Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AEP7_LEIMA

TriTrypDb:

LmjF.35.0720 , LMJLV39_350012800 , LMJSD75_350012300

Length:

501

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AEP7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEP7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	237	239	PF00675	0.686
CLV_NRD_NRD_1	314	316	PF00675	0.716
CLV_NRD_NRD_1	326	328	PF00675	0.585
CLV_NRD_NRD_1	391	393	PF00675	0.667
CLV_NRD_NRD_1	447	449	PF00675	0.603
CLV_NRD_NRD_1	460	462	PF00675	0.641
CLV_PCSK_FUR_1	389	393	PF00082	0.673
CLV_PCSK_KEX2_1	237	239	PF00082	0.686
CLV_PCSK_KEX2_1	314	316	PF00082	0.716
CLV_PCSK_KEX2_1	326	328	PF00082	0.468
CLV_PCSK_KEX2_1	391	393	PF00082	0.667
CLV_PCSK_KEX2_1	416	418	PF00082	0.656
CLV_PCSK_KEX2_1	447	449	PF00082	0.632
CLV_PCSK_KEX2_1	460	462	PF00082	0.639
CLV_PCSK_PC1ET2_1	416	418	PF00082	0.656
CLV_PCSK_SKI1_1	187	191	PF00082	0.633
CLV_PCSK_SKI1_1	92	96	PF00082	0.468
CLV_Separin_Metazoa	257	261	PF03568	0.581
DEG_APCC_DBOX_1	108	116	PF00400	0.588
DEG_APCC_DBOX_1	91	99	PF00400	0.525
DEG_Nend_Nbox_1	1	3	PF02207	0.556
DEG_SCF_FBW7_1	415	422	PF00400	0.538
DEG_SPOP_SBC_1	304	308	PF00917	0.536
DOC_CKS1_1	428	433	PF01111	0.700
DOC_CYCLIN_RxL_1	89	97	PF00134	0.384
DOC_MAPK_gen_1	109	117	PF00069	0.575
DOC_MAPK_gen_1	90	98	PF00069	0.582
DOC_MAPK_HePTP_8	176	188	PF00069	0.516
DOC_MAPK_MEF2A_6	153	161	PF00069	0.467
DOC_MAPK_MEF2A_6	179	188	PF00069	0.509
DOC_MAPK_MEF2A_6	90	98	PF00069	0.576
DOC_PP1_RVXF_1	79	85	PF00149	0.567
DOC_PP2B_LxvP_1	96	99	PF13499	0.593
DOC_PP4_FxxP_1	281	284	PF00568	0.613
DOC_USP7_MATH_1	198	202	PF00917	0.497
DOC_USP7_MATH_1	266	270	PF00917	0.745
DOC_USP7_MATH_1	298	302	PF00917	0.714
DOC_USP7_MATH_1	340	344	PF00917	0.664
DOC_USP7_MATH_1	407	411	PF00917	0.692
DOC_USP7_MATH_1	419	423	PF00917	0.711
DOC_USP7_MATH_1	459	463	PF00917	0.654
DOC_USP7_MATH_1	496	500	PF00917	0.705
DOC_USP7_MATH_1	56	60	PF00917	0.635
DOC_USP7_MATH_1	62	66	PF00917	0.681
DOC_USP7_MATH_1	70	74	PF00917	0.536
DOC_WW_Pin1_4	153	158	PF00397	0.595
DOC_WW_Pin1_4	194	199	PF00397	0.485
DOC_WW_Pin1_4	238	243	PF00397	0.685
DOC_WW_Pin1_4	415	420	PF00397	0.558
DOC_WW_Pin1_4	427	432	PF00397	0.619
LIG_14-3-3_CanoR_1	140	148	PF00244	0.513
LIG_14-3-3_CanoR_1	171	177	PF00244	0.485
LIG_14-3-3_CanoR_1	210	216	PF00244	0.639
LIG_14-3-3_CanoR_1	460	470	PF00244	0.601
LIG_BRCT_BRCA1_1	141	145	PF00533	0.596
LIG_deltaCOP1_diTrp_1	436	443	PF00928	0.678
LIG_FHA_1	176	182	PF00498	0.487
LIG_FHA_1	216	222	PF00498	0.553
LIG_FHA_2	102	108	PF00498	0.532
LIG_FHA_2	189	195	PF00498	0.627
LIG_FHA_2	306	312	PF00498	0.611
LIG_FHA_2	336	342	PF00498	0.763
