TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tetratricopeptide repeat, putative

Species:

Leishmania major

UniProt:

E9AEP4_LEIMA

TriTrypDb:

LmjF.35.0690 , LMJLV39_350012500 , LMJSD75_350012000

Length:

622

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AEP4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEP4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	165	167	PF00675	0.492
CLV_NRD_NRD_1	182	184	PF00675	0.303
CLV_NRD_NRD_1	305	307	PF00675	0.475
CLV_NRD_NRD_1	335	337	PF00675	0.425
CLV_NRD_NRD_1	352	354	PF00675	0.266
CLV_NRD_NRD_1	36	38	PF00675	0.285
CLV_NRD_NRD_1	377	379	PF00675	0.448
CLV_NRD_NRD_1	522	524	PF00675	0.290
CLV_NRD_NRD_1	561	563	PF00675	0.527
CLV_PCSK_KEX2_1	165	167	PF00082	0.544
CLV_PCSK_KEX2_1	182	184	PF00082	0.220
CLV_PCSK_KEX2_1	305	307	PF00082	0.475
CLV_PCSK_KEX2_1	335	337	PF00082	0.407
CLV_PCSK_KEX2_1	36	38	PF00082	0.285
CLV_PCSK_KEX2_1	377	379	PF00082	0.423
CLV_PCSK_KEX2_1	522	524	PF00082	0.285
CLV_PCSK_KEX2_1	548	550	PF00082	0.520
CLV_PCSK_KEX2_1	561	563	PF00082	0.445
CLV_PCSK_PC1ET2_1	548	550	PF00082	0.520
CLV_PCSK_SKI1_1	111	115	PF00082	0.424
CLV_PCSK_SKI1_1	182	186	PF00082	0.363
CLV_PCSK_SKI1_1	188	192	PF00082	0.415
CLV_PCSK_SKI1_1	256	260	PF00082	0.324
CLV_PCSK_SKI1_1	31	35	PF00082	0.252
CLV_PCSK_SKI1_1	429	433	PF00082	0.310
CLV_PCSK_SKI1_1	555	559	PF00082	0.406
DOC_MAPK_gen_1	111	119	PF00069	0.355
DOC_MAPK_gen_1	252	261	PF00069	0.363
DOC_MAPK_gen_1	302	310	PF00069	0.469
DOC_PP1_RVXF_1	186	193	PF00149	0.492
DOC_PP1_RVXF_1	559	566	PF00149	0.427
DOC_PP4_MxPP_1	585	588	PF00568	0.555
DOC_USP7_MATH_1	147	151	PF00917	0.374
DOC_USP7_MATH_1	241	245	PF00917	0.313
DOC_USP7_UBL2_3	354	358	PF12436	0.480
DOC_USP7_UBL2_3	548	552	PF12436	0.439
DOC_WW_Pin1_4	135	140	PF00397	0.602
LIG_14-3-3_CanoR_1	31	36	PF00244	0.294
LIG_14-3-3_CanoR_1	351	357	PF00244	0.561
LIG_14-3-3_CanoR_1	404	414	PF00244	0.335
LIG_14-3-3_CanoR_1	542	548	PF00244	0.376
LIG_APCC_ABBA_1	117	122	PF00400	0.323
LIG_APCC_ABBA_1	259	264	PF00400	0.363
LIG_APCC_ABBA_1	343	348	PF00400	0.416
LIG_BIR_III_4	212	216	PF00653	0.363
LIG_Clathr_ClatBox_1	387	391	PF01394	0.344
LIG_Clathr_ClatBox_1	416	420	PF01394	0.304
LIG_eIF4E_1	453	459	PF01652	0.304
LIG_FHA_1	406	412	PF00498	0.327
LIG_FHA_1	570	576	PF00498	0.455
LIG_FHA_2	435	441	PF00498	0.356
LIG_FHA_2	522	528	PF00498	0.478
LIG_FHA_2	591	597	PF00498	0.574
LIG_Integrin_RGD_1	525	527	PF01839	0.604
LIG_LIR_Gen_1	452	461	PF02991	0.285
LIG_LIR_Nem_3	327	332	PF02991	0.352
LIG_LIR_Nem_3	38	43	PF02991	0.304
LIG_LIR_Nem_3	383	388	PF02991	0.364
LIG_LIR_Nem_3	420	424	PF02991	0.285
LIG_LIR_Nem_3	452	456	PF02991	0.285
LIG_PDZ_Class_1	617	622	PF00595	0.768
LIG_Pex14_2	417	421	PF04695	0.363
LIG_SH2_CRK	329	333	PF00017	0.344
LIG_SH2_CRK	367	371	PF00017	0.326
LIG_SH2_CRK	40	44	PF00017	0.304
LIG_SH2_GRB2like	453	456	PF00017	0.285
LIG_SH2_GRB2like	466	469	PF00017	0.285
LIG_SH2_NCK_1	424	428	PF00017	0.304
LIG_SH2_NCK_1	78	82	PF00017	0.304
LIG_SH2_SRC	262	265	PF00017	0.304
LIG_SH2_SRC	89	92	PF00017	0.343
LIG_SH2_STAP1	186	190	PF00017	0.461
LIG_SH2_STAP1	269	273	PF00017	0.375
LIG_SH2_STAP1	29	33	PF00017	0.285
LIG_SH2_STAP1	453	457	PF00017	0.285
LIG_SH2_STAP1	480	484	PF00017	0.252
LIG_SH2_STAP1	89	93	PF00017	0.321
LIG_SH2_STAT3	365	368	PF00017	0.370
