Arrestin_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Arrestin (or S-antigen), N-terminal domain containing protein, putative

Species:

Leishmania major

UniProt:

E9AEM1_LEIMA

TriTrypDb:

LmjF.35.0440 , LMJLV39_350009700 , LMJSD75_350009600

Length:

638

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AEM1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEM1

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0033036	macromolecule localization	2	2
GO:0045184	establishment of protein localization	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.581
CLV_NRD_NRD_1	280	282	PF00675	0.687
CLV_NRD_NRD_1	307	309	PF00675	0.630
CLV_NRD_NRD_1	334	336	PF00675	0.583
CLV_NRD_NRD_1	378	380	PF00675	0.645
CLV_NRD_NRD_1	571	573	PF00675	0.555
CLV_PCSK_FUR_1	569	573	PF00082	0.534
CLV_PCSK_KEX2_1	278	280	PF00082	0.682
CLV_PCSK_KEX2_1	282	284	PF00082	0.663
CLV_PCSK_KEX2_1	307	309	PF00082	0.620
CLV_PCSK_KEX2_1	334	336	PF00082	0.583
CLV_PCSK_KEX2_1	378	380	PF00082	0.673
CLV_PCSK_KEX2_1	571	573	PF00082	0.555
CLV_PCSK_PC1ET2_1	278	280	PF00082	0.714
CLV_PCSK_PC1ET2_1	282	284	PF00082	0.682
CLV_PCSK_SKI1_1	307	311	PF00082	0.658
CLV_PCSK_SKI1_1	443	447	PF00082	0.540
CLV_PCSK_SKI1_1	46	50	PF00082	0.393
CLV_PCSK_SKI1_1	523	527	PF00082	0.456
CLV_PCSK_SKI1_1	530	534	PF00082	0.585
CLV_PCSK_SKI1_1	80	84	PF00082	0.482
DEG_APCC_DBOX_1	518	526	PF00400	0.476
DEG_SIAH_1	112	120	PF03145	0.564
DEG_SPOP_SBC_1	363	367	PF00917	0.565
DOC_CKS1_1	491	496	PF01111	0.637
DOC_CKS1_1	532	537	PF01111	0.525
DOC_CYCLIN_yCln2_LP_2	470	476	PF00134	0.677
DOC_CYCLIN_yCln2_LP_2	580	583	PF00134	0.560
DOC_CYCLIN_yCln2_LP_2	631	637	PF00134	0.567
DOC_MAPK_gen_1	304	314	PF00069	0.574
DOC_MAPK_MEF2A_6	25	32	PF00069	0.313
DOC_MAPK_MEF2A_6	5	13	PF00069	0.424
DOC_MAPK_MEF2A_6	519	528	PF00069	0.487
DOC_PP1_RVXF_1	44	50	PF00149	0.377
DOC_PP2B_LxvP_1	475	478	PF13499	0.603
DOC_PP2B_LxvP_1	580	583	PF13499	0.559
DOC_PP2B_LxvP_1	631	634	PF13499	0.567
DOC_PP4_FxxP_1	208	211	PF00568	0.307
DOC_USP7_MATH_1	269	273	PF00917	0.560
DOC_USP7_MATH_1	363	367	PF00917	0.705
DOC_USP7_MATH_1	462	466	PF00917	0.658
DOC_USP7_UBL2_3	278	282	PF12436	0.680
DOC_WW_Pin1_4	109	114	PF00397	0.559
DOC_WW_Pin1_4	480	485	PF00397	0.664
DOC_WW_Pin1_4	490	495	PF00397	0.481
