Thioredoxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

thioredoxin, putative

Species:

Leishmania major

UniProt:

E9AEL5_LEIMA

TriTrypDb:

LmjF.35.0380 , LMJLV39_350009100 , LMJSD75_350009000

Length:

616

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AEL5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEL5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.528
CLV_NRD_NRD_1	237	239	PF00675	0.493
CLV_NRD_NRD_1	255	257	PF00675	0.562
CLV_NRD_NRD_1	556	558	PF00675	0.275
CLV_PCSK_FUR_1	253	257	PF00082	0.607
CLV_PCSK_KEX2_1	16	18	PF00082	0.635
CLV_PCSK_KEX2_1	237	239	PF00082	0.667
CLV_PCSK_KEX2_1	255	257	PF00082	0.708
CLV_PCSK_KEX2_1	381	383	PF00082	0.394
CLV_PCSK_KEX2_1	556	558	PF00082	0.275
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.635
CLV_PCSK_PC1ET2_1	381	383	PF00082	0.394
CLV_PCSK_SKI1_1	13	17	PF00082	0.723
CLV_PCSK_SKI1_1	217	221	PF00082	0.385
CLV_PCSK_SKI1_1	437	441	PF00082	0.392
CLV_PCSK_SKI1_1	452	456	PF00082	0.306
CLV_PCSK_SKI1_1	482	486	PF00082	0.349
DEG_Nend_Nbox_1	1	3	PF02207	0.665
DEG_SCF_FBW7_1	122	129	PF00400	0.636
DEG_SPOP_SBC_1	300	304	PF00917	0.585
DOC_CKS1_1	416	421	PF01111	0.623
DOC_CKS1_1	54	59	PF01111	0.697
DOC_CYCLIN_yCln2_LP_2	285	291	PF00134	0.679
DOC_CYCLIN_yCln2_LP_2	385	391	PF00134	0.341
DOC_MAPK_gen_1	176	185	PF00069	0.478
DOC_MAPK_gen_1	381	387	PF00069	0.470
DOC_MAPK_gen_1	480	487	PF00069	0.393
DOC_MAPK_HePTP_8	183	195	PF00069	0.386
DOC_MAPK_MEF2A_6	176	185	PF00069	0.472
DOC_MAPK_MEF2A_6	186	195	PF00069	0.317
DOC_USP7_MATH_1	126	130	PF00917	0.624
DOC_USP7_MATH_1	23	27	PF00917	0.704
DOC_USP7_MATH_1	300	304	PF00917	0.685
DOC_USP7_MATH_1	312	316	PF00917	0.659
DOC_USP7_MATH_1	328	332	PF00917	0.385
DOC_USP7_MATH_1	360	364	PF00917	0.640
DOC_USP7_MATH_1	49	53	PF00917	0.625
DOC_USP7_MATH_1	563	567	PF00917	0.601
DOC_USP7_MATH_1	570	574	PF00917	0.585
DOC_USP7_MATH_1	80	84	PF00917	0.691
DOC_USP7_MATH_2	419	425	PF00917	0.452
DOC_WW_Pin1_4	106	111	PF00397	0.602
DOC_WW_Pin1_4	122	127	PF00397	0.638
DOC_WW_Pin1_4	19	24	PF00397	0.660
DOC_WW_Pin1_4	259	264	PF00397	0.616
DOC_WW_Pin1_4	415	420	PF00397	0.602
DOC_WW_Pin1_4	53	58	PF00397	0.636
DOC_WW_Pin1_4	62	67	PF00397	0.601
DOC_WW_Pin1_4	72	77	PF00397	0.591
LIG_14-3-3_CanoR_1	217	222	PF00244	0.479
LIG_14-3-3_CanoR_1	313	322	PF00244	0.569
LIG_14-3-3_CanoR_1	426	434	PF00244	0.480
LIG_14-3-3_CanoR_1	452	458	PF00244	0.424
LIG_APCC_ABBA_1	193	198	PF00400	0.464
LIG_CAP-Gly_1	613	616	PF01302	0.492
LIG_Clathr_ClatBox_1	194	198	PF01394	0.467
LIG_EVH1_1	403	407	PF00568	0.516
LIG_FHA_1	117	123	PF00498	0.745
LIG_FHA_1	132	138	PF00498	0.694
LIG_FHA_1	188	194	PF00498	0.367
LIG_FHA_1	208	214	PF00498	0.269
LIG_FHA_1	218	224	PF00498	0.451
LIG_FHA_1	300	306	PF00498	0.626
LIG_FHA_1	537	543	PF00498	0.300
LIG_FHA_1	583	589	PF00498	0.443
LIG_FHA_1	66	72	PF00498	0.657
