SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AEP8_LEIMA

TriTrypDb:

LmjF.35.0730 , LMJLV39_350012900 , LMJSD75_350012400

Length:

729

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	6
GO:0016020	membrane	2	4

Expansion

Sequence features

E9AEP8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEP8

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0008213	protein alkylation	5	2
GO:0009987	cellular process	1	2
GO:0016570	histone modification	5	2
GO:0016571	histone methylation	5	2
GO:0018022	peptidyl-lysine methylation	5	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018205	peptidyl-lysine modification	6	2
GO:0019538	protein metabolic process	3	2
GO:0032259	methylation	2	2
GO:0034968	histone lysine methylation	6	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043414	macromolecule methylation	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	2
GO:0008170	N-methyltransferase activity	5	2
GO:0008276	protein methyltransferase activity	3	2
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	2
GO:0016278	lysine N-methyltransferase activity	6	2
GO:0016279	protein-lysine N-methyltransferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2
GO:0018024	obsolete histone lysine N-methyltransferase activity	5	2
GO:0042054	histone methyltransferase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	529	533	PF00656	0.798
CLV_C14_Caspase3-7	557	561	PF00656	0.661
CLV_NRD_NRD_1	202	204	PF00675	0.439
CLV_NRD_NRD_1	223	225	PF00675	0.483
CLV_NRD_NRD_1	240	242	PF00675	0.429
CLV_NRD_NRD_1	322	324	PF00675	0.344
CLV_NRD_NRD_1	435	437	PF00675	0.264
CLV_NRD_NRD_1	686	688	PF00675	0.627
CLV_NRD_NRD_1	690	692	PF00675	0.621
CLV_NRD_NRD_1	93	95	PF00675	0.567
CLV_PCSK_KEX2_1	202	204	PF00082	0.439
CLV_PCSK_KEX2_1	322	324	PF00082	0.344
CLV_PCSK_KEX2_1	686	688	PF00082	0.627
CLV_PCSK_KEX2_1	690	692	PF00082	0.623
CLV_PCSK_KEX2_1	92	94	PF00082	0.552
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.552
CLV_PCSK_PC7_1	686	692	PF00082	0.643
CLV_PCSK_PC7_1	89	95	PF00082	0.519
CLV_PCSK_SKI1_1	202	206	PF00082	0.447
CLV_PCSK_SKI1_1	316	320	PF00082	0.264
CLV_PCSK_SKI1_1	323	327	PF00082	0.269
CLV_PCSK_SKI1_1	644	648	PF00082	0.593
DEG_APCC_DBOX_1	690	698	PF00400	0.463
DEG_Nend_UBRbox_1	1	4	PF02207	0.668
DEG_SPOP_SBC_1	49	53	PF00917	0.766
DEG_SPOP_SBC_1	500	504	PF00917	0.763
DOC_CDC14_PxL_1	550	558	PF14671	0.681
DOC_CYCLIN_yClb3_PxF_3	217	225	PF00134	0.688
DOC_MAPK_DCC_7	406	415	PF00069	0.503
DOC_MAPK_gen_1	181	190	PF00069	0.695
DOC_MAPK_gen_1	202	212	PF00069	0.657
DOC_MAPK_gen_1	224	231	PF00069	0.688
DOC_MAPK_gen_1	322	333	PF00069	0.507
DOC_MAPK_gen_1	617	627	PF00069	0.484
DOC_MAPK_gen_1	686	694	PF00069	0.473
DOC_MAPK_gen_1	89	99	PF00069	0.769
DOC_MAPK_MEF2A_6	205	214	PF00069	0.706
DOC_MAPK_MEF2A_6	621	629	PF00069	0.486
DOC_MAPK_MEF2A_6	74	82	PF00069	0.772
DOC_MAPK_RevD_3	674	688	PF00069	0.469
DOC_PIKK_1	662	669	PF02985	0.432
DOC_PP1_RVXF_1	200	207	PF00149	0.592
DOC_PP1_RVXF_1	537	544	PF00149	0.656
DOC_USP7_MATH_1	143	147	PF00917	0.832
DOC_USP7_MATH_1	388	392	PF00917	0.548
DOC_USP7_MATH_1	481	485	PF00917	0.695