LIG_FHA_2	391	397	PF00498	0.612
LIG_FHA_2	416	422	PF00498	0.538
LIG_FHA_2	473	479	PF00498	0.700
LIG_FHA_2	75	81	PF00498	0.534
LIG_LIR_Apic_2	279	284	PF02991	0.676
LIG_LIR_Apic_2	292	298	PF02991	0.652
LIG_LIR_Apic_2	362	367	PF02991	0.615
LIG_LIR_Gen_1	209	217	PF02991	0.524
LIG_LIR_Gen_1	395	406	PF02991	0.611
LIG_LIR_Nem_3	142	148	PF02991	0.502
LIG_LIR_Nem_3	209	215	PF02991	0.557
LIG_LIR_Nem_3	311	316	PF02991	0.637
LIG_LIR_Nem_3	343	349	PF02991	0.638
LIG_LIR_Nem_3	362	368	PF02991	0.573
LIG_LIR_Nem_3	395	401	PF02991	0.628
LIG_LYPXL_yS_3	346	349	PF13949	0.735
LIG_PDZ_Class_1	496	501	PF00595	0.698
LIG_Pex14_1	451	455	PF04695	0.618
LIG_SH2_CRK	398	402	PF00017	0.651
LIG_SH2_CRK	44	48	PF00017	0.448
LIG_SH2_NCK_1	398	402	PF00017	0.651
LIG_SH2_NCK_1	479	483	PF00017	0.710
LIG_SH2_PTP2	212	215	PF00017	0.638
LIG_SH2_PTP2	365	368	PF00017	0.618
LIG_SH2_SRC	309	312	PF00017	0.723
LIG_SH2_SRC	365	368	PF00017	0.618
LIG_SH2_SRC	37	40	PF00017	0.507
LIG_SH2_SRC	378	381	PF00017	0.703
LIG_SH2_STAP1	305	309	PF00017	0.641
LIG_SH2_STAP1	479	483	PF00017	0.665
LIG_SH2_STAT3	16	19	PF00017	0.525
LIG_SH2_STAT5	148	151	PF00017	0.433
LIG_SH2_STAT5	16	19	PF00017	0.480
LIG_SH2_STAT5	212	215	PF00017	0.584
LIG_SH2_STAT5	305	308	PF00017	0.681
LIG_SH2_STAT5	365	368	PF00017	0.579
LIG_SH2_STAT5	378	381	PF00017	0.680
LIG_SH3_2	428	433	PF14604	0.661
LIG_SH3_3	12	18	PF00018	0.547
LIG_SH3_3	151	157	PF00018	0.506
LIG_SH3_3	227	233	PF00018	0.600
LIG_SH3_3	236	242	PF00018	0.694
LIG_SH3_3	425	431	PF00018	0.714
LIG_SUMO_SIM_par_1	188	194	PF11976	0.636
LIG_TRAF2_1	393	396	PF00917	0.690
LIG_TYR_ITIM	344	349	PF00017	0.660
LIG_TYR_ITIM	35	40	PF00017	0.391
MOD_CDK_SPxK_1	427	433	PF00069	0.701
MOD_CDK_SPxxK_3	153	160	PF00069	0.520
MOD_CK1_1	175	181	PF00069	0.497
MOD_CK1_1	279	285	PF00069	0.659
MOD_CK1_1	335	341	PF00069	0.693
MOD_CK1_1	350	356	PF00069	0.683
MOD_CK1_1	371	377	PF00069	0.638
MOD_CK1_1	411	417	PF00069	0.689
MOD_CK1_1	462	468	PF00069	0.656
MOD_CK1_1	472	478	PF00069	0.697
MOD_CK1_1	60	66	PF00069	0.681
MOD_CK2_1	113	119	PF00069	0.531
MOD_CK2_1	305	311	PF00069	0.679
MOD_CK2_1	350	356	PF00069	0.658
MOD_CK2_1	390	396	PF00069	0.657
MOD_CK2_1	472	478	PF00069	0.626
MOD_CK2_1	74	80	PF00069	0.582
MOD_Cter_Amidation	324	327	PF01082	0.525
MOD_DYRK1A_RPxSP_1	153	157	PF00069	0.589
MOD_DYRK1A_RPxSP_1	238	242	PF00069	0.635
MOD_GlcNHglycan	129	132	PF01048	0.709
MOD_GlcNHglycan	141	144	PF01048	0.388
MOD_GlcNHglycan	163	167	PF01048	0.650
MOD_GlcNHglycan	300	303	PF01048	0.689
MOD_GlcNHglycan	370	373	PF01048	0.633
MOD_GlcNHglycan	410	413	PF01048	0.674
MOD_GlcNHglycan	471	474	PF01048	0.617
