Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nuclear transmembrane protein, putative

Species:

Leishmania major

UniProt:

E9AEQ9_LEIMA

TriTrypDb:

LmjF.35.0840 , LMJLV39_350014000 , LMJSD75_350013500

Length:

329

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0031090	organelle membrane	3	2
GO:0031965	nuclear membrane	4	2
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AEQ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEQ9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	71	73	PF00675	0.412
CLV_PCSK_KEX2_1	71	73	PF00082	0.412
CLV_PCSK_SKI1_1	138	142	PF00082	0.485
CLV_PCSK_SKI1_1	159	163	PF00082	0.454
CLV_PCSK_SKI1_1	232	236	PF00082	0.738
CLV_PCSK_SKI1_1	60	64	PF00082	0.518
CLV_PCSK_SKI1_1	90	94	PF00082	0.524
DEG_COP1_1	298	305	PF00400	0.499
DEG_SPOP_SBC_1	234	238	PF00917	0.573
DOC_CYCLIN_yCln2_LP_2	180	186	PF00134	0.411
DOC_PP2B_LxvP_1	106	109	PF13499	0.717
DOC_PP2B_LxvP_1	179	182	PF13499	0.513
DOC_USP7_MATH_1	198	202	PF00917	0.547
DOC_USP7_MATH_1	246	250	PF00917	0.493
DOC_USP7_MATH_1	278	282	PF00917	0.714
DOC_USP7_MATH_1	288	292	PF00917	0.411
DOC_USP7_MATH_1	38	42	PF00917	0.782
DOC_USP7_MATH_1	92	96	PF00917	0.709
DOC_WW_Pin1_4	194	199	PF00397	0.509
DOC_WW_Pin1_4	227	232	PF00397	0.505
DOC_WW_Pin1_4	32	37	PF00397	0.801
LIG_14-3-3_CanoR_1	232	239	PF00244	0.563
LIG_14-3-3_CanoR_1	60	67	PF00244	0.718
LIG_BIR_II_1	1	5	PF00653	0.632
LIG_BRCT_BRCA1_1	78	82	PF00533	0.729
LIG_Clathr_ClatBox_1	294	298	PF01394	0.513
LIG_FHA_1	168	174	PF00498	0.494
LIG_FHA_1	191	197	PF00498	0.420
LIG_FHA_1	228	234	PF00498	0.511
LIG_FHA_1	251	257	PF00498	0.520
LIG_FHA_1	282	288	PF00498	0.411
LIG_FHA_1	40	46	PF00498	0.745
LIG_FHA_2	198	204	PF00498	0.432
LIG_FHA_2	51	57	PF00498	0.779
LIG_GBD_Chelix_1	213	221	PF00786	0.757
LIG_LIR_Apic_2	133	139	PF02991	0.716
LIG_LIR_Apic_2	193	198	PF02991	0.445
LIG_LIR_Gen_1	120	130	PF02991	0.699
LIG_LIR_Gen_1	170	180	PF02991	0.513
LIG_LIR_Gen_1	260	268	PF02991	0.346
LIG_LIR_Gen_1	291	300	PF02991	0.513
LIG_LIR_Nem_3	120	125	PF02991	0.731
LIG_LIR_Nem_3	170	175	PF02991	0.443
LIG_LIR_Nem_3	260	264	PF02991	0.346
LIG_LIR_Nem_3	291	295	PF02991	0.513
LIG_Pex14_2	141	145	PF04695	0.527
LIG_Pex14_2	313	317	PF04695	0.474
LIG_SH2_CRK	122	126	PF00017	0.771
LIG_SH2_PTP2	136	139	PF00017	0.658
LIG_SH2_PTP2	261	264	PF00017	0.474
LIG_SH2_SRC	99	102	PF00017	0.692
LIG_SH2_STAP1	184	188	PF00017	0.636
LIG_SH2_STAT5	113	116	PF00017	0.712
LIG_SH2_STAT5	136	139	PF00017	0.713
LIG_SH2_STAT5	223	226	PF00017	0.474
LIG_SH2_STAT5	261	264	PF00017	0.474
LIG_SH2_STAT5	99	102	PF00017	0.733
