Arrestin_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

E9AEM2_LEIMA

TriTrypDb:

LmjF.35.0450 , LMJLV39_350009800 , LMJSD75_350009700

Length:

603

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AEM2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEM2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	365	369	PF00656	0.600
CLV_NRD_NRD_1	96	98	PF00675	0.652
CLV_PCSK_KEX2_1	241	243	PF00082	0.792
CLV_PCSK_KEX2_1	285	287	PF00082	0.752
CLV_PCSK_KEX2_1	416	418	PF00082	0.603
CLV_PCSK_KEX2_1	55	57	PF00082	0.658
CLV_PCSK_KEX2_1	96	98	PF00082	0.652
CLV_PCSK_PC1ET2_1	241	243	PF00082	0.666
CLV_PCSK_PC1ET2_1	285	287	PF00082	0.612
CLV_PCSK_PC1ET2_1	416	418	PF00082	0.603
CLV_PCSK_PC1ET2_1	55	57	PF00082	0.658
CLV_PCSK_SKI1_1	255	259	PF00082	0.630
CLV_PCSK_SKI1_1	317	321	PF00082	0.608
CLV_PCSK_SKI1_1	44	48	PF00082	0.775
DEG_APCC_DBOX_1	43	51	PF00400	0.636
DEG_APCC_DBOX_1	96	104	PF00400	0.665
DEG_SPOP_SBC_1	516	520	PF00917	0.428
DEG_SPOP_SBC_1	553	557	PF00917	0.530
DOC_CKS1_1	216	221	PF01111	0.635
DOC_CYCLIN_RxL_1	252	261	PF00134	0.571
DOC_CYCLIN_yCln2_LP_2	250	256	PF00134	0.615
DOC_MAPK_gen_1	205	215	PF00069	0.604
DOC_MAPK_gen_1	321	330	PF00069	0.526
DOC_MAPK_gen_1	470	478	PF00069	0.538
DOC_MAPK_gen_1	96	103	PF00069	0.551
DOC_MAPK_HePTP_8	320	332	PF00069	0.552
DOC_MAPK_MEF2A_6	208	215	PF00069	0.515
DOC_MAPK_MEF2A_6	323	332	PF00069	0.535
DOC_MAPK_MEF2A_6	351	358	PF00069	0.643
DOC_MAPK_MEF2A_6	96	105	PF00069	0.636
DOC_PP2B_LxvP_1	101	104	PF13499	0.560
DOC_PP2B_LxvP_1	160	163	PF13499	0.573
DOC_PP2B_LxvP_1	358	361	PF13499	0.671
DOC_PP2B_LxvP_1	526	529	PF13499	0.559
DOC_PP4_FxxP_1	256	259	PF00568	0.599
DOC_USP7_MATH_1	176	180	PF00917	0.620
DOC_USP7_MATH_1	372	376	PF00917	0.682
DOC_USP7_MATH_1	38	42	PF00917	0.643
DOC_USP7_MATH_1	445	449	PF00917	0.593
DOC_USP7_MATH_1	516	520	PF00917	0.540
DOC_USP7_MATH_1	69	73	PF00917	0.641
DOC_USP7_UBL2_3	480	484	PF12436	0.522
DOC_WW_Pin1_4	140	145	PF00397	0.702
DOC_WW_Pin1_4	215	220	PF00397	0.634
DOC_WW_Pin1_4	249	254	PF00397	0.620
DOC_WW_Pin1_4	295	300	PF00397	0.618
DOC_WW_Pin1_4	409	414	PF00397	0.645
DOC_WW_Pin1_4	420	425	PF00397	0.682
LIG_14-3-3_CanoR_1	184	188	PF00244	0.617
LIG_14-3-3_CanoR_1	208	214	PF00244	0.600
LIG_14-3-3_CanoR_1	345	350	PF00244	0.587
LIG_14-3-3_CanoR_1	4	8	PF00244	0.655
LIG_14-3-3_CanoR_1	401	409	PF00244	0.589
LIG_14-3-3_CanoR_1	490	495	PF00244	0.587
LIG_BIR_II_1	1	5	PF00653	0.504
LIG_BRCT_BRCA1_1	297	301	PF00533	0.608
LIG_BRCT_BRCA1_1	518	522	PF00533	0.534
LIG_CSL_BTD_1	164	167	PF09270	0.742
LIG_CtBP_PxDLS_1	523	527	PF00389	0.532
