RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoporin NUP65, putative

Species:

Leishmania major

UniProt:

E9AEN8_LEIMA

TriTrypDb:

LmjF.35.0630 , LMJLV39_350012000 , LMJSD75_350011500

Length:

597

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9AEN8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEN8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	31	35	PF00656	0.545
CLV_NRD_NRD_1	12	14	PF00675	0.678
CLV_NRD_NRD_1	16	18	PF00675	0.720
CLV_NRD_NRD_1	197	199	PF00675	0.609
CLV_NRD_NRD_1	411	413	PF00675	0.546
CLV_NRD_NRD_1	445	447	PF00675	0.445
CLV_PCSK_FUR_1	13	17	PF00082	0.677
CLV_PCSK_FUR_1	195	199	PF00082	0.575
CLV_PCSK_FUR_1	443	447	PF00082	0.490
CLV_PCSK_KEX2_1	12	14	PF00082	0.678
CLV_PCSK_KEX2_1	15	17	PF00082	0.715
CLV_PCSK_KEX2_1	197	199	PF00082	0.609
CLV_PCSK_KEX2_1	411	413	PF00082	0.546
CLV_PCSK_KEX2_1	445	447	PF00082	0.448
CLV_PCSK_PC7_1	12	18	PF00082	0.735
CLV_PCSK_PC7_1	193	199	PF00082	0.562
CLV_PCSK_PC7_1	441	447	PF00082	0.452
CLV_PCSK_SKI1_1	198	202	PF00082	0.626
CLV_PCSK_SKI1_1	41	45	PF00082	0.678
CLV_PCSK_SKI1_1	445	449	PF00082	0.379
CLV_PCSK_SKI1_1	501	505	PF00082	0.471
DEG_APCC_DBOX_1	562	570	PF00400	0.647
DEG_Nend_Nbox_1	1	3	PF02207	0.435
DEG_SCF_FBW7_1	228	234	PF00400	0.456
DEG_SPOP_SBC_1	142	146	PF00917	0.443
DEG_SPOP_SBC_1	361	365	PF00917	0.437
DOC_ANK_TNKS_1	519	526	PF00023	0.670
DOC_CKS1_1	228	233	PF01111	0.456
DOC_CYCLIN_RxL_1	193	202	PF00134	0.368
DOC_CYCLIN_yCln2_LP_2	374	380	PF00134	0.318
DOC_MAPK_gen_1	12	22	PF00069	0.430
DOC_MAPK_gen_1	172	181	PF00069	0.515
DOC_MAPK_gen_1	501	509	PF00069	0.648
DOC_MAPK_gen_1	561	570	PF00069	0.620
DOC_MAPK_MEF2A_6	172	181	PF00069	0.452
DOC_MAPK_MEF2A_6	561	570	PF00069	0.626
DOC_MAPK_MEF2A_6	580	588	PF00069	0.281
DOC_PP1_SILK_1	37	42	PF00149	0.530
DOC_PP2B_LxvP_1	430	433	PF13499	0.703
DOC_PP4_FxxP_1	132	135	PF00568	0.300
DOC_PP4_FxxP_1	358	361	PF00568	0.451
DOC_SPAK_OSR1_1	379	383	PF12202	0.403
DOC_USP7_MATH_1	156	160	PF00917	0.475
DOC_USP7_MATH_1	215	219	PF00917	0.527
DOC_USP7_MATH_1	231	235	PF00917	0.473
DOC_USP7_MATH_1	243	247	PF00917	0.490
DOC_USP7_MATH_1	285	289	PF00917	0.498
DOC_USP7_MATH_1	294	298	PF00917	0.524
DOC_USP7_MATH_1	314	318	PF00917	0.479
DOC_USP7_MATH_1	35	39	PF00917	0.492
DOC_USP7_MATH_1	361	365	PF00917	0.437
DOC_USP7_MATH_1	397	401	PF00917	0.704
DOC_USP7_MATH_1	437	441	PF00917	0.702
DOC_USP7_MATH_1	496	500	PF00917	0.586
