Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AEP9_LEIMA

TriTrypDb:

LmjF.35.0740 , LMJLV39_350013000 , LMJSD75_350012500

Length:

931

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AEP9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEP9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	238	242	PF00656	0.680
CLV_C14_Caspase3-7	837	841	PF00656	0.814
CLV_NRD_NRD_1	3	5	PF00675	0.712
CLV_NRD_NRD_1	312	314	PF00675	0.694
CLV_NRD_NRD_1	413	415	PF00675	0.724
CLV_NRD_NRD_1	484	486	PF00675	0.588
CLV_NRD_NRD_1	713	715	PF00675	0.709
CLV_NRD_NRD_1	803	805	PF00675	0.734
CLV_NRD_NRD_1	866	868	PF00675	0.746
CLV_NRD_NRD_1	869	871	PF00675	0.717
CLV_NRD_NRD_1	878	880	PF00675	0.705
CLV_NRD_NRD_1	881	883	PF00675	0.676
CLV_PCSK_FUR_1	867	871	PF00082	0.820
CLV_PCSK_FUR_1	879	883	PF00082	0.622
CLV_PCSK_KEX2_1	3	5	PF00082	0.687
CLV_PCSK_KEX2_1	312	314	PF00082	0.694
CLV_PCSK_KEX2_1	413	415	PF00082	0.724
CLV_PCSK_KEX2_1	484	486	PF00082	0.590
CLV_PCSK_KEX2_1	535	537	PF00082	0.823
CLV_PCSK_KEX2_1	611	613	PF00082	0.620
CLV_PCSK_KEX2_1	681	683	PF00082	0.764
CLV_PCSK_KEX2_1	713	715	PF00082	0.709
CLV_PCSK_KEX2_1	868	870	PF00082	0.765
CLV_PCSK_KEX2_1	880	882	PF00082	0.804
CLV_PCSK_PC1ET2_1	535	537	PF00082	0.823
CLV_PCSK_PC1ET2_1	611	613	PF00082	0.618
CLV_PCSK_PC1ET2_1	681	683	PF00082	0.764
CLV_PCSK_PC1ET2_1	868	870	PF00082	0.765
CLV_PCSK_PC1ET2_1	880	882	PF00082	0.804
CLV_PCSK_SKI1_1	379	383	PF00082	0.576
CLV_PCSK_SKI1_1	471	475	PF00082	0.645
CLV_PCSK_SKI1_1	678	682	PF00082	0.603
CLV_PCSK_SKI1_1	920	924	PF00082	0.746
DEG_APCC_DBOX_1	475	483	PF00400	0.565
DEG_SPOP_SBC_1	290	294	PF00917	0.758
DEG_SPOP_SBC_1	518	522	PF00917	0.626
DEG_SPOP_SBC_1	839	843	PF00917	0.593
DEG_SPOP_SBC_1	898	902	PF00917	0.584
DOC_CDC14_PxL_1	131	139	PF14671	0.552
DOC_CKS1_1	438	443	PF01111	0.706
DOC_CKS1_1	52	57	PF01111	0.642
DOC_CKS1_1	909	914	PF01111	0.723
DOC_CYCLIN_RxL_1	465	475	PF00134	0.614
DOC_CYCLIN_RxL_1	644	654	PF00134	0.701
DOC_CYCLIN_yCln2_LP_2	438	444	PF00134	0.597
DOC_CYCLIN_yCln2_LP_2	52	58	PF00134	0.634
DOC_CYCLIN_yCln2_LP_2	623	626	PF00134	0.789
DOC_MAPK_DCC_7	700	710	PF00069	0.502
DOC_MAPK_gen_1	700	708	PF00069	0.650
DOC_MAPK_JIP1_4	702	708	PF00069	0.753
DOC_MAPK_MEF2A_6	702	710	PF00069	0.661
