Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AEL6_LEIMA

TriTrypDb:

LmjF.35.0390 , LMJLV39_350009300 , LMJSD75_350009200

Length:

547

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AEL6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEL6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.618
CLV_C14_Caspase3-7	161	165	PF00656	0.618
CLV_C14_Caspase3-7	484	488	PF00656	0.722
CLV_NRD_NRD_1	118	120	PF00675	0.544
CLV_NRD_NRD_1	174	176	PF00675	0.763
CLV_NRD_NRD_1	406	408	PF00675	0.464
CLV_NRD_NRD_1	480	482	PF00675	0.775
CLV_PCSK_KEX2_1	118	120	PF00082	0.514
CLV_PCSK_KEX2_1	172	174	PF00082	0.644
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.644
CLV_PCSK_SKI1_1	325	329	PF00082	0.659
CLV_PCSK_SKI1_1	411	415	PF00082	0.526
CLV_PCSK_SKI1_1	466	470	PF00082	0.643
DEG_SPOP_SBC_1	126	130	PF00917	0.702
DOC_ANK_TNKS_1	44	51	PF00023	0.720
DOC_CDC14_PxL_1	363	371	PF14671	0.626
DOC_CKS1_1	191	196	PF01111	0.596
DOC_MAPK_gen_1	118	125	PF00069	0.549
DOC_MAPK_MEF2A_6	118	125	PF00069	0.620
DOC_PP2B_LxvP_1	123	126	PF13499	0.556
DOC_USP7_MATH_1	108	112	PF00917	0.530
DOC_USP7_MATH_1	113	117	PF00917	0.470
DOC_USP7_MATH_1	215	219	PF00917	0.639
DOC_USP7_MATH_1	22	26	PF00917	0.555
DOC_USP7_MATH_1	33	37	PF00917	0.433
DOC_USP7_MATH_1	71	75	PF00917	0.757
DOC_WW_Pin1_4	101	106	PF00397	0.686
DOC_WW_Pin1_4	190	195	PF00397	0.605
DOC_WW_Pin1_4	350	355	PF00397	0.774
DOC_WW_Pin1_4	73	78	PF00397	0.700
LIG_14-3-3_CanoR_1	197	203	PF00244	0.670
LIG_14-3-3_CanoR_1	208	216	PF00244	0.545
LIG_14-3-3_CanoR_1	269	277	PF00244	0.631
LIG_14-3-3_CanoR_1	373	379	PF00244	0.535
LIG_14-3-3_CanoR_1	411	421	PF00244	0.447
LIG_14-3-3_CanoR_1	508	514	PF00244	0.672
LIG_14-3-3_CanoR_1	95	99	PF00244	0.485
LIG_Actin_WH2_2	405	422	PF00022	0.552
LIG_APCC_ABBA_1	96	101	PF00400	0.573
LIG_APCC_ABBAyCdc20_2	95	101	PF00400	0.544
LIG_BIR_II_1	1	5	PF00653	0.675
LIG_BRCT_BRCA1_1	1	5	PF00533	0.593
LIG_BRCT_BRCA1_1	216	220	PF00533	0.720
LIG_CSL_BTD_1	123	126	PF09270	0.612
LIG_CSL_BTD_1	191	194	PF09270	0.612
LIG_EH_1	388	392	PF12763	0.545
LIG_eIF4E_1	254	260	PF01652	0.581
LIG_FHA_1	150	156	PF00498	0.545
LIG_FHA_1	276	282	PF00498	0.522
LIG_FHA_1	290	296	PF00498	0.304
LIG_FHA_1	373	379	PF00498	0.552
LIG_FHA_2	128	134	PF00498	0.734
LIG_FHA_2	174	180	PF00498	0.680
LIG_FHA_2	299	305	PF00498	0.476
