HAP2-GCS1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Generative cell specific 1 protein, putative

Species:

Leishmania major

UniProt:

E9AEM3_LEIMA

TriTrypDb:

LmjF.35.0460 , LMJLV39_350009900 , LMJSD75_350009800

Length:

917

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	7
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9AEM3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEM3

Function

Biological processes
Term	Name	Level	Count
GO:0007338	single fertilization	3	7
GO:0009566	fertilization	2	7
GO:0022414	reproductive process	1	7

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0008289	lipid binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	622	626	PF00656	0.259
CLV_NRD_NRD_1	654	656	PF00675	0.556
CLV_NRD_NRD_1	696	698	PF00675	0.558
CLV_NRD_NRD_1	718	720	PF00675	0.601
CLV_NRD_NRD_1	905	907	PF00675	0.609
CLV_PCSK_KEX2_1	653	655	PF00082	0.552
CLV_PCSK_KEX2_1	696	698	PF00082	0.558
CLV_PCSK_KEX2_1	717	719	PF00082	0.599
CLV_PCSK_KEX2_1	905	907	PF00082	0.609
CLV_PCSK_PC1ET2_1	717	719	PF00082	0.577
CLV_PCSK_SKI1_1	101	105	PF00082	0.410
CLV_PCSK_SKI1_1	127	131	PF00082	0.734
CLV_PCSK_SKI1_1	373	377	PF00082	0.626
DEG_APCC_DBOX_1	203	211	PF00400	0.426
DEG_SCF_FBW7_1	872	878	PF00400	0.844
DEG_SPOP_SBC_1	724	728	PF00917	0.680
DEG_SPOP_SBC_1	867	871	PF00917	0.674
DOC_CKS1_1	872	877	PF01111	0.844
DOC_CYCLIN_yCln2_LP_2	122	128	PF00134	0.686
DOC_CYCLIN_yCln2_LP_2	375	381	PF00134	0.353
DOC_CYCLIN_yCln2_LP_2	808	811	PF00134	0.740
DOC_MAPK_gen_1	151	159	PF00069	0.351
DOC_MAPK_gen_1	653	662	PF00069	0.455
DOC_MAPK_gen_1	75	85	PF00069	0.549
DOC_MAPK_HePTP_8	652	664	PF00069	0.470
DOC_MAPK_MEF2A_6	151	159	PF00069	0.351
DOC_MAPK_MEF2A_6	63	71	PF00069	0.434
DOC_MAPK_MEF2A_6	655	664	PF00069	0.370
DOC_MAPK_MEF2A_6	78	85	PF00069	0.561
DOC_PP1_RVXF_1	601	608	PF00149	0.353
DOC_PP2B_LxvP_1	375	378	PF13499	0.353
DOC_PP2B_LxvP_1	395	398	PF13499	0.190
DOC_PP2B_LxvP_1	796	799	PF13499	0.748
DOC_PP2B_LxvP_1	808	811	PF13499	0.777
DOC_PP4_FxxP_1	846	849	PF00568	0.758
DOC_PP4_MxPP_1	809	812	PF00568	0.770
DOC_USP7_MATH_1	129	133	PF00917	0.506
DOC_USP7_MATH_1	418	422	PF00917	0.353
DOC_USP7_MATH_1	624	628	PF00917	0.301
DOC_USP7_MATH_1	724	728	PF00917	0.680
DOC_USP7_MATH_1	774	778	PF00917	0.804
DOC_USP7_MATH_1	785	789	PF00917	0.739
DOC_USP7_MATH_1	840	844	PF00917	0.755
DOC_USP7_MATH_1	875	879	PF00917	0.846
DOC_WW_Pin1_4	187	192	PF00397	0.353
DOC_WW_Pin1_4	336	341	PF00397	0.353
DOC_WW_Pin1_4	471	476	PF00397	0.311
DOC_WW_Pin1_4	480	485	PF00397	0.311
