Cytochrome c domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AER1_LEIMA

TriTrypDb:

LmjF.35.0860 , LMJLV39_350014200 , LMJSD75_350013700

Length:

424

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AER1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AER1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006399	tRNA metabolic process	7	11
GO:0006400	tRNA modification	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008033	tRNA processing	8	11
GO:0008152	metabolic process	1	11
GO:0009451	RNA modification	5	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0003824	catalytic activity	1	4
GO:0005488	binding	1	11
GO:0009055	electron transfer activity	3	4
GO:0016491	oxidoreductase activity	2	4
GO:0020037	heme binding	4	4
GO:0043167	ion binding	2	3
GO:0043169	cation binding	3	3
GO:0046872	metal ion binding	4	3
GO:0046906	tetrapyrrole binding	3	4
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	216	220	PF00656	0.781
CLV_C14_Caspase3-7	286	290	PF00656	0.554
CLV_C14_Caspase3-7	4	8	PF00656	0.717
CLV_C14_Caspase3-7	74	78	PF00656	0.679
CLV_C14_Caspase3-7	85	89	PF00656	0.524
CLV_NRD_NRD_1	151	153	PF00675	0.680
CLV_NRD_NRD_1	157	159	PF00675	0.686
CLV_NRD_NRD_1	275	277	PF00675	0.448
CLV_NRD_NRD_1	315	317	PF00675	0.582
CLV_NRD_NRD_1	334	336	PF00675	0.497
CLV_NRD_NRD_1	386	388	PF00675	0.541
CLV_PCSK_FUR_1	149	153	PF00082	0.733
CLV_PCSK_FUR_1	313	317	PF00082	0.574
CLV_PCSK_KEX2_1	123	125	PF00082	0.705
CLV_PCSK_KEX2_1	149	151	PF00082	0.658
CLV_PCSK_KEX2_1	157	159	PF00082	0.686
CLV_PCSK_KEX2_1	2	4	PF00082	0.727
CLV_PCSK_KEX2_1	315	317	PF00082	0.592
CLV_PCSK_KEX2_1	386	388	PF00082	0.561
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.746
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.714
CLV_PCSK_SKI1_1	19	23	PF00082	0.665
CLV_PCSK_SKI1_1	248	252	PF00082	0.453
CLV_PCSK_SKI1_1	276	280	PF00082	0.530
CLV_PCSK_SKI1_1	386	390	PF00082	0.591
DEG_Nend_UBRbox_1	1	4	PF02207	0.682
DEG_SCF_FBW7_2	410	417	PF00400	0.482
DEG_SPOP_SBC_1	212	216	PF00917	0.723
DOC_CKS1_1	411	416	PF01111	0.480
DOC_CYCLIN_RxL_1	273	280	PF00134	0.404
DOC_MAPK_gen_1	14	22	PF00069	0.537
DOC_MAPK_gen_1	276	283	PF00069	0.465
DOC_MAPK_gen_1	313	323	PF00069	0.532
DOC_MAPK_gen_1	41	50	PF00069	0.445
DOC_MAPK_MEF2A_6	170	177	PF00069	0.388
DOC_MAPK_MEF2A_6	276	283	PF00069	0.533
DOC_MAPK_MEF2A_6	316	325	PF00069	0.431
DOC_MAPK_NFAT4_5	170	178	PF00069	0.523
DOC_MAPK_NFAT4_5	276	284	PF00069	0.538
DOC_MAPK_RevD_3	323	337	PF00069	0.467
DOC_PP1_RVXF_1	295	301	PF00149	0.504
DOC_PP2B_LxvP_1	175	178	PF13499	0.520
DOC_SPAK_OSR1_1	352	356	PF12202	0.395
DOC_USP7_MATH_1	107	111	PF00917	0.483
DOC_USP7_MATH_1	211	215	PF00917	0.704
DOC_USP7_MATH_1	230	234	PF00917	0.338
DOC_USP7_MATH_1	305	309	PF00917	0.720
DOC_USP7_MATH_1	314	318	PF00917	0.669
DOC_USP7_MATH_1	339	343	PF00917	0.605
DOC_USP7_MATH_1	357	361	PF00917	0.382
DOC_USP7_MATH_1	79	83	PF00917	0.717
DOC_USP7_MATH_1	94	98	PF00917	0.493
DOC_WW_Pin1_4	133	138	PF00397	0.820
DOC_WW_Pin1_4	151	156	PF00397	0.703
DOC_WW_Pin1_4	410	415	PF00397	0.566
LIG_14-3-3_CanoR_1	118	125	PF00244	0.627
LIG_14-3-3_CanoR_1	157	165	PF00244	0.596
LIG_14-3-3_CanoR_1	234	240	PF00244	0.634
LIG_14-3-3_CanoR_1	276	282	PF00244	0.425
LIG_14-3-3_CanoR_1	313	319	PF00244	0.554
LIG_14-3-3_CanoR_1	386	394	PF00244	0.650
LIG_BIR_III_2	219	223	PF00653	0.538
LIG_BIR_III_4	113	117	PF00653	0.710
LIG_BIR_III_4	77	81	PF00653	0.625
LIG_BRCT_BRCA1_1	158	162	PF00533	0.596
LIG_BRCT_BRCA1_1	279	283	PF00533	0.420
LIG_FHA_1	223	229	PF00498	0.588
