Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AEL2_LEIMA

TriTrypDb:

LmjF.35.0350 , LMJLV39_350008800 , LMJSD75_350008700

Length:

703

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AEL2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEL2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	455	459	PF00656	0.706
CLV_NRD_NRD_1	258	260	PF00675	0.565
CLV_NRD_NRD_1	335	337	PF00675	0.350
CLV_NRD_NRD_1	650	652	PF00675	0.455
CLV_NRD_NRD_1	669	671	PF00675	0.430
CLV_PCSK_FUR_1	648	652	PF00082	0.473
CLV_PCSK_KEX2_1	149	151	PF00082	0.499
CLV_PCSK_KEX2_1	258	260	PF00082	0.621
CLV_PCSK_KEX2_1	335	337	PF00082	0.367
CLV_PCSK_KEX2_1	650	652	PF00082	0.457
CLV_PCSK_KEX2_1	669	671	PF00082	0.429
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.453
CLV_PCSK_PC1ET2_1	669	671	PF00082	0.429
CLV_PCSK_SKI1_1	118	122	PF00082	0.545
CLV_PCSK_SKI1_1	240	244	PF00082	0.321
CLV_PCSK_SKI1_1	296	300	PF00082	0.494
CLV_PCSK_SKI1_1	413	417	PF00082	0.455
CLV_PCSK_SKI1_1	558	562	PF00082	0.368
CLV_PCSK_SKI1_1	586	590	PF00082	0.442
DEG_APCC_DBOX_1	239	247	PF00400	0.331
DEG_APCC_DBOX_1	262	270	PF00400	0.341
DEG_MDM2_SWIB_1	627	635	PF02201	0.439
DOC_ANK_TNKS_1	155	162	PF00023	0.434
DOC_ANK_TNKS_1	287	294	PF00023	0.411
DOC_ANK_TNKS_1	604	611	PF00023	0.301
DOC_ANK_TNKS_1	649	656	PF00023	0.536
DOC_CYCLIN_RxL_1	115	123	PF00134	0.400
DOC_CYCLIN_yCln2_LP_2	74	80	PF00134	0.451
DOC_CYCLIN_yCln2_LP_2	98	104	PF00134	0.467
DOC_MAPK_FxFP_2	551	554	PF00069	0.314
DOC_MAPK_gen_1	258	266	PF00069	0.408
DOC_MAPK_gen_1	479	488	PF00069	0.530
DOC_MAPK_gen_1	669	681	PF00069	0.353
DOC_MAPK_MEF2A_6	258	266	PF00069	0.408
DOC_MAPK_MEF2A_6	629	637	PF00069	0.306
DOC_MAPK_MEF2A_6	674	681	PF00069	0.323
DOC_MAPK_NFAT4_5	259	267	PF00069	0.385
DOC_PP2B_LxvP_1	181	184	PF13499	0.496
DOC_PP2B_LxvP_1	74	77	PF13499	0.502
DOC_PP2B_LxvP_1	98	101	PF13499	0.456
DOC_PP4_FxxP_1	235	238	PF00568	0.430
DOC_PP4_FxxP_1	551	554	PF00568	0.321
DOC_USP7_MATH_1	109	113	PF00917	0.462
DOC_USP7_MATH_1	176	180	PF00917	0.738
DOC_USP7_MATH_1	188	192	PF00917	0.589
DOC_USP7_MATH_1	516	520	PF00917	0.646
DOC_USP7_MATH_1	653	657	PF00917	0.417
DOC_WW_Pin1_4	105	110	PF00397	0.386
DOC_WW_Pin1_4	113	118	PF00397	0.431
LIG_14-3-3_CanoR_1	261	267	PF00244	0.469
LIG_14-3-3_CanoR_1	448	453	PF00244	0.593
LIG_14-3-3_CanoR_1	9	17	PF00244	0.371
LIG_Actin_WH2_2	250	265	PF00022	0.429
LIG_Actin_WH2_2	674	689	PF00022	0.397
LIG_AP2alpha_1	588	592	PF02296	0.346
LIG_APCC_ABBA_1	677	682	PF00400	0.304
LIG_BIR_II_1	1	5	PF00653	0.389
LIG_BRCT_BRCA1_1	111	115	PF00533	0.459
LIG_BRCT_BRCA1_1	309	313	PF00533	0.404