DOC_USP7_MATH_1	532	536	PF00917	0.746
DOC_USP7_MATH_1	67	71	PF00917	0.527
DOC_USP7_MATH_2	460	466	PF00917	0.669
DOC_WW_Pin1_4	131	136	PF00397	0.279
DOC_WW_Pin1_4	21	26	PF00397	0.549
DOC_WW_Pin1_4	227	232	PF00397	0.512
DOC_WW_Pin1_4	362	367	PF00397	0.479
DOC_WW_Pin1_4	428	433	PF00397	0.725
DOC_WW_Pin1_4	456	461	PF00397	0.623
LIG_14-3-3_CanoR_1	143	148	PF00244	0.446
LIG_14-3-3_CanoR_1	232	236	PF00244	0.534
LIG_14-3-3_CanoR_1	276	281	PF00244	0.516
LIG_14-3-3_CanoR_1	449	455	PF00244	0.630
LIG_14-3-3_CanoR_1	580	585	PF00244	0.403
LIG_Actin_WH2_2	389	407	PF00022	0.472
LIG_APCC_ABBAyCdc20_2	185	191	PF00400	0.425
LIG_BRCT_BRCA1_1	145	149	PF00533	0.437
LIG_BRCT_BRCA1_1	355	359	PF00533	0.450
LIG_eIF4E_1	581	587	PF01652	0.318
LIG_FHA_1	307	313	PF00498	0.451
LIG_FHA_1	34	40	PF00498	0.538
LIG_FHA_1	350	356	PF00498	0.477
LIG_FHA_1	369	375	PF00498	0.354
LIG_FHA_1	425	431	PF00498	0.709
LIG_FHA_1	85	91	PF00498	0.340
LIG_FHA_2	153	159	PF00498	0.458
LIG_FHA_2	281	287	PF00498	0.530
LIG_FHA_2	3	9	PF00498	0.445
LIG_FHA_2	536	542	PF00498	0.695
LIG_FHA_2	550	556	PF00498	0.607
LIG_FHA_2	71	77	PF00498	0.522
LIG_IBAR_NPY_1	493	495	PF08397	0.642
LIG_LIR_Apic_2	356	361	PF02991	0.452
LIG_LIR_Gen_1	126	136	PF02991	0.279
LIG_LIR_Gen_1	367	378	PF02991	0.427
LIG_LIR_Gen_1	387	397	PF02991	0.235
LIG_LIR_Gen_1	459	469	PF02991	0.614
LIG_LIR_Gen_1	487	496	PF02991	0.614
LIG_LIR_Gen_1	535	545	PF02991	0.688
LIG_LIR_Gen_1	585	594	PF02991	0.348
LIG_LIR_Gen_1	70	80	PF02991	0.525
LIG_LIR_Gen_1	86	96	PF02991	0.234
LIG_LIR_LC3C_4	176	181	PF02991	0.314
LIG_LIR_Nem_3	104	109	PF02991	0.191
LIG_LIR_Nem_3	126	132	PF02991	0.279
LIG_LIR_Nem_3	319	325	PF02991	0.534
LIG_LIR_Nem_3	367	373	PF02991	0.462
LIG_LIR_Nem_3	387	392	PF02991	0.193
LIG_LIR_Nem_3	462	466	PF02991	0.599
LIG_LIR_Nem_3	487	491	PF02991	0.609
LIG_LIR_Nem_3	535	540	PF02991	0.657
LIG_LIR_Nem_3	585	590	PF02991	0.348
LIG_LIR_Nem_3	70	75	PF02991	0.548
LIG_LIR_Nem_3	86	91	PF02991	0.234
LIG_MLH1_MIPbox_1	355	359	PF16413	0.450
LIG_PCNA_yPIPBox_3	74	84	PF02747	0.476
LIG_Pex14_1	488	492	PF04695	0.569
LIG_Pex14_1	577	581	PF04695	0.318
LIG_SH2_CRK	469	473	PF00017	0.611
LIG_SH2_CRK	581	585	PF00017	0.318
LIG_SH2_NCK_1	325	329	PF00017	0.512
LIG_SH2_STAP1	147	151	PF00017	0.375
LIG_SH2_STAT3	495	498	PF00017	0.678
LIG_SH2_STAT5	105	108	PF00017	0.346
LIG_SH2_STAT5	109	112	PF00017	0.316
LIG_SH2_STAT5	117	120	PF00017	0.271
