GPI transamidase component PIG-S

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

E9AEN7_LEIMA

TriTrypDb:

LmjF.35.0620 , LMJLV39_350011900 , LMJSD75_350011400

Length:

378

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AEN7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEN7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.450
CLV_C14_Caspase3-7	163	167	PF00656	0.525
CLV_C14_Caspase3-7	249	253	PF00656	0.481
CLV_C14_Caspase3-7	369	373	PF00656	0.465
CLV_NRD_NRD_1	199	201	PF00675	0.610
CLV_NRD_NRD_1	22	24	PF00675	0.428
CLV_NRD_NRD_1	29	31	PF00675	0.377
CLV_NRD_NRD_1	56	58	PF00675	0.622
CLV_PCSK_KEX2_1	199	201	PF00082	0.603
CLV_PCSK_KEX2_1	22	24	PF00082	0.428
CLV_PCSK_KEX2_1	28	30	PF00082	0.390
CLV_PCSK_KEX2_1	56	58	PF00082	0.622
CLV_PCSK_SKI1_1	200	204	PF00082	0.624
CLV_PCSK_SKI1_1	30	34	PF00082	0.272
CLV_PCSK_SKI1_1	64	68	PF00082	0.682
DEG_APCC_DBOX_1	130	138	PF00400	0.438
DEG_APCC_DBOX_1	63	71	PF00400	0.479
DEG_MDM2_SWIB_1	34	42	PF02201	0.308
DEG_SIAH_1	340	348	PF03145	0.500
DOC_CYCLIN_yCln2_LP_2	357	363	PF00134	0.501
DOC_MAPK_DCC_7	348	357	PF00069	0.417
DOC_MAPK_gen_1	173	182	PF00069	0.516
DOC_MAPK_HePTP_8	332	344	PF00069	0.384
DOC_MAPK_MEF2A_6	335	344	PF00069	0.385
DOC_PP2B_LxvP_1	69	72	PF13499	0.478
DOC_PP4_FxxP_1	138	141	PF00568	0.399
DOC_PP4_FxxP_1	46	49	PF00568	0.308
DOC_WW_Pin1_4	350	355	PF00397	0.486
LIG_14-3-3_CanoR_1	173	178	PF00244	0.477
LIG_14-3-3_CanoR_1	298	302	PF00244	0.503
LIG_14-3-3_CanoR_1	89	94	PF00244	0.436
LIG_CaM_IQ_9	74	90	PF13499	0.397
LIG_Clathr_ClatBox_1	355	359	PF01394	0.468
LIG_FHA_1	214	220	PF00498	0.395
LIG_FHA_1	22	28	PF00498	0.646
LIG_FHA_1	255	261	PF00498	0.416
LIG_FHA_1	71	77	PF00498	0.466
LIG_FHA_2	130	136	PF00498	0.442
LIG_FHA_2	174	180	PF00498	0.479
LIG_FHA_2	317	323	PF00498	0.456
LIG_FHA_2	367	373	PF00498	0.471
LIG_GBD_Chelix_1	218	226	PF00786	0.575
LIG_LIR_Apic_2	135	141	PF02991	0.449
LIG_LIR_Apic_2	44	49	PF02991	0.308
LIG_NRBOX	260	266	PF00104	0.450
LIG_Pex14_2	120	124	PF04695	0.376
LIG_Pex14_2	34	38	PF04695	0.351
LIG_Pex14_2	46	50	PF04695	0.351
LIG_SH2_CRK	52	56	PF00017	0.438
LIG_SH2_SRC	125	128	PF00017	0.448
LIG_SH2_STAT5	125	128	PF00017	0.540
LIG_SH2_STAT5	142	145	PF00017	0.445
LIG_SH2_STAT5	329	332	PF00017	0.428
LIG_SH2_STAT5	35	38	PF00017	0.284