DOC_USP7_MATH_1	50	54	PF00917	0.790
DOC_USP7_MATH_1	500	504	PF00917	0.763
DOC_USP7_MATH_1	56	60	PF00917	0.782
DOC_USP7_MATH_1	658	662	PF00917	0.441
DOC_USP7_MATH_1	72	76	PF00917	0.678
DOC_USP7_MATH_2	111	117	PF00917	0.752
DOC_USP7_MATH_2	29	35	PF00917	0.737
DOC_USP7_UBL2_3	205	209	PF12436	0.707
DOC_WW_Pin1_4	195	200	PF00397	0.673
DOC_WW_Pin1_4	21	26	PF00397	0.817
DOC_WW_Pin1_4	241	246	PF00397	0.673
DOC_WW_Pin1_4	29	34	PF00397	0.747
DOC_WW_Pin1_4	609	614	PF00397	0.644
LIG_14-3-3_CanoR_1	19	25	PF00244	0.732
LIG_14-3-3_CanoR_1	287	291	PF00244	0.624
LIG_14-3-3_CanoR_1	43	48	PF00244	0.704
LIG_14-3-3_CanoR_1	642	647	PF00244	0.363
LIG_14-3-3_CanoR_1	83	91	PF00244	0.708
LIG_Actin_WH2_2	631	649	PF00022	0.405
LIG_APCC_ABBA_1	249	254	PF00400	0.701
LIG_APCC_ABBA_1	463	468	PF00400	0.484
LIG_BIR_III_4	397	401	PF00653	0.548
LIG_BRCT_BRCA1_1	197	201	PF00533	0.710
LIG_CaM_IQ_9	330	345	PF13499	0.544
LIG_DLG_GKlike_1	642	650	PF00625	0.364
LIG_FHA_1	261	267	PF00498	0.686
LIG_FHA_1	319	325	PF00498	0.464
LIG_FHA_1	327	333	PF00498	0.464
LIG_FHA_1	352	358	PF00498	0.544
LIG_FHA_1	390	396	PF00498	0.477
LIG_FHA_1	455	461	PF00498	0.465
LIG_FHA_2	102	108	PF00498	0.780
LIG_FHA_2	123	129	PF00498	0.760
LIG_FHA_2	478	484	PF00498	0.718
LIG_FHA_2	555	561	PF00498	0.665
LIG_FHA_2	83	89	PF00498	0.762
LIG_Integrin_isoDGR_2	298	300	PF01839	0.426
LIG_KLC1_Yacidic_2	470	474	PF13176	0.573
LIG_LIR_Apic_2	583	587	PF02991	0.525
LIG_LIR_Gen_1	457	466	PF02991	0.464
LIG_LIR_Gen_1	616	627	PF02991	0.589
LIG_LIR_Gen_1	651	660	PF02991	0.421
LIG_LIR_Nem_3	198	204	PF02991	0.650
LIG_LIR_Nem_3	216	222	PF02991	0.597
LIG_LIR_Nem_3	280	284	PF02991	0.629
LIG_LIR_Nem_3	616	622	PF02991	0.641
LIG_LIR_Nem_3	651	657	PF02991	0.434
LIG_LYPXL_yS_3	553	556	PF13949	0.676
LIG_NRP_CendR_1	726	729	PF00754	0.684
LIG_PTB_Apo_2	590	597	PF02174	0.527
LIG_PTB_Phospho_1	590	596	PF10480	0.529
LIG_REV1ctd_RIR_1	541	550	PF16727	0.575
LIG_SH2_CRK	281	285	PF00017	0.701
LIG_SH2_CRK	619	623	PF00017	0.616
LIG_SH2_NCK_1	619	623	PF00017	0.616
LIG_SH2_PTP2	584	587	PF00017	0.526
LIG_SH2_SRC	584	587	PF00017	0.526
LIG_SH2_STAP1	654	658	PF00017	0.404
LIG_SH2_STAT5	370	373	PF00017	0.545
LIG_SH2_STAT5	441	444	PF00017	0.490
LIG_SH2_STAT5	472	475	PF00017	0.570
LIG_SH2_STAT5	564	567	PF00017	0.484
LIG_SH2_STAT5	584	587	PF00017	0.404
LIG_SH2_STAT5	596	599	PF00017	0.520
LIG_SH3_1	242	248	PF00018	0.671
LIG_SH3_3	133	139	PF00018	0.753
LIG_SH3_3	188	194	PF00018	0.648
LIG_SH3_3	211	217	PF00018	0.666
LIG_SH3_3	242	248	PF00018	0.741
LIG_SH3_5	215	219	PF00018	0.699
LIG_SUMO_SIM_anti_2	328	336	PF11976	0.464
LIG_SUMO_SIM_par_1	420	426	PF11976	0.550
LIG_SUMO_SIM_par_1	628	633	PF11976	0.419
LIG_TRAF2_1	148	151	PF00917	0.704
LIG_TRAF2_1	233	236	PF00917	0.658
LIG_TRAF2_1	484	487	PF00917	0.719
LIG_TRAF2_1	576	579	PF00917	0.587
LIG_TRAF2_1	661	664	PF00917	0.410
LIG_TRAF2_1	85	88	PF00917	0.809
LIG_TRAF2_1	98	101	PF00917	0.633
LIG_ULM_U2AF65_1	202	207	PF00076	0.598
LIG_WRC_WIRS_1	219	224	PF05994	0.751
LIG_WRC_WIRS_1	424	429	PF05994	0.464
MOD_CDC14_SPxK_1	32	35	PF00782	0.794
MOD_CDK_SPxK_1	29	35	PF00069	0.762
