Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AEM4_LEIMA

TriTrypDb:

LmjF.35.0470 , LMJLV39_350010100 , LMJSD75_350010000

Length:

196

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AEM4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEM4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	55	59	PF00656	0.647
CLV_NRD_NRD_1	40	42	PF00675	0.423
CLV_PCSK_KEX2_1	40	42	PF00082	0.423
CLV_PCSK_SKI1_1	139	143	PF00082	0.453
CLV_PCSK_SKI1_1	3	7	PF00082	0.655
DEG_Nend_UBRbox_3	1	3	PF02207	0.465
DOC_CKS1_1	191	196	PF01111	0.434
DOC_CYCLIN_RxL_1	136	143	PF00134	0.610
DOC_CYCLIN_yClb1_LxF_4	1	6	PF00134	0.459
DOC_PP1_RVXF_1	1	7	PF00149	0.458
DOC_PP2B_LxvP_1	66	69	PF13499	0.692
DOC_PP4_FxxP_1	163	166	PF00568	0.549
DOC_PP4_FxxP_1	6	9	PF00568	0.448
DOC_USP7_MATH_1	115	119	PF00917	0.576
DOC_USP7_MATH_1	96	100	PF00917	0.651
DOC_WW_Pin1_4	122	127	PF00397	0.650
DOC_WW_Pin1_4	183	188	PF00397	0.430
DOC_WW_Pin1_4	190	195	PF00397	0.410
DOC_WW_Pin1_4	4	9	PF00397	0.460
DOC_WW_Pin1_4	72	77	PF00397	0.778
LIG_14-3-3_CanoR_1	40	45	PF00244	0.662
LIG_14-3-3_CanoR_1	62	67	PF00244	0.788
LIG_FHA_1	101	107	PF00498	0.694
LIG_FHA_1	159	165	PF00498	0.518
LIG_Integrin_RGD_1	56	58	PF01839	0.448
LIG_LIR_Apic_2	161	166	PF02991	0.551
LIG_MYND_1	11	15	PF01753	0.539
LIG_NRBOX	136	142	PF00104	0.590
LIG_PTB_Apo_2	141	148	PF02174	0.585
LIG_SH2_CRK	171	175	PF00017	0.476
LIG_SH2_STAP1	171	175	PF00017	0.476
LIG_SH2_STAT5	162	165	PF00017	0.552
LIG_SH2_STAT5	171	174	PF00017	0.386
LIG_SH3_3	120	126	PF00018	0.712
LIG_SH3_3	151	157	PF00018	0.279
LIG_SH3_3	184	190	PF00018	0.432
LIG_SH3_3	5	11	PF00018	0.541
LIG_SUMO_SIM_anti_2	22	28	PF11976	0.279
LIG_SUMO_SIM_par_1	96	104	PF11976	0.646
LIG_TRFH_1	162	166	PF08558	0.552
LIG_TYR_ITIM	169	174	PF00017	0.434
LIG_WRC_WIRS_1	170	175	PF05994	0.439
MOD_CDK_SPK_2	183	188	PF00069	0.430
MOD_CDK_SPxxK_3	72	79	PF00069	0.690
MOD_CK1_1	186	192	PF00069	0.464
MOD_CK1_1	83	89	PF00069	0.746
MOD_CK1_1	99	105	PF00069	0.612
MOD_CK2_1	72	78	PF00069	0.687
MOD_GlcNHglycan	106	109	PF01048	0.520
MOD_GlcNHglycan	116	120	PF01048	0.444
MOD_GlcNHglycan	62	65	PF01048	0.504
MOD_GlcNHglycan	85	88	PF01048	0.537
MOD_GSK3_1	169	176	PF00069	0.435
MOD_GSK3_1	186	193	PF00069	0.413
MOD_GSK3_1	58	65	PF00069	0.694
MOD_GSK3_1	68	75	PF00069	0.713
MOD_GSK3_1	81	88	PF00069	0.730
MOD_GSK3_1	96	103	PF00069	0.629
MOD_N-GLC_1	58	63	PF02516	0.448
MOD_NEK2_1	27	32	PF00069	0.438
MOD_NEK2_1	81	86	PF00069	0.712
MOD_PIKK_1	164	170	PF00454	0.438
MOD_PKA_1	40	46	PF00069	0.629
MOD_PKA_2	164	170	PF00069	0.438
MOD_PKA_2	40	46	PF00069	0.668
MOD_Plk_4	158	164	PF00069	0.422
MOD_Plk_4	169	175	PF00069	0.464
MOD_Plk_4	62	68	PF00069	0.811
MOD_ProDKin_1	122	128	PF00069	0.650
MOD_ProDKin_1	183	189	PF00069	0.431
MOD_ProDKin_1	190	196	PF00069	0.414
MOD_ProDKin_1	4	10	PF00069	0.457
MOD_ProDKin_1	72	78	PF00069	0.778
TRG_DiLeu_BaEn_2	142	148	PF01217	0.641
TRG_DiLeu_BaLyEn_6	129	134	PF01217	0.645
TRG_DiLeu_BaLyEn_6	136	141	PF01217	0.607
TRG_ENDOCYTIC_2	171	174	PF00928	0.474
TRG_Pf-PMV_PEXEL_1	139	143	PF00026	0.404

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X8T7	Leishmania donovani	73%	89%
A4IAU6	Leishmania infantum	79%	98%