Glycerophosphocholine acyltransferase 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2838), putative

Species:

Leishmania major

UniProt:

E9AER0_LEIMA

TriTrypDb:

LmjF.35.0850 , LMJLV39_350014100 , LMJSD75_350013600

Length:

531

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9AER0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AER0

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	7
GO:0006644	phospholipid metabolic process	4	7
GO:0006650	glycerophospholipid metabolic process	5	2
GO:0006656	phosphatidylcholine biosynthetic process	5	2
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	7
GO:0008610	lipid biosynthetic process	4	7
GO:0008654	phospholipid biosynthetic process	5	7
GO:0009058	biosynthetic process	2	7
GO:0009987	cellular process	1	7
GO:0019637	organophosphate metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044249	cellular biosynthetic process	3	2
GO:0044255	cellular lipid metabolic process	3	7
GO:0045017	glycerolipid biosynthetic process	4	2
GO:0046470	phosphatidylcholine metabolic process	4	2
GO:0046474	glycerophospholipid biosynthetic process	5	2
GO:0046486	glycerolipid metabolic process	4	2
GO:0071704	organic substance metabolic process	2	7
GO:0090407	organophosphate biosynthetic process	4	7
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901566	organonitrogen compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016740	transferase activity	2	7
GO:0016746	acyltransferase activity	3	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	393	397	PF00656	0.583
CLV_C14_Caspase3-7	77	81	PF00656	0.354
CLV_NRD_NRD_1	110	112	PF00675	0.652
CLV_NRD_NRD_1	320	322	PF00675	0.379
CLV_NRD_NRD_1	350	352	PF00675	0.350
CLV_NRD_NRD_1	417	419	PF00675	0.408
CLV_PCSK_KEX2_1	110	112	PF00082	0.652
CLV_PCSK_KEX2_1	320	322	PF00082	0.379
CLV_PCSK_KEX2_1	350	352	PF00082	0.350
CLV_PCSK_KEX2_1	360	362	PF00082	0.399
CLV_PCSK_KEX2_1	504	506	PF00082	0.373
CLV_PCSK_PC1ET2_1	360	362	PF00082	0.356
CLV_PCSK_PC1ET2_1	504	506	PF00082	0.373
CLV_PCSK_SKI1_1	101	105	PF00082	0.657
CLV_PCSK_SKI1_1	180	184	PF00082	0.277
CLV_PCSK_SKI1_1	210	214	PF00082	0.329
CLV_PCSK_SKI1_1	321	325	PF00082	0.333
CLV_PCSK_SKI1_1	361	365	PF00082	0.347
CLV_PCSK_SKI1_1	419	423	PF00082	0.361
CLV_PCSK_SKI1_1	424	428	PF00082	0.341
DOC_MAPK_gen_1	124	133	PF00069	0.411
DOC_MAPK_gen_1	367	375	PF00069	0.581
DOC_MAPK_MEF2A_6	127	135	PF00069	0.428
DOC_PP1_RVXF_1	328	334	PF00149	0.569
DOC_PP2B_LxvP_1	117	120	PF13499	0.444
DOC_PP2B_PxIxI_1	456	462	PF00149	0.320
DOC_USP7_MATH_1	390	394	PF00917	0.647
DOC_USP7_MATH_1	514	518	PF00917	0.586
DOC_USP7_UBL2_3	360	364	PF12436	0.565
DOC_USP7_UBL2_3	493	497	PF12436	0.599
DOC_WW_Pin1_4	104	109	PF00397	0.437