DOC_MAPK_RevD_3	699	714	PF00069	0.763
DOC_PP2B_LxvP_1	623	626	PF13499	0.789
DOC_PP4_FxxP_1	197	200	PF00568	0.654
DOC_PP4_FxxP_1	734	737	PF00568	0.612
DOC_PP4_FxxP_1	905	908	PF00568	0.685
DOC_SPAK_OSR1_1	563	567	PF12202	0.823
DOC_USP7_MATH_1	15	19	PF00917	0.744
DOC_USP7_MATH_1	271	275	PF00917	0.604
DOC_USP7_MATH_1	283	287	PF00917	0.592
DOC_USP7_MATH_1	290	294	PF00917	0.532
DOC_USP7_MATH_1	408	412	PF00917	0.748
DOC_USP7_MATH_1	588	592	PF00917	0.747
DOC_USP7_MATH_1	643	647	PF00917	0.663
DOC_USP7_MATH_1	686	690	PF00917	0.788
DOC_USP7_MATH_1	70	74	PF00917	0.627
DOC_USP7_MATH_1	748	752	PF00917	0.720
DOC_USP7_MATH_1	79	83	PF00917	0.575
DOC_USP7_MATH_1	834	838	PF00917	0.769
DOC_USP7_MATH_1	839	843	PF00917	0.707
DOC_USP7_UBL2_3	512	516	PF12436	0.752
DOC_WW_Pin1_4	18	23	PF00397	0.658
DOC_WW_Pin1_4	345	350	PF00397	0.755
DOC_WW_Pin1_4	379	384	PF00397	0.632
DOC_WW_Pin1_4	402	407	PF00397	0.796
DOC_WW_Pin1_4	415	420	PF00397	0.662
DOC_WW_Pin1_4	437	442	PF00397	0.713
DOC_WW_Pin1_4	463	468	PF00397	0.672
DOC_WW_Pin1_4	496	501	PF00397	0.755
DOC_WW_Pin1_4	504	509	PF00397	0.608
DOC_WW_Pin1_4	51	56	PF00397	0.512
DOC_WW_Pin1_4	514	519	PF00397	0.610
DOC_WW_Pin1_4	541	546	PF00397	0.806
DOC_WW_Pin1_4	550	555	PF00397	0.793
DOC_WW_Pin1_4	610	615	PF00397	0.702
DOC_WW_Pin1_4	682	687	PF00397	0.749
DOC_WW_Pin1_4	712	717	PF00397	0.714
DOC_WW_Pin1_4	733	738	PF00397	0.814
DOC_WW_Pin1_4	75	80	PF00397	0.597
DOC_WW_Pin1_4	813	818	PF00397	0.797
DOC_WW_Pin1_4	821	826	PF00397	0.698
DOC_WW_Pin1_4	9	14	PF00397	0.822
DOC_WW_Pin1_4	908	913	PF00397	0.718
DOC_WW_Pin1_4	914	919	PF00397	0.671
DOC_WW_Pin1_4	922	927	PF00397	0.579
LIG_14-3-3_CanoR_1	289	297	PF00244	0.755
LIG_14-3-3_CanoR_1	432	438	PF00244	0.681
LIG_14-3-3_CanoR_1	556	564	PF00244	0.742
LIG_14-3-3_CanoR_1	565	569	PF00244	0.659
LIG_14-3-3_CanoR_1	592	597	PF00244	0.741
LIG_14-3-3_CanoR_1	682	686	PF00244	0.751
LIG_14-3-3_CanoR_1	732	737	PF00244	0.814
LIG_14-3-3_CanoR_1	75	79	PF00244	0.620
LIG_14-3-3_CanoR_1	861	871	PF00244	0.605
LIG_14-3-3_CanoR_1	881	888	PF00244	0.705
LIG_14-3-3_CanoR_1	920	926	PF00244	0.775
LIG_14-3-3_CanoR_1	96	104	PF00244	0.523
LIG_14-3-3_CterR_2	927	931	PF00244	0.749
LIG_APCC_ABBA_1	656	661	PF00400	0.594
