PF00069	0.574
DOC_PP1_RVXF_1	328	334	PF00149	0.511
DOC_PP4_FxxP_1	489	492	PF00568	0.618
DOC_USP7_MATH_1	164	168	PF00917	0.665
DOC_USP7_MATH_1	182	186	PF00917	0.340
DOC_USP7_MATH_1	452	456	PF00917	0.715
DOC_USP7_MATH_1	6	10	PF00917	0.528
DOC_USP7_MATH_1	98	102	PF00917	0.604
DOC_WW_Pin1_4	133	138	PF00397	0.653
DOC_WW_Pin1_4	228	233	PF00397	0.680
DOC_WW_Pin1_4	462	467	PF00397	0.670
LIG_14-3-3_CanoR_1	378	382	PF00244	0.560
LIG_14-3-3_CanoR_1	442	446	PF00244	0.644
LIG_14-3-3_CanoR_1	451	461	PF00244	0.590
LIG_14-3-3_CterR_2	516	519	PF00244	0.677
LIG_Actin_WH2_2	363	380	PF00022	0.522
LIG_BIR_III_4	428	432	PF00653	0.550
LIG_BRCT_BRCA1_1	362	366	PF00533	0.511
LIG_CtBP_PxDLS_1	290	294	PF00389	0.597
LIG_DLG_GKlike_1	65	72	PF00625	0.645
LIG_FHA_1	110	116	PF00498	0.541
LIG_FHA_1	202	208	PF00498	0.363
LIG_FHA_1	275	281	PF00498	0.538
LIG_FHA_1	5	11	PF00498	0.584
LIG_FHA_1	68	74	PF00498	0.629
LIG_FHA_2	192	198	PF00498	0.571
LIG_FHA_2	240	246	PF00498	0.772
LIG_FHA_2	248	254	PF00498	0.777
LIG_FHA_2	277	283	PF00498	0.589
LIG_FHA_2	307	313	PF00498	0.597
LIG_FHA_2	389	395	PF00498	0.624
LIG_FHA_2	495	501	PF00498	0.670
LIG_FHA_2	6	12	PF00498	0.496
LIG_FHA_2	62	68	PF00498	0.644
LIG_Integrin_RGD_1	65	67	PF01839	0.550
LIG_LIR_Gen_1	125	133	PF02991	0.508
LIG_LIR_Gen_1	75	83	PF02991	0.576
LIG_LIR_Nem_3	125	131	PF02991	0.508
LIG_LIR_Nem_3	258	264	PF02991	0.399
LIG_LIR_Nem_3	75	80	PF02991	0.605
LIG_NBox_RRM_1	397	407	PF00076	0.627
LIG_NRBOX	217	223	PF00104	0.517
LIG_SH2_CRK	128	132	PF00017	0.597
LIG_SH2_CRK	77	81	PF00017	0.653
LIG_SH2_SRC	319	322	PF00017	0.597
LIG_SH2_STAP1	266	270	PF00017	0.441
LIG_SH2_STAP1	319	323	PF00017	0.646
LIG_SH2_STAT3	266	269	PF00017	0.551
LIG_SH2_STAT3	271	274	PF00017	0.404
LIG_SH2_STAT5	272	275	PF00017	0.587
LIG_SH2_STAT5	474	477	PF00017	0.632
LIG_SH3_3	328	334	PF00018	0.686
LIG_SH3_3	346	352	PF00018	0.662
LIG_SH3_3	463	469	PF00018	0.660
LIG_TRAF2_1	406	409	PF00917	0.547
LIG_TRAF2_1	430	433	PF00917	0.683
LIG_WW_3	483	487	PF00397	0.567
MOD_CDK_SPxxK_3	133	140	PF00069	0.595
MOD_CDK_SPxxK_3	228	235	PF00069	0.651
MOD_CK1_1	165	171	PF00069	0.571
MOD_CK1_1	185	191	PF00069	0.494
MOD_CK1_1	220	226	PF00069	0.635
MOD_CK1_1	227	233	PF00069	0.725
MOD_CK1_1	236	242	PF00069	0.670
MOD_CK1_1	332	338	PF00069	0.616
MOD_CK1_1	465	471	PF00069	0.729
MOD_CK1_1	75	81	PF00069	0.687
MOD_CK2_1	132	138	PF00069	0.575
MOD_CK2_1	191	197	PF00069	0.513
MOD_CK2_1	228	234	PF00069	0.681
MOD_CK2_1	247	253	PF00069	0.780
MOD_CK2_1	276	282	PF00069	0.545