LIG_FHA_2	269	275	PF00498	0.744
LIG_FHA_2	302	308	PF00498	0.582
LIG_FHA_2	416	422	PF00498	0.594
LIG_FHA_2	438	444	PF00498	0.358
LIG_FHA_2	5	11	PF00498	0.738
LIG_GBD_Chelix_1	514	522	PF00786	0.341
LIG_LIR_Apic_2	490	494	PF02991	0.276
LIG_LIR_Gen_1	458	469	PF02991	0.253
LIG_LIR_Gen_1	539	548	PF02991	0.333
LIG_LIR_Nem_3	449	454	PF02991	0.349
LIG_LIR_Nem_3	458	464	PF02991	0.365
LIG_LIR_Nem_3	530	534	PF02991	0.289
LIG_LIR_Nem_3	539	543	PF02991	0.303
LIG_MYND_1	384	388	PF01753	0.487
LIG_PDZ_Class_3	611	616	PF00595	0.479
LIG_Pex14_2	451	455	PF04695	0.371
LIG_Pex14_2	612	616	PF04695	0.485
LIG_SH2_NCK_1	231	235	PF00017	0.462
LIG_SH2_SRC	231	234	PF00017	0.388
LIG_SH2_STAP1	575	579	PF00017	0.418
LIG_SH2_STAT3	411	414	PF00017	0.623
LIG_SH2_STAT5	486	489	PF00017	0.276
LIG_SH2_STAT5	531	534	PF00017	0.393
LIG_SH3_3	140	146	PF00018	0.676
LIG_SH3_3	17	23	PF00018	0.684
LIG_SH3_3	401	407	PF00018	0.527
LIG_SH3_3	413	419	PF00018	0.617
LIG_SH3_5	227	231	PF00018	0.524
LIG_SH3_5	527	531	PF00018	0.393
LIG_SUMO_SIM_anti_2	189	195	PF11976	0.344
LIG_SUMO_SIM_par_1	290	296	PF11976	0.526
LIG_SUMO_SIM_par_1	350	356	PF11976	0.519
LIG_SUMO_SIM_par_1	432	438	PF11976	0.417
LIG_TRAF2_1	399	402	PF00917	0.457
LIG_TRAF2_1	578	581	PF00917	0.422
LIG_TRAF2_1	9	12	PF00917	0.777
LIG_UBA3_1	218	225	PF00899	0.254
LIG_WRC_WIRS_1	537	542	PF05994	0.276
LIG_WRC_WIRS_1	599	604	PF05994	0.395
MOD_CDK_SPxxK_3	106	113	PF00069	0.626
MOD_CK1_1	116	122	PF00069	0.652
MOD_CK1_1	129	135	PF00069	0.673
MOD_CK1_1	169	175	PF00069	0.582
MOD_CK1_1	201	207	PF00069	0.539
MOD_CK1_1	242	248	PF00069	0.540
MOD_CK1_1	259	265	PF00069	0.788
MOD_CK1_1	331	337	PF00069	0.435
MOD_CK1_1	36	42	PF00069	0.720
MOD_CK1_1	561	567	PF00069	0.513
MOD_CK1_1	604	610	PF00069	0.497
MOD_CK1_1	83	89	PF00069	0.739
MOD_CK2_1	272	278	PF00069	0.718
MOD_CK2_1	301	307	PF00069	0.582
MOD_CK2_1	4	10	PF00069	0.732
MOD_CK2_1	415	421	PF00069	0.604
MOD_CK2_1	581	587	PF00069	0.453
MOD_Cter_Amidation	379	382	PF01082	0.576
MOD_GlcNHglycan	114	118	PF01048	0.643
MOD_GlcNHglycan	128	131	PF01048	0.638
MOD_GlcNHglycan	173	176	PF01048	0.536
MOD_GlcNHglycan	23	26	PF01048	0.653
MOD_GlcNHglycan	241	244	PF01048	0.667
MOD_GlcNHglycan	316	319	PF01048	0.553
MOD_GlcNHglycan	333	336	PF01048	0.583
MOD_GlcNHglycan	427	430	PF01048	0.477
MOD_GlcNHglycan	51	54	PF01048	0.687
MOD_GlcNHglycan	560	563	PF01048	0.583
MOD_GlcNHglycan	565	568	PF01048	0.659
MOD_GSK3_1	116	123	PF00069	0.767
MOD_GSK3_1	131	138	PF00069	0.664
MOD_GSK3_1	152	159	PF00069	0.398
MOD_GSK3_1	162	169	PF00069	0.389
MOD_GSK3_1	19	26	PF00069	0.564
MOD_GSK3_1	197	204	PF00069	0.429
MOD_GSK3_1	2	9	PF00069	0.704
MOD_GSK3_1	207	214	PF00069	0.326
MOD_GSK3_1	239	246	PF00069	0.643
MOD_GSK3_1	268	275	PF00069	0.655
MOD_GSK3_1	338	345	PF00069	0.535
MOD_GSK3_1	421	428	PF00069	0.414
MOD_GSK3_1	460	467	PF00069	0.363