DOC_WW_Pin1_4	747	752	PF00397	0.804
DOC_WW_Pin1_4	781	786	PF00397	0.730
DOC_WW_Pin1_4	787	792	PF00397	0.797
DOC_WW_Pin1_4	836	841	PF00397	0.746
DOC_WW_Pin1_4	868	873	PF00397	0.841
DOC_WW_Pin1_4	880	885	PF00397	0.703
DOC_WW_Pin1_4	889	894	PF00397	0.720
DOC_WW_Pin1_4	900	905	PF00397	0.610
DOC_WW_Pin1_4	906	911	PF00397	0.757
DOC_WW_Pin1_4	93	98	PF00397	0.808
LIG_14-3-3_CanoR_1	193	201	PF00244	0.426
LIG_14-3-3_CanoR_1	22	29	PF00244	0.689
LIG_14-3-3_CanoR_1	38	42	PF00244	0.570
LIG_14-3-3_CanoR_1	603	608	PF00244	0.426
LIG_14-3-3_CanoR_1	877	885	PF00244	0.821
LIG_14-3-3_CanoR_1	898	904	PF00244	0.792
LIG_14-3-3_CanoR_1	90	94	PF00244	0.730
LIG_BIR_III_4	246	250	PF00653	0.426
LIG_BRCT_BRCA1_1	168	172	PF00533	0.426
LIG_BRCT_BRCA1_1	185	189	PF00533	0.225
LIG_BRCT_BRCA1_1	254	258	PF00533	0.353
LIG_BRCT_BRCA1_1	610	614	PF00533	0.426
LIG_BRCT_BRCA1_1	842	846	PF00533	0.813
LIG_Clathr_ClatBox_1	401	405	PF01394	0.327
LIG_Clathr_ClatBox_1	659	663	PF01394	0.396
LIG_CtBP_PxDLS_1	367	371	PF00389	0.353
LIG_EVH1_1	796	800	PF00568	0.829
LIG_FHA_1	154	160	PF00498	0.426
LIG_FHA_1	238	244	PF00498	0.347
LIG_FHA_1	265	271	PF00498	0.426
LIG_FHA_1	311	317	PF00498	0.314
LIG_FHA_1	397	403	PF00498	0.426
LIG_FHA_1	441	447	PF00498	0.353
LIG_FHA_1	48	54	PF00498	0.427
LIG_FHA_1	499	505	PF00498	0.421
LIG_FHA_1	527	533	PF00498	0.348
LIG_FHA_1	537	543	PF00498	0.260
LIG_FHA_1	570	576	PF00498	0.354
LIG_FHA_1	587	593	PF00498	0.234
LIG_FHA_1	643	649	PF00498	0.346
LIG_FHA_1	78	84	PF00498	0.581
LIG_FHA_1	788	794	PF00498	0.841
LIG_FHA_1	868	874	PF00498	0.675
LIG_LIR_Apic_2	843	849	PF02991	0.761
LIG_LIR_Apic_2	92	97	PF02991	0.643
LIG_LIR_Gen_1	349	358	PF02991	0.426
LIG_LIR_Gen_1	393	402	PF02991	0.353
LIG_LIR_Gen_1	415	420	PF02991	0.353
LIG_LIR_Gen_1	663	673	PF02991	0.509
LIG_LIR_LC3C_4	539	544	PF02991	0.337
LIG_LIR_Nem_3	186	192	PF02991	0.279
LIG_LIR_Nem_3	310	314	PF02991	0.335
LIG_LIR_Nem_3	360	364	PF02991	0.404
LIG_LIR_Nem_3	393	397	PF02991	0.353
LIG_LIR_Nem_3	415	419	PF02991	0.333
LIG_LIR_Nem_3	460	465	PF02991	0.353
LIG_LIR_Nem_3	473	479	PF02991	0.330
LIG_LIR_Nem_3	572	576	PF02991	0.314
LIG_LIR_Nem_3	663	668	PF02991	0.509
LIG_LIR_Nem_3	710	715	PF02991	0.663
LIG_LIR_Nem_3	788	792	PF02991	0.676
LIG_NRBOX	65	71	PF00104	0.456
LIG_PCNA_PIPBox_1	658	667	PF02747	0.370
LIG_PCNA_yPIPBox_3	653	665	PF02747	0.370
LIG_Pex14_1	299	303	PF04695	0.353
LIG_Pex14_2	295	299	PF04695	0.311
LIG_Pex14_2	680	684	PF04695	0.436
LIG_Pex14_2	896	900	PF04695	0.835
LIG_REV1ctd_RIR_1	677	686	PF16727	0.442