LIG_14-3-3_CanoR_1	190	198	PF00244	0.500
LIG_14-3-3_CanoR_1	210	219	PF00244	0.450
LIG_14-3-3_CanoR_1	279	285	PF00244	0.728
LIG_14-3-3_CanoR_1	320	326	PF00244	0.519
LIG_14-3-3_CanoR_1	403	408	PF00244	0.568
LIG_14-3-3_CanoR_1	433	439	PF00244	0.638
LIG_Actin_WH2_2	281	298	PF00022	0.666
LIG_APCC_ABBA_1	426	431	PF00400	0.600
LIG_BRCT_BRCA1_1	156	160	PF00533	0.299
LIG_BRCT_BRCA1_1	454	458	PF00533	0.362
LIG_FHA_1	113	119	PF00498	0.445
LIG_FHA_1	301	307	PF00498	0.637
LIG_FHA_1	441	447	PF00498	0.453
LIG_FHA_2	148	154	PF00498	0.369
LIG_FHA_2	343	349	PF00498	0.649
LIG_FHA_2	379	385	PF00498	0.578
LIG_IRF3_LxIS_1	131	136	PF10401	0.350
LIG_LIR_Apic_2	97	102	PF02991	0.495
LIG_LIR_Gen_1	136	145	PF02991	0.382
LIG_LIR_Gen_1	156	166	PF02991	0.291
LIG_LIR_Gen_1	187	196	PF02991	0.481
LIG_LIR_Gen_1	282	290	PF02991	0.676
LIG_LIR_Gen_1	35	44	PF02991	0.315
LIG_LIR_Gen_1	371	378	PF02991	0.604
LIG_LIR_Gen_1	455	466	PF02991	0.362
LIG_LIR_Nem_3	129	135	PF02991	0.287
LIG_LIR_Nem_3	136	140	PF02991	0.319
LIG_LIR_Nem_3	156	161	PF02991	0.291
LIG_LIR_Nem_3	168	172	PF02991	0.321
LIG_LIR_Nem_3	18	24	PF02991	0.463
LIG_LIR_Nem_3	192	198	PF02991	0.509
LIG_LIR_Nem_3	282	288	PF02991	0.687
LIG_LIR_Nem_3	324	328	PF02991	0.511
LIG_LIR_Nem_3	35	39	PF02991	0.212
LIG_LIR_Nem_3	371	375	PF02991	0.602
LIG_LIR_Nem_3	453	459	PF02991	0.325
LIG_LIR_Nem_3	97	103	PF02991	0.461
LIG_LYPXL_yS_3	456	459	PF13949	0.395
LIG_NRP_CendR_1	529	531	PF00754	0.406
LIG_PCNA_yPIPBox_3	236	246	PF02747	0.620
LIG_PCNA_yPIPBox_3	41	51	PF02747	0.395
LIG_Pex14_1	339	343	PF04695	0.513
LIG_Pex14_1	74	78	PF04695	0.429
LIG_Pex14_2	158	162	PF04695	0.315
LIG_Pex14_2	342	346	PF04695	0.584
LIG_Pex14_2	425	429	PF04695	0.538
LIG_SH2_CRK	285	289	PF00017	0.639
LIG_SH2_CRK	312	316	PF00017	0.621
LIG_SH2_CRK	325	329	PF00017	0.457
LIG_SH2_GRB2like	228	231	PF00017	0.587
LIG_SH2_NCK_1	228	232	PF00017	0.618
LIG_SH2_SRC	132	135	PF00017	0.387
LIG_SH2_SRC	228	231	PF00017	0.623
LIG_SH2_STAT3	24	27	PF00017	0.477
LIG_SH2_STAT5	132	135	PF00017	0.415
LIG_SH2_STAT5	144	147	PF00017	0.373
LIG_SH2_STAT5	195	198	PF00017	0.495
LIG_SH2_STAT5	21	24	PF00017	0.315
LIG_SH2_STAT5	31	34	PF00017	0.446
LIG_SH2_STAT5	36	39	PF00017	0.253
LIG_SH2_STAT5	9	12	PF00017	0.315
LIG_SH3_3	128	134	PF00018	0.389
LIG_TYR_ITIM	29	34	PF00017	0.462
LIG_TYR_ITIM	323	328	PF00017	0.508
LIG_UBA3_1	13	20	PF00899	0.395
LIG_WRC_WIRS_1	155	160	PF05994	0.287
LIG_WRC_WIRS_1	185	190	PF05994	0.477
LIG_WRC_WIRS_1	343	348	PF05994	0.583
MOD_CDK_SPxK_1	104	110	PF00069	0.492
MOD_CDK_SPxxK_3	104	111	PF00069	0.457
MOD_CK1_1	241	247	PF00069	0.656
MOD_CK1_1	257	263	PF00069	0.570
MOD_CK1_1	283	289	PF00069	0.658
MOD_CK1_1	524	530	PF00069	0.572
MOD_CK2_1	147	153	PF00069	0.402
MOD_CK2_1	342	348	PF00069	0.647
