Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

E9AEQ3_LEIMA

TriTrypDb:

LmjF.35.0780 , LMJLV39_350013400 , LMJSD75_350012900

Length:

779

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AEQ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEQ3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	611	615	PF00656	0.702
CLV_C14_Caspase3-7	662	666	PF00656	0.706
CLV_C14_Caspase3-7	727	731	PF00656	0.685
CLV_NRD_NRD_1	195	197	PF00675	0.774
CLV_NRD_NRD_1	324	326	PF00675	0.575
CLV_NRD_NRD_1	411	413	PF00675	0.565
CLV_NRD_NRD_1	450	452	PF00675	0.709
CLV_NRD_NRD_1	581	583	PF00675	0.681
CLV_NRD_NRD_1	653	655	PF00675	0.722
CLV_NRD_NRD_1	707	709	PF00675	0.742
CLV_PCSK_FUR_1	651	655	PF00082	0.725
CLV_PCSK_KEX2_1	126	128	PF00082	0.844
CLV_PCSK_KEX2_1	162	164	PF00082	0.837
CLV_PCSK_KEX2_1	195	197	PF00082	0.774
CLV_PCSK_KEX2_1	324	326	PF00082	0.575
CLV_PCSK_KEX2_1	363	365	PF00082	0.595
CLV_PCSK_KEX2_1	411	413	PF00082	0.565
CLV_PCSK_KEX2_1	449	451	PF00082	0.701
CLV_PCSK_KEX2_1	581	583	PF00082	0.678
CLV_PCSK_KEX2_1	637	639	PF00082	0.867
CLV_PCSK_KEX2_1	653	655	PF00082	0.722
CLV_PCSK_KEX2_1	707	709	PF00082	0.742
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.844
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.737
CLV_PCSK_PC1ET2_1	363	365	PF00082	0.595
CLV_PCSK_PC1ET2_1	637	639	PF00082	0.867
CLV_PCSK_SKI1_1	103	107	PF00082	0.832
CLV_PCSK_SKI1_1	126	130	PF00082	0.836
CLV_PCSK_SKI1_1	324	328	PF00082	0.546
CLV_PCSK_SKI1_1	363	367	PF00082	0.557
CLV_PCSK_SKI1_1	406	410	PF00082	0.684
CLV_PCSK_SKI1_1	426	430	PF00082	0.319
CLV_PCSK_SKI1_1	588	592	PF00082	0.773
CLV_PCSK_SKI1_1	604	608	PF00082	0.609
DEG_APCC_DBOX_1	448	456	PF00400	0.681
DEG_APCC_DBOX_1	508	516	PF00400	0.593
DEG_SPOP_SBC_1	664	668	PF00917	0.718
DOC_ANK_TNKS_1	164	171	PF00023	0.832
DOC_ANK_TNKS_1	41	48	PF00023	0.731
DOC_CKS1_1	456	461	PF01111	0.845
DOC_CYCLIN_RxL_1	601	611	PF00134	0.805
DOC_CYCLIN_yCln2_LP_2	657	663	PF00134	0.806
DOC_MAPK_DCC_7	449	457	PF00069	0.828
DOC_MAPK_gen_1	324	334	PF00069	0.538
DOC_MAPK_gen_1	449	457	PF00069	0.828
DOC_MAPK_MEF2A_6	241	248	PF00069	0.692
DOC_MAPK_MEF2A_6	449	457	PF00069	0.828
DOC_MAPK_NFAT4_5	241	249	PF00069	0.693
DOC_PP1_RVXF_1	706	713	PF00149	0.680
DOC_PP2B_LxvP_1	149	152	PF13499	0.826
DOC_PP2B_LxvP_1	680	683	PF13499	0.706
DOC_PP4_FxxP_1	128	131	PF00568	0.710