LIG_SH2_CRK	203	207	PF00017	0.329
LIG_SH2_CRK	74	78	PF00017	0.403
LIG_SH2_CRK	94	98	PF00017	0.743
LIG_SH2_NCK_1	245	249	PF00017	0.370
LIG_SH2_NCK_1	287	291	PF00017	0.353
LIG_SH2_NCK_1	361	365	PF00017	0.370
LIG_SH2_NCK_1	768	772	PF00017	0.757
LIG_SH2_PTP2	115	118	PF00017	0.345
LIG_SH2_PTP2	761	764	PF00017	0.649
LIG_SH2_SRC	361	364	PF00017	0.426
LIG_SH2_SRC	761	764	PF00017	0.703
LIG_SH2_SRC	768	771	PF00017	0.712
LIG_SH2_STAP1	218	222	PF00017	0.353
LIG_SH2_STAP1	312	316	PF00017	0.426
LIG_SH2_STAP1	416	420	PF00017	0.353
LIG_SH2_STAT5	115	118	PF00017	0.345
LIG_SH2_STAT5	138	141	PF00017	0.409
LIG_SH2_STAT5	209	212	PF00017	0.353
LIG_SH2_STAT5	287	290	PF00017	0.353
LIG_SH2_STAT5	303	306	PF00017	0.353
LIG_SH2_STAT5	312	315	PF00017	0.353
LIG_SH2_STAT5	476	479	PF00017	0.353
LIG_SH2_STAT5	500	503	PF00017	0.353
LIG_SH2_STAT5	576	579	PF00017	0.327
LIG_SH2_STAT5	667	670	PF00017	0.414
LIG_SH2_STAT5	689	692	PF00017	0.761
LIG_SH2_STAT5	761	764	PF00017	0.743
LIG_SH2_STAT5	84	87	PF00017	0.771
LIG_SH3_2	872	877	PF14604	0.844
LIG_SH3_3	361	367	PF00018	0.400
LIG_SH3_3	375	381	PF00018	0.306
LIG_SH3_3	745	751	PF00018	0.750
LIG_SH3_3	759	765	PF00018	0.721
LIG_SH3_3	794	800	PF00018	0.766
LIG_SH3_3	834	840	PF00018	0.762
LIG_SH3_3	847	853	PF00018	0.670
LIG_SH3_3	869	875	PF00018	0.777
LIG_SH3_3	901	907	PF00018	0.839
LIG_SH3_4	516	523	PF00018	0.342
LIG_SUMO_SIM_anti_2	36	44	PF11976	0.570
LIG_SUMO_SIM_anti_2	52	58	PF11976	0.240
LIG_SUMO_SIM_par_1	153	158	PF11976	0.353
LIG_SUMO_SIM_par_1	365	372	PF11976	0.337
LIG_SUMO_SIM_par_1	399	405	PF11976	0.353
LIG_SUMO_SIM_par_1	487	492	PF11976	0.353
LIG_SUMO_SIM_par_1	658	663	PF11976	0.370
LIG_TRAF2_1	165	168	PF00917	0.353
LIG_TRAF2_1	631	634	PF00917	0.337
LIG_TRAF2_1	878	881	PF00917	0.850
LIG_TYR_ITIM	113	118	PF00017	0.287
LIG_WRC_WIRS_1	841	846	PF05994	0.732
LIG_WW_3	810	814	PF00397	0.775
MOD_CDC14_SPxK_1	190	193	PF00782	0.426
MOD_CDK_SPK_2	889	894	PF00069	0.823
MOD_CDK_SPK_2	900	905	PF00069	0.713
MOD_CDK_SPK_2	93	98	PF00069	0.724
MOD_CDK_SPxK_1	187	193	PF00069	0.426
MOD_CDK_SPxK_1	871	877	PF00069	0.843
MOD_CDK_SPxK_1	900	906	PF00069	0.708
MOD_CDK_SPxxK_3	880	887	PF00069	0.675
MOD_CK1_1	134	140	PF00069	0.399
MOD_CK1_1	301	307	PF00069	0.353
MOD_CK1_1	37	43	PF00069	0.579
MOD_CK1_1	432	438	PF00069	0.353
MOD_CK1_1	569	575	PF00069	0.330
MOD_CK1_1	58	64	PF00069	0.393
MOD_CK1_1	580	586	PF00069	0.381
MOD_CK1_1	636	642	PF00069	0.353
MOD_CK1_1	722	728	PF00069	0.787
MOD_CK1_1	736	742	PF00069	0.602
MOD_CK1_1	866	872	PF00069	0.790
