Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

E9AEQ5_LEIMA

TriTrypDb:

LmjF.35.0800 , LMJLV39_350013600 , LMJSD75_350013100

Length:

1015

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AEQ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEQ5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	364	368	PF00656	0.603
CLV_C14_Caspase3-7	606	610	PF00656	0.671
CLV_C14_Caspase3-7	628	632	PF00656	0.603
CLV_C14_Caspase3-7	687	691	PF00656	0.649
CLV_C14_Caspase3-7	760	764	PF00656	0.607
CLV_C14_Caspase3-7	932	936	PF00656	0.761
CLV_C14_Caspase3-7	944	948	PF00656	0.610
CLV_NRD_NRD_1	104	106	PF00675	0.693
CLV_NRD_NRD_1	23	25	PF00675	0.630
CLV_NRD_NRD_1	684	686	PF00675	0.696
CLV_NRD_NRD_1	872	874	PF00675	0.685
CLV_PCSK_KEX2_1	104	106	PF00082	0.702
CLV_PCSK_KEX2_1	23	25	PF00082	0.630
CLV_PCSK_KEX2_1	684	686	PF00082	0.696
CLV_PCSK_KEX2_1	766	768	PF00082	0.629
CLV_PCSK_KEX2_1	872	874	PF00082	0.685
CLV_PCSK_KEX2_1	968	970	PF00082	0.685
CLV_PCSK_PC1ET2_1	766	768	PF00082	0.608
CLV_PCSK_PC1ET2_1	968	970	PF00082	0.649
CLV_PCSK_SKI1_1	1007	1011	PF00082	0.667
CLV_PCSK_SKI1_1	151	155	PF00082	0.661
CLV_PCSK_SKI1_1	220	224	PF00082	0.594
CLV_PCSK_SKI1_1	42	46	PF00082	0.593
CLV_PCSK_SKI1_1	658	662	PF00082	0.601
CLV_PCSK_SKI1_1	663	667	PF00082	0.607
CLV_PCSK_SKI1_1	784	788	PF00082	0.684
CLV_PCSK_SKI1_1	855	859	PF00082	0.771
CLV_PCSK_SKI1_1	968	972	PF00082	0.645
CLV_Separin_Metazoa	955	959	PF03568	0.711
DEG_SCF_FBW7_1	733	738	PF00400	0.696
DEG_SPOP_SBC_1	178	182	PF00917	0.627
DEG_SPOP_SBC_1	243	247	PF00917	0.687
DEG_SPOP_SBC_1	794	798	PF00917	0.696
DOC_CKS1_1	152	157	PF01111	0.657
DOC_CKS1_1	470	475	PF01111	0.779
DOC_CKS1_1	732	737	PF01111	0.723
DOC_CYCLIN_RxL_1	39	49	PF00134	0.587
DOC_CYCLIN_yCln2_LP_2	539	545	PF00134	0.601
DOC_MAPK_DCC_7	907	917	PF00069	0.662
DOC_MAPK_DCC_7	918	928	PF00069	0.718
DOC_MAPK_gen_1	918	928	PF00069	0.699
DOC_MAPK_MEF2A_6	907	914	PF00069	0.631
DOC_MAPK_MEF2A_6	921	928	PF00069	0.706
DOC_PP2B_LxvP_1	424	427	PF13499	0.617
DOC_PP2B_LxvP_1	458	461	PF13499	0.714
DOC_PP2B_LxvP_1	555	558	PF13499	0.548
DOC_PP2B_LxvP_1	910	913	PF13499	0.699
DOC_PP4_FxxP_1	86	89	PF00568	0.715
DOC_PP4_MxPP_1	831	834	PF00568	0.708
DOC_USP7_MATH_1	111	115	PF00917	0.731
DOC_USP7_MATH_1	144	148	PF00917	0.675
DOC_USP7_MATH_1	178	182	PF00917	0.748
DOC_USP7_MATH_1	221	225	PF00917	0.559
DOC_USP7_MATH_1	243	247	PF00917	0.726
DOC_USP7_MATH_1	261	265	PF00917	0.512