MOD_CK2_1	306	312	PF00069	0.493
MOD_CK2_1	427	433	PF00069	0.684
MOD_CK2_1	443	449	PF00069	0.460
MOD_CK2_1	494	500	PF00069	0.574
MOD_Cter_Amidation	505	508	PF01082	0.652
MOD_GlcNHglycan	234	238	PF01048	0.780
MOD_GlcNHglycan	320	324	PF01048	0.619
MOD_GlcNHglycan	428	432	PF01048	0.650
MOD_GSK3_1	129	136	PF00069	0.575
MOD_GSK3_1	164	171	PF00069	0.592
MOD_GSK3_1	176	183	PF00069	0.634
MOD_GSK3_1	216	223	PF00069	0.534
MOD_GSK3_1	224	231	PF00069	0.632
MOD_GSK3_1	235	242	PF00069	0.502
MOD_GSK3_1	276	283	PF00069	0.602
MOD_GSK3_1	329	336	PF00069	0.621
MOD_GSK3_1	57	64	PF00069	0.632
MOD_N-GLC_1	120	125	PF02516	0.631
MOD_N-GLC_1	176	181	PF02516	0.633
MOD_N-GLC_2	348	350	PF02516	0.607
MOD_NEK2_1	129	134	PF00069	0.610
MOD_NEK2_1	226	231	PF00069	0.709
MOD_NEK2_1	329	334	PF00069	0.548
MOD_NEK2_1	438	443	PF00069	0.724
MOD_PIKK_1	165	171	PF00454	0.643
MOD_PIKK_1	185	191	PF00454	0.436
MOD_PKA_1	388	394	PF00069	0.623
MOD_PKA_2	162	168	PF00069	0.625
MOD_PKA_2	280	286	PF00069	0.656
MOD_PKA_2	377	383	PF00069	0.547
MOD_PKA_2	388	394	PF00069	0.508
MOD_PKA_2	438	444	PF00069	0.753
MOD_Plk_1	176	182	PF00069	0.595
MOD_Plk_1	408	414	PF00069	0.558
MOD_Plk_1	75	81	PF00069	0.587
MOD_Plk_2-3	306	312	PF00069	0.549
MOD_Plk_4	182	188	PF00069	0.575
MOD_Plk_4	191	197	PF00069	0.585
MOD_Plk_4	217	223	PF00069	0.533
MOD_Plk_4	388	394	PF00069	0.631
MOD_ProDKin_1	133	139	PF00069	0.650
MOD_ProDKin_1	228	234	PF00069	0.683
MOD_ProDKin_1	462	468	PF00069	0.659
MOD_SUMO_for_1	342	345	PF00179	0.715
MOD_SUMO_for_1	387	390	PF00179	0.628
MOD_SUMO_rev_2	29	34	PF00179	0.571
TRG_DiLeu_BaEn_1	433	438	PF01217	0.544
TRG_ENDOCYTIC_2	128	131	PF00928	0.547
TRG_ENDOCYTIC_2	476	479	PF00928	0.576
TRG_ENDOCYTIC_2	77	80	PF00928	0.618
TRG_ER_diArg_1	126	128	PF00400	0.587
TRG_ER_diArg_1	25	27	PF00400	0.459
TRG_ER_diArg_1	377	379	PF00400	0.639
TRG_ER_diArg_1	504	507	PF00400	0.599
TRG_ER_diArg_1	508	510	PF00400	0.558
TRG_NLS_MonoExtC_3	300	306	PF00514	0.557
TRG_NLS_MonoExtN_4	299	305	PF00514	0.544
TRG_Pf-PMV_PEXEL_1	205	209	PF00026	0.546
TRG_Pf-PMV_PEXEL_1	25	29	PF00026	0.602
TRG_Pf-PMV_PEXEL_1	314	318	PF00026	0.611

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0N1	Leptomonas seymouri	53%	90%
A0A1X0NJ03	Trypanosomatidae	30%	89%
A0A3S7X8Y2	Leishmania donovani	91%	100%
A0A422NI80	Trypanosoma rangeli	31%	92%
A4HMB9	Leishmania braziliensis	77%	100%
A4IAY5	Leishmania infantum	91%	100%
C9ZNI2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	89%
E9B5W8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%