LIG_BIR_II_1	1	5	PF00653	0.582
LIG_BIR_III_2	652	656	PF00653	0.792
LIG_BRCT_BRCA1_1	293	297	PF00533	0.737
LIG_BRCT_BRCA1_1	901	905	PF00533	0.689
LIG_Clathr_ClatBox_1	510	514	PF01394	0.641
LIG_deltaCOP1_diTrp_1	475	480	PF00928	0.662
LIG_EVH1_1	134	138	PF00568	0.625
LIG_EVH1_2	177	181	PF00568	0.641
LIG_FHA_1	30	36	PF00498	0.493
LIG_FHA_1	330	336	PF00498	0.598
LIG_FHA_1	438	444	PF00498	0.698
LIG_FHA_1	52	58	PF00498	0.532
LIG_FHA_1	522	528	PF00498	0.830
LIG_FHA_1	618	624	PF00498	0.697
LIG_FHA_1	646	652	PF00498	0.710
LIG_FHA_1	750	756	PF00498	0.788
LIG_FHA_1	923	929	PF00498	0.744
LIG_FHA_2	144	150	PF00498	0.666
LIG_FHA_2	161	167	PF00498	0.720
LIG_FHA_2	260	266	PF00498	0.606
LIG_FHA_2	568	574	PF00498	0.614
LIG_FHA_2	597	603	PF00498	0.597
LIG_FHA_2	632	638	PF00498	0.675
LIG_FHA_2	639	645	PF00498	0.677
LIG_FHA_2	841	847	PF00498	0.585
LIG_GBD_Chelix_1	443	451	PF00786	0.586
LIG_Integrin_RGD_1	164	166	PF01839	0.726
LIG_LIR_Apic_2	733	737	PF02991	0.610
LIG_LIR_Apic_2	902	908	PF02991	0.686
LIG_LIR_Gen_1	184	193	PF02991	0.485
LIG_LIR_Gen_1	357	362	PF02991	0.670
LIG_LIR_Gen_1	845	855	PF02991	0.782
LIG_LIR_Nem_3	184	189	PF02991	0.447
LIG_LIR_Nem_3	273	279	PF02991	0.750
LIG_LIR_Nem_3	311	317	PF02991	0.696
LIG_LIR_Nem_3	59	65	PF02991	0.595
LIG_LIR_Nem_3	845	851	PF02991	0.788
LIG_LYPXL_yS_3	134	137	PF13949	0.608
LIG_MYND_1	493	497	PF01753	0.606
LIG_Pex14_1	80	84	PF04695	0.520
LIG_PTB_Apo_2	191	198	PF02174	0.631
LIG_SH2_SRC	659	662	PF00017	0.690
LIG_SH2_STAP1	65	69	PF00017	0.646
LIG_SH2_STAP1	730	734	PF00017	0.623
LIG_SH2_STAT5	120	123	PF00017	0.492
LIG_SH2_STAT5	186	189	PF00017	0.470
LIG_SH2_STAT5	709	712	PF00017	0.698
LIG_SH2_STAT5	721	724	PF00017	0.721
LIG_SH3_1	132	138	PF00018	0.631
LIG_SH3_3	132	138	PF00018	0.551
LIG_SH3_3	166	172	PF00018	0.726
LIG_SH3_3	24	30	PF00018	0.803
LIG_SH3_3	299	305	PF00018	0.740
LIG_SH3_3	365	371	PF00018	0.653
LIG_SH3_3	44	50	PF00018	0.321
LIG_SH3_3	461	467	PF00018	0.781
LIG_SH3_3	494	500	PF00018	0.714
LIG_SH3_3	563	569	PF00018	0.583
LIG_SH3_3	819	825	PF00018	0.732
LIG_SH3_CIN85_PxpxPR_1	419	424	PF14604	0.730
LIG_Sin3_3	470	477	PF02671	0.698
LIG_SUMO_SIM_anti_2	153	160	PF11976	0.706
LIG_SUMO_SIM_par_1	153	160	PF11976	0.706
LIG_TRAF2_1	615	618	PF00917	0.603