DOC_USP7_MATH_1	356	360	PF00917	0.767
DOC_USP7_MATH_1	476	480	PF00917	0.696
DOC_USP7_MATH_1	490	494	PF00917	0.696
DOC_USP7_MATH_1	511	515	PF00917	0.684
DOC_USP7_MATH_1	528	532	PF00917	0.556
DOC_USP7_MATH_1	569	573	PF00917	0.670
DOC_USP7_MATH_1	594	598	PF00917	0.705
DOC_USP7_MATH_1	626	630	PF00917	0.786
DOC_USP7_MATH_1	675	679	PF00917	0.782
DOC_USP7_MATH_1	705	709	PF00917	0.699
DOC_USP7_MATH_1	712	716	PF00917	0.636
DOC_USP7_MATH_1	735	739	PF00917	0.807
DOC_USP7_MATH_1	746	750	PF00917	0.747
DOC_USP7_MATH_1	752	756	PF00917	0.643
DOC_USP7_MATH_1	806	810	PF00917	0.736
DOC_USP7_MATH_1	931	935	PF00917	0.720
DOC_USP7_UBL2_3	762	766	PF12436	0.594
DOC_WW_Pin1_4	151	156	PF00397	0.657
DOC_WW_Pin1_4	199	204	PF00397	0.763
DOC_WW_Pin1_4	313	318	PF00397	0.766
DOC_WW_Pin1_4	469	474	PF00397	0.812
DOC_WW_Pin1_4	486	491	PF00397	0.756
DOC_WW_Pin1_4	541	546	PF00397	0.708
DOC_WW_Pin1_4	549	554	PF00397	0.587
DOC_WW_Pin1_4	716	721	PF00397	0.800
DOC_WW_Pin1_4	731	736	PF00397	0.574
DOC_WW_Pin1_4	742	747	PF00397	0.615
DOC_WW_Pin1_4	754	759	PF00397	0.571
DOC_WW_Pin1_4	81	86	PF00397	0.595
DOC_WW_Pin1_4	919	924	PF00397	0.756
DOC_WW_Pin1_4	990	995	PF00397	0.677
LIG_14-3-3_CanoR_1	104	112	PF00244	0.639
LIG_14-3-3_CanoR_1	220	230	PF00244	0.715
LIG_14-3-3_CanoR_1	31	37	PF00244	0.575
LIG_14-3-3_CanoR_1	345	354	PF00244	0.734
LIG_14-3-3_CanoR_1	589	594	PF00244	0.671
LIG_14-3-3_CanoR_1	684	689	PF00244	0.747
LIG_14-3-3_CanoR_1	710	720	PF00244	0.837
LIG_14-3-3_CanoR_1	784	793	PF00244	0.688
LIG_14-3-3_CanoR_1	83	89	PF00244	0.728
LIG_14-3-3_CanoR_1	960	970	PF00244	0.664
LIG_14-3-3_CanoR_1	985	994	PF00244	0.700
LIG_Actin_WH2_2	7	25	PF00022	0.625
LIG_BIR_II_1	1	5	PF00653	0.784
LIG_BIR_III_3	1	5	PF00653	0.708
LIG_BIR_III_4	273	277	PF00653	0.738
LIG_BIR_III_4	821	825	PF00653	0.763
LIG_BRCT_BRCA1_1	543	547	PF00533	0.686
LIG_BRCT_BRCA1_1	778	782	PF00533	0.739
LIG_deltaCOP1_diTrp_1	378	386	PF00928	0.676
LIG_deltaCOP1_diTrp_1	777	782	PF00928	0.742
LIG_FHA_1	178	184	PF00498	0.630
LIG_FHA_1	263	269	PF00498	0.703
LIG_FHA_1	36	42	PF00498	0.614
LIG_FHA_1	498	504	PF00498	0.746
LIG_FHA_1	52	58	PF00498	0.433
LIG_FHA_1	579	585	PF00498	0.659
LIG_FHA_1	606	612	PF00498	0.614
LIG_FHA_1	769	775	PF00498	0.699
LIG_FHA_1	785	791	PF00498	0.590
LIG_FHA_1	95	101	PF00498	0.769
LIG_FHA_2	152	158	PF00498	0.748
LIG_FHA_2	626	632	PF00498	0.607
LIG_FHA_2	738	744	PF00498	0.748
LIG_FHA_2	77	83	PF00498	0.582