MOD_CK1_1	876	882	PF00069	0.748
MOD_CK1_1	89	95	PF00069	0.730
MOD_CK1_1	899	905	PF00069	0.843
MOD_CK2_1	139	145	PF00069	0.510
MOD_CK2_1	433	439	PF00069	0.353
MOD_CK2_1	628	634	PF00069	0.340
MOD_CK2_1	696	702	PF00069	0.776
MOD_CK2_1	774	780	PF00069	0.678
MOD_CK2_1	875	881	PF00069	0.838
MOD_DYRK1A_RPxSP_1	906	910	PF00069	0.805
MOD_GlcNHglycan	141	144	PF01048	0.715
MOD_GlcNHglycan	174	177	PF01048	0.553
MOD_GlcNHglycan	198	201	PF01048	0.553
MOD_GlcNHglycan	30	33	PF01048	0.549
MOD_GlcNHglycan	300	303	PF01048	0.553
MOD_GlcNHglycan	324	327	PF01048	0.535
MOD_GlcNHglycan	493	496	PF01048	0.568
MOD_GlcNHglycan	505	508	PF01048	0.486
MOD_GlcNHglycan	568	571	PF01048	0.627
MOD_GlcNHglycan	57	60	PF01048	0.625
MOD_GlcNHglycan	582	585	PF01048	0.508
MOD_GlcNHglycan	621	624	PF01048	0.596
MOD_GlcNHglycan	625	629	PF01048	0.568
MOD_GlcNHglycan	633	638	PF01048	0.497
MOD_GlcNHglycan	698	701	PF01048	0.560
MOD_GlcNHglycan	735	738	PF01048	0.512
MOD_GlcNHglycan	776	779	PF01048	0.592
MOD_GlcNHglycan	859	864	PF01048	0.525
MOD_GSK3_1	130	137	PF00069	0.453
MOD_GSK3_1	183	190	PF00069	0.330
MOD_GSK3_1	192	199	PF00069	0.417
MOD_GSK3_1	218	225	PF00069	0.349
MOD_GSK3_1	260	267	PF00069	0.325
MOD_GSK3_1	310	317	PF00069	0.316
MOD_GSK3_1	33	40	PF00069	0.720
MOD_GSK3_1	396	403	PF00069	0.353
MOD_GSK3_1	429	436	PF00069	0.353
MOD_GSK3_1	471	478	PF00069	0.353
MOD_GSK3_1	480	487	PF00069	0.353
MOD_GSK3_1	532	539	PF00069	0.400
MOD_GSK3_1	543	550	PF00069	0.315
MOD_GSK3_1	576	583	PF00069	0.344
MOD_GSK3_1	603	610	PF00069	0.376
MOD_GSK3_1	615	622	PF00069	0.267
MOD_GSK3_1	624	631	PF00069	0.335
MOD_GSK3_1	632	639	PF00069	0.252
MOD_GSK3_1	719	726	PF00069	0.758
MOD_GSK3_1	781	788	PF00069	0.783
MOD_GSK3_1	836	843	PF00069	0.734
MOD_GSK3_1	859	866	PF00069	0.733
MOD_GSK3_1	867	874	PF00069	0.780
MOD_GSK3_1	876	883	PF00069	0.751
MOD_GSK3_1	89	96	PF00069	0.729
MOD_GSK3_1	896	903	PF00069	0.770
MOD_LATS_1	20	26	PF00433	0.825
MOD_N-GLC_1	145	150	PF02516	0.521
MOD_N-GLC_1	182	187	PF02516	0.562
MOD_N-GLC_1	314	319	PF02516	0.525
MOD_N-GLC_1	320	325	PF02516	0.503
MOD_N-GLC_1	547	552	PF02516	0.570
MOD_N-GLC_1	584	589	PF02516	0.590
MOD_N-GLC_1	615	620	PF02516	0.553
MOD_N-GLC_2	228	230	PF02516	0.553
MOD_N-GLC_2	424	426	PF02516	0.553
MOD_NEK2_1	114	119	PF00069	0.443
MOD_NEK2_1	130	135	PF00069	0.505
MOD_NEK2_1	153	158	PF00069	0.372
MOD_NEK2_1	172	177	PF00069	0.311
MOD_NEK2_1	192	197	PF00069	0.354
MOD_NEK2_1	264	269	PF00069	0.318
MOD_NEK2_1	316	321	PF00069	0.325
MOD_NEK2_1	368	373	PF00069	0.410
MOD_NEK2_1	41	46	PF00069	0.383