MOD_GlcNHglycan	480	483	PF01048	0.603
MOD_GlcNHglycan	498	501	PF01048	0.449
MOD_GlcNHglycan	64	67	PF01048	0.659
MOD_GlcNHglycan	72	75	PF01048	0.574
MOD_GSK3_1	113	120	PF00069	0.520
MOD_GSK3_1	127	134	PF00069	0.676
MOD_GSK3_1	135	142	PF00069	0.476
MOD_GSK3_1	194	201	PF00069	0.661
MOD_GSK3_1	211	218	PF00069	0.621
MOD_GSK3_1	296	303	PF00069	0.675
MOD_GSK3_1	390	397	PF00069	0.765
MOD_GSK3_1	407	414	PF00069	0.549
MOD_GSK3_1	415	422	PF00069	0.714
MOD_GSK3_1	491	498	PF00069	0.655
MOD_GSK3_1	56	63	PF00069	0.612
MOD_GSK3_1	70	77	PF00069	0.654
MOD_N-GLC_1	198	203	PF02516	0.637
MOD_N-GLC_1	215	220	PF02516	0.568
MOD_NEK2_1	133	138	PF00069	0.554
MOD_NEK2_1	139	144	PF00069	0.489
MOD_NEK2_1	172	177	PF00069	0.543
MOD_NEK2_1	215	220	PF00069	0.623
MOD_NEK2_1	265	270	PF00069	0.687
MOD_NEK2_1	94	99	PF00069	0.395
MOD_PIKK_1	117	123	PF00454	0.479
MOD_PIKK_1	133	139	PF00454	0.578
MOD_PIKK_1	350	356	PF00454	0.644
MOD_PIKK_1	42	48	PF00454	0.409
MOD_PIKK_1	484	490	PF00454	0.688
MOD_PKA_1	460	466	PF00069	0.660
MOD_PKA_2	139	145	PF00069	0.525
MOD_PKA_2	325	331	PF00069	0.659
MOD_PKA_2	390	396	PF00069	0.632
MOD_PKA_2	459	465	PF00069	0.642
MOD_PKB_1	392	400	PF00069	0.734
MOD_Plk_1	215	221	PF00069	0.614
MOD_Plk_1	340	346	PF00069	0.694
MOD_Plk_1	394	400	PF00069	0.730
MOD_Plk_1	420	426	PF00069	0.745
MOD_Plk_4	113	119	PF00069	0.552
MOD_Plk_4	332	338	PF00069	0.734
MOD_ProDKin_1	153	159	PF00069	0.596
MOD_ProDKin_1	194	200	PF00069	0.484
MOD_ProDKin_1	238	244	PF00069	0.686
MOD_ProDKin_1	415	421	PF00069	0.561
MOD_ProDKin_1	427	433	PF00069	0.619
MOD_SUMO_rev_2	182	189	PF00179	0.621
TRG_DiLeu_BaEn_1	185	190	PF01217	0.608
TRG_DiLeu_BaEn_1	332	337	PF01217	0.735
TRG_DiLeu_BaLyEn_6	154	159	PF01217	0.493
TRG_DiLeu_BaLyEn_6	230	235	PF01217	0.522
TRG_ENDOCYTIC_2	12	15	PF00928	0.521
TRG_ENDOCYTIC_2	212	215	PF00928	0.583
TRG_ENDOCYTIC_2	346	349	PF00928	0.633
TRG_ENDOCYTIC_2	365	368	PF00928	0.618
TRG_ENDOCYTIC_2	37	40	PF00928	0.453
TRG_ENDOCYTIC_2	398	401	PF00928	0.612
TRG_ENDOCYTIC_2	44	47	PF00928	0.404
TRG_ER_diArg_1	237	239	PF00400	0.630
TRG_ER_diArg_1	286	289	PF00400	0.628
TRG_ER_diArg_1	313	315	PF00400	0.699
TRG_ER_diArg_1	388	391	PF00400	0.690
TRG_ER_diArg_1	446	448	PF00400	0.644
TRG_ER_diArg_1	459	461	PF00400	0.647
TRG_NES_CRM1_1	107	119	PF08389	0.586
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5S8	Leptomonas seymouri	41%	97%
A0A0S4JCU2	Bodo saltans	23%	100%
A0A3S7X8U0	Leishmania donovani	93%	100%
A4HMA4	Leishmania braziliensis	73%	98%
A4IAW9	Leishmania infantum	93%	100%
E9B5V2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5DJL7	Trypanosoma cruzi	27%	100%