LIG_WRC_WIRS_1	216	221	PF05994	0.542
LIG_WW_2	135	138	PF00397	0.638
MOD_CDC14_SPxK_1	553	556	PF00782	0.608
MOD_CDC14_SPxK_1	78	81	PF00782	0.630
MOD_CDK_SPK_2	733	738	PF00069	0.574
MOD_CDK_SPK_2	922	927	PF00069	0.742
MOD_CDK_SPxK_1	550	556	PF00069	0.616
MOD_CDK_SPxK_1	75	81	PF00069	0.564
MOD_CDK_SPxK_1	914	920	PF00069	0.644
MOD_CDK_SPxxK_3	417	424	PF00069	0.730
MOD_CDK_SPxxK_3	496	503	PF00069	0.757
MOD_CDK_SPxxK_3	908	915	PF00069	0.724
MOD_CK1_1	18	24	PF00069	0.700
MOD_CK1_1	288	294	PF00069	0.754
MOD_CK1_1	343	349	PF00069	0.641
MOD_CK1_1	395	401	PF00069	0.736
MOD_CK1_1	567	573	PF00069	0.738
MOD_CK1_1	575	581	PF00069	0.716
MOD_CK1_1	613	619	PF00069	0.724
MOD_CK1_1	726	732	PF00069	0.739
MOD_CK1_1	73	79	PF00069	0.594
MOD_CK1_1	733	739	PF00069	0.676
MOD_CK1_1	749	755	PF00069	0.621
MOD_CK1_1	787	793	PF00069	0.594
MOD_CK1_1	813	819	PF00069	0.729
MOD_CK1_1	916	922	PF00069	0.714
MOD_CK2_1	143	149	PF00069	0.679
MOD_CK2_1	215	221	PF00069	0.538
MOD_CK2_1	259	265	PF00069	0.655
MOD_CK2_1	596	602	PF00069	0.641
MOD_CK2_1	631	637	PF00069	0.595
MOD_CK2_1	787	793	PF00069	0.594
MOD_CK2_1	839	845	PF00069	0.727
MOD_CK2_1	886	892	PF00069	0.679
MOD_Cter_Amidation	608	611	PF01082	0.722
MOD_Cter_Amidation	871	874	PF01082	0.820
MOD_DYRK1A_RPxSP_1	379	383	PF00069	0.576
MOD_DYRK1A_RPxSP_1	417	421	PF00069	0.766
MOD_DYRK1A_RPxSP_1	714	718	PF00069	0.704
MOD_GlcNHglycan	225	230	PF01048	0.698
MOD_GlcNHglycan	241	244	PF01048	0.600
MOD_GlcNHglycan	280	284	PF01048	0.704
MOD_GlcNHglycan	285	288	PF01048	0.745
MOD_GlcNHglycan	362	365	PF01048	0.637
MOD_GlcNHglycan	375	378	PF01048	0.717
MOD_GlcNHglycan	393	397	PF01048	0.742
MOD_GlcNHglycan	665	668	PF01048	0.808
MOD_GlcNHglycan	671	674	PF01048	0.763
MOD_GlcNHglycan	688	691	PF01048	0.671
MOD_GlcNHglycan	748	751	PF01048	0.641
MOD_GlcNHglycan	752	755	PF01048	0.633
MOD_GlcNHglycan	875	878	PF01048	0.774
MOD_GlcNHglycan	888	891	PF01048	0.661
MOD_GlcNHglycan	97	100	PF01048	0.539
MOD_GSK3_1	18	25	PF00069	0.682
MOD_GSK3_1	279	286	PF00069	0.758
MOD_GSK3_1	288	295	PF00069	0.702
MOD_GSK3_1	29	36	PF00069	0.494
MOD_GSK3_1	356	363	PF00069	0.710
MOD_GSK3_1	369	376	PF00069	0.620
MOD_GSK3_1	413	420	PF00069	0.742
MOD_GSK3_1	514	521	PF00069	0.710