LIG_Integrin_RGD_1	767	769	PF01839	0.777
LIG_LIR_Apic_2	84	89	PF02991	0.604
LIG_LIR_Gen_1	110	120	PF02991	0.564
LIG_LIR_Gen_1	777	788	PF02991	0.742
LIG_LIR_Nem_3	110	115	PF02991	0.564
LIG_LIR_Nem_3	147	152	PF02991	0.657
LIG_LIR_Nem_3	378	383	PF02991	0.677
LIG_LIR_Nem_3	544	550	PF02991	0.681
LIG_LIR_Nem_3	777	783	PF02991	0.740
LIG_MAD2	969	977	PF02301	0.611
LIG_SH2_GRB2like	37	40	PF00017	0.617
LIG_SH2_NCK_1	5	9	PF00017	0.611
LIG_SH2_STAP1	37	41	PF00017	0.645
LIG_SH2_STAP1	890	894	PF00017	0.575
LIG_SH2_STAT3	13	16	PF00017	0.603
LIG_SH2_STAT3	232	235	PF00017	0.743
LIG_SH2_STAT5	13	16	PF00017	0.486
LIG_SH2_STAT5	327	330	PF00017	0.677
LIG_SH2_STAT5	37	40	PF00017	0.617
LIG_SH2_STAT5	5	8	PF00017	0.614
LIG_SH2_STAT5	51	54	PF00017	0.434
LIG_SH2_STAT5	579	582	PF00017	0.623
LIG_SH2_STAT5	849	852	PF00017	0.602
LIG_SH3_1	315	321	PF00018	0.848
LIG_SH3_3	314	320	PF00018	0.840
LIG_SH3_3	417	423	PF00018	0.675
LIG_SH3_3	436	442	PF00018	0.531
LIG_SH3_3	443	449	PF00018	0.659
LIG_SH3_3	458	464	PF00018	0.653
LIG_SH3_3	470	476	PF00018	0.680
LIG_SH3_3	539	545	PF00018	0.592
LIG_SH3_3	54	60	PF00018	0.664
LIG_SH3_3	563	569	PF00018	0.704
LIG_SH3_3	571	577	PF00018	0.606
LIG_SH3_3	580	586	PF00018	0.531
LIG_SH3_3	618	624	PF00018	0.759
LIG_SH3_3	668	674	PF00018	0.583
LIG_SH3_3	714	720	PF00018	0.773
LIG_SH3_3	727	733	PF00018	0.602
LIG_SH3_3	905	911	PF00018	0.687
LIG_Sin3_3	580	587	PF02671	0.650
LIG_SUMO_SIM_anti_2	346	355	PF11976	0.549
LIG_SUMO_SIM_par_1	288	295	PF11976	0.671
LIG_TRAF2_1	952	955	PF00917	0.655
LIG_TRAF2_2	320	325	PF00917	0.591
LIG_TRAF2_2	977	982	PF00917	0.604
LIG_WRC_WIRS_1	383	388	PF05994	0.575
LIG_WW_3	832	836	PF00397	0.619
LIG_WW_3	88	92	PF00397	0.710
MOD_CK1_1	107	113	PF00069	0.627
MOD_CK1_1	138	144	PF00069	0.753
MOD_CK1_1	197	203	PF00069	0.726
MOD_CK1_1	226	232	PF00069	0.679
MOD_CK1_1	245	251	PF00069	0.542
MOD_CK1_1	264	270	PF00069	0.505
MOD_CK1_1	281	287	PF00069	0.661
MOD_CK1_1	302	308	PF00069	0.622
MOD_CK1_1	339	345	PF00069	0.712
MOD_CK1_1	346	352	PF00069	0.712
MOD_CK1_1	361	367	PF00069	0.604
MOD_CK1_1	401	407	PF00069	0.648
MOD_CK1_1	462	468	PF00069	0.808
MOD_CK1_1	469	475	PF00069	0.747
MOD_CK1_1	501	507	PF00069	0.685
MOD_CK1_1	686	692	PF00069	0.624
MOD_CK1_1	719	725	PF00069	0.763
MOD_CK1_1	81	87	PF00069	0.613
MOD_CK1_1	878	884	PF00069	0.741
MOD_CK1_1	987	993	PF00069	0.617
MOD_CK2_1	151	157	PF00069	0.749
MOD_CK2_1	221	227	PF00069	0.673