LIG_BRCT_BRCA1_1	535	539	PF00533	0.340
LIG_CaM_IQ_9	148	164	PF13499	0.490
LIG_Clathr_ClatBox_1	33	37	PF01394	0.299
LIG_deltaCOP1_diTrp_1	363	368	PF00928	0.417
LIG_FHA_1	114	120	PF00498	0.589
LIG_FHA_1	170	176	PF00498	0.681
LIG_FHA_1	354	360	PF00498	0.425
LIG_FHA_1	526	532	PF00498	0.339
LIG_FHA_1	545	551	PF00498	0.340
LIG_FHA_1	567	573	PF00498	0.375
LIG_FHA_1	695	701	PF00498	0.369
LIG_FHA_2	222	228	PF00498	0.594
LIG_FHA_2	378	384	PF00498	0.657
LIG_FHA_2	385	391	PF00498	0.529
LIG_FHA_2	623	629	PF00498	0.321
LIG_FHA_2	82	88	PF00498	0.636
LIG_HP1_1	117	121	PF01393	0.412
LIG_IBAR_NPY_1	612	614	PF08397	0.449
LIG_LIR_Apic_2	549	554	PF02991	0.319
LIG_LIR_Gen_1	133	139	PF02991	0.443
LIG_LIR_Gen_1	200	209	PF02991	0.461
LIG_LIR_Gen_1	363	373	PF02991	0.469
LIG_LIR_Gen_1	484	491	PF02991	0.484
LIG_LIR_Gen_1	49	58	PF02991	0.441
LIG_LIR_Gen_1	587	595	PF02991	0.427
LIG_LIR_Nem_3	127	132	PF02991	0.405
LIG_LIR_Nem_3	200	205	PF02991	0.451
LIG_LIR_Nem_3	363	368	PF02991	0.384
LIG_LIR_Nem_3	447	452	PF02991	0.430
LIG_LIR_Nem_3	484	488	PF02991	0.507
LIG_LIR_Nem_3	49	54	PF02991	0.435
LIG_LIR_Nem_3	555	560	PF02991	0.464
LIG_LIR_Nem_3	587	591	PF02991	0.433
LIG_LIR_Nem_3	96	102	PF02991	0.478
LIG_LYPXL_yS_3	553	556	PF13949	0.353
LIG_MYND_1	207	211	PF01753	0.394
LIG_PAM2_1	120	132	PF00658	0.388
LIG_PCNA_yPIPBox_3	685	698	PF02747	0.463
LIG_Pex14_1	193	197	PF04695	0.399
LIG_Pex14_1	231	235	PF04695	0.451
LIG_Pex14_2	198	202	PF04695	0.408
LIG_Pex14_2	588	592	PF04695	0.346
LIG_Pex14_2	627	631	PF04695	0.312
LIG_Pex14_2	692	696	PF04695	0.309
LIG_REV1ctd_RIR_1	152	160	PF16727	0.471
LIG_SH2_NCK_1	431	435	PF00017	0.474
LIG_SH2_NCK_1	453	457	PF00017	0.574
LIG_SH2_PTP2	614	617	PF00017	0.472
LIG_SH2_STAP1	134	138	PF00017	0.266
LIG_SH2_STAP1	431	435	PF00017	0.474
LIG_SH2_STAT3	58	61	PF00017	0.503
LIG_SH2_STAT5	197	200	PF00017	0.373
LIG_SH2_STAT5	485	488	PF00017	0.478
LIG_SH2_STAT5	51	54	PF00017	0.328
LIG_SH2_STAT5	603	606	PF00017	0.306
LIG_SH2_STAT5	614	617	PF00017	0.340
LIG_SH2_STAT5	65	68	PF00017	0.418
LIG_SH3_3	116	122	PF00018	0.357
LIG_SH3_3	180	186	PF00018	0.631
LIG_SH3_3	397	403	PF00018	0.360
LIG_SH3_3	493	499	PF00018	0.652
LIG_SH3_3	660	666	PF00018	0.387
LIG_SH3_3	98	104	PF00018	0.467
LIG_SUMO_SIM_anti_2	484	490	PF11976	0.508
LIG_SUMO_SIM_par_1	31	37	PF11976	0.316
LIG_UBA3_1	208	216	PF00899	0.465
LIG_UBA3_1	98	103	PF00899	0.418
LIG_WRC_WIRS_1	121	126	PF05994	0.574
LIG_WW_3	237	241	PF00397	0.467
MOD_CDK_SPK_2	113	118	PF00069	0.459
MOD_CK1_1	191	197	PF00069	0.533
MOD_CK1_1	454	460	PF00069	0.619
MOD_CK1_1	519	525	PF00069	0.612
MOD_CK1_1	542	548	PF00069	0.463