MOD_NEK2_1	458	463	PF00069	0.396
MOD_NEK2_1	49	54	PF00069	0.412
MOD_NEK2_1	498	503	PF00069	0.401
MOD_NEK2_1	55	60	PF00069	0.423
MOD_NEK2_1	896	901	PF00069	0.844
MOD_NEK2_2	218	223	PF00069	0.353
MOD_OFUCOSY	426	433	PF10250	0.553
MOD_PIKK_1	252	258	PF00454	0.353
MOD_PIKK_1	418	424	PF00454	0.353
MOD_PIKK_1	433	439	PF00454	0.353
MOD_PIKK_1	58	64	PF00454	0.287
MOD_PIKK_1	615	621	PF00454	0.353
MOD_PIKK_1	876	882	PF00454	0.852
MOD_PKA_1	696	702	PF00069	0.744
MOD_PKA_2	192	198	PF00069	0.426
MOD_PKA_2	37	43	PF00069	0.601
MOD_PKA_2	532	538	PF00069	0.370
MOD_PKA_2	696	702	PF00069	0.729
MOD_PKA_2	728	734	PF00069	0.849
MOD_PKA_2	77	83	PF00069	0.641
MOD_PKA_2	876	882	PF00069	0.852
MOD_PKA_2	89	95	PF00069	0.732
MOD_Plk_1	166	172	PF00069	0.319
MOD_Plk_1	177	183	PF00069	0.331
MOD_Plk_1	218	224	PF00069	0.353
MOD_Plk_1	260	266	PF00069	0.353
MOD_Plk_1	314	320	PF00069	0.325
MOD_Plk_1	498	504	PF00069	0.426
MOD_Plk_1	707	713	PF00069	0.798
MOD_Plk_4	114	120	PF00069	0.460
MOD_Plk_4	131	137	PF00069	0.493
MOD_Plk_4	166	172	PF00069	0.353
MOD_Plk_4	222	228	PF00069	0.398
MOD_Plk_4	307	313	PF00069	0.321
MOD_Plk_4	37	43	PF00069	0.570
MOD_Plk_4	484	490	PF00069	0.426
MOD_Plk_4	526	532	PF00069	0.353
MOD_Plk_4	586	592	PF00069	0.337
MOD_Plk_4	89	95	PF00069	0.658
MOD_ProDKin_1	187	193	PF00069	0.353
MOD_ProDKin_1	336	342	PF00069	0.353
MOD_ProDKin_1	471	477	PF00069	0.311
MOD_ProDKin_1	480	486	PF00069	0.311
MOD_ProDKin_1	747	753	PF00069	0.802
MOD_ProDKin_1	781	787	PF00069	0.732
MOD_ProDKin_1	836	842	PF00069	0.746
MOD_ProDKin_1	868	874	PF00069	0.842
MOD_ProDKin_1	880	886	PF00069	0.701
MOD_ProDKin_1	889	895	PF00069	0.720
MOD_ProDKin_1	900	906	PF00069	0.611
MOD_ProDKin_1	93	99	PF00069	0.806
MOD_SUMO_for_1	705	708	PF00179	0.790
MOD_SUMO_rev_2	726	736	PF00179	0.789
TRG_DiLeu_BaEn_3	167	173	PF01217	0.426
TRG_ENDOCYTIC_2	115	118	PF00928	0.315
TRG_ENDOCYTIC_2	205	208	PF00928	0.325
TRG_ENDOCYTIC_2	361	364	PF00928	0.391
TRG_ENDOCYTIC_2	416	419	PF00928	0.353
TRG_ENDOCYTIC_2	667	670	PF00928	0.414
TRG_ENDOCYTIC_2	74	77	PF00928	0.321
TRG_ENDOCYTIC_2	761	764	PF00928	0.669
TRG_ER_diArg_1	652	655	PF00400	0.337
TRG_ER_diArg_1	904	906	PF00400	0.849
TRG_NES_CRM1_1	456	470	PF08389	0.426

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P372	Leptomonas seymouri	54%	94%
A0A3S7X8Q7	Leishmania donovani	92%	100%
A4GRC6	Chlamydomonas reinhardtii	26%	81%
A4HM81	Leishmania braziliensis	71%	100%
A4IAU5	Leishmania infantum	92%	100%
E9B5T2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%