LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
E9AEN4_LEIMA
TriTrypDb:
LmjF.35.0590 , LMJLV39_350011600 * , LMJSD75_350011100 *
Length:
712

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AEN4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEN4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 353 357 PF00656 0.696
CLV_C14_Caspase3-7 516 520 PF00656 0.727
CLV_MEL_PAP_1 40 46 PF00089 0.710
CLV_NRD_NRD_1 301 303 PF00675 0.678
CLV_NRD_NRD_1 306 308 PF00675 0.689
CLV_NRD_NRD_1 468 470 PF00675 0.747
CLV_NRD_NRD_1 55 57 PF00675 0.585
CLV_NRD_NRD_1 555 557 PF00675 0.674
CLV_NRD_NRD_1 688 690 PF00675 0.742
CLV_PCSK_FUR_1 302 306 PF00082 0.681
CLV_PCSK_KEX2_1 196 198 PF00082 0.672
CLV_PCSK_KEX2_1 273 275 PF00082 0.588
CLV_PCSK_KEX2_1 303 305 PF00082 0.684
CLV_PCSK_KEX2_1 306 308 PF00082 0.689
CLV_PCSK_KEX2_1 467 469 PF00082 0.761
CLV_PCSK_KEX2_1 55 57 PF00082 0.585
CLV_PCSK_KEX2_1 555 557 PF00082 0.674
CLV_PCSK_KEX2_1 688 690 PF00082 0.742
CLV_PCSK_PC1ET2_1 196 198 PF00082 0.672
CLV_PCSK_PC1ET2_1 273 275 PF00082 0.588
CLV_PCSK_PC1ET2_1 303 305 PF00082 0.680
CLV_PCSK_PC7_1 300 306 PF00082 0.691
CLV_PCSK_SKI1_1 434 438 PF00082 0.669
CLV_PCSK_SKI1_1 468 472 PF00082 0.746
DEG_APCC_DBOX_1 157 165 PF00400 0.690
DEG_APCC_DBOX_1 467 475 PF00400 0.742
DEG_SCF_FBW7_1 508 515 PF00400 0.727
DEG_SPOP_SBC_1 512 516 PF00917 0.718
DOC_MAPK_gen_1 467 476 PF00069 0.647
DOC_MAPK_MEF2A_6 695 704 PF00069 0.712
DOC_MAPK_NFAT4_5 695 703 PF00069 0.710
DOC_PP2B_LxvP_1 259 262 PF13499 0.670
DOC_PP2B_LxvP_1 437 440 PF13499 0.655
DOC_PP2B_LxvP_1 86 89 PF13499 0.677
DOC_PP4_MxPP_1 585 588 PF00568 0.547
DOC_USP7_MATH_1 107 111 PF00917 0.676
DOC_USP7_MATH_1 348 352 PF00917 0.659
DOC_USP7_MATH_1 354 358 PF00917 0.623
DOC_USP7_MATH_1 373 377 PF00917 0.503
DOC_USP7_MATH_1 402 406 PF00917 0.648
DOC_USP7_MATH_1 432 436 PF00917 0.736
DOC_USP7_MATH_1 623 627 PF00917 0.542
DOC_USP7_MATH_1 654 658 PF00917 0.796
DOC_USP7_MATH_1 680 684 PF00917 0.724
DOC_WW_Pin1_4 266 271 PF00397 0.742
DOC_WW_Pin1_4 395 400 PF00397 0.728
DOC_WW_Pin1_4 506 511 PF00397 0.790
LIG_14-3-3_CanoR_1 219 228 PF00244 0.599
LIG_14-3-3_CanoR_1 232 240 PF00244 0.578
LIG_14-3-3_CanoR_1 336 344 PF00244 0.756
LIG_14-3-3_CanoR_1 43 53 PF00244 0.692
LIG_14-3-3_CanoR_1 490 500 PF00244 0.641
LIG_14-3-3_CanoR_1 55 61 PF00244 0.562
LIG_14-3-3_CanoR_1 580 586 PF00244 0.663
LIG_14-3-3_CanoR_1 605 615 PF00244 0.664
LIG_14-3-3_CanoR_1 67 77 PF00244 0.528
LIG_14-3-3_CanoR_1 681 685 PF00244 0.598
LIG_BRCT_BRCA1_1 208 212 PF00533 0.677
LIG_Clathr_ClatBox_1 246 250 PF01394 0.547
LIG_deltaCOP1_diTrp_1 153 157 PF00928 0.626
LIG_deltaCOP1_diTrp_1 169 172 PF00928 0.501
LIG_FHA_1 120 126 PF00498 0.635
LIG_FHA_1 281 287 PF00498 0.759
LIG_FHA_1 519 525 PF00498 0.744
LIG_FHA_2 261 267 PF00498 0.775
LIG_FHA_2 351 357 PF00498 0.697