DOC_WW_Pin1_4	531	536	PF00397	0.532
LIG_14-3-3_CanoR_1	186	196	PF00244	0.522
LIG_14-3-3_CanoR_1	307	313	PF00244	0.652
LIG_14-3-3_CanoR_1	460	470	PF00244	0.599
LIG_14-3-3_CanoR_1	5	10	PF00244	0.396
LIG_14-3-3_CanoR_1	80	85	PF00244	0.467
LIG_14-3-3_CterR_2	636	638	PF00244	0.577
LIG_BRCT_BRCA1_1	245	249	PF00533	0.628
LIG_BRCT_BRCA1_1	592	596	PF00533	0.474
LIG_CSL_BTD_1	212	215	PF09270	0.307
LIG_DLG_GKlike_1	5	13	PF00625	0.392
LIG_eIF4E_1	130	136	PF01652	0.523
LIG_eIF4E_1	42	48	PF01652	0.392
LIG_FHA_1	148	154	PF00498	0.534
LIG_FHA_1	319	325	PF00498	0.470
LIG_FHA_1	344	350	PF00498	0.609
LIG_FHA_1	394	400	PF00498	0.665
LIG_FHA_1	442	448	PF00498	0.535
LIG_FHA_1	499	505	PF00498	0.512
LIG_FHA_1	510	516	PF00498	0.425
LIG_FHA_1	547	553	PF00498	0.416
LIG_FHA_1	621	627	PF00498	0.605
LIG_FHA_1	95	101	PF00498	0.548
LIG_FHA_2	129	135	PF00498	0.614
LIG_FHA_2	188	194	PF00498	0.585
LIG_FHA_2	573	579	PF00498	0.553
LIG_FHA_2	604	610	PF00498	0.483
LIG_FHA_2	87	93	PF00498	0.527
LIG_IRF3_LxIS_1	7	12	PF10401	0.417
LIG_LIR_Apic_2	545	551	PF02991	0.430
LIG_LIR_Gen_1	112	122	PF02991	0.570
LIG_LIR_Gen_1	217	225	PF02991	0.286
LIG_LIR_Gen_1	410	421	PF02991	0.467
LIG_LIR_Gen_1	542	551	PF02991	0.439
LIG_LIR_Gen_1	593	604	PF02991	0.447
LIG_LIR_Gen_1	63	71	PF02991	0.528
LIG_LIR_LC3C_4	436	440	PF02991	0.510
LIG_LIR_Nem_3	112	117	PF02991	0.556
LIG_LIR_Nem_3	125	130	PF02991	0.567
LIG_LIR_Nem_3	191	197	PF02991	0.492
LIG_LIR_Nem_3	201	207	PF02991	0.205
LIG_LIR_Nem_3	217	223	PF02991	0.239
LIG_LIR_Nem_3	246	251	PF02991	0.591
LIG_LIR_Nem_3	340	344	PF02991	0.720
LIG_LIR_Nem_3	410	416	PF02991	0.473
LIG_LIR_Nem_3	527	532	PF02991	0.507
LIG_LIR_Nem_3	537	541	PF02991	0.500
LIG_LIR_Nem_3	542	546	PF02991	0.453
LIG_LIR_Nem_3	593	599	PF02991	0.450
LIG_LIR_Nem_3	63	67	PF02991	0.524
LIG_MYND_1	195	199	PF01753	0.307
LIG_MYND_1	212	216	PF01753	0.307
LIG_Pex14_2	204	208	PF04695	0.307
LIG_Pex14_2	218	222	PF04695	0.307
LIG_Pex14_2	416	420	PF04695	0.490
LIG_SH2_CRK	114	118	PF00017	0.568
LIG_SH2_CRK	220	224	PF00017	0.438
LIG_SH2_CRK	548	552	PF00017	0.413
LIG_SH2_NCK_1	114	118	PF00017	0.568
LIG_SH2_STAP1	114	118	PF00017	0.556
LIG_SH2_STAP1	231	235	PF00017	0.307
LIG_SH2_STAT5	130	133	PF00017	0.571
LIG_SH2_STAT5	148	151	PF00017	0.489
LIG_SH2_STAT5	509	512	PF00017	0.459
LIG_SH2_STAT5	548	551	PF00017	0.424
LIG_SH2_STAT5	605	608	PF00017	0.484
LIG_SH2_STAT5	71	74	PF00017	0.545
LIG_SH2_STAT5	77	80	PF00017	0.497
LIG_SH3_1	209	215	PF00018	0.307
LIG_SH3_1	548	554	PF00018	0.415
LIG_SH3_2	119	124	PF14604	0.609
LIG_SH3_3	116	122	PF00018	0.648
LIG_SH3_3	150	156	PF00018	0.538
LIG_SH3_3	189	195	PF00018	0.553
LIG_SH3_3	209	215	PF00018	0.325
LIG_SH3_3	311	317	PF00018	0.580
LIG_SH3_3	456	462	PF00018	0.623
LIG_SH3_3	478	484	PF00018	0.612
LIG_SH3_3	485	491	PF00018	0.618
LIG_SH3_3	548	554	PF00018	0.433
LIG_SH3_3	596	602	PF00018	0.426
LIG_SUMO_SIM_anti_2	327	333	PF11976	0.502
LIG_SUMO_SIM_anti_2	436	441	PF11976	0.448
LIG_SUMO_SIM_par_1	291	300	PF11976	0.650
LIG_SUMO_SIM_par_1	443	450	PF11976	0.574
LIG_TRAF2_1	131	134	PF00917	0.527
LIG_TRAF2_2	171	176	PF00917	0.570
LIG_TRFH_1	208	212	PF08558	0.307
LIG_TYR_ITIM	40	45	PF00017	0.399
LIG_TYR_ITSM	110	117	PF00017	0.559
LIG_UBA3_1	525	533	PF00899	0.584
LIG_WRC_WIRS_1	219	224	PF05994	0.307
LIG_WRC_WIRS_1	413	418	PF05994	0.437
LIG_WRC_WIRS_1	543	548	PF05994	0.436
MOD_CK1_1	318	324	PF00069	0.415
MOD_CK1_1	365	371	PF00069	0.580
MOD_CK1_1	392	398	PF00069	0.657
MOD_CK1_1	531	537	PF00069	0.570
MOD_CK1_1	542	548	PF00069	0.473
MOD_CK2_1	128	134	PF00069	0.555
MOD_CK2_1	187	193	PF00069	0.589
MOD_CK2_1	572	578	PF00069	0.575
MOD_CK2_1	603	609	PF00069	0.477
MOD_CK2_1	86	92	PF00069	0.521
MOD_CK2_1	9	15	PF00069	0.425
MOD_Cter_Amidation	276	279	PF01082	0.600
MOD_GlcNHglycan	179	182	PF01048	0.797
MOD_GlcNHglycan	231	234	PF01048	0.317
MOD_GlcNHglycan	254	258	PF01048	0.716
MOD_GlcNHglycan	271	274	PF01048	0.552
MOD_GlcNHglycan	275	278	PF01048	0.690
MOD_GlcNHglycan	287	291	PF01048	0.643
MOD_GlcNHglycan	391	394	PF01048	0.644
MOD_GlcNHglycan	409	412	PF01048	0.431
MOD_GSK3_1	1	8	PF00069	0.462
MOD_GSK3_1	142	149	PF00069	0.584
MOD_GSK3_1	155	162	PF00069	0.595
MOD_GSK3_1	214	221	PF00069	0.431
MOD_GSK3_1	229	236	PF00069	0.352
MOD_GSK3_1	269	276	PF00069	0.571
MOD_GSK3_1	315	322	PF00069	0.654
MOD_GSK3_1	389	396	PF00069	0.611
MOD_GSK3_1	542	549	PF00069	0.442
MOD_GSK3_1	572	579	PF00069	0.578
MOD_GSK3_1	585	592	PF00069	0.546
MOD_GSK3_1	82	89	PF00069	0.527
MOD_N-GLC_1	158	163	PF02516	0.536
MOD_N-GLC_1	589	594	PF02516	0.500
MOD_N-GLC_2	163	165	PF02516	0.639
