Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AEL1_LEIMA

TriTrypDb:

LmjF.35.0340 , LMJLV39_350008700 , LMJSD75_350008600

Length:

497

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9AEL1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AEL1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.577
CLV_MEL_PAP_1	311	317	PF00089	0.558
CLV_NRD_NRD_1	37	39	PF00675	0.584
CLV_NRD_NRD_1	471	473	PF00675	0.415
CLV_NRD_NRD_1	97	99	PF00675	0.637
CLV_PCSK_FUR_1	35	39	PF00082	0.598
CLV_PCSK_KEX2_1	368	370	PF00082	0.519
CLV_PCSK_KEX2_1	37	39	PF00082	0.581
CLV_PCSK_KEX2_1	418	420	PF00082	0.515
CLV_PCSK_KEX2_1	471	473	PF00082	0.402
CLV_PCSK_KEX2_1	97	99	PF00082	0.596
CLV_PCSK_PC1ET2_1	368	370	PF00082	0.596
CLV_PCSK_PC1ET2_1	418	420	PF00082	0.490
CLV_PCSK_PC7_1	467	473	PF00082	0.407
CLV_PCSK_SKI1_1	130	134	PF00082	0.746
CLV_PCSK_SKI1_1	180	184	PF00082	0.620
CLV_PCSK_SKI1_1	222	226	PF00082	0.340
CLV_PCSK_SKI1_1	285	289	PF00082	0.605
CLV_PCSK_SKI1_1	467	471	PF00082	0.493
DEG_APCC_DBOX_1	263	271	PF00400	0.463
DOC_ANK_TNKS_1	183	190	PF00023	0.635
DOC_CDC14_PxL_1	215	223	PF14671	0.373
DOC_CDC14_PxL_1	5	13	PF14671	0.705
DOC_CKS1_1	356	361	PF01111	0.662
DOC_CYCLIN_RxL_1	368	379	PF00134	0.543
DOC_CYCLIN_yCln2_LP_2	229	235	PF00134	0.462
DOC_MAPK_gen_1	261	270	PF00069	0.434
DOC_MAPK_gen_1	35	43	PF00069	0.545
DOC_MAPK_gen_1	368	378	PF00069	0.421
DOC_MAPK_gen_1	62	70	PF00069	0.529
DOC_MAPK_MEF2A_6	368	377	PF00069	0.430
DOC_MAPK_MEF2A_6	84	92	PF00069	0.618
DOC_PP1_RVXF_1	465	471	PF00149	0.473
DOC_PP2B_LxvP_1	216	219	PF13499	0.379
DOC_PP2B_LxvP_1	229	232	PF13499	0.331
DOC_PP4_FxxP_1	411	414	PF00568	0.382
DOC_PP4_FxxP_1	6	9	PF00568	0.623
DOC_PP4_FxxP_1	73	76	PF00568	0.410
DOC_USP7_MATH_1	132	136	PF00917	0.680
DOC_USP7_MATH_1	139	143	PF00917	0.636
DOC_USP7_MATH_1	151	155	PF00917	0.421
DOC_USP7_MATH_1	176	180	PF00917	0.704
DOC_USP7_MATH_1	208	212	PF00917	0.431
DOC_USP7_MATH_1	389	393	PF00917	0.409
DOC_USP7_MATH_1	439	443	PF00917	0.539
DOC_USP7_MATH_1	452	456	PF00917	0.575
DOC_WW_Pin1_4	345	350	PF00397	0.580
DOC_WW_Pin1_4	355	360	PF00397	0.461
DOC_WW_Pin1_4	401	406	PF00397	0.435
LIG_14-3-3_CanoR_1	201	207	PF00244	0.536
LIG_14-3-3_CanoR_1	222	232	PF00244	0.357
LIG_AP2alpha_1	377	381	PF02296	0.372
LIG_BRCT_BRCA1_1	391	395	PF00533	0.382
LIG_BRCT_BRCA1_1	99	103	PF00533	0.679
LIG_Clathr_ClatBox_1	267	271	PF01394	0.442
LIG_Clathr_ClatBox_1	375	379	PF01394	0.438
LIG_eIF4E_1	156	162	PF01652	0.307
LIG_FHA_1	105	111	PF00498	0.652
LIG_FHA_1	139	145	PF00498	0.624
LIG_FHA_1	21	27	PF00498	0.520
LIG_FHA_1	288	294	PF00498	0.590
LIG_FHA_2	117	123	PF00498	0.679
LIG_FHA_2	165	171	PF00498	0.559
LIG_FHA_2	389	395	PF00498	0.505
LIG_LIR_Apic_2	3	9	PF02991	0.650
LIG_LIR_Apic_2	477	483	PF02991	0.521
LIG_LIR_Apic_2	72	76	PF02991	0.404
LIG_LIR_Gen_1	153	163	PF02991	0.410
LIG_LIR_Gen_1	226	235	PF02991	0.406
LIG_LIR_Gen_1	374	382	PF02991	0.378
LIG_LIR_Gen_1	392	403	PF02991	0.390
LIG_LIR_Nem_3	153	159	PF02991	0.502
LIG_LIR_Nem_3	226	231	PF02991	0.376
LIG_LIR_Nem_3	3	8	PF02991	0.624
LIG_LIR_Nem_3	374	380	PF02991	0.364
LIG_LIR_Nem_3	392	398	PF02991	0.398
LIG_LIR_Nem_3	72	77	PF02991	0.470
LIG_PCNA_yPIPBox_3	276	288	PF02747	0.541
LIG_Pex14_2	224	228	PF04695	0.416
LIG_Pex14_2	377	381	PF04695	0.372