LIG_FHA_2	453	459	PF00498	0.506
LIG_FHA_2	61	67	PF00498	0.765
LIG_Integrin_RGD_1	47	49	PF01839	0.693
LIG_LIR_Apic_2	97	102	PF02991	0.648
LIG_LIR_Gen_1	2	13	PF02991	0.558
LIG_LIR_Gen_1	252	262	PF02991	0.555
LIG_LIR_Nem_3	189	195	PF02991	0.512
LIG_LIR_Nem_3	2	8	PF02991	0.549
LIG_LIR_Nem_3	252	257	PF02991	0.512
LIG_MAD2	119	127	PF02301	0.616
LIG_MYND_1	367	371	PF01753	0.649
LIG_NRBOX	81	87	PF00104	0.567
LIG_PCNA_PIPBox_1	117	126	PF02747	0.612
LIG_Pex14_2	156	160	PF04695	0.536
LIG_Pex14_2	409	413	PF04695	0.560
LIG_Rb_pABgroove_1	297	305	PF01858	0.491
LIG_SH2_NCK_1	99	103	PF00017	0.656
LIG_SH2_SRC	421	424	PF00017	0.438
LIG_SH2_STAP1	318	322	PF00017	0.612
LIG_SH2_STAT3	318	321	PF00017	0.615
LIG_SH2_STAT5	20	23	PF00017	0.624
LIG_SH2_STAT5	421	424	PF00017	0.528
LIG_SH3_1	99	105	PF00018	0.669
LIG_SH3_2	368	373	PF14604	0.640
LIG_SH3_3	188	194	PF00018	0.622
LIG_SH3_3	277	283	PF00018	0.578
LIG_SH3_3	302	308	PF00018	0.535
LIG_SH3_3	362	368	PF00018	0.703
LIG_SH3_3	99	105	PF00018	0.640
LIG_SH3_4	482	489	PF00018	0.679
LIG_SUMO_SIM_par_1	246	252	PF11976	0.440
LIG_SUMO_SIM_par_1	291	296	PF11976	0.556
LIG_SUMO_SIM_par_1	309	316	PF11976	0.605
LIG_UBA3_1	446	452	PF00899	0.638
LIG_Vh1_VBS_1	412	430	PF01044	0.538
LIG_Vh1_VBS_1	449	467	PF01044	0.718
MOD_CDK_SPxxK_3	190	197	PF00069	0.531
MOD_CK1_1	149	155	PF00069	0.557
MOD_CK1_1	200	206	PF00069	0.679
MOD_CK1_1	211	217	PF00069	0.590
MOD_CK1_1	4	10	PF00069	0.525
MOD_CK1_1	425	431	PF00069	0.537
MOD_CK1_1	514	520	PF00069	0.610
MOD_CK2_1	162	168	PF00069	0.594
MOD_CK2_1	246	252	PF00069	0.518
MOD_CK2_1	310	316	PF00069	0.622
MOD_CK2_1	317	323	PF00069	0.591
MOD_CK2_1	338	344	PF00069	0.688
MOD_CK2_1	452	458	PF00069	0.503
MOD_CK2_1	60	66	PF00069	0.772
MOD_CK2_1	73	79	PF00069	0.692
MOD_GlcNHglycan	110	113	PF01048	0.535
MOD_GlcNHglycan	130	133	PF01048	0.411
MOD_GlcNHglycan	160	163	PF01048	0.622
MOD_GlcNHglycan	213	216	PF01048	0.643
MOD_GlcNHglycan	241	244	PF01048	0.641
MOD_GlcNHglycan	308	311	PF01048	0.573
MOD_GlcNHglycan	31	34	PF01048	0.613
MOD_GlcNHglycan	340	343	PF01048	0.782
MOD_GlcNHglycan	73	76	PF01048	0.675
MOD_GlcNHglycan	91	94	PF01048	0.593
MOD_GSK3_1	158	165	PF00069	0.500
MOD_GSK3_1	173	180	PF00069	0.704
MOD_GSK3_1	197	204	PF00069	0.584
MOD_GSK3_1	211	218	PF00069	0.587
MOD_GSK3_1	235	242	PF00069	0.611
MOD_GSK3_1	267	274	PF00069	0.500