MOD_CK2_1	386	392	PF00069	0.658
MOD_CK2_1	754	760	PF00069	0.697
MOD_CK2_1	76	82	PF00069	0.573
MOD_CK2_1	947	953	PF00069	0.777
MOD_Cter_Amidation	102	105	PF01082	0.699
MOD_Cter_Amidation	682	685	PF01082	0.697
MOD_Cter_Amidation	966	969	PF01082	0.700
MOD_DYRK1A_RPxSP_1	754	758	PF00069	0.635
MOD_GlcNHglycan	107	110	PF01048	0.751
MOD_GlcNHglycan	118	121	PF01048	0.603
MOD_GlcNHglycan	141	144	PF01048	0.763
MOD_GlcNHglycan	146	149	PF01048	0.715
MOD_GlcNHglycan	161	164	PF01048	0.509
MOD_GlcNHglycan	270	273	PF01048	0.702
MOD_GlcNHglycan	283	286	PF01048	0.598
MOD_GlcNHglycan	294	297	PF01048	0.599
MOD_GlcNHglycan	338	341	PF01048	0.823
MOD_GlcNHglycan	358	361	PF01048	0.465
MOD_GlcNHglycan	403	406	PF01048	0.674
MOD_GlcNHglycan	435	438	PF01048	0.756
MOD_GlcNHglycan	439	442	PF01048	0.704
MOD_GlcNHglycan	478	481	PF01048	0.730
MOD_GlcNHglycan	493	496	PF01048	0.606
MOD_GlcNHglycan	513	516	PF01048	0.728
MOD_GlcNHglycan	571	574	PF01048	0.657
MOD_GlcNHglycan	628	631	PF01048	0.794
MOD_GlcNHglycan	677	680	PF01048	0.801
MOD_GlcNHglycan	693	696	PF01048	0.595
MOD_GlcNHglycan	703	706	PF01048	0.670
MOD_GlcNHglycan	748	751	PF01048	0.748
MOD_GlcNHglycan	86	89	PF01048	0.706
MOD_GlcNHglycan	963	966	PF01048	0.600
MOD_GSK3_1	107	114	PF00069	0.679
MOD_GSK3_1	131	138	PF00069	0.737
MOD_GSK3_1	194	201	PF00069	0.746
MOD_GSK3_1	231	238	PF00069	0.799
MOD_GSK3_1	242	249	PF00069	0.643
MOD_GSK3_1	264	271	PF00069	0.690
MOD_GSK3_1	3	10	PF00069	0.671
MOD_GSK3_1	339	346	PF00069	0.751
MOD_GSK3_1	382	389	PF00069	0.677
MOD_GSK3_1	390	397	PF00069	0.588
MOD_GSK3_1	433	440	PF00069	0.831
MOD_GSK3_1	459	466	PF00069	0.735
MOD_GSK3_1	486	493	PF00069	0.736
MOD_GSK3_1	497	504	PF00069	0.601
MOD_GSK3_1	638	645	PF00069	0.695
MOD_GSK3_1	701	708	PF00069	0.839
MOD_GSK3_1	712	719	PF00069	0.664
MOD_GSK3_1	731	738	PF00069	0.763
MOD_GSK3_1	742	749	PF00069	0.682
MOD_GSK3_1	752	759	PF00069	0.683
MOD_GSK3_1	784	791	PF00069	0.780
MOD_GSK3_1	801	808	PF00069	0.833
MOD_GSK3_1	878	885	PF00069	0.646
MOD_GSK3_1	986	993	PF00069	0.773
MOD_N-GLC_1	135	140	PF02516	0.675
MOD_N-GLC_1	300	305	PF02516	0.592
MOD_N-GLC_1	432	437	PF02516	0.698
MOD_N-GLC_1	882	887	PF02516	0.685
MOD_N-GLC_1	947	952	PF02516	0.776
MOD_N-GLC_1	990	995	PF02516	0.677
MOD_N-GLC_2	166	168	PF02516	0.682
MOD_N-GLC_2	216	218	PF02516	0.561
MOD_NEK2_1	1008	1013	PF00069	0.684
MOD_NEK2_1	196	201	PF00069	0.746
MOD_NEK2_1	231	236	PF00069	0.818