LIG_SH2_STAT3	502	505	PF00017	0.415
LIG_SH2_STAT5	100	103	PF00017	0.338
LIG_SH2_STAT5	365	368	PF00017	0.370
LIG_SH2_STAT5	385	388	PF00017	0.206
LIG_SH2_STAT5	418	421	PF00017	0.285
LIG_SH2_STAT5	460	463	PF00017	0.304
LIG_SH2_STAT5	544	547	PF00017	0.381
LIG_SH3_1	137	143	PF00018	0.586
LIG_SH3_2	140	145	PF14604	0.584
LIG_SH3_3	137	143	PF00018	0.539
LIG_SUMO_SIM_anti_2	91	97	PF11976	0.332
LIG_SUMO_SIM_par_1	386	391	PF11976	0.356
LIG_TRAF2_1	588	591	PF00917	0.550
LIG_TRAF2_1	593	596	PF00917	0.544
LIG_TYR_ITIM	98	103	PF00017	0.324
MOD_CK1_1	265	271	PF00069	0.342
MOD_CK1_1	614	620	PF00069	0.676
MOD_CK2_1	434	440	PF00069	0.354
MOD_CK2_1	590	596	PF00069	0.549
MOD_GlcNHglycan	149	152	PF01048	0.369
MOD_GlcNHglycan	608	611	PF01048	0.732
MOD_GlcNHglycan	613	616	PF01048	0.727
MOD_GSK3_1	235	242	PF00069	0.314
MOD_GSK3_1	324	331	PF00069	0.354
MOD_GSK3_1	445	452	PF00069	0.350
MOD_GSK3_1	521	528	PF00069	0.486
MOD_GSK3_1	611	618	PF00069	0.762
MOD_N-GLC_1	128	133	PF02516	0.436
MOD_N-GLC_1	395	400	PF02516	0.473
MOD_N-GLC_1	611	616	PF02516	0.560
MOD_N-GLC_2	221	223	PF02516	0.341
MOD_NEK2_1	113	118	PF00069	0.356
MOD_NEK2_1	184	189	PF00069	0.398
MOD_NEK2_1	328	333	PF00069	0.372
MOD_NEK2_1	402	407	PF00069	0.381
MOD_NEK2_1	98	103	PF00069	0.358
MOD_NEK2_2	300	305	PF00069	0.377
MOD_NEK2_2	47	52	PF00069	0.285
MOD_PIKK_1	569	575	PF00454	0.509
MOD_PKA_2	352	358	PF00069	0.565
MOD_PKA_2	521	527	PF00069	0.479
MOD_PKB_1	523	531	PF00069	0.481
MOD_Plk_1	128	134	PF00069	0.450
MOD_Plk_1	300	306	PF00069	0.393
MOD_Plk_1	395	401	PF00069	0.477
MOD_Plk_1	83	89	PF00069	0.497
MOD_Plk_2-3	24	30	PF00069	0.304
MOD_Plk_4	128	134	PF00069	0.413
MOD_Plk_4	324	330	PF00069	0.358
MOD_ProDKin_1	135	141	PF00069	0.607
MOD_SUMO_for_1	580	583	PF00179	0.448
MOD_SUMO_rev_2	131	139	PF00179	0.513
TRG_DiLeu_BaEn_1	383	388	PF01217	0.346
TRG_DiLeu_BaEn_1	559	564	PF01217	0.492
TRG_DiLeu_BaEn_1	91	96	PF01217	0.316
TRG_DiLeu_BaEn_2	179	185	PF01217	0.346
TRG_DiLeu_BaEn_4	7	13	PF01217	0.302
TRG_ENDOCYTIC_2	100	103	PF00928	0.338
TRG_ENDOCYTIC_2	329	332	PF00928	0.345
TRG_ENDOCYTIC_2	367	370	PF00928	0.329
TRG_ENDOCYTIC_2	385	388	PF00928	0.341
TRG_ENDOCYTIC_2	40	43	PF00928	0.304
TRG_ENDOCYTIC_2	418	421	PF00928	0.285
TRG_ENDOCYTIC_2	453	456	PF00928	0.285
TRG_ENDOCYTIC_2	544	547	PF00928	0.381
TRG_ENDOCYTIC_2	554	557	PF00928	0.380
TRG_ENDOCYTIC_2	78	81	PF00928	0.285
TRG_ER_diArg_1	164	166	PF00400	0.555
TRG_ER_diArg_1	181	183	PF00400	0.214
TRG_ER_diArg_1	304	306	PF00400	0.471
TRG_ER_diArg_1	335	337	PF00400	0.531
TRG_ER_diArg_1	35	37	PF00400	0.285
TRG_ER_diArg_1	350	353	PF00400	0.378
TRG_ER_diArg_1	376	378	PF00400	0.413
TRG_ER_diArg_1	521	523	PF00400	0.285
TRG_ER_diArg_1	561	563	PF00400	0.528
TRG_NES_CRM1_1	409	420	PF08389	0.304
TRG_Pf-PMV_PEXEL_1	104	108	PF00026	0.452
TRG_Pf-PMV_PEXEL_1	335	340	PF00026	0.452
TRG_Pf-PMV_PEXEL_1	561	566	PF00026	0.457

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK39	Leptomonas seymouri	88%	89%
A0A0S4J9A2	Bodo saltans	64%	96%
A0A1X0NJ22	Trypanosomatidae	68%	83%
A0A3S7X8T6	Leishmania donovani	98%	100%
A4HMA1	Leishmania braziliensis	94%	100%
A4IAW6	Leishmania infantum	98%	100%
D0A290	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	89%
E9B5U9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
V5BIM5	Trypanosoma cruzi	72%	89%