DOC_USP7_MATH_1	131	135	PF00917	0.689
DOC_USP7_MATH_1	175	179	PF00917	0.731
DOC_USP7_MATH_1	201	205	PF00917	0.772
DOC_USP7_MATH_1	376	380	PF00917	0.617
DOC_USP7_MATH_1	481	485	PF00917	0.742
DOC_USP7_MATH_1	592	596	PF00917	0.729
DOC_USP7_MATH_1	633	637	PF00917	0.849
DOC_USP7_MATH_1	66	70	PF00917	0.809
DOC_USP7_MATH_1	663	667	PF00917	0.722
DOC_USP7_MATH_1	685	689	PF00917	0.783
DOC_USP7_MATH_1	763	767	PF00917	0.772
DOC_USP7_MATH_1	94	98	PF00917	0.810
DOC_USP7_UBL2_3	122	126	PF12436	0.732
DOC_USP7_UBL2_3	359	363	PF12436	0.561
DOC_WW_Pin1_4	114	119	PF00397	0.738
DOC_WW_Pin1_4	127	132	PF00397	0.778
DOC_WW_Pin1_4	147	152	PF00397	0.485
DOC_WW_Pin1_4	275	280	PF00397	0.829
DOC_WW_Pin1_4	288	293	PF00397	0.557
DOC_WW_Pin1_4	34	39	PF00397	0.684
DOC_WW_Pin1_4	455	460	PF00397	0.804
DOC_WW_Pin1_4	465	470	PF00397	0.702
DOC_WW_Pin1_4	594	599	PF00397	0.770
DOC_WW_Pin1_4	766	771	PF00397	0.765
DOC_WW_Pin1_4	90	95	PF00397	0.806
LIG_14-3-3_CanoR_1	120	128	PF00244	0.823
LIG_14-3-3_CanoR_1	218	224	PF00244	0.657
LIG_14-3-3_CanoR_1	596	606	PF00244	0.706
LIG_14-3-3_CanoR_1	638	644	PF00244	0.854
LIG_Actin_WH2_2	344	361	PF00022	0.553
LIG_Actin_WH2_2	675	693	PF00022	0.822
LIG_BIR_II_1	1	5	PF00653	0.607
LIG_BRCT_BRCA1_1	226	230	PF00533	0.608
LIG_BRCT_BRCA1_1	694	698	PF00533	0.719
LIG_EVH1_1	452	456	PF00568	0.730
LIG_EVH1_2	21	25	PF00568	0.786
LIG_FHA_1	209	215	PF00498	0.813
LIG_FHA_1	219	225	PF00498	0.592
LIG_FHA_1	284	290	PF00498	0.807
LIG_FHA_1	538	544	PF00498	0.761
LIG_FHA_1	91	97	PF00498	0.700
LIG_FHA_2	134	140	PF00498	0.843
LIG_FHA_2	397	403	PF00498	0.606
LIG_FHA_2	517	523	PF00498	0.580
LIG_FHA_2	561	567	PF00498	0.713
LIG_FHA_2	665	671	PF00498	0.723
LIG_LIR_Gen_1	308	317	PF02991	0.686
LIG_LIR_Gen_1	605	615	PF02991	0.687
LIG_LIR_Nem_3	308	312	PF02991	0.704
LIG_LIR_Nem_3	605	610	PF02991	0.688
LIG_NRBOX	560	566	PF00104	0.617
LIG_PCNA_yPIPBox_3	324	338	PF02747	0.541
LIG_PCNA_yPIPBox_3	342	352	PF02747	0.539
LIG_PTAP_UEV_1	165	170	PF05743	0.826
LIG_SH2_CRK	338	342	PF00017	0.528
LIG_SH2_STAP1	26	30	PF00017	0.812
LIG_SH2_STAP1	309	313	PF00017	0.579
LIG_SH2_STAT3	3	6	PF00017	0.721
LIG_SH2_STAT5	656	659	PF00017	0.773
LIG_SH3_1	163	169	PF00018	0.831
LIG_SH3_1	450	456	PF00018	0.826
LIG_SH3_3	15	21	PF00018	0.769
LIG_SH3_3	163	169	PF00018	0.831
LIG_SH3_3	286	292	PF00018	0.793
LIG_SH3_3	301	307	PF00018	0.695
LIG_SH3_3	450	456	PF00018	0.826