LIG_FHA_2 406 412 PF00498 0.594
LIG_FHA_2 643 649 PF00498 0.623
LIG_LIR_Gen_1 121 132 PF02991 0.645
LIG_LIR_Gen_1 168 174 PF02991 0.701
LIG_LIR_Gen_1 248 259 PF02991 0.475
LIG_LIR_Gen_1 530 539 PF02991 0.736
LIG_LIR_Nem_3 121 127 PF02991 0.641
LIG_LIR_Nem_3 140 144 PF02991 0.722
LIG_LIR_Nem_3 168 173 PF02991 0.599
LIG_LIR_Nem_3 209 215 PF02991 0.676
LIG_LIR_Nem_3 248 254 PF02991 0.636
LIG_LIR_Nem_3 356 362 PF02991 0.543
LIG_LIR_Nem_3 530 535 PF02991 0.626
LIG_MLH1_MIPbox_1 208 212 PF16413 0.677
LIG_MYND_3 29 33 PF01753 0.717
LIG_NRBOX 701 707 PF00104 0.486
LIG_PCNA_PIPBox_1 205 214 PF02747 0.580
LIG_Pex14_1 690 694 PF04695 0.723
LIG_SH2_NCK_1 221 225 PF00017 0.495
LIG_SH2_SRC 59 62 PF00017 0.682
LIG_SH2_STAP1 166 170 PF00017 0.692
LIG_SH2_STAP1 422 426 PF00017 0.683
LIG_SH2_STAT3 607 610 PF00017 0.498
LIG_SH2_STAT5 359 362 PF00017 0.644
LIG_SH2_STAT5 407 410 PF00017 0.720
LIG_SH2_STAT5 426 429 PF00017 0.550
LIG_SH2_STAT5 438 441 PF00017 0.576
LIG_SH3_3 20 26 PF00018 0.677
LIG_SH3_3 282 288 PF00018 0.797
LIG_SH3_3 396 402 PF00018 0.776
LIG_SH3_3 583 589 PF00018 0.764
LIG_SUMO_SIM_par_1 244 250 PF11976 0.555
LIG_TRAF2_1 150 153 PF00917 0.660
LIG_TRAF2_1 175 178 PF00917 0.687
LIG_TRAF2_1 470 473 PF00917 0.738
LIG_UBA3_1 363 367 PF00899 0.744
LIG_ULM_U2AF65_1 302 309 PF00076 0.690
LIG_WRC_WIRS_1 208 213 PF05994 0.677
MOD_CDK_SPxxK_3 266 273 PF00069 0.741
MOD_CK1_1 116 122 PF00069 0.725
MOD_CK1_1 143 149 PF00069 0.673
MOD_CK1_1 327 333 PF00069 0.678
MOD_CK1_1 343 349 PF00069 0.712
MOD_CK1_1 380 386 PF00069 0.791
MOD_CK1_1 405 411 PF00069 0.647
MOD_CK1_1 491 497 PF00069 0.645
MOD_CK1_1 533 539 PF00069 0.545
MOD_CK1_1 545 551 PF00069 0.605
MOD_CK1_1 644 650 PF00069 0.800
MOD_CK1_1 8 14 PF00069 0.711
MOD_CK2_1 134 140 PF00069 0.674
MOD_CK2_1 172 178 PF00069 0.613
MOD_CK2_1 250 256 PF00069 0.496
MOD_CK2_1 405 411 PF00069 0.679
MOD_CK2_1 54 60 PF00069 0.763
MOD_CK2_1 659 665 PF00069 0.579
MOD_CK2_1 680 686 PF00069 0.650
MOD_CK2_1 79 85 PF00069 0.691
MOD_CMANNOS 154 157 PF00535 0.719
MOD_GlcNHglycan 103 106 PF01048 0.743
MOD_GlcNHglycan 110 113 PF01048 0.649
MOD_GlcNHglycan 136 139 PF01048 0.679
MOD_GlcNHglycan 145 148 PF01048 0.788
MOD_GlcNHglycan 326 329 PF01048 0.709
MOD_GlcNHglycan 350 353 PF01048 0.580
MOD_GlcNHglycan 373 376 PF01048 0.809
MOD_GlcNHglycan 434 437 PF01048 0.753
MOD_GlcNHglycan 441 444 PF01048 0.661
MOD_GlcNHglycan 541 545 PF01048 0.689
MOD_GlcNHglycan 56 59 PF01048 0.750
MOD_GlcNHglycan 637 641 PF01048 0.785
MOD_GlcNHglycan 655 659 PF01048 0.547
MOD_GlcNHglycan 673 676 PF01048 0.488
MOD_GSK3_1 130 137 PF00069 0.717
MOD_GSK3_1 180 187 PF00069 0.616
MOD_GSK3_1 327 334 PF00069 0.702
MOD_GSK3_1 340 347 PF00069 0.703
MOD_GSK3_1 350 357 PF00069 0.621
MOD_GSK3_1 373 380 PF00069 0.727
MOD_GSK3_1 402 409 PF00069 0.623
MOD_GSK3_1 42 49 PF00069 0.672
MOD_GSK3_1 486 493 PF00069 0.605