MOD_GSK3_1	575	582	PF00069	0.785
MOD_GSK3_1	584	591	PF00069	0.771
MOD_GSK3_1	592	599	PF00069	0.630
MOD_GSK3_1	613	620	PF00069	0.787
MOD_GSK3_1	659	666	PF00069	0.738
MOD_GSK3_1	669	676	PF00069	0.677
MOD_GSK3_1	682	689	PF00069	0.799
MOD_GSK3_1	70	77	PF00069	0.705
MOD_GSK3_1	719	726	PF00069	0.819
MOD_GSK3_1	733	740	PF00069	0.581
MOD_GSK3_1	746	753	PF00069	0.726
MOD_GSK3_1	784	791	PF00069	0.704
MOD_GSK3_1	821	828	PF00069	0.764
MOD_GSK3_1	834	841	PF00069	0.605
MOD_GSK3_1	910	917	PF00069	0.649
MOD_LATS_1	246	252	PF00433	0.736
MOD_N-GLC_1	189	194	PF02516	0.500
MOD_N-GLC_2	39	41	PF02516	0.567
MOD_NEK2_1	181	186	PF00069	0.639
MOD_NEK2_1	33	38	PF00069	0.453
MOD_NEK2_1	354	359	PF00069	0.615
MOD_NEK2_1	548	553	PF00069	0.843
MOD_NEK2_1	564	569	PF00069	0.643
MOD_NEK2_1	572	577	PF00069	0.722
MOD_NEK2_1	584	589	PF00069	0.675
MOD_NEK2_1	604	609	PF00069	0.691
MOD_NEK2_1	74	79	PF00069	0.580
MOD_NEK2_2	529	534	PF00069	0.745
MOD_NEK2_2	70	75	PF00069	0.690
MOD_PIKK_1	330	336	PF00454	0.747
MOD_PIKK_1	408	414	PF00454	0.830
MOD_PIKK_1	673	679	PF00454	0.829
MOD_PK_1	248	254	PF00069	0.730
MOD_PK_1	369	375	PF00069	0.630
MOD_PK_1	592	598	PF00069	0.664
MOD_PKA_1	4	10	PF00069	0.808
MOD_PKA_1	413	419	PF00069	0.728
MOD_PKA_1	681	687	PF00069	0.752
MOD_PKA_1	804	810	PF00069	0.719
MOD_PKA_1	873	879	PF00069	0.792
MOD_PKA_1	881	887	PF00069	0.712
MOD_PKA_2	247	253	PF00069	0.611
MOD_PKA_2	288	294	PF00069	0.728
MOD_PKA_2	329	335	PF00069	0.739
MOD_PKA_2	343	349	PF00069	0.568
MOD_PKA_2	413	419	PF00069	0.767
MOD_PKA_2	431	437	PF00069	0.682
MOD_PKA_2	555	561	PF00069	0.737
MOD_PKA_2	564	570	PF00069	0.671
MOD_PKA_2	604	610	PF00069	0.629
MOD_PKA_2	681	687	PF00069	0.825
MOD_PKA_2	737	743	PF00069	0.586
MOD_PKA_2	74	80	PF00069	0.607
MOD_PKA_2	787	793	PF00069	0.640
MOD_PKA_2	803	809	PF00069	0.691
MOD_PKA_2	881	887	PF00069	0.805
MOD_PKA_2	95	101	PF00069	0.512
MOD_PKB_1	786	794	PF00069	0.748
MOD_PKB_1	879	887	PF00069	0.808
MOD_Plk_1	248	254	PF00069	0.606
MOD_Plk_1	572	578	PF00069	0.659
MOD_Plk_1	723	729	PF00069	0.815
MOD_Plk_1	844	850	PF00069	0.718
MOD_Plk_1	898	904	PF00069	0.586
MOD_Plk_2-3	215	221	PF00069	0.538
MOD_Plk_4	181	187	PF00069	0.600
MOD_Plk_4	215	221	PF00069	0.640
MOD_Plk_4	271	277	PF00069	0.702
MOD_Plk_4	33	39	PF00069	0.418