LIG_TRAF2_1	343	346	PF00917	0.648
LIG_TRAF2_1	519	522	PF00917	0.584
LIG_TRAF2_1	672	675	PF00917	0.824
LIG_TYR_ITIM	13	18	PF00017	0.717
LIG_WW_2	453	456	PF00397	0.830
LIG_WW_3	117	121	PF00397	0.720
LIG_WW_3	151	155	PF00397	0.822
MOD_CDC14_SPxK_1	117	120	PF00782	0.738
MOD_CDC14_SPxK_1	291	294	PF00782	0.679
MOD_CDK_SPK_2	465	470	PF00069	0.853
MOD_CDK_SPxK_1	114	120	PF00069	0.720
MOD_CDK_SPxK_1	288	294	PF00069	0.685
MOD_CDK_SPxK_1	34	40	PF00069	0.688
MOD_CDK_SPxxK_3	147	154	PF00069	0.834
MOD_CK1_1	130	136	PF00069	0.833
MOD_CK1_1	178	184	PF00069	0.793
MOD_CK1_1	208	214	PF00069	0.813
MOD_CK1_1	222	228	PF00069	0.587
MOD_CK1_1	288	294	PF00069	0.760
MOD_CK1_1	379	385	PF00069	0.751
MOD_CK1_1	443	449	PF00069	0.645
MOD_CK1_1	461	467	PF00069	0.791
MOD_CK1_1	520	526	PF00069	0.582
MOD_CK1_1	547	553	PF00069	0.666
MOD_CK1_1	572	578	PF00069	0.686
MOD_CK1_1	594	600	PF00069	0.732
MOD_CK1_1	697	703	PF00069	0.692
MOD_CK1_1	766	772	PF00069	0.805
MOD_CK2_1	133	139	PF00069	0.842
MOD_CK2_1	396	402	PF00069	0.614
MOD_CK2_1	516	522	PF00069	0.585
MOD_CK2_1	560	566	PF00069	0.715
MOD_CK2_1	572	578	PF00069	0.636
MOD_GlcNHglycan	166	169	PF01048	0.735
MOD_GlcNHglycan	189	192	PF01048	0.858
MOD_GlcNHglycan	214	217	PF01048	0.689
MOD_GlcNHglycan	224	227	PF01048	0.665
MOD_GlcNHglycan	28	31	PF01048	0.772
MOD_GlcNHglycan	381	384	PF01048	0.684
MOD_GlcNHglycan	442	445	PF01048	0.752
MOD_GlcNHglycan	460	463	PF01048	0.706
MOD_GlcNHglycan	483	486	PF01048	0.729
MOD_GlcNHglycan	547	550	PF01048	0.667
MOD_GlcNHglycan	571	574	PF01048	0.762
MOD_GlcNHglycan	58	61	PF01048	0.820
MOD_GlcNHglycan	661	664	PF01048	0.801
MOD_GlcNHglycan	702	705	PF01048	0.688
MOD_GlcNHglycan	726	729	PF01048	0.731
MOD_GlcNHglycan	744	747	PF01048	0.723
MOD_GlcNHglycan	83	86	PF01048	0.708
MOD_GlcNHglycan	96	99	PF01048	0.638
MOD_GSK3_1	126	133	PF00069	0.720
MOD_GSK3_1	183	190	PF00069	0.732
MOD_GSK3_1	201	208	PF00069	0.844
MOD_GSK3_1	218	225	PF00069	0.566
MOD_GSK3_1	266	273	PF00069	0.667
MOD_GSK3_1	460	467	PF00069	0.734
MOD_GSK3_1	516	523	PF00069	0.585
MOD_GSK3_1	545	552	PF00069	0.767
MOD_GSK3_1	592	599	PF00069	0.758
MOD_GSK3_1	659	666	PF00069	0.704
MOD_GSK3_1	690	697	PF00069	0.719
MOD_GSK3_1	699	706	PF00069	0.720
MOD_GSK3_1	90	97	PF00069	0.652
MOD_LATS_1	203	209	PF00433	0.753
MOD_LATS_1	689	695	PF00433	0.721
MOD_N-GLC_1	464	469	PF02516	0.849
MOD_N-GLC_1	545	550	PF02516	0.690