MOD_GSK3_1 508 515 PF00069 0.746
MOD_GSK3_1 533 540 PF00069 0.558
MOD_GSK3_1 619 626 PF00069 0.666
MOD_GSK3_1 642 649 PF00069 0.775
MOD_GSK3_1 680 687 PF00069 0.594
MOD_LATS_1 217 223 PF00433 0.460
MOD_N-GLC_1 116 121 PF02516 0.679
MOD_N-GLC_2 393 395 PF02516 0.705
MOD_N-GLC_2 558 560 PF02516 0.728
MOD_NEK2_1 172 177 PF00069 0.602
MOD_NEK2_1 190 195 PF00069 0.685
MOD_NEK2_1 293 298 PF00069 0.740
MOD_NEK2_1 340 345 PF00069 0.803
MOD_NEK2_1 417 422 PF00069 0.604
MOD_NEK2_1 513 518 PF00069 0.784
MOD_NEK2_1 542 547 PF00069 0.683
MOD_NEK2_1 614 619 PF00069 0.563
MOD_NEK2_1 670 675 PF00069 0.665
MOD_NEK2_2 207 212 PF00069 0.683
MOD_NEK2_2 354 359 PF00069 0.560
MOD_NEK2_2 575 580 PF00069 0.652
MOD_NEK2_2 680 685 PF00069 0.676
MOD_OFUCOSY 488 495 PF10250 0.615
MOD_OFUCOSY 672 677 PF10250 0.698
MOD_PIKK_1 119 125 PF00454 0.642
MOD_PIKK_1 172 178 PF00454 0.712
MOD_PIKK_1 307 313 PF00454 0.789
MOD_PIKK_1 530 536 PF00454 0.693
MOD_PIKK_1 606 612 PF00454 0.651
MOD_PIKK_1 623 629 PF00454 0.475
MOD_PKA_2 101 107 PF00069 0.596
MOD_PKA_2 231 237 PF00069 0.703
MOD_PKA_2 332 338 PF00069 0.800
MOD_PKA_2 42 48 PF00069 0.735
MOD_PKA_2 489 495 PF00069 0.611
MOD_PKA_2 54 60 PF00069 0.581
MOD_PKA_2 642 648 PF00069 0.694
MOD_PKA_2 680 686 PF00069 0.693
MOD_PKB_1 128 136 PF00069 0.639
MOD_PKB_1 158 166 PF00069 0.712
MOD_PKB_1 305 313 PF00069 0.676
MOD_Plk_1 197 203 PF00069 0.661
MOD_Plk_1 280 286 PF00069 0.608
MOD_Plk_1 518 524 PF00069 0.749
MOD_Plk_1 8 14 PF00069 0.711
MOD_Plk_1 94 100 PF00069 0.718
MOD_Plk_2-3 250 256 PF00069 0.510
MOD_Plk_4 160 166 PF00069 0.610
MOD_Plk_4 207 213 PF00069 0.682
MOD_Plk_4 281 287 PF00069 0.799
MOD_Plk_4 354 360 PF00069 0.557
MOD_Plk_4 402 408 PF00069 0.584
MOD_Plk_4 46 52 PF00069 0.642
MOD_Plk_4 518 524 PF00069 0.713
MOD_Plk_4 581 587 PF00069 0.578
MOD_Plk_4 94 100 PF00069 0.739
MOD_ProDKin_1 266 272 PF00069 0.741
MOD_ProDKin_1 395 401 PF00069 0.727
MOD_ProDKin_1 506 512 PF00069 0.792
MOD_SUMO_for_1 195 198 PF00179 0.754
TRG_DiLeu_LyEn_5 242 247 PF01217 0.575
TRG_ENDOCYTIC_2 426 429 PF00928 0.609
TRG_ER_diArg_1 127 130 PF00400 0.678
TRG_ER_diArg_1 157 160 PF00400 0.704
TRG_ER_diArg_1 302 305 PF00400 0.684
TRG_ER_diArg_1 306 308 PF00400 0.690
TRG_ER_diArg_1 319 322 PF00400 0.703
TRG_ER_diArg_1 466 469 PF00400 0.757
TRG_ER_diArg_1 555 557 PF00400 0.701
TRG_ER_diArg_1 688 690 PF00400 0.641
TRG_NLS_MonoCore_2 301 306 PF00514 0.676
TRG_NLS_MonoExtC_3 301 306 PF00514 0.681
TRG_NLS_MonoExtN_4 300 307 PF00514 0.681
TRG_Pf-PMV_PEXEL_1 307 311 PF00026 0.709
TRG_Pf-PMV_PEXEL_1 469 473 PF00026 0.741

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3A3 Leptomonas seymouri 29% 100%
A0A3S7X8U8 Leishmania donovani 87% 100%
A4HM92 Leishmania braziliensis 64% 100%
A4IAV6 Leishmania infantum 88% 100%
E9B5U0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS