Arrestin_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Arrestin (or S-antigen), N-terminal domain containing protein, putative

Species:

Leishmania major

UniProt:

E9AEM1_LEIMA

TriTrypDb:

LmjF.35.0440 , LMJLV39_350009700 , LMJSD75_350009600

Length:

638

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

E9AEM1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEM1

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0033036	macromolecule localization	2	2
GO:0045184	establishment of protein localization	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0070727	cellular macromolecule localization	3	2

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.581
CLV_NRD_NRD_1	280	282	PF00675	0.687
CLV_NRD_NRD_1	307	309	PF00675	0.630
CLV_NRD_NRD_1	334	336	PF00675	0.583
CLV_NRD_NRD_1	378	380	PF00675	0.645
CLV_NRD_NRD_1	571	573	PF00675	0.555
CLV_PCSK_FUR_1	569	573	PF00082	0.534
CLV_PCSK_KEX2_1	278	280	PF00082	0.682
CLV_PCSK_KEX2_1	282	284	PF00082	0.663
CLV_PCSK_KEX2_1	307	309	PF00082	0.620

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSS5	Leptomonas seymouri	62%	96%
A0A3S5H7Y4	Leishmania donovani	94%	100%
A4HM80	Leishmania braziliensis	79%	100%
A4IAU3	Leishmania infantum	94%	100%
E9B5T0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%

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