MOD_CK1_1	622	628	PF00069	0.325
MOD_CK1_1	656	662	PF00069	0.431
MOD_CK1_1	90	96	PF00069	0.638
MOD_CK2_1	212	218	PF00069	0.491
MOD_CK2_1	221	227	PF00069	0.595
MOD_CK2_1	384	390	PF00069	0.518
MOD_CK2_1	622	628	PF00069	0.325
MOD_GlcNHglycan	1	4	PF01048	0.404
MOD_GlcNHglycan	109	112	PF01048	0.447
MOD_GlcNHglycan	12	15	PF01048	0.298
MOD_GlcNHglycan	336	339	PF01048	0.432
MOD_GlcNHglycan	369	372	PF01048	0.478
MOD_GlcNHglycan	377	380	PF01048	0.520
MOD_GlcNHglycan	513	516	PF01048	0.628
MOD_GlcNHglycan	544	547	PF01048	0.463
MOD_GSK3_1	105	112	PF00069	0.413
MOD_GSK3_1	184	191	PF00069	0.711
MOD_GSK3_1	303	310	PF00069	0.460
MOD_GSK3_1	330	337	PF00069	0.452
MOD_GSK3_1	363	370	PF00069	0.440
MOD_GSK3_1	507	514	PF00069	0.626
MOD_GSK3_1	521	528	PF00069	0.440
MOD_GSK3_1	535	542	PF00069	0.356
MOD_GSK3_1	65	72	PF00069	0.532
MOD_N-GLC_2	374	376	PF02516	0.577
MOD_NEK2_1	1	6	PF00069	0.447
MOD_NEK2_1	132	137	PF00069	0.439
MOD_NEK2_1	16	21	PF00069	0.239
MOD_NEK2_1	212	217	PF00069	0.521
MOD_NEK2_1	262	267	PF00069	0.456
MOD_NEK2_1	425	430	PF00069	0.380
MOD_NEK2_1	539	544	PF00069	0.325
MOD_NEK2_2	177	182	PF00069	0.668
MOD_PIKK_1	280	286	PF00454	0.427
MOD_PIKK_1	539	545	PF00454	0.460
MOD_PKA_1	558	564	PF00069	0.400
MOD_PKA_2	262	268	PF00069	0.462
MOD_PKA_2	334	340	PF00069	0.496
MOD_PKA_2	87	93	PF00069	0.604
MOD_PKB_1	446	454	PF00069	0.541
MOD_Plk_1	177	183	PF00069	0.613
MOD_Plk_1	539	545	PF00069	0.460
MOD_Plk_1	622	628	PF00069	0.325
MOD_Plk_2-3	384	390	PF00069	0.457
MOD_Plk_2-3	460	466	PF00069	0.744
MOD_Plk_4	132	138	PF00069	0.388
MOD_Plk_4	188	194	PF00069	0.665
MOD_Plk_4	262	268	PF00069	0.462
MOD_Plk_4	69	75	PF00069	0.528
MOD_ProDKin_1	105	111	PF00069	0.381
MOD_ProDKin_1	113	119	PF00069	0.435
MOD_SUMO_for_1	198	201	PF00179	0.364
TRG_DiLeu_BaEn_4	200	206	PF01217	0.478
TRG_DiLeu_BaLyEn_6	204	209	PF01217	0.398
TRG_DiLeu_BaLyEn_6	400	405	PF01217	0.428
TRG_ENDOCYTIC_2	134	137	PF00928	0.322
TRG_ENDOCYTIC_2	485	488	PF00928	0.478
TRG_ENDOCYTIC_2	51	54	PF00928	0.441
TRG_ENDOCYTIC_2	553	556	PF00928	0.353
TRG_ER_diArg_1	257	259	PF00400	0.480
TRG_ER_diArg_1	260	263	PF00400	0.391
TRG_ER_diArg_1	334	336	PF00400	0.449
TRG_NLS_MonoExtN_4	666	673	PF00514	0.387

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HV24	Leptomonas seymouri	62%	95%
A0A1X0NJK7	Trypanosomatidae	41%	91%
A0A3Q8IHZ3	Leishmania donovani	92%	100%
A0A3R7L3P1	Trypanosoma rangeli	47%	100%
A4HM73	Leishmania braziliensis	82%	100%
A4IAT6	Leishmania infantum	93%	100%
D0A2C2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9B5S3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BSU8	Trypanosoma cruzi	45%	100%