LIG_SH3_2	188	193	PF14604	0.441
LIG_SH3_3	150	156	PF00018	0.482
LIG_SH3_3	162	168	PF00018	0.432
LIG_SH3_3	185	191	PF00018	0.445
LIG_SH3_3	234	240	PF00018	0.524
LIG_SH3_3	335	341	PF00018	0.469
LIG_SUMO_SIM_par_1	340	346	PF11976	0.403
LIG_SUMO_SIM_par_1	72	77	PF11976	0.465
LIG_TRAF2_1	221	224	PF00917	0.434
LIG_TRAF2_1	277	280	PF00917	0.478
LIG_TRAF2_1	319	322	PF00917	0.581
LIG_TRFH_1	124	128	PF08558	0.407
LIG_TRFH_1	356	360	PF08558	0.419
LIG_TYR_ITIM	2	7	PF00017	0.593
LIG_UBA3_1	264	273	PF00899	0.427
LIG_WW_3	19	23	PF00397	0.627
MOD_CK1_1	129	135	PF00069	0.512
MOD_CK1_1	227	233	PF00069	0.449
MOD_CK1_1	366	372	PF00069	0.541
MOD_CK1_1	41	47	PF00069	0.318
MOD_CK2_1	173	179	PF00069	0.482
MOD_CK2_1	316	322	PF00069	0.468
MOD_CK2_1	59	65	PF00069	0.453
MOD_GlcNHglycan	229	232	PF01048	0.738
MOD_GlcNHglycan	303	306	PF01048	0.655
MOD_GlcNHglycan	348	351	PF01048	0.723
MOD_GSK3_1	293	300	PF00069	0.455
MOD_GSK3_1	346	353	PF00069	0.515
MOD_GSK3_1	70	77	PF00069	0.449
MOD_NEK2_1	222	227	PF00069	0.509
MOD_NEK2_1	266	271	PF00069	0.428
MOD_NEK2_1	293	298	PF00069	0.528
MOD_NEK2_1	301	306	PF00069	0.472
MOD_PIKK_1	224	230	PF00454	0.443
MOD_PIKK_1	74	80	PF00454	0.411
MOD_PKA_1	22	28	PF00069	0.586
MOD_PKA_2	21	27	PF00069	0.623
MOD_PKA_2	297	303	PF00069	0.487
MOD_PKB_1	57	65	PF00069	0.449
MOD_Plk_1	74	80	PF00069	0.415
MOD_Plk_4	3	9	PF00069	0.590
MOD_Plk_4	41	47	PF00069	0.323
MOD_ProDKin_1	350	356	PF00069	0.487
MOD_SUMO_rev_2	207	216	PF00179	0.428
TRG_DiLeu_BaEn_1	214	219	PF01217	0.467
TRG_DiLeu_BaEn_1	65	70	PF01217	0.482
TRG_ENDOCYTIC_2	329	332	PF00928	0.428
TRG_ENDOCYTIC_2	4	7	PF00928	0.614
TRG_ENDOCYTIC_2	52	55	PF00928	0.436
TRG_ER_diArg_1	131	134	PF00400	0.451
TRG_ER_diArg_1	172	175	PF00400	0.513
TRG_ER_diArg_1	198	200	PF00400	0.403
TRG_ER_diArg_1	21	23	PF00400	0.656
TRG_ER_diArg_1	27	30	PF00400	0.571
TRG_ER_diArg_1	55	57	PF00400	0.418
TRG_Pf-PMV_PEXEL_1	175	179	PF00026	0.725
TRG_Pf-PMV_PEXEL_1	200	204	PF00026	0.643
TRG_Pf-PMV_PEXEL_1	56	61	PF00026	0.617

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGT9	Leptomonas seymouri	42%	100%
A0A3Q8IEV9	Leishmania donovani	88%	100%
A4HM95	Leishmania braziliensis	74%	100%
A4IAV9	Leishmania infantum	88%	98%
E9B5U3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%