MOD_N-GLC_2	423	425	PF02516	0.512
MOD_N-GLC_2	508	510	PF02516	0.399
MOD_NEK2_1	142	147	PF00069	0.616
MOD_NEK2_1	218	223	PF00069	0.307
MOD_NEK2_1	229	234	PF00069	0.307
MOD_NEK2_1	262	267	PF00069	0.578
MOD_NEK2_1	407	412	PF00069	0.514
MOD_NEK2_1	546	551	PF00069	0.426
MOD_NEK2_1	597	602	PF00069	0.490
MOD_NEK2_1	620	625	PF00069	0.476
MOD_NEK2_1	9	14	PF00069	0.428
MOD_NEK2_2	498	503	PF00069	0.515
MOD_PIKK_1	165	171	PF00454	0.715
MOD_PIKK_1	86	92	PF00454	0.578
MOD_PKA_1	307	313	PF00069	0.611
MOD_PKA_2	307	313	PF00069	0.611
MOD_PKA_2	351	357	PF00069	0.810
MOD_Plk_1	402	408	PF00069	0.637
MOD_Plk_1	52	58	PF00069	0.467
MOD_Plk_1	546	552	PF00069	0.486
MOD_Plk_4	214	220	PF00069	0.307
MOD_Plk_4	233	239	PF00069	0.307
MOD_Plk_4	243	249	PF00069	0.541
MOD_Plk_4	327	333	PF00069	0.526
MOD_Plk_4	576	582	PF00069	0.570
MOD_Plk_4	592	598	PF00069	0.626
MOD_Plk_4	603	609	PF00069	0.477
MOD_ProDKin_1	109	115	PF00069	0.558
MOD_ProDKin_1	480	486	PF00069	0.663
MOD_ProDKin_1	490	496	PF00069	0.513
MOD_ProDKin_1	531	537	PF00069	0.530
MOD_SUMO_rev_2	383	392	PF00179	0.634
MOD_SUMO_rev_2	516	525	PF00179	0.429
MOD_SUMO_rev_2	609	617	PF00179	0.524
TRG_DiLeu_BaEn_1	193	198	PF01217	0.543
TRG_DiLeu_BaEn_1	43	48	PF01217	0.391
TRG_DiLeu_BaEn_1	434	439	PF01217	0.431
TRG_DiLeu_BaEn_1	63	68	PF01217	0.397
TRG_DiLeu_BaEn_2	101	107	PF01217	0.630
TRG_DiLeu_BaEn_4	102	108	PF01217	0.628
TRG_ENDOCYTIC_2	114	117	PF00928	0.553
TRG_ENDOCYTIC_2	219	222	PF00928	0.307
TRG_ENDOCYTIC_2	341	344	PF00928	0.596
TRG_ENDOCYTIC_2	413	416	PF00928	0.439
TRG_ENDOCYTIC_2	42	45	PF00928	0.423
TRG_ENDOCYTIC_2	543	546	PF00928	0.463
TRG_ENDOCYTIC_2	605	608	PF00928	0.475
TRG_ER_diArg_1	281	284	PF00400	0.689
TRG_ER_diArg_1	307	309	PF00400	0.629
TRG_ER_diArg_1	333	335	PF00400	0.571
TRG_ER_diArg_1	378	380	PF00400	0.645
TRG_ER_diArg_1	502	505	PF00400	0.433
TRG_ER_diArg_1	570	572	PF00400	0.541
TRG_NLS_MonoExtC_3	277	282	PF00514	0.585
TRG_NLS_MonoExtN_4	275	282	PF00514	0.578
TRG_Pf-PMV_PEXEL_1	335	340	PF00026	0.560

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSS5	Leptomonas seymouri	62%	96%
A0A3S5H7Y4	Leishmania donovani	94%	100%
A4HM80	Leishmania braziliensis	79%	100%
A4IAU3	Leishmania infantum	94%	100%
E9B5T0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%