MOD_GSK3_1	29	36	PF00069	0.582
MOD_GSK3_1	306	313	PF00069	0.613
MOD_GSK3_1	450	457	PF00069	0.669
MOD_GSK3_1	504	511	PF00069	0.629
MOD_GSK3_1	531	538	PF00069	0.524
MOD_GSK3_1	71	78	PF00069	0.756
MOD_GSK3_1	85	92	PF00069	0.521
MOD_GSK3_1	97	104	PF00069	0.506
MOD_LATS_1	450	456	PF00433	0.644
MOD_N-GLC_2	139	141	PF02516	0.578
MOD_NEK2_1	1	6	PF00069	0.568
MOD_NEK2_1	220	225	PF00069	0.651
MOD_NEK2_1	235	240	PF00069	0.589
MOD_NEK2_1	29	34	PF00069	0.551
MOD_NEK2_1	374	379	PF00069	0.576
MOD_NEK2_1	412	417	PF00069	0.498
MOD_NEK2_1	485	490	PF00069	0.674
MOD_NEK2_1	509	514	PF00069	0.698
MOD_NEK2_2	162	167	PF00069	0.483
MOD_NEK2_2	215	220	PF00069	0.663
MOD_NEK2_2	298	303	PF00069	0.437
MOD_NEK2_2	501	506	PF00069	0.660
MOD_PIKK_1	113	119	PF00454	0.536
MOD_PIKK_1	317	323	PF00454	0.591
MOD_PIKK_1	39	45	PF00454	0.691
MOD_PIKK_1	466	472	PF00454	0.725
MOD_PKA_1	173	179	PF00069	0.715
MOD_PKA_2	173	179	PF00069	0.790
MOD_PKA_2	22	28	PF00069	0.611
MOD_PKA_2	372	378	PF00069	0.537
MOD_PKA_2	507	513	PF00069	0.673
MOD_PKA_2	57	63	PF00069	0.756
MOD_PKA_2	94	100	PF00069	0.516
MOD_PKB_1	506	514	PF00069	0.621
MOD_Plk_2-3	454	460	PF00069	0.507
MOD_Plk_4	215	221	PF00069	0.685
MOD_Plk_4	289	295	PF00069	0.434
MOD_Plk_4	298	304	PF00069	0.394
MOD_Plk_4	414	420	PF00069	0.493
MOD_Plk_4	94	100	PF00069	0.575
MOD_ProDKin_1	101	107	PF00069	0.690
MOD_ProDKin_1	190	196	PF00069	0.600
MOD_ProDKin_1	350	356	PF00069	0.773
MOD_ProDKin_1	73	79	PF00069	0.696
MOD_SUMO_rev_2	484	491	PF00179	0.712
TRG_DiLeu_BaEn_4	458	464	PF01217	0.497
TRG_DiLeu_BaLyEn_6	255	260	PF01217	0.505
TRG_DiLeu_BaLyEn_6	365	370	PF01217	0.694
TRG_DiLeu_BaLyEn_6	442	447	PF01217	0.587
TRG_ENDOCYTIC_2	254	257	PF00928	0.571
TRG_ER_diArg_1	118	120	PF00400	0.544
TRG_ER_diArg_1	173	175	PF00400	0.758
TRG_ER_diArg_1	505	508	PF00400	0.588
TRG_NLS_MonoExtC_3	473	479	PF00514	0.752
TRG_Pf-PMV_PEXEL_1	182	187	PF00026	0.695

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II05	Leptomonas seymouri	56%	96%
A0A0S4JU63	Bodo saltans	26%	100%
A0A1X0NIV1	Trypanosomatidae	32%	100%
A0A3S7X8R0	Leishmania donovani	93%	100%
A4HM76	Leishmania braziliensis	77%	100%
A4IAT9	Leishmania infantum	93%	100%
D0A2B2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B5S7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BNA1	Trypanosoma cruzi	30%	100%