MOD_NEK2_1	121	126	PF00069	0.732
MOD_NEK2_1	183	188	PF00069	0.785
MOD_NEK2_1	219	224	PF00069	0.703
MOD_NEK2_1	270	275	PF00069	0.732
MOD_NEK2_1	285	290	PF00069	0.618
MOD_NEK2_1	337	342	PF00069	0.486
MOD_NEK2_1	544	549	PF00069	0.780
MOD_NEK2_1	602	607	PF00069	0.750
MOD_NEK2_1	690	695	PF00069	0.703
MOD_PIKK_1	121	127	PF00454	0.748
MOD_PIKK_1	219	225	PF00454	0.767
MOD_PIKK_1	406	412	PF00454	0.686
MOD_PKA_1	126	132	PF00069	0.833
MOD_PKA_2	126	132	PF00069	0.738
MOD_PKA_2	164	170	PF00069	0.676
MOD_PKA_2	217	223	PF00069	0.659
MOD_PKA_2	232	238	PF00069	0.579
MOD_PKA_2	305	311	PF00069	0.665
MOD_PKA_2	440	446	PF00069	0.667
MOD_PKA_2	690	696	PF00069	0.721
MOD_Plk_1	156	162	PF00069	0.789
MOD_Plk_1	664	670	PF00069	0.720
MOD_Plk_1	685	691	PF00069	0.681
MOD_Plk_2-3	305	311	PF00069	0.735
MOD_Plk_2-3	560	566	PF00069	0.661
MOD_Plk_2-3	665	671	PF00069	0.723
MOD_Plk_4	280	286	PF00069	0.799
MOD_Plk_4	560	566	PF00069	0.762
MOD_Plk_4	66	72	PF00069	0.791
MOD_Plk_4	76	82	PF00069	0.651
MOD_ProDKin_1	114	120	PF00069	0.739
MOD_ProDKin_1	127	133	PF00069	0.778
MOD_ProDKin_1	147	153	PF00069	0.483
MOD_ProDKin_1	275	281	PF00069	0.829
MOD_ProDKin_1	288	294	PF00069	0.557
MOD_ProDKin_1	34	40	PF00069	0.688
MOD_ProDKin_1	455	461	PF00069	0.805
MOD_ProDKin_1	465	471	PF00069	0.703
MOD_ProDKin_1	594	600	PF00069	0.769
MOD_ProDKin_1	766	772	PF00069	0.762
MOD_ProDKin_1	90	96	PF00069	0.806
MOD_SUMO_for_1	502	505	PF00179	0.558
MOD_SUMO_rev_2	614	623	PF00179	0.777
MOD_SUMO_rev_2	624	632	PF00179	0.674
TRG_DiLeu_BaEn_1	560	565	PF01217	0.643
TRG_ENDOCYTIC_2	15	18	PF00928	0.722
TRG_ENDOCYTIC_2	309	312	PF00928	0.586
TRG_ENDOCYTIC_2	338	341	PF00928	0.531
TRG_ER_diArg_1	163	166	PF00400	0.828
TRG_ER_diArg_1	195	197	PF00400	0.759
TRG_ER_diArg_1	323	325	PF00400	0.572
TRG_ER_diArg_1	39	42	PF00400	0.729
TRG_ER_diArg_1	411	413	PF00400	0.565
TRG_ER_diArg_1	431	434	PF00400	0.339
TRG_ER_diArg_1	449	451	PF00400	0.818
TRG_ER_diArg_1	580	582	PF00400	0.679
TRG_ER_diArg_1	651	654	PF00400	0.729
TRG_ER_diArg_1	707	709	PF00400	0.748
TRG_ER_FFAT_2	692	703	PF00635	0.714
TRG_Pf-PMV_PEXEL_1	154	158	PF00026	0.838
TRG_Pf-PMV_PEXEL_1	187	192	PF00026	0.847
TRG_Pf-PMV_PEXEL_1	412	416	PF00026	0.557

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4N2	Leptomonas seymouri	40%	92%
E9B5V8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	99%