MOD_Plk_4	506	512	PF00069	0.671
MOD_Plk_4	567	573	PF00069	0.697
MOD_Plk_4	592	598	PF00069	0.642
MOD_Plk_4	844	850	PF00069	0.718
MOD_ProDKin_1	18	24	PF00069	0.657
MOD_ProDKin_1	345	351	PF00069	0.755
MOD_ProDKin_1	379	385	PF00069	0.631
MOD_ProDKin_1	402	408	PF00069	0.796
MOD_ProDKin_1	415	421	PF00069	0.661
MOD_ProDKin_1	437	443	PF00069	0.706
MOD_ProDKin_1	463	469	PF00069	0.663
MOD_ProDKin_1	496	502	PF00069	0.753
MOD_ProDKin_1	504	510	PF00069	0.610
MOD_ProDKin_1	51	57	PF00069	0.510
MOD_ProDKin_1	514	520	PF00069	0.608
MOD_ProDKin_1	541	547	PF00069	0.809
MOD_ProDKin_1	550	556	PF00069	0.794
MOD_ProDKin_1	610	616	PF00069	0.699
MOD_ProDKin_1	682	688	PF00069	0.746
MOD_ProDKin_1	712	718	PF00069	0.713
MOD_ProDKin_1	733	739	PF00069	0.815
MOD_ProDKin_1	75	81	PF00069	0.596
MOD_ProDKin_1	813	819	PF00069	0.799
MOD_ProDKin_1	821	827	PF00069	0.700
MOD_ProDKin_1	9	15	PF00069	0.823
MOD_ProDKin_1	908	914	PF00069	0.719
MOD_ProDKin_1	922	928	PF00069	0.579
MOD_SUMO_for_1	386	389	PF00179	0.722
MOD_SUMO_for_1	511	514	PF00179	0.778
MOD_SUMO_rev_2	509	518	PF00179	0.741
MOD_SUMO_rev_2	889	896	PF00179	0.679
TRG_DiLeu_BaEn_2	192	198	PF01217	0.536
TRG_DiLeu_BaLyEn_6	468	473	PF01217	0.606
TRG_ENDOCYTIC_2	134	137	PF00928	0.608
TRG_ENDOCYTIC_2	185	188	PF00928	0.446
TRG_ER_diArg_1	104	107	PF00400	0.500
TRG_ER_diArg_1	138	141	PF00400	0.565
TRG_ER_diArg_1	312	314	PF00400	0.698
TRG_ER_diArg_1	483	485	PF00400	0.581
TRG_ER_diArg_1	699	702	PF00400	0.629
TRG_ER_diArg_1	867	870	PF00400	0.776
TRG_ER_diArg_1	879	882	PF00400	0.665
TRG_NLS_Bipartite_1	867	884	PF00514	0.817
TRG_NLS_MonoCore_2	866	871	PF00514	0.819
TRG_NLS_MonoCore_2	878	883	PF00514	0.624
TRG_NLS_MonoExtC_3	609	614	PF00514	0.763
TRG_NLS_MonoExtC_3	866	871	PF00514	0.794
TRG_NLS_MonoExtC_3	879	885	PF00514	0.629
TRG_NLS_MonoExtN_4	867	872	PF00514	0.756
TRG_NLS_MonoExtN_4	879	884	PF00514	0.786
TRG_Pf-PMV_PEXEL_1	471	475	PF00026	0.588
TRG_Pf-PMV_PEXEL_1	647	652	PF00026	0.703

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDY7	Leptomonas seymouri	36%	100%
A0A3Q8IP33	Leishmania donovani	87%	100%
A4HMA6	Leishmania braziliensis	66%	100%
A4IAX1	Leishmania infantum	88%	100%
E9B5V4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%