MOD_CDK_SPxxK_3	195	202	PF00069	0.675
MOD_CK1_1	146	152	PF00069	0.770
MOD_CK1_1	431	437	PF00069	0.548
MOD_CK1_1	526	532	PF00069	0.734
MOD_CK2_1	101	107	PF00069	0.785
MOD_CK2_1	122	128	PF00069	0.707
MOD_CK2_1	269	275	PF00069	0.703
MOD_CK2_1	379	385	PF00069	0.482
MOD_CK2_1	429	435	PF00069	0.509
MOD_CK2_1	477	483	PF00069	0.677
MOD_CK2_1	658	664	PF00069	0.422
MOD_CK2_1	82	88	PF00069	0.771
MOD_GlcNHglycan	113	118	PF01048	0.551
MOD_GlcNHglycan	483	486	PF01048	0.448
MOD_GlcNHglycan	54	57	PF01048	0.561
MOD_GlcNHglycan	60	63	PF01048	0.574
MOD_GSK3_1	122	129	PF00069	0.687
MOD_GSK3_1	138	145	PF00069	0.785
MOD_GSK3_1	307	314	PF00069	0.561
MOD_GSK3_1	374	381	PF00069	0.475
MOD_GSK3_1	386	393	PF00069	0.483
MOD_GSK3_1	477	484	PF00069	0.708
MOD_GSK3_1	48	55	PF00069	0.784
MOD_GSK3_1	501	508	PF00069	0.679
MOD_GSK3_1	522	529	PF00069	0.675
MOD_GSK3_1	56	63	PF00069	0.771
MOD_N-GLC_1	448	453	PF02516	0.270
MOD_N-GLC_1	454	459	PF02516	0.266
MOD_N-GLC_1	521	526	PF02516	0.466
MOD_NEK2_1	268	273	PF00069	0.734
MOD_NEK2_1	311	316	PF00069	0.581
MOD_NEK2_1	428	433	PF00069	0.485
MOD_NEK2_1	448	453	PF00069	0.487
MOD_NEK2_1	82	87	PF00069	0.753
MOD_NEK2_2	72	77	PF00069	0.770
MOD_PIKK_1	146	152	PF00454	0.705
MOD_PIKK_1	523	529	PF00454	0.740
MOD_PIKK_1	83	89	PF00454	0.762
MOD_PKA_2	286	292	PF00069	0.665
MOD_PKA_2	42	48	PF00069	0.705
MOD_PKA_2	466	472	PF00069	0.619
MOD_PKA_2	477	483	PF00069	0.701
MOD_PKA_2	82	88	PF00069	0.739
MOD_Plk_1	268	274	PF00069	0.715
MOD_Plk_1	429	435	PF00069	0.468
MOD_Plk_1	454	460	PF00069	0.468
MOD_Plk_1	474	480	PF00069	0.510
MOD_Plk_2-3	269	275	PF00069	0.720
MOD_Plk_4	326	332	PF00069	0.519
MOD_Plk_4	379	385	PF00069	0.475
MOD_Plk_4	423	429	PF00069	0.464
MOD_Plk_4	630	636	PF00069	0.409
MOD_ProDKin_1	195	201	PF00069	0.673
MOD_ProDKin_1	21	27	PF00069	0.817
MOD_ProDKin_1	241	247	PF00069	0.672
MOD_ProDKin_1	29	35	PF00069	0.749
MOD_ProDKin_1	609	615	PF00069	0.653
MOD_SUMO_for_1	210	213	PF00179	0.748
MOD_SUMO_for_1	325	328	PF00179	0.548
MOD_SUMO_for_1	342	345	PF00179	0.482
MOD_SUMO_rev_2	430	439	PF00179	0.531
MOD_SUMO_rev_2	612	620	PF00179	0.668
TRG_DiLeu_BaEn_2	164	170	PF01217	0.604
TRG_ENDOCYTIC_2	219	222	PF00928	0.686
TRG_ENDOCYTIC_2	281	284	PF00928	0.695
TRG_ENDOCYTIC_2	458	461	PF00928	0.464
TRG_ENDOCYTIC_2	553	556	PF00928	0.648
TRG_ENDOCYTIC_2	619	622	PF00928	0.596
TRG_ENDOCYTIC_2	654	657	PF00928	0.454
TRG_ER_diArg_1	201	203	PF00400	0.637
TRG_ER_diArg_1	322	324	PF00400	0.544
TRG_ER_diArg_1	641	644	PF00400	0.426
TRG_ER_diArg_1	690	692	PF00400	0.429
TRG_NLS_MonoExtC_3	686	691	PF00514	0.421
TRG_NLS_MonoExtN_4	686	691	PF00514	0.419
TRG_NLS_MonoExtN_4	89	96	PF00514	0.755
TRG_Pf-PMV_PEXEL_1	292	296	PF00026	0.385
TRG_Pf-PMV_PEXEL_1	300	304	PF00026	0.358

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5D5	Leptomonas seymouri	61%	99%
A0A0S4JG56	Bodo saltans	46%	100%
A0A3S5H7Y5	Leishmania donovani	93%	100%
A4HMA5	Leishmania braziliensis	79%	100%
A4IAX0	Leishmania infantum	93%	100%
D0A284	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9B5V3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	99%
V5B354	Trypanosoma cruzi	51%	100%