MOD_NEK2_1	343	348	PF00069	0.657
MOD_NEK2_1	386	391	PF00069	0.674
MOD_NEK2_1	491	496	PF00069	0.633
MOD_NEK2_1	661	666	PF00069	0.751
MOD_NEK2_1	94	99	PF00069	0.779
MOD_NEK2_1	941	946	PF00069	0.652
MOD_NEK2_2	179	184	PF00069	0.629
MOD_NEK2_2	813	818	PF00069	0.598
MOD_OFUCOSY	168	174	PF10250	0.644
MOD_PIKK_1	231	237	PF00454	0.788
MOD_PIKK_1	58	64	PF00454	0.582
MOD_PIKK_1	94	100	PF00454	0.783
MOD_PIKK_1	975	981	PF00454	0.699
MOD_PK_1	308	314	PF00069	0.636
MOD_PKA_1	104	110	PF00069	0.596
MOD_PKA_1	684	690	PF00069	0.685
MOD_PKA_2	104	110	PF00069	0.639
MOD_PKA_2	159	165	PF00069	0.715
MOD_PKA_2	30	36	PF00069	0.624
MOD_PKA_2	344	350	PF00069	0.608
MOD_PKA_2	683	689	PF00069	0.687
MOD_PKA_2	813	819	PF00069	0.795
MOD_PKA_2	827	833	PF00069	0.594
MOD_PKA_2	906	912	PF00069	0.686
MOD_PKA_2	961	967	PF00069	0.686
MOD_PKA_2	984	990	PF00069	0.734
MOD_PKB_1	306	314	PF00069	0.634
MOD_Plk_1	135	141	PF00069	0.611
MOD_Plk_1	226	232	PF00069	0.610
MOD_Plk_1	661	667	PF00069	0.553
MOD_Plk_1	776	782	PF00069	0.712
MOD_Plk_2-3	278	284	PF00069	0.732
MOD_Plk_4	226	232	PF00069	0.738
MOD_Plk_4	264	270	PF00069	0.696
MOD_Plk_4	382	388	PF00069	0.576
MOD_Plk_4	607	613	PF00069	0.647
MOD_Plk_4	712	718	PF00069	0.588
MOD_Plk_4	895	901	PF00069	0.755
MOD_ProDKin_1	151	157	PF00069	0.658
MOD_ProDKin_1	199	205	PF00069	0.764
MOD_ProDKin_1	313	319	PF00069	0.764
MOD_ProDKin_1	469	475	PF00069	0.811
MOD_ProDKin_1	486	492	PF00069	0.758
MOD_ProDKin_1	541	547	PF00069	0.708
MOD_ProDKin_1	549	555	PF00069	0.589
MOD_ProDKin_1	716	722	PF00069	0.801
MOD_ProDKin_1	731	737	PF00069	0.573
MOD_ProDKin_1	742	748	PF00069	0.617
MOD_ProDKin_1	754	760	PF00069	0.572
MOD_ProDKin_1	81	87	PF00069	0.595
MOD_ProDKin_1	919	925	PF00069	0.757
MOD_ProDKin_1	990	996	PF00069	0.669
TRG_DiLeu_BaEn_1	649	654	PF01217	0.595
TRG_DiLeu_BaEn_1	998	1003	PF01217	0.648
TRG_DiLeu_BaEn_2	381	387	PF01217	0.665
TRG_DiLeu_BaLyEn_6	551	556	PF01217	0.548
TRG_ER_diArg_1	1005	1008	PF00400	0.653
TRG_ER_diArg_1	104	106	PF00400	0.597
TRG_ER_diArg_1	22	24	PF00400	0.647
TRG_ER_diArg_1	872	874	PF00400	0.685
TRG_ER_diArg_1	90	93	PF00400	0.759
TRG_ER_diArg_1	957	960	PF00400	0.774
TRG_Pf-PMV_PEXEL_1	969	973	PF00026	0.643

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X8V2	Leishmania donovani	83%	100%
A4HMB1	Leishmania braziliensis	59%	100%
A4IAX7	Leishmania infantum	83%	100%
E9B5W0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%