LIG_FHA_1	318	324	PF00498	0.615
LIG_FHA_1	343	349	PF00498	0.494
LIG_FHA_1	368	374	PF00498	0.499
LIG_FHA_1	52	58	PF00498	0.576
LIG_FHA_2	195	201	PF00498	0.552
LIG_FHA_2	214	220	PF00498	0.761
LIG_FHA_2	265	271	PF00498	0.445
LIG_FHA_2	329	335	PF00498	0.464
LIG_GBD_Chelix_1	231	239	PF00786	0.456
LIG_LIR_Apic_2	159	164	PF02991	0.594
LIG_LIR_Gen_1	237	247	PF02991	0.493
LIG_LIR_Nem_3	159	165	PF02991	0.604
LIG_LIR_Nem_3	237	243	PF02991	0.462
LIG_NRBOX	274	280	PF00104	0.460
LIG_NRBOX	97	103	PF00104	0.561
LIG_PALB2_WD40_1	157	165	PF16756	0.610
LIG_Pex14_2	251	255	PF04695	0.531
LIG_SH2_STAT5	172	175	PF00017	0.450
LIG_SH2_STAT5	49	52	PF00017	0.445
LIG_SH3_3	181	187	PF00018	0.541
LIG_SH3_3	224	230	PF00018	0.503
LIG_SH3_3	263	269	PF00018	0.399
LIG_SH3_3	353	359	PF00018	0.414
LIG_SH3_3	88	94	PF00018	0.703
LIG_TRAF2_1	36	39	PF00917	0.475
LIG_TRFH_1	255	259	PF08558	0.404
MOD_CDK_SPK_2	410	415	PF00069	0.566
MOD_CDK_SPxK_1	151	157	PF00069	0.699
MOD_CDK_SPxxK_3	151	158	PF00069	0.693
MOD_CK1_1	233	239	PF00069	0.527
MOD_CK1_1	317	323	PF00069	0.525
MOD_CK1_1	342	348	PF00069	0.460
MOD_CK1_1	360	366	PF00069	0.405
MOD_CK1_1	51	57	PF00069	0.594
MOD_CK1_1	67	73	PF00069	0.650
MOD_CK1_1	97	103	PF00069	0.557
MOD_CK2_1	194	200	PF00069	0.754
MOD_CK2_1	211	217	PF00069	0.650
MOD_CK2_1	264	270	PF00069	0.455
MOD_CK2_1	328	334	PF00069	0.456
MOD_CK2_1	52	58	PF00069	0.641
MOD_GlcNHglycan	341	344	PF01048	0.498
MOD_GlcNHglycan	73	76	PF01048	0.802
MOD_GlcNHglycan	94	97	PF01048	0.740
MOD_GSK3_1	1	8	PF00069	0.521
MOD_GSK3_1	141	148	PF00069	0.763
MOD_GSK3_1	176	183	PF00069	0.582
MOD_GSK3_1	190	197	PF00069	0.567
MOD_GSK3_1	260	267	PF00069	0.444
MOD_GSK3_1	363	370	PF00069	0.581
MOD_GSK3_1	386	393	PF00069	0.704
MOD_GSK3_1	48	55	PF00069	0.500
MOD_GSK3_1	64	71	PF00069	0.677
MOD_GSK3_1	92	99	PF00069	0.672
MOD_N-GLC_1	119	124	PF02516	0.628
MOD_N-GLC_1	180	185	PF02516	0.524
MOD_N-GLC_1	328	333	PF02516	0.436
MOD_NEK2_1	1	6	PF00069	0.722
MOD_NEK2_1	119	124	PF00069	0.663
MOD_NEK2_1	287	292	PF00069	0.521
MOD_NEK2_1	30	35	PF00069	0.447
MOD_NEK2_1	323	328	PF00069	0.516
MOD_NEK2_1	404	409	PF00069	0.575
MOD_NEK2_1	48	53	PF00069	0.585
MOD_NEK2_1	64	69	PF00069	0.654
MOD_NEK2_2	314	319	PF00069	0.541
MOD_PKA_1	386	392	PF00069	0.656
MOD_PKA_2	156	162	PF00069	0.648
MOD_PKA_2	233	239	PF00069	0.629
MOD_PKA_2	314	320	PF00069	0.552
MOD_PKA_2	386	392	PF00069	0.656
MOD_PKA_2	5	11	PF00069	0.534
MOD_PKA_2	80	86	PF00069	0.776
MOD_Plk_1	180	186	PF00069	0.607
MOD_Plk_1	288	294	PF00069	0.587
MOD_Plk_1	328	334	PF00069	0.502
MOD_Plk_1	367	373	PF00069	0.456
MOD_Plk_1	87	93	PF00069	0.687
MOD_Plk_4	222	228	PF00069	0.525
MOD_Plk_4	97	103	PF00069	0.544
MOD_ProDKin_1	133	139	PF00069	0.821
MOD_ProDKin_1	151	157	PF00069	0.699
MOD_ProDKin_1	410	416	PF00069	0.566
MOD_SUMO_for_1	414	417	PF00179	0.577
MOD_SUMO_rev_2	4	10	PF00179	0.703
TRG_DiLeu_BaEn_4	401	407	PF01217	0.454
TRG_ENDOCYTIC_2	172	175	PF00928	0.450
TRG_ER_diArg_1	149	152	PF00400	0.667
TRG_ER_diArg_1	313	316	PF00400	0.607
TRG_ER_diArg_1	386	388	PF00400	0.538
TRG_NLS_MonoCore_2	122	127	PF00514	0.724
TRG_NLS_MonoExtC_3	122	128	PF00514	0.742

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGK4	Leptomonas seymouri	66%	99%
A0A0S4J2S0	Bodo saltans	29%	100%
A0A1X0NJH1	Trypanosomatidae	37%	100%
A0A3Q8IHS0	Leishmania donovani	90%	99%
A0A3R7NE95	Trypanosoma rangeli	40%	100%
A4HMB7	Leishmania braziliensis	79%	100%
A4IAY3	Leishmania infantum	90%	99%
D0A272	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9B5W6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%