LIG_SH2_STAT5	322	325	PF00017	0.424
LIG_SH2_STAT5	471	474	PF00017	0.652
LIG_SH2_STAT5	72	75	PF00017	0.528
LIG_SH3_1	470	476	PF00018	0.621
LIG_SH3_2	170	175	PF14604	0.502
LIG_SH3_2	429	434	PF14604	0.706
LIG_SH3_3	167	173	PF00018	0.543
LIG_SH3_3	260	266	PF00018	0.518
LIG_SH3_3	275	281	PF00018	0.519
LIG_SH3_3	293	299	PF00018	0.485
LIG_SH3_3	426	432	PF00018	0.702
LIG_SH3_3	470	476	PF00018	0.621
LIG_SUMO_SIM_anti_2	176	181	PF11976	0.351
LIG_SUMO_SIM_par_1	380	385	PF11976	0.321
LIG_SUMO_SIM_par_1	97	104	PF11976	0.279
LIG_TYR_ITIM	467	472	PF00017	0.599
LIG_WRC_WIRS_1	463	468	PF05994	0.656
LIG_WW_3	172	176	PF00397	0.487
LIG_WW_3	431	435	PF00397	0.704
MOD_CDC14_SPxK_1	431	434	PF00782	0.704
MOD_CDK_SPK_2	227	232	PF00069	0.475
MOD_CDK_SPxK_1	428	434	PF00069	0.707
MOD_CDK_SPxxK_3	362	369	PF00069	0.484
MOD_CK1_1	119	125	PF00069	0.334
MOD_CK1_1	145	151	PF00069	0.440
MOD_CK1_1	159	165	PF00069	0.437
MOD_CK1_1	238	244	PF00069	0.515
MOD_CK1_1	279	285	PF00069	0.514
MOD_CK1_1	290	296	PF00069	0.532
MOD_CK1_1	297	303	PF00069	0.470
MOD_CK1_1	305	311	PF00069	0.556
MOD_CK1_1	342	348	PF00069	0.464
MOD_CK1_1	364	370	PF00069	0.442
MOD_CK1_1	535	541	PF00069	0.650
MOD_CK1_1	582	588	PF00069	0.332
MOD_CK1_1	70	76	PF00069	0.502
MOD_CK2_1	152	158	PF00069	0.453
MOD_CK2_1	280	286	PF00069	0.522
MOD_CK2_1	456	462	PF00069	0.621
MOD_CK2_1	535	541	PF00069	0.692
MOD_CK2_1	549	555	PF00069	0.609
MOD_CK2_1	70	76	PF00069	0.531
MOD_CMANNOS	386	389	PF00535	0.403
MOD_GlcNHglycan	122	125	PF01048	0.485
MOD_GlcNHglycan	233	236	PF01048	0.771
MOD_GlcNHglycan	240	244	PF01048	0.851
MOD_GlcNHglycan	272	275	PF01048	0.768
MOD_GlcNHglycan	292	295	PF01048	0.785
MOD_GlcNHglycan	296	299	PF01048	0.724
MOD_GlcNHglycan	304	307	PF01048	0.697
MOD_GlcNHglycan	31	34	PF01048	0.709
MOD_GlcNHglycan	316	319	PF01048	0.770
MOD_GlcNHglycan	344	347	PF01048	0.647
MOD_GlcNHglycan	366	369	PF01048	0.636
MOD_GlcNHglycan	399	402	PF01048	0.480
MOD_GlcNHglycan	456	459	PF01048	0.422
MOD_GlcNHglycan	514	517	PF01048	0.471
MOD_GlcNHglycan	91	94	PF01048	0.540
MOD_GSK3_1	116	123	PF00069	0.319
MOD_GSK3_1	141	148	PF00069	0.372
MOD_GSK3_1	152	159	PF00069	0.436
MOD_GSK3_1	210	217	PF00069	0.509
MOD_GSK3_1	223	230	PF00069	0.543
MOD_GSK3_1	231	238	PF00069	0.492
MOD_GSK3_1	239	246	PF00069	0.460
MOD_GSK3_1	270	277	PF00069	0.549
MOD_GSK3_1	280	287	PF00069	0.483
MOD_GSK3_1	29	36	PF00069	0.482
MOD_GSK3_1	290	297	PF00069	0.492