MOD_CK2_1	378	384	PF00069	0.556
MOD_Cter_Amidation	416	419	PF01082	0.412
MOD_GlcNHglycan	213	216	PF01048	0.399
MOD_GlcNHglycan	376	379	PF01048	0.406
MOD_GlcNHglycan	387	390	PF01048	0.350
MOD_GlcNHglycan	467	470	PF01048	0.508
MOD_GlcNHglycan	523	526	PF01048	0.367
MOD_GlcNHglycan	65	68	PF01048	0.573
MOD_GSK3_1	254	261	PF00069	0.649
MOD_GSK3_1	265	272	PF00069	0.673
MOD_GSK3_1	279	286	PF00069	0.620
MOD_GSK3_1	374	381	PF00069	0.613
MOD_GSK3_1	514	521	PF00069	0.578
MOD_N-GLC_1	229	234	PF02516	0.354
MOD_N-GLC_1	238	243	PF02516	0.361
MOD_N-GLC_1	254	259	PF02516	0.371
MOD_N-GLC_1	265	270	PF02516	0.432
MOD_N-GLC_1	80	85	PF02516	0.665
MOD_N-GLC_1	95	100	PF02516	0.571
MOD_NEK2_1	160	165	PF00069	0.362
MOD_NEK2_1	211	216	PF00069	0.590
MOD_NEK2_1	238	243	PF00069	0.643
MOD_NEK2_1	280	285	PF00069	0.695
MOD_NEK2_1	295	300	PF00069	0.532
MOD_NEK2_1	342	347	PF00069	0.525
MOD_NEK2_1	385	390	PF00069	0.546
MOD_NEK2_1	39	44	PF00069	0.395
MOD_NEK2_1	440	445	PF00069	0.478
MOD_NEK2_1	450	455	PF00069	0.474
MOD_NEK2_1	498	503	PF00069	0.575
MOD_NEK2_1	518	523	PF00069	0.532
MOD_NEK2_1	85	90	PF00069	0.447
MOD_PIKK_1	295	301	PF00454	0.667
MOD_PIKK_1	440	446	PF00454	0.491
MOD_PKA_1	110	116	PF00069	0.441
MOD_PKA_2	110	116	PF00069	0.454
MOD_PKA_2	189	195	PF00069	0.477
MOD_PKA_2	295	301	PF00069	0.669
MOD_PKA_2	402	408	PF00069	0.577
MOD_Plk_1	238	244	PF00069	0.583
MOD_Plk_1	95	101	PF00069	0.477
MOD_Plk_2-3	218	224	PF00069	0.577
MOD_Plk_4	154	160	PF00069	0.293
MOD_Plk_4	202	208	PF00069	0.543
MOD_Plk_4	241	247	PF00069	0.624
MOD_Plk_4	248	254	PF00069	0.620
MOD_Plk_4	280	286	PF00069	0.692
MOD_Plk_4	39	45	PF00069	0.345
MOD_Plk_4	434	440	PF00069	0.643
MOD_Plk_4	95	101	PF00069	0.437
MOD_ProDKin_1	104	110	PF00069	0.437
MOD_SUMO_for_1	363	366	PF00179	0.600
TRG_DiLeu_BaLyEn_6	113	118	PF01217	0.465
TRG_DiLeu_BaLyEn_6	276	281	PF01217	0.696
TRG_ENDOCYTIC_2	132	135	PF00928	0.329
TRG_ENDOCYTIC_2	195	198	PF00928	0.495
TRG_ENDOCYTIC_2	228	231	PF00928	0.623
TRG_ENDOCYTIC_2	285	288	PF00928	0.648
TRG_ENDOCYTIC_2	31	34	PF00928	0.468
TRG_ENDOCYTIC_2	312	315	PF00928	0.630
TRG_ENDOCYTIC_2	325	328	PF00928	0.459
TRG_ENDOCYTIC_2	343	346	PF00928	0.525
TRG_ENDOCYTIC_2	36	39	PF00928	0.298
TRG_ENDOCYTIC_2	407	410	PF00928	0.563
TRG_ENDOCYTIC_2	456	459	PF00928	0.315
TRG_ER_diArg_1	109	111	PF00400	0.459
TRG_ER_diArg_1	319	321	PF00400	0.577
TRG_ER_diArg_1	349	351	PF00400	0.556
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.612

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NKF9	Trypanosomatidae	41%	93%
A0A3S7X8X9	Leishmania donovani	95%	100%
A4HMB6	Leishmania braziliensis	83%	100%
A4IAY2	Leishmania infantum	95%	100%
E9B5W5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%