LIG_FHA_1	108	114	PF00498	0.715
LIG_FHA_1	11	17	PF00498	0.626
LIG_FHA_1	210	216	PF00498	0.623
LIG_FHA_1	304	310	PF00498	0.575
LIG_FHA_1	471	477	PF00498	0.630
LIG_FHA_1	548	554	PF00498	0.588
LIG_FHA_1	586	592	PF00498	0.737
LIG_FHA_2	29	35	PF00498	0.636
LIG_FHA_2	324	330	PF00498	0.533
LIG_FHA_2	507	513	PF00498	0.527
LIG_FHA_2	516	522	PF00498	0.468
LIG_FHA_2	71	77	PF00498	0.566
LIG_LIR_Apic_2	169	174	PF02991	0.622
LIG_LIR_Apic_2	540	545	PF02991	0.609
LIG_LIR_Gen_1	276	284	PF02991	0.623
LIG_LIR_Gen_1	555	566	PF02991	0.661
LIG_LIR_Nem_3	276	280	PF02991	0.659
LIG_LIR_Nem_3	306	310	PF02991	0.522
LIG_LIR_Nem_3	555	561	PF02991	0.656
LIG_LIR_Nem_3	562	566	PF02991	0.556
LIG_MYND_1	164	168	PF01753	0.629
LIG_MYND_1	249	253	PF01753	0.625
LIG_NRBOX	315	321	PF00104	0.602
LIG_PTB_Apo_2	319	326	PF02174	0.577
LIG_PTB_Phospho_1	319	325	PF10480	0.586
LIG_SH2_CRK	312	316	PF00017	0.461
LIG_SH2_NCK_1	185	189	PF00017	0.630
LIG_SH2_NCK_1	325	329	PF00017	0.532
LIG_SH2_NCK_1	396	400	PF00017	0.681
LIG_SH2_NCK_1	503	507	PF00017	0.528
LIG_SH2_PTP2	154	157	PF00017	0.596
LIG_SH2_SRC	154	157	PF00017	0.596
LIG_SH2_STAP1	121	125	PF00017	0.563
LIG_SH2_STAP1	185	189	PF00017	0.756
LIG_SH2_STAP1	312	316	PF00017	0.461
LIG_SH2_STAT5	121	124	PF00017	0.687
LIG_SH2_STAT5	154	157	PF00017	0.596
LIG_SH2_STAT5	185	188	PF00017	0.632
LIG_SH2_STAT5	325	328	PF00017	0.530
LIG_SH2_STAT5	503	506	PF00017	0.662
LIG_SH2_STAT5	508	511	PF00017	0.610
LIG_SH3_3	161	167	PF00018	0.730
LIG_SH3_3	210	216	PF00018	0.624
LIG_SH3_3	589	595	PF00018	0.642
LIG_SH3_3	65	71	PF00018	0.728
LIG_SUMO_SIM_anti_2	199	204	PF11976	0.611
LIG_SUMO_SIM_anti_2	576	584	PF11976	0.641
LIG_SUMO_SIM_par_1	576	584	PF11976	0.686
LIG_TRAF2_1	49	52	PF00917	0.616
LIG_TRAF2_1	74	77	PF00917	0.657
LIG_WW_1	167	170	PF00397	0.626
MOD_CDC14_SPxK_1	252	255	PF00782	0.579
MOD_CDK_SPxK_1	249	255	PF00069	0.592
MOD_CDK_SPxxK_3	140	147	PF00069	0.699
MOD_CDK_SPxxK_3	295	302	PF00069	0.613
MOD_CDK_SPxxK_3	409	416	PF00069	0.594
MOD_CK1_1	106	112	PF00069	0.560
MOD_CK1_1	179	185	PF00069	0.615
MOD_CK1_1	228	234	PF00069	0.555
MOD_CK1_1	375	381	PF00069	0.677
MOD_CK1_1	434	440	PF00069	0.682
MOD_CK1_1	448	454	PF00069	0.542
MOD_CK2_1	506	512	PF00069	0.526
MOD_CK2_1	515	521	PF00069	0.477
MOD_CK2_1	70	76	PF00069	0.566
MOD_Cter_Amidation	414	417	PF01082	0.605
MOD_Cter_Amidation	53	56	PF01082	0.657
MOD_GlcNHglycan	123	126	PF01048	0.614
MOD_GlcNHglycan	174	177	PF01048	0.665
MOD_GlcNHglycan	246	249	PF01048	0.637
MOD_GlcNHglycan	280	283	PF01048	0.630
MOD_GlcNHglycan	335	338	PF01048	0.603