LIG_SH3_3	25	31	PF00018	0.826
LIG_SUMO_SIM_anti_2	260	266	PF11976	0.339
LIG_SUMO_SIM_anti_2	286	291	PF11976	0.411
LIG_SUMO_SIM_par_1	291	299	PF11976	0.416
LIG_TRAF2_1	117	120	PF00917	0.711
LIG_TRAF2_1	140	143	PF00917	0.706
LIG_TRAF2_1	53	56	PF00917	0.808
LIG_WRC_WIRS_1	289	294	PF05994	0.513
MOD_CDK_SPK_2	227	232	PF00069	0.421
MOD_CK1_1	17	23	PF00069	0.725
MOD_CK1_1	187	193	PF00069	0.497
MOD_CK1_1	197	203	PF00069	0.536
MOD_CK1_1	226	232	PF00069	0.503
MOD_CK1_1	281	287	PF00069	0.465
MOD_CK1_1	41	47	PF00069	0.826
MOD_CK1_1	84	90	PF00069	0.792
MOD_CK2_1	114	120	PF00069	0.716
MOD_CK2_1	50	56	PF00069	0.782
MOD_GlcNHglycan	10	13	PF01048	0.506
MOD_GlcNHglycan	298	301	PF01048	0.411
MOD_GlcNHglycan	67	70	PF01048	0.546
MOD_GlcNHglycan	78	81	PF01048	0.513
MOD_GlcNHglycan	94	97	PF01048	0.506
MOD_GSK3_1	10	17	PF00069	0.702
MOD_GSK3_1	124	131	PF00069	0.700
MOD_GSK3_1	190	197	PF00069	0.487
MOD_GSK3_1	2	9	PF00069	0.769
MOD_GSK3_1	223	230	PF00069	0.572
MOD_GSK3_1	233	240	PF00069	0.523
MOD_GSK3_1	246	253	PF00069	0.394
MOD_GSK3_1	41	48	PF00069	0.710
MOD_GSK3_1	81	88	PF00069	0.791
MOD_N-GLC_1	125	130	PF02516	0.553
MOD_N-GLC_1	190	195	PF02516	0.632
MOD_NEK2_1	114	119	PF00069	0.714
MOD_NEK2_1	216	221	PF00069	0.555
MOD_NEK2_1	239	244	PF00069	0.595
MOD_NEK2_1	271	276	PF00069	0.433
MOD_NEK2_1	45	50	PF00069	0.702
MOD_OFUCOSY	269	275	PF10250	0.411
MOD_PIKK_1	107	113	PF00454	0.706
MOD_PIKK_1	14	20	PF00454	0.620
MOD_PIKK_1	190	196	PF00454	0.464
MOD_PIKK_1	2	8	PF00454	0.645
MOD_PIKK_1	60	66	PF00454	0.769
MOD_PKA_2	18	24	PF00069	0.776
MOD_PKA_2	226	232	PF00069	0.579
MOD_PKA_2	278	284	PF00069	0.546
MOD_PKA_2	76	82	PF00069	0.726
MOD_PKA_2	84	90	PF00069	0.763
MOD_PKB_1	8	16	PF00069	0.690
MOD_Plk_1	128	134	PF00069	0.658
MOD_Plk_1	190	196	PF00069	0.435
MOD_Plk_1	204	210	PF00069	0.469
MOD_Plk_1	246	252	PF00069	0.528
MOD_Plk_1	85	91	PF00069	0.726
MOD_Plk_4	167	173	PF00069	0.359
MOD_Plk_4	246	252	PF00069	0.459
MOD_Plk_4	260	266	PF00069	0.405
MOD_Plk_4	288	294	PF00069	0.513
MOD_ProDKin_1	194	200	PF00069	0.511
MOD_ProDKin_1	227	233	PF00069	0.508
MOD_ProDKin_1	32	38	PF00069	0.800
TRG_ENDOCYTIC_2	122	125	PF00928	0.729
TRG_ENDOCYTIC_2	261	264	PF00928	0.513
TRG_ER_diArg_1	156	159	PF00400	0.652
TRG_ER_diArg_1	70	72	PF00400	0.720
TRG_ER_diArg_1	74	77	PF00400	0.735

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHG2	Leptomonas seymouri	47%	77%
A0A3Q8IP51	Leishmania donovani	88%	77%
A4HMB5	Leishmania braziliensis	67%	81%
A4IAY1	Leishmania infantum	89%	77%
E9B5W4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	78%