LeishMANIAdb
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Endo/exonuclease/phosphatase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Endo/exonuclease/phosphatase domain-containing protein
Gene product:
Endonuclease/Exonuclease/phosphatase family, putative
Species:
Leishmania major
UniProt:
E9AEP6_LEIMA
TriTrypDb:
LmjF.35.0710 , LMJLV39_350012700 , LMJSD75_350012200 *
Length:
531

Annotations

LeishMANIAdb annotations

A tail-anchored nuclease (hydrolase) domain protein

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 2
GO:0110165 cellular anatomical entity 1 9
GO:0016020 membrane 2 7

Expansion

Sequence features

E9AEP6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEP6

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 10
GO:0004518 nuclease activity 4 2
GO:0004519 endonuclease activity 5 2
GO:0004527 exonuclease activity 5 2
GO:0016787 hydrolase activity 2 2
GO:0016788 hydrolase activity, acting on ester bonds 3 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 107 111 PF00656 0.248
CLV_C14_Caspase3-7 132 136 PF00656 0.325
CLV_NRD_NRD_1 160 162 PF00675 0.485
CLV_NRD_NRD_1 189 191 PF00675 0.501
CLV_NRD_NRD_1 299 301 PF00675 0.494
CLV_NRD_NRD_1 81 83 PF00675 0.501
CLV_PCSK_KEX2_1 160 162 PF00082 0.469
CLV_PCSK_KEX2_1 189 191 PF00082 0.500
CLV_PCSK_KEX2_1 81 83 PF00082 0.485
CLV_PCSK_SKI1_1 11 15 PF00082 0.651
CLV_PCSK_SKI1_1 145 149 PF00082 0.551
CLV_PCSK_SKI1_1 160 164 PF00082 0.514
CLV_PCSK_SKI1_1 193 197 PF00082 0.487
CLV_PCSK_SKI1_1 300 304 PF00082 0.498
CLV_PCSK_SKI1_1 52 56 PF00082 0.555
DEG_APCC_DBOX_1 382 390 PF00400 0.365
DEG_SCF_TRCP1_1 135 141 PF00400 0.214
DEG_SPOP_SBC_1 497 501 PF00917 0.372
DOC_CYCLIN_RxL_1 280 294 PF00134 0.409
DOC_CYCLIN_yCln2_LP_2 113 119 PF00134 0.377
DOC_MAPK_gen_1 189 200 PF00069 0.347
DOC_MAPK_gen_1 383 391 PF00069 0.338
DOC_MAPK_HePTP_8 509 521 PF00069 0.359
DOC_MAPK_MEF2A_6 193 200 PF00069 0.362
DOC_MAPK_MEF2A_6 353 361 PF00069 0.391
DOC_MAPK_MEF2A_6 512 521 PF00069 0.428
DOC_PP1_RVXF_1 282 288 PF00149 0.327
DOC_PP1_RVXF_1 383 389 PF00149 0.314
DOC_PP1_RVXF_1 42 49 PF00149 0.306
DOC_PP2B_LxvP_1 113 116 PF13499 0.369
DOC_USP7_MATH_1 146 150 PF00917 0.356
DOC_USP7_MATH_1 244 248 PF00917 0.364
DOC_USP7_UBL2_3 90 94 PF12436 0.362
DOC_WW_Pin1_4 171 176 PF00397 0.325
LIG_14-3-3_CanoR_1 160 165 PF00244 0.339
LIG_14-3-3_CanoR_1 190 200 PF00244 0.335
LIG_14-3-3_CanoR_1 205 213 PF00244 0.288
LIG_14-3-3_CanoR_1 286 291 PF00244 0.362
LIG_14-3-3_CanoR_1 36 46 PF00244 0.410