MOD_GlcNHglycan	365	368	PF01048	0.725
MOD_GlcNHglycan	374	377	PF01048	0.701
MOD_GlcNHglycan	40	43	PF01048	0.615
MOD_GlcNHglycan	433	436	PF01048	0.700
MOD_GlcNHglycan	450	453	PF01048	0.535
MOD_GlcNHglycan	492	495	PF01048	0.591
MOD_GSK3_1	10	17	PF00069	0.708
MOD_GSK3_1	103	110	PF00069	0.691
MOD_GSK3_1	115	122	PF00069	0.649
MOD_GSK3_1	135	142	PF00069	0.608
MOD_GSK3_1	172	179	PF00069	0.710
MOD_GSK3_1	225	232	PF00069	0.677
MOD_GSK3_1	371	378	PF00069	0.572
MOD_GSK3_1	383	390	PF00069	0.499
MOD_GSK3_1	472	479	PF00069	0.538
MOD_GSK3_1	490	497	PF00069	0.565
MOD_GSK3_1	504	511	PF00069	0.580
MOD_LATS_1	468	474	PF00433	0.430
MOD_N-GLC_1	363	368	PF02516	0.681
MOD_N-GLC_1	516	521	PF02516	0.553
MOD_NEK2_1	183	188	PF00069	0.676
MOD_NEK2_1	209	214	PF00069	0.551
MOD_NEK2_1	3	8	PF00069	0.723
MOD_NEK2_1	559	564	PF00069	0.663
MOD_NEK2_1	587	592	PF00069	0.681
MOD_NEK2_1	64	69	PF00069	0.663
MOD_NEK2_1	83	88	PF00069	0.447
MOD_PIKK_1	445	451	PF00454	0.573
MOD_PIKK_1	494	500	PF00454	0.484
MOD_PK_1	345	351	PF00069	0.646
MOD_PK_1	472	478	PF00069	0.537
MOD_PKA_1	241	247	PF00069	0.784
MOD_PKA_2	10	16	PF00069	0.555
MOD_PKA_2	183	189	PF00069	0.626
MOD_PKA_2	225	231	PF00069	0.662
MOD_PKA_2	241	247	PF00069	0.784
MOD_PKA_2	293	299	PF00069	0.701
MOD_PKA_2	3	9	PF00069	0.596
MOD_PKA_2	489	495	PF00069	0.581
MOD_PKA_2	83	89	PF00069	0.604
MOD_PKB_1	470	478	PF00069	0.527
MOD_PKB_1	488	496	PF00069	0.583
MOD_Plk_1	107	113	PF00069	0.667
MOD_Plk_1	275	281	PF00069	0.627
MOD_Plk_4	107	113	PF00069	0.555
MOD_Plk_4	166	172	PF00069	0.764
MOD_Plk_4	209	215	PF00069	0.621
MOD_Plk_4	310	316	PF00069	0.561
MOD_Plk_4	345	351	PF00069	0.646
MOD_Plk_4	383	389	PF00069	0.565
MOD_Plk_4	434	440	PF00069	0.671
MOD_Plk_4	554	560	PF00069	0.548
MOD_ProDKin_1	140	146	PF00069	0.700
MOD_ProDKin_1	215	221	PF00069	0.633
MOD_ProDKin_1	249	255	PF00069	0.620
MOD_ProDKin_1	295	301	PF00069	0.614
MOD_ProDKin_1	409	415	PF00069	0.645
MOD_ProDKin_1	420	426	PF00069	0.683
MOD_SUMO_for_1	284	287	PF00179	0.606
TRG_DiLeu_BaEn_1	261	266	PF01217	0.578
TRG_DiLeu_BaEn_1	576	581	PF01217	0.639
TRG_DiLeu_BaEn_1	60	65	PF01217	0.650
TRG_DiLeu_BaLyEn_6	246	251	PF01217	0.637
TRG_DiLeu_BaLyEn_6	96	101	PF01217	0.551
TRG_ENDOCYTIC_2	312	315	PF00928	0.503
TRG_ENDOCYTIC_2	325	328	PF00928	0.484
TRG_ER_diArg_1	469	472	PF00400	0.651
TRG_NLS_MonoExtN_4	413	420	PF00514	0.598
TRG_Pf-PMV_PEXEL_1	286	290	PF00026	0.733

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IP18	Leishmania donovani	90%	100%
A4IAU4	Leishmania infantum	90%	100%
E9B5T1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%