MOD_GSK3_1	474	481	PF00069	0.355
MOD_GSK3_1	49	56	PF00069	0.702
MOD_GSK3_1	510	517	PF00069	0.393
MOD_GSK3_1	557	564	PF00069	0.413
MOD_GSK3_1	597	604	PF00069	0.422
MOD_GSK3_1	72	79	PF00069	0.731
MOD_GSK3_1	83	90	PF00069	0.697
MOD_N-GLC_1	170	175	PF02516	0.526
MOD_N-GLC_1	239	244	PF02516	0.739
MOD_N-GLC_1	248	253	PF02516	0.471
MOD_N-GLC_1	81	86	PF02516	0.749
MOD_N-GLC_2	35	37	PF02516	0.597
MOD_NEK2_1	166	171	PF00069	0.468
MOD_NEK2_1	197	202	PF00069	0.394
MOD_NEK2_1	2	7	PF00069	0.651
MOD_NEK2_1	211	216	PF00069	0.274
MOD_NEK2_1	239	244	PF00069	0.709
MOD_NEK2_1	460	465	PF00069	0.305
MOD_NEK2_1	487	492	PF00069	0.297
MOD_NEK2_1	591	596	PF00069	0.440
MOD_NEK2_1	598	603	PF00069	0.391
MOD_NEK2_2	153	158	PF00069	0.362
MOD_NEK2_2	551	556	PF00069	0.275
MOD_PIKK_1	211	217	PF00454	0.448
MOD_PIKK_1	265	271	PF00454	0.701
MOD_PIKK_1	360	366	PF00454	0.576
MOD_PIKK_1	410	416	PF00454	0.624
MOD_PIKK_1	568	574	PF00454	0.467
MOD_PIKK_1	604	610	PF00454	0.437
MOD_PKA_2	120	126	PF00069	0.687
MOD_PKA_2	312	318	PF00069	0.648
MOD_PKA_2	425	431	PF00069	0.496
MOD_PKA_2	474	480	PF00069	0.480
MOD_PKA_2	86	92	PF00069	0.750
MOD_PKB_1	85	93	PF00069	0.672
MOD_Plk_1	11	17	PF00069	0.611
MOD_Plk_1	197	203	PF00069	0.497
MOD_Plk_1	211	217	PF00069	0.460
MOD_Plk_4	162	168	PF00069	0.408
MOD_Plk_4	187	193	PF00069	0.354
MOD_Plk_4	353	359	PF00069	0.453
MOD_Plk_4	446	452	PF00069	0.313
MOD_Plk_4	460	466	PF00069	0.314
MOD_Plk_4	510	516	PF00069	0.357
MOD_Plk_4	536	542	PF00069	0.276
MOD_Plk_4	598	604	PF00069	0.459
MOD_ProDKin_1	106	112	PF00069	0.601
MOD_ProDKin_1	122	128	PF00069	0.637
MOD_ProDKin_1	19	25	PF00069	0.660
MOD_ProDKin_1	259	265	PF00069	0.616
MOD_ProDKin_1	415	421	PF00069	0.601
MOD_ProDKin_1	53	59	PF00069	0.637
MOD_ProDKin_1	62	68	PF00069	0.602
MOD_ProDKin_1	72	78	PF00069	0.592
MOD_SUMO_for_1	532	535	PF00179	0.393
MOD_SUMO_rev_2	92	102	PF00179	0.600
TRG_DiLeu_BaEn_1	189	194	PF01217	0.459
TRG_DiLeu_BaEn_1	501	506	PF01217	0.319
TRG_DiLeu_BaLyEn_6	381	386	PF01217	0.537
TRG_ENDOCYTIC_2	529	532	PF00928	0.393
TRG_ENDOCYTIC_2	552	555	PF00928	0.393
TRG_ER_diArg_1	237	239	PF00400	0.506
TRG_ER_diArg_1	253	256	PF00400	0.582
TRG_ER_diArg_1	555	557	PF00400	0.275
TRG_NES_CRM1_1	342	355	PF08389	0.457
TRG_NES_CRM1_1	523	535	PF08389	0.300
TRG_NLS_MonoExtC_3	15	21	PF00514	0.617
TRG_NLS_MonoExtN_4	13	20	PF00514	0.659
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.398
TRG_Pf-PMV_PEXEL_1	577	581	PF00026	0.481

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA84	Leptomonas seymouri	57%	98%
A0A1X0NIY2	Trypanosomatidae	35%	100%
A0A3R7NI96	Trypanosoma rangeli	33%	100%
A0A3S7X8S7	Leishmania donovani	92%	100%
A4HM75	Leishmania braziliensis	78%	100%
A4IAT8	Leishmania infantum	93%	100%
E9B5S6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BSU4	Trypanosoma cruzi	33%	100%