LIG_BRCT_BRCA1_1 148 152 PF00533 0.344
LIG_BRCT_BRCA1_1 317 321 PF00533 0.422
LIG_BRCT_BRCA1_1 364 368 PF00533 0.402
LIG_BRCT_BRCA1_1 39 43 PF00533 0.403
LIG_FHA_1 280 286 PF00498 0.384
LIG_FHA_1 40 46 PF00498 0.373
LIG_FHA_1 509 515 PF00498 0.341
LIG_FHA_2 130 136 PF00498 0.319
LIG_FHA_2 161 167 PF00498 0.290
LIG_FHA_2 345 351 PF00498 0.422
LIG_FHA_2 467 473 PF00498 0.398
LIG_GBD_Chelix_1 92 100 PF00786 0.513
LIG_Integrin_isoDGR_2 484 486 PF01839 0.612
LIG_LIR_Gen_1 105 113 PF02991 0.276
LIG_LIR_Gen_1 318 326 PF02991 0.446
LIG_LIR_Gen_1 327 338 PF02991 0.399
LIG_LIR_Gen_1 365 376 PF02991 0.351
LIG_LIR_Gen_1 387 396 PF02991 0.301
LIG_LIR_Gen_1 459 468 PF02991 0.369
LIG_LIR_Gen_1 499 510 PF02991 0.292
LIG_LIR_Gen_1 69 78 PF02991 0.354
LIG_LIR_Gen_1 83 93 PF02991 0.296
LIG_LIR_Nem_3 105 109 PF02991 0.276
LIG_LIR_Nem_3 289 293 PF02991 0.407
LIG_LIR_Nem_3 318 322 PF02991 0.381
LIG_LIR_Nem_3 327 333 PF02991 0.345
LIG_LIR_Nem_3 337 343 PF02991 0.222
LIG_LIR_Nem_3 365 371 PF02991 0.348
LIG_LIR_Nem_3 377 381 PF02991 0.341
LIG_LIR_Nem_3 387 391 PF02991 0.294
LIG_LIR_Nem_3 40 46 PF02991 0.332
LIG_LIR_Nem_3 459 464 PF02991 0.376
LIG_LIR_Nem_3 499 505 PF02991 0.291
LIG_LIR_Nem_3 69 73 PF02991 0.320
LIG_LIR_Nem_3 83 88 PF02991 0.213
LIG_MYND_1 126 130 PF01753 0.298
LIG_PCNA_yPIPBox_3 336 348 PF02747 0.408
LIG_Pex14_1 340 344 PF04695 0.332
LIG_Pex14_2 317 321 PF04695 0.349
LIG_PTB_Apo_2 372 379 PF02174 0.382
LIG_PTB_Apo_2 462 469 PF02174 0.352
LIG_PTB_Phospho_1 372 378 PF10480 0.426
LIG_PTB_Phospho_1 462 468 PF10480 0.408
LIG_SH2_CRK 319 323 PF00017 0.394
LIG_SH2_CRK 330 334 PF00017 0.345
LIG_SH2_CRK 85 89 PF00017 0.274
LIG_SH2_GRB2like 85 88 PF00017 0.362
LIG_SH2_NCK_1 85 89 PF00017 0.298
LIG_SH2_SRC 342 345 PF00017 0.383
LIG_SH2_SRC 362 365 PF00017 0.167
LIG_SH2_SRC 429 432 PF00017 0.419
LIG_SH2_SRC 85 88 PF00017 0.358
LIG_SH2_STAP1 425 429 PF00017 0.415
LIG_SH2_STAP1 498 502 PF00017 0.412
LIG_SH2_STAT5 101 104 PF00017 0.285
LIG_SH2_STAT5 214 217 PF00017 0.277
LIG_SH2_STAT5 314 317 PF00017 0.363
LIG_SH2_STAT5 342 345 PF00017 0.399
LIG_SH2_STAT5 429 432 PF00017 0.392
LIG_SH2_STAT5 461 464 PF00017 0.328
LIG_SH2_STAT5 468 471 PF00017 0.345
LIG_SH2_STAT5 498 501 PF00017 0.396
LIG_SH3_3 514 520 PF00018 0.242
LIG_SUMO_SIM_anti_2 410 415 PF11976 0.442
LIG_UBA3_1 12 17 PF00899 0.432
LIG_UBA3_1 59 64 PF00899 0.329
MOD_CK1_1 136 142 PF00069 0.349
MOD_CK1_1 419 425 PF00069 0.358
MOD_CK1_1 445 451 PF00069 0.562
MOD_CK2_1 160 166 PF00069 0.342