LIG_Pex14_2	99	103	PF04695	0.491
LIG_REV1ctd_RIR_1	3	8	PF16727	0.585
LIG_SH2_CRK	156	160	PF00017	0.505
LIG_SH2_CRK	434	438	PF00017	0.480
LIG_SH2_CRK	480	484	PF00017	0.475
LIG_SH2_NCK_1	484	488	PF00017	0.420
LIG_SH2_PTP2	74	77	PF00017	0.504
LIG_SH2_SRC	74	77	PF00017	0.533
LIG_SH2_STAP1	156	160	PF00017	0.505
LIG_SH2_STAT5	215	218	PF00017	0.363
LIG_SH2_STAT5	220	223	PF00017	0.341
LIG_SH2_STAT5	257	260	PF00017	0.445
LIG_SH2_STAT5	303	306	PF00017	0.448
LIG_SH2_STAT5	310	313	PF00017	0.446
LIG_SH2_STAT5	4	7	PF00017	0.582
LIG_SH2_STAT5	74	77	PF00017	0.431
LIG_SH3_3	157	163	PF00018	0.504
LIG_SUMO_SIM_par_1	158	165	PF11976	0.494
LIG_SUMO_SIM_par_1	22	28	PF11976	0.611
LIG_SUMO_SIM_par_1	266	271	PF11976	0.440
LIG_TRFH_1	228	232	PF08558	0.368
LIG_WRC_WIRS_1	70	75	PF05994	0.512
MOD_CK1_1	104	110	PF00069	0.590
MOD_CK1_1	112	118	PF00069	0.615
MOD_CK1_1	165	171	PF00069	0.577
MOD_CK1_1	330	336	PF00069	0.669
MOD_CK2_1	388	394	PF00069	0.545
MOD_CK2_1	438	444	PF00069	0.543
MOD_CMANNOS	494	497	PF00535	0.454
MOD_GlcNHglycan	111	114	PF01048	0.668
MOD_GlcNHglycan	167	170	PF01048	0.596
MOD_GlcNHglycan	171	174	PF01048	0.633
MOD_GlcNHglycan	225	228	PF01048	0.355
MOD_GlcNHglycan	27	30	PF01048	0.558
MOD_GlcNHglycan	329	332	PF01048	0.690
MOD_GlcNHglycan	335	338	PF01048	0.694
MOD_GlcNHglycan	340	343	PF01048	0.601
MOD_GlcNHglycan	365	368	PF01048	0.598
MOD_GlcNHglycan	45	48	PF01048	0.327
MOD_GlcNHglycan	454	457	PF01048	0.617
MOD_GlcNHglycan	475	479	PF01048	0.546
MOD_GlcNHglycan	53	57	PF01048	0.484
MOD_GlcNHglycan	99	102	PF01048	0.663
MOD_GSK3_1	109	116	PF00069	0.593
MOD_GSK3_1	161	168	PF00069	0.502
MOD_GSK3_1	381	388	PF00069	0.551
MOD_GSK3_1	97	104	PF00069	0.615
MOD_N-GLC_1	104	109	PF02516	0.616
MOD_N-GLC_1	113	118	PF02516	0.637
MOD_N-GLC_1	139	144	PF02516	0.637
MOD_NEK2_1	287	292	PF00069	0.586
MOD_NEK2_1	33	38	PF00069	0.603
MOD_NEK2_2	14	19	PF00069	0.610
MOD_PIKK_1	200	206	PF00454	0.545
MOD_PIKK_1	233	239	PF00454	0.471
MOD_PKA_1	97	103	PF00069	0.606
MOD_PKA_2	165	171	PF00069	0.692
MOD_PKA_2	200	206	PF00069	0.543
MOD_PKA_2	362	368	PF00069	0.687
MOD_PKA_2	399	405	PF00069	0.517
MOD_PKA_2	97	103	PF00069	0.653
MOD_Plk_1	139	145	PF00069	0.595
MOD_Plk_4	139	145	PF00069	0.577
MOD_Plk_4	14	20	PF00069	0.658
MOD_Plk_4	88	94	PF00069	0.641
MOD_ProDKin_1	345	351	PF00069	0.571
MOD_ProDKin_1	355	361	PF00069	0.462
MOD_ProDKin_1	401	407	PF00069	0.431
MOD_SUMO_for_1	50	53	PF00179	0.580
TRG_DiLeu_BaLyEn_6	464	469	PF01217	0.472
TRG_ENDOCYTIC_2	156	159	PF00928	0.382
TRG_ENDOCYTIC_2	220	223	PF00928	0.381
TRG_ENDOCYTIC_2	74	77	PF00928	0.453
TRG_ER_diArg_1	34	37	PF00400	0.521
TRG_ER_diArg_1	470	472	PF00400	0.411
TRG_ER_diArg_1	96	98	PF00400	0.630
TRG_NES_CRM1_1	372	385	PF08389	0.513
TRG_Pf-PMV_PEXEL_1	180	185	PF00026	0.564

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3M2	Leptomonas seymouri	59%	95%
A0A0S4JN24	Bodo saltans	34%	100%
A0A1X0NKI9	Trypanosomatidae	41%	100%
A0A3Q8ILR1	Leishmania donovani	95%	100%
A0A3R7NSD3	Trypanosoma rangeli	44%	100%
A4HM72	Leishmania braziliensis	80%	100%
A4IAT5	Leishmania infantum	95%	100%
D0A2C3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	96%
E9B5S2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BIP8	Trypanosoma cruzi	41%	100%