MOD_GSK3_1	302	309	PF00069	0.522
MOD_GSK3_1	349	356	PF00069	0.399
MOD_GSK3_1	360	367	PF00069	0.421
MOD_GSK3_1	424	431	PF00069	0.739
MOD_GSK3_1	532	539	PF00069	0.683
MOD_GSK3_1	549	556	PF00069	0.567
MOD_NEK2_1	118	123	PF00069	0.341
MOD_NEK2_1	239	244	PF00069	0.524
MOD_NEK2_1	292	297	PF00069	0.564
MOD_NEK2_1	340	345	PF00069	0.536
MOD_NEK2_1	349	354	PF00069	0.440
MOD_NEK2_1	384	389	PF00069	0.403
MOD_NEK2_1	503	508	PF00069	0.609
MOD_NEK2_1	83	88	PF00069	0.446
MOD_NEK2_2	156	161	PF00069	0.480
MOD_NEK2_2	496	501	PF00069	0.628
MOD_PIKK_1	204	210	PF00454	0.482
MOD_PIKK_1	285	291	PF00454	0.510
MOD_PIKK_1	424	430	PF00454	0.749
MOD_PIKK_1	553	559	PF00454	0.591
MOD_PIKK_1	67	73	PF00454	0.498
MOD_PKA_2	142	148	PF00069	0.440
MOD_PKA_2	231	237	PF00069	0.553
MOD_PKA_2	243	249	PF00069	0.482
MOD_PKA_2	270	276	PF00069	0.578
MOD_PKA_2	368	374	PF00069	0.521
MOD_PKA_2	448	454	PF00069	0.669
MOD_PKA_2	549	555	PF00069	0.706
MOD_PKA_2	579	585	PF00069	0.403
MOD_Plk_4	35	41	PF00069	0.534
MOD_Plk_4	350	356	PF00069	0.499
MOD_Plk_4	462	468	PF00069	0.621
MOD_Plk_4	503	509	PF00069	0.610
MOD_Plk_4	52	58	PF00069	0.418
MOD_Plk_4	582	588	PF00069	0.318
MOD_Plk_4	84	90	PF00069	0.264
MOD_ProDKin_1	131	137	PF00069	0.279
MOD_ProDKin_1	21	27	PF00069	0.549
MOD_ProDKin_1	227	233	PF00069	0.513
MOD_ProDKin_1	362	368	PF00069	0.473
MOD_ProDKin_1	428	434	PF00069	0.727
MOD_ProDKin_1	456	462	PF00069	0.621
TRG_DiLeu_BaEn_1	565	570	PF01217	0.618
TRG_DiLeu_BaEn_2	461	467	PF01217	0.601
TRG_DiLeu_BaLyEn_6	260	265	PF01217	0.519
TRG_DiLeu_BaLyEn_6	498	503	PF01217	0.644
TRG_ENDOCYTIC_2	117	120	PF00928	0.339
TRG_ENDOCYTIC_2	129	132	PF00928	0.236
TRG_ENDOCYTIC_2	375	378	PF00928	0.318
TRG_ENDOCYTIC_2	463	466	PF00928	0.595
TRG_ENDOCYTIC_2	469	472	PF00928	0.610
TRG_ENDOCYTIC_2	581	584	PF00928	0.318
TRG_ENDOCYTIC_2	72	75	PF00928	0.528
TRG_ER_diArg_1	12	15	PF00400	0.484
TRG_ER_diArg_1	195	198	PF00400	0.397
TRG_ER_diArg_1	442	445	PF00400	0.711
TRG_ER_diArg_1	560	563	PF00400	0.584
TRG_Pf-PMV_PEXEL_1	198	202	PF00026	0.615
TRG_Pf-PMV_PEXEL_1	434	438	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	501	505	PF00026	0.471

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRZ6	Leptomonas seymouri	47%	100%
A0A3S7X8T0	Leishmania donovani	90%	100%
A4HM96	Leishmania braziliensis	77%	100%
A4IAW0	Leishmania infantum	91%	100%
E9B5U4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%