MOD_CK2_1 286 292 PF00069 0.334
MOD_CK2_1 344 350 PF00069 0.342
MOD_GlcNHglycan 135 138 PF01048 0.524
MOD_GlcNHglycan 193 196 PF01048 0.560
MOD_GlcNHglycan 206 209 PF01048 0.567
MOD_GlcNHglycan 425 428 PF01048 0.560
MOD_GlcNHglycan 450 454 PF01048 0.683
MOD_GSK3_1 129 136 PF00069 0.372
MOD_GSK3_1 156 163 PF00069 0.259
MOD_GSK3_1 362 369 PF00069 0.338
MOD_GSK3_1 416 423 PF00069 0.358
MOD_GSK3_1 445 452 PF00069 0.511
MOD_GSK3_1 496 503 PF00069 0.422
MOD_N-GLC_1 416 421 PF02516 0.596
MOD_N-GLC_1 466 471 PF02516 0.620
MOD_NEK2_1 109 114 PF00069 0.353
MOD_NEK2_1 332 337 PF00069 0.333
MOD_NEK2_1 389 394 PF00069 0.257
MOD_NEK2_1 39 44 PF00069 0.422
MOD_NEK2_1 421 426 PF00069 0.394
MOD_NEK2_1 476 481 PF00069 0.405
MOD_NEK2_1 508 513 PF00069 0.346
MOD_NEK2_2 429 434 PF00069 0.389
MOD_PIKK_1 121 127 PF00454 0.319
MOD_PK_1 367 373 PF00069 0.335
MOD_PK_1 416 422 PF00069 0.416
MOD_PKA_1 160 166 PF00069 0.310
MOD_PKA_2 160 166 PF00069 0.248
MOD_PKA_2 204 210 PF00069 0.368
MOD_PKA_2 274 280 PF00069 0.277
MOD_PKA_2 352 358 PF00069 0.375
MOD_PKA_2 80 86 PF00069 0.301
MOD_PKB_1 284 292 PF00069 0.338
MOD_Plk_1 109 115 PF00069 0.353
MOD_Plk_1 139 145 PF00069 0.313
MOD_Plk_1 442 448 PF00069 0.529
MOD_Plk_4 165 171 PF00069 0.362
MOD_Plk_4 334 340 PF00069 0.351
MOD_Plk_4 374 380 PF00069 0.298
MOD_Plk_4 416 422 PF00069 0.412
MOD_Plk_4 429 435 PF00069 0.374
MOD_ProDKin_1 171 177 PF00069 0.325
MOD_SUMO_rev_2 5 13 PF00179 0.450
MOD_SUMO_rev_2 57 66 PF00179 0.362
TRG_ENDOCYTIC_2 314 317 PF00928 0.453
TRG_ENDOCYTIC_2 319 322 PF00928 0.426
TRG_ENDOCYTIC_2 330 333 PF00928 0.327
TRG_ENDOCYTIC_2 378 381 PF00928 0.375
TRG_ENDOCYTIC_2 461 464 PF00928 0.331
TRG_ENDOCYTIC_2 85 88 PF00928 0.287
TRG_ER_diArg_1 188 190 PF00400 0.337
TRG_ER_diArg_1 196 199 PF00400 0.336
TRG_ER_diArg_1 253 256 PF00400 0.214
TRG_ER_diArg_1 284 287 PF00400 0.323
TRG_NES_CRM1_1 62 75 PF08389 0.339
TRG_NES_CRM1_1 91 105 PF08389 0.214
TRG_Pf-PMV_PEXEL_1 231 235 PF00026 0.476

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HWC2 Leptomonas seymouri 65% 100%
A0A0S4JD46 Bodo saltans 39% 100%
A0A1X0NIT2 Trypanosomatidae 49% 99%
A0A3Q8IG08 Leishmania donovani 92% 100%
A0A3R7MBG8 Trypanosoma rangeli 45% 100%
A4HMA3 Leishmania braziliensis 79% 100%
A4IAW8 Leishmania infantum 91% 100%
D0A288 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
E9B5V1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
V5BN83 Trypanosoma cruzi 47% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS